检索结果-南通市图书馆

Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui Niu xiaodong he Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Variable Tension Control for Discontinuous Tape Winding of Composites Based on Constant Extension Ratio

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2012年第5期25卷 1022-1028页

作者： SHI Yaoyao YAN Long he xiaodong Key Laboratory of Contemporary Design and Integrated Manufacturing Technology Minnistry of EducationNorthwestern Polyteehnical UniversityXi'an 710072China

Discontinuous tape winding, which has obvious advantages in large extension ratio winding, is widely used in the molding of composites. Therefore, the research on technological parameters becomes the focus of many scholars. However, how to accomplish the variable tension control is usually not fully considered. Accordingly, the constant extension ratio and the smoothness of winding process cannot be ensured. Aiming at the problem of tension control, this paper first gives a comparatively deep research on the control method and the interaction mechanism of tension, extension ratio, automatic lap and automatic rectification. Then, according to the winding process features, the mechanical device and the mathematical model of tension control system are established respectively. With regard to the characteristics of PID controller and fuzzy controller, the fuzzy self-tuning PID controller is designed. As a result, the variable tension control is realized during the winding and lapping process, and the constant extension ratio is guaranteed. Finally, a sample application is presented for demonstration. By presenting the variable tension control techniques for discontinuous tape winding, the constant extension ratio of tapes is achieved, the consecution and the automation degree of winding process is improved as well. Thus, the quality of wound products is guaranteed.

关键词： tape winding tension control constant extension ratio automatic lap and rectification

Leader-follower formation control of underactuated surface vessels

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第10期65卷 297-298页

作者： xiaodong he Zhiyong GENG State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering Science College of Engineering Peking University

Dear editor,Leader-follower formation control of underactuated surface vessels has attracted much attention in past decades. The challenge arises from the second-order nonholonomic constraint on acceleration. To overcome the difficulty, plenty of nonlinear techniques are applied, such as robust adaptive control [1], dynamic surface control [2],

关键词：

文旅数字化发展的理论与实践研究——以四川为例

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

四川旅游学院学报 2025年第1期 52-58页

作者：何小东易敏任啸成都大学四川成都610044 西南民族大学四川成都610041 四川省旅游投资集团四川成都610147

四川省高度关注文旅产业数字化转型,积极探索“数字+文旅”发展路径,各级政府相继出台系列文件,助力数字文旅发展。文章以四川省数字文旅资金投入情况、数字化项目建设情况、文旅重点行业数字化建设情况等为基础,分析四川数字文旅发展... 详细信息

四川省高度关注文旅产业数字化转型,积极探索“数字+文旅”发展路径,各级政府相继出台系列文件,助力数字文旅发展。文章以四川省数字文旅资金投入情况、数字化项目建设情况、文旅重点行业数字化建设情况等为基础,分析四川数字文旅发展现存问题,探索数字文旅发展路径,并围绕管理、市场、产品等方面提出四川数字文旅发展建议,以期推动四川省数字文旅融合高质量发展,并为其他地区数字文旅发展提供相关借鉴。

关键词：数字文旅高质量发展四川

Numerical Simulation of Residual Stress during Microlayer Composite Material Processing by EBPVD Technique

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2003年第z1期19卷 80-82页

作者： Liping SHI Yao LI xiaodong he Centerfor Composite Materials Harbin Institute of Technology Harbin 150001 China Centerfor Composite Materials Harbin Institute of Technology Harbin 150001 China Centerfor Composite Materials Harbin Institute of Technology Harbin 150001 China

The preparation technology of microlayer composite material by the electron beam physical vapor deposition (EBPVD) technique was briefly introduced. Taking the advantage of the large-scale commercial softvare of finite element analysis, areasonable physical model was built up during the deposition processing and the distribution of residual stress was analyzedbetween substrate and deposition layer or among deposition layers. The results show that: with the increasing substrate preheating temperature, the interlaminar shear stress increases but the axial residual stress decreases. The probability of curlingup after de-bonding tends to enhance as the thickness of deposition film increases.

关键词： Microlayer composite material, EBPVD, Residual stress, Numerical simulation

Exponential Set-Point Stabilization of Underactuated Vehicles Moving in Three-Dimensional Space

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 270-282页

作者： xiaodong he Zhiyong Sun Zhiyong Geng Anders Robertsson State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of EngineeringPeking UniversityBeijing 100871China IEEE Department of Electrical Engineering Eindhoven University of Technology(TU/e)5600 MB Eindhoventhe Netherlands Department of Automatic Control LTHLund University22100 LundSweden

This paper investigates the stabilization of underactuated vehicles moving in a three-dimensional vector *** vehicle’s model is established on the matrix Lie group SE(3),which describes the configuration of rigid bodies globally and *** focus on the kinematic model of the underactuated vehicle,which features an underactuation form that has no sway and heave *** compensate for the lack of these two velocities,we construct additional rotation matrices to generate a motion of rotation coupled with ***,the state feedback is designed with the help of the logarithmic map,and we prove that the proposed control law can exponentially stabilize the underactuated vehicle to the identity group element with an almost global domain of ***,the presented control strategy is extended to set-point stabilization in the sense that the underactuated vehicle can be stabilized to an arbitrary desired configuration specified in ***,simulation examples are provided to verify the effectiveness of the stabilization controller.

