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Preparation of MXene-based hybrids and their application in neuromorphic devices

International Journal of Extreme Manufacturing 2024年第2期6卷 164-188页

作者： Zhuohao xiao xiaodong xiao Ling Bing Kong Hongbo Dong Xiuying Li Bin He Shuangchen Ruan Jianpang Zhai Kun Zhou Qin Huang Liang Chu School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403JiangxiPeople’s Republic of China School of Mechanical and Vehicle Engineering Linyi UniversityLinyi 276000ShandongPeople’s Republic of China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118GuangdongPeople’s Republic of China School of Mechanical&Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Ningbo Institute of Materials Engineering and Technology Chinese Academy of ScienceNingbo 315201ZhejiangPeople’s Republic of China Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018ZhejiangPeople’s Republic of China

The traditional von Neumann computing architecture has relatively-low information processing speed and high power consumption,making it difficult to meet the computing needs of artificial intelligence(AI).Neuromorphic computing systems,with massively parallel computing capability and low power consumption,have been considered as an ideal option for data storage and AI computing in the ***,as the fourth basic electronic component besides resistance,capacitance and inductance,is one of the most competitive candidates for neuromorphic computing systems benefiting from the simple structure,continuously adjustable conductivity state,ultra-low power consumption,high switching speed and compatibility with existing CMOS *** memristors with applying MXene-based hybrids have attracted significant attention in recent ***,we introduce the latest progress in the synthesis of MXene-based hybrids and summarize their potential applications in memristor devices and neuromorphological *** explore the development trend of memristors constructed by combining MXenes with other functional materials and emphatically discuss the potential mechanism of MXenes-based memristor ***,the future prospects and directions of MXene-based memristors are briefly described.

关键词： MXene etching fabrication memristor neuromorphic

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Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes

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Genes & Diseases 2024年第4期11卷 134-137页

作者： Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang xiaodong xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Jecho Laboratories Inc.FrederickMD 21704USA Jecho Institute Co. Ltd.Shanghai 200240China

The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic *** and recent studies indicate that monoclonal antibodies can be efficacious in preventing and treating SARSCoV-1 and SARS-CoV-2 *** a phage display platform,we have identified dozens of monoclonal antibodies that bind to diverse epitope groups on the SARS-CoV-2 spike *** of them bound to the receptor binding domain(RBD)and inhibited ACE2-RBD interaction.

关键词： antibodies inhibited monoclonal

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加热速率对中心直裂纹巴西圆盘试样断裂行为影响规律研究

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矿业科学学报 2024年第4期9卷 586-596页

作者：肖晓冬周磊梁贤梁王骞李尧王浩涵四川大学建筑与环境学院深地工程智能建造与健康运维全国重点实验室四川成都610065

为了研究不同加热速率处理后花岗岩的断裂特性与损伤机理,对中心直裂纹巴西圆盘(CSTBD)试样在4组加热温度下分别进行4种加热速率的高温处理,冷却至室温后使用电液伺服压力机进行巴西劈裂实验,分析其静力学断裂过程。结果表明:(1)经过不... 详细信息

为了研究不同加热速率处理后花岗岩的断裂特性与损伤机理,对中心直裂纹巴西圆盘(CSTBD)试样在4组加热温度下分别进行4种加热速率的高温处理,冷却至室温后使用电液伺服压力机进行巴西劈裂实验,分析其静力学断裂过程。结果表明:(1)经过不同高温处理的花岗岩,从脆性破坏向延性破坏转变。(2)在同一目标温度下,经不同加热速率处理的花岗岩,峰值破坏载荷随着加热速率的增大而降低。表观颜色无明显区别,而表观裂缝逐渐增多。(3)不同加热速率下,200℃和400℃下的纵波波速和弹性模量变化较小,而600℃以上时,随着加热速率的增大,纵波波速和弹性模量显著降低。(4)花岗岩的断裂韧度随着温度升高呈现逐渐衰减特征,同一温度下花岗岩试样的I型断裂韧度值随加热速率的增大而减小,400℃下加热速率对花岗岩断裂韧度的影响最大。

关键词：加热速率裂隙岩体破坏峰值强度纵波波速断裂韧度

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分析肿痛安胶囊联合西地碘含片对老年糖尿病性牙龈炎患者的临床疗效

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中外医疗 2024年第8期43卷 97-99,133页

作者：冯莉肖晓东杨芳辉福建省明溪县总医院口腔科福建三明365299

目的评估老年糖尿病性牙龈炎患者中实施肿痛安胶囊与西地碘含片联合治疗的临床效果。方法随机选取2021年11月—2022年11月福建省明溪县总医院口腔科收治的70例老年糖尿病性牙龈炎患者为研究对象,按照随机数表法分为研究组和常规组,各35... 详细信息

