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JOINT　MODEL　AND　CRITERION　OPTIMAL　EXPERIMENT　DESIGN

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Applied Mathematics(A Journal of Chinese Universities) 1997年第1期12卷 41-48页

作者： LIU HANCONG, ZHU WEIYONG AND duan xiaodong

Abstract In this paper, a new optimal design criterion——joint model and criterion optimal design criterion is put forward. The design that is subject to this criterion satisfies many kinds of linear optimal criterion and D optimal criterion on several experiment models at the same time. The equivalent condition of this optimal design is given. Its iterative algorithm and the algorithm covergence are stated.

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Semantic Knowledge based on Fuzzy System for Describing Facial Expression 36

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Semantic Knowledge based on Fuzzy System for Describing Faci...

Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing the production of reactive oxygen species

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作者： Zedong Li Qingling zhang xiaodong duan Wei Wei Institute of System Science Northeastern University Dalian Key Lab of Digital Technology for National Culture Dalian MinZu University Computer Science and Engineering College Dalian MinZu University

ISBN: (纸本)9781538629185

We propose a new approach to describe facial expressions based on axiomatic fuzzy set（AFS）,which can convert the features to semantic *** method has two advantages:the first one is that the semantic concepts are gained by data *** means that the concepts can be directly obtained from data set,and the priori model is not *** second one is the semantic concepts can be operated for representing expression ***,an optimized criterion is designed to select the best semantic concept set for representing each ***,we execute the experiments on CK+database,and have an interpretation for corresponding *** addition,the performance of this method is estimated with state-of-the-art methods such as C4.5,Repeated Incremental Pruning to Produce Error Reduction（Ripper）,DecisionTable,Cart.

关键词： Facial Expressions Axiomatic Fuzzy Set Semantic Knowledge Data Distribution

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Frontiers of Medicine 2018年第3期12卷 289-300页

作者： xiaodong duan Daizhi Peng Yilan Zhang Yalan Huang Xiao Liu Ruifu Li Xin Zhou Jing Liu Institute of Burn Research Southwest Hospital Third Military Medical University Chongqing 400038 China Burn and Plastic Surgery Department 209 Hospital of PLA Mudanjiang 157011 China Tissue Engineering Research Unit State Key Laboratory of Trauma Burns and Combined Injury Third Military Medical University Chongqing 400038 China

Silver-containing preparations are widely used in the management of skin wounds, but the effects of silver ions on skin wound healing remain poorly understood. This study investigated the effects of silver ions （Ag^＋） on the proliferation of human skin keratinocytes （HaCaT） and the production of intracellular reactive oxygen species （ROS）. After treating HaCaT cells with Ag^＋ and/or the active oxygen scavenger N-acetyl cysteine （NAC）, cell proliferation and intracellular ROS generation were assessed using CCK-8 reagent and DCFH-DA fluorescent probe, respectively. In addition, 5-bromo-2-deoxyUridine （BrdU） incorporation assays, cell cycle flow cytometry, and proliferating cell nuclear antigen （PCNA） immunocytochemistry were conducted to further evaluate the effects of sub-cytotoxic Ag^＋ concentrations on HaCaT cells. The proliferation of HaCaT cells was promoted in the presence of 10^-6 and 10^-5s mol/L Ag^＋at 24, 48, and 72 h. Intracellular ROS generation also significantly increased for 5 60 min after exposure to Ag^＋ The number of BrdU-positive cells and the presence of PCNA in HaCaT cells increased 48 h after the addition of 10^-6 and 10^-5 mol/L Ag^＋, with 10^-5 mol/L Ag^＋ markedly increasing the cell proliferation index. These effects of sub-cytotoxic Ag^＋ concentrations were repressed by 5 mmol/L NAC. Our results suggest that sub-cytotoxic Ag^＋ concentrations promote the proliferation of human keratinocytes and might be associated with a moderate increase in intracellular ROS levels. This study provides important experimental evidence for developing novel silver-based wound agents or dressings with few or no cytotoxicity.

