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Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Huanhuan Liu Hongli Liu Chunhong Yan Jiaxiu Liu Yu Cao Guopeng Li xiaodong xia State Key Laboratory of Marine Food Processing and Safety Control National Engineering Research Center of Seafood School of Food Science and Technology Dalian Polytechnic University Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional Engineering China Agricultural University

Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties， but whether and how it could impact hypercholesterolemia remains not fully explored. The aim of this study was to investigate the influence of punicalagin on hypercholesterolemia in mice and its related mechanisms. After 6 weeks’ intervention， punicalagin significantly reduced serum total cholesterol and low density lipoprotein cholesterol (LDL-C) levels in mice fed a high-fat high-cholesterol (HFHC) diet. Meanwhile， punicalagin supplementation lowered hepatic cholesterol level， which corresponded to the down-regulation of cholesterol synthesis genes (Fdps， Cyp51) and up-regulated bile acid synthesis genes (Cyp7a1， Cyp27a1). In addition， bile acid reabsorption was retarded in punicalagin-fed mice through down-regulating ileal apical sodium-dependent BA transporter (ASBT). Furthermore， intestinal farnesoid X receptor (FXR)-fibroblast growth factor 15 (Fgf15) pathway was inhibited while hepatic FXR-small heterodimeric partner (SHP) pathway was activated in punicalagin group. Microbiota analysis and targeted metabolomics showed that punicalagin decreased the abundance of bile-salt hydrolase (BSH)-producing bacteria (Clostridiaceae and Bifidobacteriaceae) and the ratio of primary BAs to secondary BAs. In conclusion， the cholesterol-lowering effect of punicalagin partly through down-regulating cholesterol synthesis and increasing cholesterol catabolism， which could be achieved by regulating gut microbiota， altering bile acid composition and modulating FXR signaling pathway. These findings indicate the potential application of punicalagin-related products as an alternative strategy for hypercholesterolemia prevention and mitigation.

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Titanium dioxide E171 consumption exacerbates Listeria monocytogenes infection in mice

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Food Quality and Safety 2024年第1期8卷 68-80页

作者：滕跃王瑷琳赵东云李国鹏刘泷泽邹悦夏效东 State Key Laboratory of Marine Food Processing and Safety Control National Engineering Research Center of SeafoodSchool of Food Science and TechnologyDalian Polytechnic UniversityDalianChina

The food additive titanium dioxide is commonly utilized to enhance the appearance and flavor of food ***,this substance has been linked to gastrointestinal *** aim of this study was to investigate the impact of dietary exposure of titanium dioxide E171 on Listeria monocytogenes infection in *** were mainly divided into the control,LM group(*** infection),and E171+LM groups(E171 supplementation before *** infection).Pre-exposure to E171 resulted in increased bacterial counts in the liver,spleen,ileum,colon,mesenteric lymph nodes,and feces of mice after *** ***,E171 exposure increased the levels of pro-inflammatory cytokines while attenuating the levels of anti-inflammatory cytokines in mice infected with ***,mice in the E171+LM group exhibited considerably more severe colonic inflammation and worse intestinal barrier function than mice in the LM *** 16S rRNA gene sequencing revealed a shift in the composition of the gut microbiota of mice in the E171+LM group,characterized by a decrease in the relative abundance of Firmicutes and a decrease in the Firmicutes-to-Bacteroidetes *** levels of acetate,butyrate,and isobutyrate were markedly decreased within the cecum of mice in the E171+LM group in comparison to mice in the LM *** conclusion,these results suggest that E171 exposure could exacerbate *** infection in mice,which may provide useful information for future risk assessment of this commonly used food additive.

关键词： E171 L.monocytogenes intestinal barrier function inflammatory responses gut microbiota.