目的评估老年糖尿病性牙龈炎患者中实施肿痛安胶囊与西地碘含片联合治疗的临床效果。方法随机选取2021年11月—2022年11月福建省明溪县总医院口腔科收治的70例老年糖尿病性牙龈炎患者为研究对象,按照随机数表法分为研究组和常规组,各35例。常规组采用西地碘含片治疗,研究组采用肿痛安胶囊与西地碘含片联合治疗。比较两组治疗前后临床指标、症状评分、龈沟液炎性因子指标。结果治疗前,两组临床指标、症状评分、龈沟液炎性因子指标比较,差异无统计学意义(P均>0.05)。治疗后,研究组牙龈指数、菌斑指数、出血指数等临床指标评分均低于常规组,差异有统计学意义(t=4.462、6.358、4.300,P均<0.05)。治疗后,研究组的症状评分、龈沟液炎性因子指标均优于常规组,差异有统计学意义(P均<0.05)。结论对于老年糖尿病性牙龈炎患者,肿痛安胶囊与西地碘含片联合治疗的效果确切。

关键词：老年患者糖尿病性牙龈炎肿痛安胶囊西地碘含片

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基于离散元法三裂纹岩石裂纹扩展特征的试验与数值研究

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矿业安全与环保 2024年第3期51卷 107-115页

作者：祁敬茗张红丹周磊陈剑星马雷钧肖晓冬四川大学建筑与环境学院四川成都610065 深地工程智能建造与健康运维全国重点实验室四川成都610065

为研究三裂纹岩石的静力学破坏特征,采用离散元数值模拟软件PFC2D和模型试验方法,分析三裂纹岩石的峰值应力、应力—应变曲线及裂纹扩展特性,验证离散元数值模拟方法的可行性。通过改变岩石的水平围压和裂纹长度,分析单轴压缩载荷作用... 详细信息

为研究三裂纹岩石的静力学破坏特征,采用离散元数值模拟软件PFC2D和模型试验方法,分析三裂纹岩石的峰值应力、应力—应变曲线及裂纹扩展特性,验证离散元数值模拟方法的可行性。通过改变岩石的水平围压和裂纹长度,分析单轴压缩载荷作用下三裂纹岩石的力学响应机制。研究结果表明:中间横向裂纹对裂纹岩石的峰值应力影响较大,中间竖向裂纹对裂纹岩石的峰值应力影响较小;加载过程中裂纹尖端最先出现应力集中现象,最后形成2条约70°的主裂纹贯通3条预制裂纹;随着围压的增大,三裂纹岩石的峰值应力先增大后减小;随着裂纹长度的增加,三裂纹岩石的峰值应力不断减小。

关键词：三裂纹岩石裂纹扩展数值模拟离散元法裂纹倾角预应力裂纹长度峰值应力

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MXenes and MXene-based composites for energy conversion and storage applications

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Journal of Materiomics 2023年第6期9卷 1067-1112页

作者： Zhuohao xiao xiaodong xiao Ling Bing Kong Hongbo Dong Xiuying Li Xinyuan Sun Bin He Shuangchen Ruan Jianpang Zhai School of Mechanical and Vehicle Engineering Linyi UniversityLinyi276000ShandongChina School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen333403JiangxiChina College of New Materials and New Energies Shenzhen Technology UniversityShenzhen518118GuangdongChina Department of Physics Jinggangshan UniversityJi'an343009JiangxiChina

MXenes have received extensive attention from scholars due to their unique layered structure,significant electrical conductivity,and excellent mechanical *** addition to their pristine forms,they could also be incorporated with other components for attaining hybrids and nanocomposites,accompanying with amplified *** has been widely used in lithium batteries,supercapacitors,electromagnetic shielding,tumor therapy,biosensors,photocatalysis,and other fields,and has shown great application potential in energy conversion and *** purpose of this article is to encyclopaedically overview the latest progress in synthesis and characterization of MXenes,while their potential applications in energy conversation such as water splitting and solar cells,as well as in energy storage such as Li-ion batteries,supercapacitors,and hydrogen energy will be comprehensively *** opportunities and challenges are summarized.

关键词： MXenes 2D materials Materials characterization Energy converstion Energy storage

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A Degradable Quaternary Ammonium-Based Pesticide Safe for Humans

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CCS Chemistry 2024年第6期6卷 1499-1511页

作者： Wenwen Han xiao-Qi Xu xiaodong Lian Yanji Chu Yapei Wang Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of ChemistryRenmin University of ChinaBeijing 100872

Reducing the emission of agrochemicals hazardous to the environment and human health is one of the key targets of the UN’s Sustainable Development Goal ***,we report a kind of quaternary ammonium pesticides with an acid-cleavable silaketal linkage on their backbones that enables control of *** pesticides possess outstanding bactericidal and insecticidal properties but become harmless to humans and other organisms after *** on the conditions of use,the hydrolytic process can be controlled over the time range of 10 min to 3 *** laboratory simulations and agricultural field demonstrations confirm that these pesticides can effectively protect crops from bacterial diseases and *** the sametime,single-dose intragastric administration using diisopropylsilyloxy bisquaternary ammonium salt 9(ISBQAS-9)in mice demonstrates its safety for multiple *** to the advantages of controllable degradability,environmental friendliness,and the low financial cost of these pesticides,this welldesigned strategy holds great promise for the generation of environmentally harmless pesticides and the development of green agriculture.