关键词： ionic silver human keratinocyte cell proliferation reactive oxygen species active oxygen scavenger NAC

Cognitive Intelligence Based 6G Distributed Network Architecture

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China Communications 2022年第6期19卷 137-153页

作者： xiaodong duan Tao Sun Chao Liu Xiao Ma Zheng Hu Lu Lu Chunhong Zhang Benhui Zhuang Weiyuan Li Shangguang Wang China Mobile Research Institute Beijing 100053China Beijing University of Posts and Telecommunications Beijing 100086China

5G is envisioned to guarantee high transmission rate,ultra-low latency,high reliability and massive *** satisfy the above requirements,the 5G architecture is designed with the properties of using service-based architecture,cloud-native oriented,adopting IT-based API interfaces and introduction of the Network Repository ***,with the wide commercialization of 5G network and the exploration towards 6G,the 5G architecture exposes the disadvantages of high architecture complexity,difficult inter-interface communication,low cognitive capability,bad instantaneity,and deficient *** overcome these limitations,this paper investigates 6G network architecture,and proposes a cognitive intelligence based distributed 6G network *** architecture consists of a physical network layer and an intelligent decision *** two layers coordinate through flexible service interfaces,supporting function decoupling and joint evolution of intelligence services and network *** the above design,the proposed 6G architecture can be updated autonomously to deal with the future unpredicted complex services.

关键词： cognitive intelligence service-based architecture physical network layer intelligent decision layer

Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway

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Burns & Trauma 2023年第1期11卷 229-244页

作者： Tianyi Chen Peiyang Song Min He Shunli Rui xiaodong duan Yu Ma David G.Armstrong Wuquan Deng Department of Endocrinology Chongqing Emergency Medical CenterChongqing University Central HospitalSchool of MedicineChongqing UniversityChongqing400014China Department of Rehabilitation The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan646000China Department of Surgery Keck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033USA

Background:Sphingosine-1-phosphate(S1P),a key regulator of vascular homeostasis and angiogenesis,is enriched in exosomes derived from platelet-rich plasma(PRP-Exos).However,the potential role of PRP-Exos-S1P in diabetic wound healing remains *** this study,we investigated the underlying mechanism of PRP-Exos-S1P in diabetic angiogenesis and wound ***:Exosomes were isolated from PRP by ultracentrifugation and analysed by transmission electron microscopy,nanoparticle tracking analysis and western *** concentration of S1P derived from PRP-Exos was measured by enzyme-linked immunosorbent *** expression level of S1P receptor1–3(S1PR1–3)in diabetic skin was analysed by *** analysis and proteomic sequencing were conducted to explore the possible signalling pathway mediated by PRP-Exos-S1P.A diabetic mouse model was used to evaluate the effect of PRP-Exos on wound *** for cluster of differentiation 31(CD31)was used to assess angiogenesis in a diabetic wound ***:In vitro,PRP-Exos significantly promoted cell proliferation,migration and tube ***,PRP-Exos accelerated the process of diabetic angiogenesis and wound closure in vivo.S1P derived from PRP-Exos was present at a high level,and S1PR1 expression was significantly elevated compared with S1PR2 and S1PR3 in the skin of diabetic patients and ***,cell migration and tube formation were not promoted by PRP-Exos-S1P in human umbilical vein endothelial cells treated with *** the diabetic mouse model,inhibition of S1PR1 expression at wounding sites decreased the formation of new blood vessels and delayed the process of wound *** analysis and proteomics indicated that fibronectin 1(FN1)was closely related to S1PR1 due to its colocalization in the endothelial cells of human *** study supported that FN1 plays an important role in the PRP-Exos-S1Pmediated S1PR1/protein kinase B signalling

关键词： Exosomes Platelet-rich plasma Diabetic foot ulcer Wound healing Sphingosine-1-phosphate

Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1389-1391页

作者： Fei Chen xiaodong duan Yao Yu Shang Yang Yuanyuan Chen Christine EGee Georg Nagel Kang Zhang Shiqiang Gao Yin Shen Eye Center Wuhan University Renmin HospitalWuhanChina Department of Neurophysiology Institute of PhysiologyBiocenterUniversity of WuerzburgWuerzburgGermany Institute for Synaptic Physiology University Medical Center Hamburg EppendorfHamburgGermany Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and Technology and University HospitalMacaoChina Frontier Science Center for Immunology and Metabolism and Medical Research Institute at School of MedicineWuhan UniversityWuhanChina