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岁晏桥钢箱梁拼装支架设计与施工技术应用研究

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工程技术研究 2024年第2期9卷 127-129页

作者：夏晓东中铁二十局集团第四工程有限公司河北沧州061000

岁晏桥是横跨南运河的一项桥梁工程,也是城市发展战略的重要组成部分,桥梁建设选择钢箱梁结构,在提高工程安全性和稳定性的同时,施工期间的拼装支架设计和技术应用成为质量控制重点内容。文章对岁晏桥进行全面介绍,重点论述了其钢箱梁... 详细信息

岁晏桥是横跨南运河的一项桥梁工程,也是城市发展战略的重要组成部分,桥梁建设选择钢箱梁结构,在提高工程安全性和稳定性的同时,施工期间的拼装支架设计和技术应用成为质量控制重点内容。文章对岁晏桥进行全面介绍,重点论述了其钢箱梁施工中的拼装支架设计和技术应用要点,列举了相关注意事项,旨在为施工企业和作业人员提供参考,通过标准化的设计和规范化的技术应用,铸造精品桥梁工程。

关键词：钢箱梁支架设计钢管桩

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基于FastFlow的复杂纹理图像异常检测

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计算机应用 2024年第S1期44卷 256-261页

作者：张果夏小东付茂栗魏麟中国科学院成都计算机应用研究所中国科学院大学计算机科学与技术学院深圳市中钞科信金融科技有限公司

为了提高FastFlow的缺陷检测准确率和分割能力，分析FastFlow在复杂图像异常检测上性能下降的原因，提出一种基于FastFlow的改进模型SAFlow(Self-Attention-Flow)。为了解决异常检测准确率低的问题，首先，采用ResNet18为特征提取器，Fa... 详细信息

为了提高FastFlow的缺陷检测准确率和分割能力，分析FastFlow在复杂图像异常检测上性能下降的原因，提出一种基于FastFlow的改进模型SAFlow(Self-Attention-Flow)。为了解决异常检测准确率低的问题，首先，采用ResNet18为特征提取器，FastFlow为主干网络，均值方差阈值分割作为分割方法；其次，添加一条特征信息添加分支，包含特征金字塔（FP）模块与自注意力（SA）机制模块，旨在给予网络更多的特征信息参考；最后，采用K-sigma动态阈值作为生成的热力图分割阈值，使分割结果更准确。实验结果表明，与FastFlow模型相比，SAFlow在4个复杂纹理图像数据集上的Pixel-AUC(Area Under Receiver Operating Characteristic Curve)精度分别提升了4.98、3.05、1.44和3.88个百分点；在总数据集上，Pixel-AUC平均精度提升了3.34个百分点。所提网络结构使样本数据最后形成的正态分布更具有代表性、更集中，分布中异常负对数似然得分更高，异常检测准确率更高，解决了复杂纹理图像中异常缺陷的检测问题难点。

关键词：深度学习 FastFlow 自注意力复杂纹理图像特征金字塔

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基于改进DFVDFF网络的变焦深度测量

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计算机应用 2024年第S1期44卷 223-228页

作者：赵涂昊夏小东付茂栗王觅中国科学院成都计算机应用研究所中国科学院大学计算机科学与技术学院深圳市中钞科信金融科技有限公司

针对差分聚焦体（DFV）与变焦深度测量（DFF）联合应用的网络（简称为DFVDFF）精度较低的问题，首先，将特征提取模块的网络结构替换为UNet++，并在深度信息提取模块内增加注意力机制，通过关注重要的特征并融合深层特征和浅层特征提升... 详细信息