关键词： Exponential stabilization logarithmic feedback matrix Lie group underactuated vehicle

Abundance and biomass of heterotrophic microbes in the Kongsfjorden, Svalbard

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2005年第6期24卷 143-152页

作者： JIANG xiaodong he Jianfeng CAI Minghong State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of China Shanghai 200136 China State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of China Shanghai 200136 China State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of China Shanghai 200136 China

Abundance and biomass of heterotrophic microbes were investigated usingepifluorescense microscopy in August 2004 along a transect in the Kongsfjorden, a glacial fjord inthe high arctic, located in the north-western part of Svalbard. A bacterial abundance was low atouter fjord stations (on average 2.29 x 10~8 ind./dm^3) and was higher at inner fjord stations (onaverage 3.52 x 10~8 ind./dm^3).The biomass of bacteria ranged from 3.69 to 8.01 mg/m^*** abundanceof bacteria was low at the surface of water(0 m), whereas the higher abundances often occurred atdepths of 30～50 *** abundance of heterotrophic flagellates varied from 2.785 to 8.891 x 10~4 ind./dm^3. The assemblage was numerically dominated by less than 5 μm heterotrophic flagellates(78.67%～94.80%).The biomass of heterotrophic flagellates varied from 0.37 to 2.30 mg/m^*** meanbiomass distribution for all stations was 4.91% for less than 5 μm heterotrophic flagellates,86.74% for 6～20 μm flagellates and 8.35% for greater than 20 μm sized *** low biomassof heterotrophic flagellates often occurred at the surface of water (0 m),while the maximum valueof biomass occurred at different depths. The biomass of total heterotrophic microbial communityranged from 4.20 to 10.03 mg/m^*** mean biomass distribution for all stations was 82.58% forbacteria, 15.77% for flagellates and 1.66% for ciliates.

关键词： abundance biomass bacteria flagellate kongsfjorden

Numerical simulation of the influence of aerosol radiation effect on urban boundary layer

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2018年第12期61卷 1844-1858页

作者： Xinran WANG xiaodong he Shiguang MIAO Youjun DOU China Institute of Atomic Energy Beo'ing 102413China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China

With the intensification of pollution and urbanization, the aerosol radiation effect continues to play an important role in the urban boundary layer. In this paper, a winter pollution process in Beijing has been taken as an example, and a new aerosol vertical profile in the radiative parameterization scheme within the Weather Forecast Research and Forecasting(WRF) model has been updated to study the effect of aerosols on radiation and the boundary layer. Furthermore, the interactions among aerosols,urbanization, and planetary boundary layer(PBL) meteorology were discussed through a series of numerical experiments. The results show the following:(1) The optimization improves the performance of the model in simulating the distribution features of air temperature, humidity, and wind in Beijing.(2) The aerosols reduce the surface temperature by reducing solar radiation and increasing the temperature in the upper layer by absorbing or backscattering solar radiation. The changes in the PBL temperature lead to more stable atmospheric stratification, reducing the energy transfer from the surface and the height of the boundary layer.(3) With the increase in the aerosol optical depth, the atmospheric stratification most likely becomes stable over rural areas, most likely becomes stable over suburb areas, and has great difficultly becoming stable over urban areas. Aerosol radiative forcing,underlying urban surfaces, and the interaction between them are the main factors that affect the changes in the meteorological elements in the PBL.

关键词： Aerosol Urbanization Boundary layer Meteorological elements WRF

Analysis and control of the compaction force in the composite prepreg tape winding process for rocket motor nozzles

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2017年第2期30卷 836-845页

作者： he xiaodong Shi Yaoyao Kang Chao Yu Tao School of Mechanical Engineering Northwestern Polytechnical University Xi'an 710072 China

In the process of composite prepreg tape winding,the compaction force could influence the quality of winding *** to the analysis and experiments,during the winding process of a rocket motor nozzle aft exit cone with a winding angle,there would be an error between the deposition speed of tape layers and the feeding speed of the compaction roller,which could influence the compaction *** a lack of compaction and overcompaction related to the feeding of the compaction roller could result in defects of winding ***,a flexible winding system has been developed for rocket motor nozzle *** the system,feeding of the compaction roller could be adjusted in real time to achieve an invariable compaction *** to experiments,the force deformation model of the winding tape is a time-varying ***,a forgetting factor recursive least square based parameter estimation proportional-integral-differential（PID）controller has been developed,which could estimate the time-varying parameter and control the compaction force by adjusting the feeding of the compaction roller during the winding *** to the experimental results,a winding nozzle with fewer voids and a smooth surface could be wounded by the invariable compaction force in the flexible winding system.

关键词： Compaction Composite material Rocket nozzles Parameter estimation Voids Winding processes

Self-propagating High-temperature Synthesis, Microstructure and Mechanical Properties of TiC-TiB_2-Cu Composites

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2006年第1期22卷 78-82页

作者： Chuncheng ZHU Xinghong ZHANG xiaodong he Qiang XU Department of Chemistry Harbin Normal University Harbin 150080 China Center for Composite Materials and Structure Harbin Institute of Technology Harbin 150001 China Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

TiC-TiB2-Cu composites were produced by self-propagating high-temperature synthesis combined with pseudo hot isostatic pressing using Ti, B4C and Cu powders. The microstructure and mechanical properties of the composites were investigated. The X-ray diffraction （XRD） and scanning electron microscopy （SEM） results showed that the final products were only TiC, TiB2 and Cu phases. The clubbed TiB2 grains and spheroidal or irregular TiC grains were found in the microstructure of synthesized products. The reaction temperature and grain size of TiB2 and TiC particles decreased with increasing Cu content. The introduction of Cu into the composites resulted in a drastic increase in the relative density and flexual strength, and the maximum values were obtained with the addition of 20 wt pct, while the fracture toughness was the best when Cu content was 40 wt pct.

关键词： Composite TiB2-TiC-Cu Self-propagating high-temperature synthesis (SHS) Cu content