Inherited and age-related retinal degenerative diseases cause progressive loss of photoreceptors,ultimately leading to *** is a promising strategy for restoring visual function through photosensitive proteins’ectopic expression in surviving retinal neurons.1 Very recently,the optogenetic method with a red-shifted Channelrhodopsin was clinically applied for partial recovery of visual function in a blind patient.2 However,major obstacles to achieving optimal optogenetic vision restoration are either the low light sensitivity or the slow kinetics of existing rhodopsin-based optogenetic tools,which can be improved by molecular engineering to enhance the efficacy of fast Channelrhodopsins(ChRs).

关键词： Visual visual function

Computing-aware network (CAN): a systematic design of computing and network convergence

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 633-644页

作者： Xiaoyun WANG xiaodong duan Kehan YAO Tao SUN Peng LIU Hongwei YANG Zhiqiang LI China Mobile Communications Corporation Beijing 100032China China Mobile Research Institute Beijing 100053China

The coverage of network resources is increasingly extensive,and computing resources have likewise gradually become fundamental infrastructures,providing ubiquitous computing ***,in wide area networks(WANs),the underlying network and computing resources are not closely investigated or co-designed,and there are still problems reflected in slow computing service scheduling,inflexible data distribution,and inefficient data transmission.

关键词： computing network service

A digital twin network solution for end-to-end network service level agreement (SLA) assurance [version 1;peer review: awaiting peer review]

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Digital Twin 2021年第1期1卷 122-130页

作者： Xiaowen Sun Cheng Zhou xiaodong duan Tao Sun China Mobile Research Institute Beijing100053China

With the gradual development of the 5G industry network and applications,each industry application has various network performance requirements,while customers hope to upgrade their industrial structures by leveraging 5G *** guarantee of service level agreement(SLA)requirements is becoming more and more important,especially SLA performance indicators,such as delay,jitter,bandwidth,*** network operators to fulfill customer’s requirements,emerging network technologies such as time-sensitive networking(TSN),edge computing(EC)and network slicing are introduced into the mobile network to improve network performance,which increase the complexity of the network operation and maintenance(O&M),as well as the network *** a result,operators urgently need new solutions to achieve low-cost and high-efficiency network SLA *** this paper,a digital twin network(DTN)solution is innovatively proposed to achieve the mapping and full lifecycle management of the end-to-end physical *** the network operation policies such as configuration and modification can be generated and verified inside the digital twin network first to make sure that the SLA requirements can be fulfilled without affecting the related network environment and the performance of the other network services,making network operation and maintenance more effective and accurate.

关键词： Digital Twin Network End-to-end Network SLA Assurance

面向跨模态检索的自监督深度语义保持Hash

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清华大学学报（自然科学版） 2022年第9期62卷 1442-1449页

作者：逯波段晓东袁野大连民族大学大数据应用技术国家民委重点实验室大连116600 北京理工大学计算机科学与技术学院北京100081

在跨模态媒体检索任务中,如何最大化保持异构媒体数据映射后的语义关联成为跨模态Hash的关键问题,该文提出一种基于自监督学习的深度语义保持Hash网络框架用于生成紧凑的Hash编码。首先,针对图像和文本数据,分别训练2个单一模态的深度H... 详细信息

在跨模态媒体检索任务中,如何最大化保持异构媒体数据映射后的语义关联成为跨模态Hash的关键问题,该文提出一种基于自监督学习的深度语义保持Hash网络框架用于生成紧凑的Hash编码。首先,针对图像和文本数据,分别训练2个单一模态的深度Hash网络并生成高层语义特征及各自的Hash编码。同时,利用跨模态注意力机制度量不同模态高层语义特征之间的相似性,最大化异构媒体数据间的局部语义关联性。其次,利用训练数据的多标签语义信息建立深度语义Hash网络,并以自监督对抗学习的方式同时监督指导2个单一模态的深度Hash网络的训练过程,从而在全局角度保持不同模态数据之间的语义关联,提高生成Hash编码的区分能力。最后,在3个被广泛使用的大规模多模态媒体数据集上验证了提出框架的有效性。

关键词：深度跨模态Hash 对抗学习语义Hash 跨模态注意力机制