针对差分聚焦体（DFV）与变焦深度测量（DFF）联合应用的网络（简称为DFVDFF）精度较低的问题，首先，将特征提取模块的网络结构替换为UNet++，并在深度信息提取模块内增加注意力机制，通过关注重要的特征并融合深层特征和浅层特征提升网络预测的精度；然后，针对DFVDFF生成的深度图纹理边界模糊的问题，使用结构相似度和平滑平均绝对误差融合的损失函数替换原有的平滑平均绝对误差损失函数，通过提升损失函数对纹理边界的敏感程度引导网络生成更清晰的边界。实验结果表明，改进后的网络在有噪声的DDFF-12数据集上，相较于原始DFVDFF网络，均方误差下降了7.40%；在无噪声的FoD500数据集上，相较于原始DFVDFF网络，均方误差下降了19.07%。并且，改进后的网络在两个数据集上生成的深度图比DFVDFF网络生成的深度图具有更清晰的纹理边界。

关键词：深度学习变焦深度测量 DFVDFF 结构相似度损失函数

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儿童体力活动对认知能力影响的研究进展

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四川体育科学 2024年第3期43卷 44-48,60页

作者：唐浩伦夏晓冬南京体育学院研究生部江苏南京210014 营山县机关幼儿园四川南充637700

近年来,儿童体力活动与认知能力关系日益受到关注,体力活动对认知能力的促进作用具有重要的现实意义。本综述通过追踪梳理国内外有关儿童体力活动和认知能力关联的文献,深入了解两者的关系,并探索体力活动对认知能力影响的机制,最后分... 详细信息

近年来,儿童体力活动与认知能力关系日益受到关注,体力活动对认知能力的促进作用具有重要的现实意义。本综述通过追踪梳理国内外有关儿童体力活动和认知能力关联的文献,深入了解两者的关系,并探索体力活动对认知能力影响的机制,最后分析相关研究存在的局限以及对未来研究提出建议,为促进儿童认知能力发展提供参考。

关键词：体力活动运动儿童认知能力

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Classification of Arrhythmia Based on Convolutional Neural Networks and Encoder-Decoder Model

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Computers, Materials & Continua 2022年第10期73卷 265-278页

作者： Jian Liu xiaodong xia Chunyang Han Jiao Hui Jim Feng School of Computer&Communication Engineering University of Science and Technology BeijingBeijing100083China Beijing Satellite Navigation Center Beijing100093China The Institute of NBC Defense Chinese PLA ArmyBeijing102205China Amphenol Global Interconnect Systems San JoseCA 95131US

As a common and high-risk type of disease,heart disease seriously threatens people’s *** the same time,in the era of the Internet of Thing(IoT),smart medical device has strong practical significance for medical workers and patients because of its ability to assist in the diagnosis of ***,the research of real-time diagnosis and classification algorithms for arrhythmia can help to improve the diagnostic efficiency of *** this paper,we design an automatic arrhythmia classification algorithm model based on Convolutional Neural Network(CNN)and Encoder-Decoder *** model uses Long Short-Term Memory(LSTM)to consider the influence of time series features on classification ***,it is trained and tested by the MIT-BIH arrhythmia ***,Generative Adversarial Networks(GAN)is adopted as a method of data equalization for solving data imbalance *** simulation results show that for the inter-patient arrhythmia classification,the hybrid model combining CNN and Encoder-Decoder model has the best classification accuracy,of which the accuracy can reach 94.05%.Especially,it has a better advantage for the classification effect of supraventricular ectopic beats(class S)and fusion beats(class F).

关键词： Electroencephalography convolutional neural network long short-term memory encoder-decoder model generative adversarial network

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Mapping and Functional Analysis of LE Gene in a Lethal Etiolated Rice Mutant at Seedling Stage

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Rice science 2023年第6期30卷 567-576页

作者： xia xiaodong ZHANG xiaobo WANG Zhonghao CHENG Benyi Sun Huifeng XU xia GONG Junyi YANG Shihua WU Jianli SHI Yongfeng XU Rugen College of Agronomy Yangzhou UniversityYangzhou 225009China China National Rice Research Institute Hangzhou 310006China Agro-Tech Extension Center of Haiyan County Jiaxing 314300China