关键词： antimicrobial materials degradable pesticides insecticidal materials quaternary ammonium surfactants stimulus-cleavable chemistry

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Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

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Cancer Biology & Medicine 2024年第4期21卷 331-346页

作者： Shuangcheng Li Tianci Wang Xinghui xiao xiaodong Zheng Haoyu Sun Rui Sun Hongdi Ma Zhigang Tian xiaohu Zheng Hefei National Research Center for Physical Sciences at Microscale The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Institute of Immunology University of Science and Technology of ChinaHefei 230027China Hefei TG ImmunoPharma Corporation Limited Hefei 230601China Research Unit of NK Cell Study Chinese Academy of Medical SciencesBeijing 100864China Key Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(NK) cells targeting hematologic malignancies(HMs).Methods: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine(PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings. Furthermore, we explored the association between CD300A and HM progression in ***: Our findings indicated that PS hampers the function of NK cells. Increased CD300A expression inhibited HM lysis by NK cells. CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells. Blocking PS–CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells, thereby augmenting the ability to lyse HMs. Clinically, heightened CD300A expression correlated with shorter survival and an “exhausted” phenotype of intratumoral NK cells in patients with HMs or solid ***: These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.

关键词： NK cell CD300A phosphatidylserine immune checkpoint hematologic malignancy

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Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1928-1942页

作者： Zhidi Pan Jie Chen xiaodong xiao Yueqing Xie Hua Jiang Baohong Zhang Huili Lu Yunsheng Yuan Lei Han Yuexian Zhou Huifang Zong Lei Wang Rui Sun Jianwei Zhu Engineering Research Center of Cell&Therapeutic Antibody MOESchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Jecho Laboratories Inc.FrederickMD 21704USA Jecho Biopharmaceuticals Co. Ltd.Tianjin 300467China

T cell engaging bispecific antibody(TCB)is an effective immunotherapy for cancer *** co-targeting CD3 and tumor-associated antigen(TAA),TCB can redirect CD3+T cells to eliminate tumor cells regardless of the specificity of T cell *** factor(TF)is a TAA that involved in tumor ***,we designed and characterized a novel TCB targeting TF(TF-TCB)for the treatment of TF-positive *** vitro,robust T cell activation,tumor cell lysis and T cell proliferation were induced by *** tumor cell lysis activity was dependent upon both CD3 and TF binding moieties of the TF-TCB,and was related to TF expression level of tumor *** vivo,in both tumor cell/human peripheral blood mononuclear cells(PBMC)co-grafting model and established tumor models with poor T cell infiltration,tumor growth was strongly inhibited by TF-TCB.T cell infiltration into tumors was induced during the ***,efficacy of TF-TCB was further improved by combination with immune checkpoint *** the first time,our results validated the feasibility of using TF as a target for TCB and highlighted the potential for TF-TCB to demonstrate efficacy in solid tumor treatment.

关键词： T cell engaging bispecific antibody Immunotherapy Tissue factor Solid tumor Pancreatic cancer Lung cancer PD-1 antibody

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An Exergy Analysis Model for the Optimal Operation of Integrated Heat-and-Electricity-Based Energy Systems

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Protection and Control of Modern Power Systems 2024年第1期9卷 1-18页

作者： Jianrun Chen Haoyong Chen Zipeng Liang xiaodong Zheng Dongliang xiao Yirui Li Huaguang Yan South China University of Technology China School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China Department of Electrical Engineering Hong Kong Polytechnic UniversityHong Kong SARChina Department of Electric Power South China University of TechnologyGuangzhouChina Electricity Using and Efficiency Department China Electric Power Research Institute

Exergy analysis is a unified approach to evaluating the quantity and quality of energy in integrated energy systems(IESs).However,exergy analysis models have been relatively underexplored for IES operation in energy transmission *** study addresses this gap by developing an input-benefit exergy model and an exergy loss calculation model for each link within heat-and-electricity-based IESs(HE-IESs),encompassing the transmission ***,an exergy-based unified optimal operation model for HE-IESs is introduced by minimizing the total exergy loss of the *** addition,the effect of load rate on the energy efficiency of energy conversion equipment is *** applying piecewise linearization to the non-convex terms in the objective function and the equality constraints,the proposed optimization model is accurately and efficiently analyzed as a mixed-integer second-order cone pro-gramming *** case study results demonstrate that the proposed model reduces equipment-related ex-ergy loss,with approximately 3.2 times the heat net-work-related exergy ***,the average deviation gaps of the overall system's exergy loss and equipment's output exergy power between the proposed and the existing models reach 12.94%and 27.83%,*** maximum relative error of the solution results with the proposed linearization method remains below 1.2%,satisfying the requirements of practical application.

关键词： unified linearization satisfying

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