An EMS(ethy methanesulfonate)-induced lethal etiolated(le)mutant obtained from the rice variety Zhongjian 100 was characterized by lethal etiolated phenotypes,with significantly reduced levels of chlorophyll a,chlorophyll b,total chlorophyll,and ***,the mutant displayed a significantly decreased number of chloroplast grana,along with irregular and less-stacked grana *** le mutant showed markedly diminished root length,root surface area,and root volume compared with the wild *** also exhibited significantly lower catalase activity and total protein content,while peroxidase activity was significantly *** the map-based cloning method,we successfully mapped the LE gene to a 48-kb interval between markers RM16107 and RM16110 on rice chromosome 3.A mutation(from T to C)was identified at nucleotide position 692 bp of LOC_Os03g59640(ChlD),resulting in a change from leucine to *** crossing HM133(a pale green mutant with a single-base substitution of A for G in exon 10 of ChlD subunit)with a heterozygous line of le(LEle),we obtained two plant lines heterozygous at both the LE and HM133 *** 15 transgenic plants,3 complementation lines displayed normal leaf color with significantly higher total chlorophyll,chlorophyll a,and chlorophyll b *** mutation in le led to a lethal etiolated phenotype,which has not been observed in other ChlD *** mutation in the AAA+domain of ChlD disrupted the interaction of ChlDle with ChlI as demonstrated by a yeast two-hybrid assay,leading to the loss of ChlD function and hindering chlorophyll synthesis and chloroplast ***,this disruption is responsible for the lethal etiolated phenotype in the mutant.

关键词： Oryza sativa lethal etiolated mutant gene cloning functional analysis reactive oxygen species

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Tuning of non-uniform switch toughening in ferroelectric composites by an electric field

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Acta Mechanica Sinica 2016年第5期32卷 866-880页

作者： xiaodong xia Zheng Zhong School of Aerospace Engineering and Applied Mechanics Tongji University

This paper deals with a mode III interfacial crack subject to anti-plane stress and in-plane electric fields. The analysis concentrates on the tuning of fracture toughness from non-uniform ferroelectric-ferroelastic domain switching by an electric field. The electric loading changes the size of the asymmetric switching zone. Employing the weight function method, we obtain the electrically-dependent switch toughening for stationary and quasi-static growing interfacial cracks, respectively. Multi-domain solutions are derived for non-poled and fully-poled ferroelectric composites. Numerical results are presented on the electric field tuning of the critical applied stress intensity factor. The research provides ways to optimize fracture properties of ferroelectric composites by altering the electric field.

关键词： Interfacial crack Electric field tuning Domain switching Ferroelectric-ferroelastic Toughening

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Semi-permeable Yoffe-type interfacial crack analysis in MEE composites based on the strip electro-magnetic polarization saturation model

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Acta Mechanica Solida Sinica 2017年第4期30卷 354-368页

作者： xiaodong xia Zheng Zhong School of Aerospace Engineering and Applied Mechanics Tongji University School of Science Harbin Institute of Technology

Fracture analysis of a semi-permeable Yoffe-type interfacial crack propagating subsonically in magneto-electro-elastic （MEE） composites is presented based on the strip electro- magnetic polarization saturation （SEMPS） model. The electro-magnetic fields inside the crack are considered under the semi-permeable boundary condition. Nonlinear effects near the interfacial crack tip are represented by different electro-magnetic saturation zones. Utilizing the extended Stroh＇s method, we derive the moving dislocation densities as well as intensity factor and energy release rate for Yoffe-type MEE interracial crack. Numerical re- sults through an iterative approach are presented to show the characteristics of fracturedominant parameters with respect to propagation velocity and boundary condition category. The fracture-dominant parameters under the semi-permeable boundary condition are lower than those under the impermeable one, which implies that the electro-magnetic fields in the crack gap can retard the propagation of MEE interfacial crack.

关键词： Yoffe-type interracial crack Semi-permeable boundary condition Polarization saturation Fracture toughness Magneto-electro-elastic

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