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A Study on Dual-Load-Zone Model of Overlying Strata andEvolution Law of Mining Stress

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Computers, Materials & Continua 2019年第2期58卷 391-407页

作者： Yuejin Zhou Mingpeng Li xiaoding xu Meng Li State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining&TechnologyXuzhou221116China

The changeable structure and movement law of overlying strata are the maincontributor to the change of mining *** from the relevant theory of keystratum and particularly based on the theory of mine ground pressure and strata control,this research proposed a new solution to mining stress problems by establishing adual-load-zone stratum structural *** foundation beam theory was used tosolve the stress of overlying strata of the dual-load-zones with superposition method,which revised the traditional calculation method of mining *** abnormal increaseof lead abutment pressure in the mining area was explained effectively,through which theevolution law of mining stress in the case of hard rock was *** results indicatethat mining stress experiences a drastic change within the range of 50 m ahead of the coalwall due to the collapse of main roof;under the influence of main key stratum andinferior key strata,the influence range of lead abutment pressure is extended up toapproximately 120 m in the working face;this remarkable increase can be attributed tothe excessive length of sagging *** from both the dual-load-zone modelexperiment and field measurement demonstrate high *** model can predictthe influence range of abutment pressure effectively and thus guide the safety productionof mining.

关键词： Overlying strata structure dual-load-zone mining stress evolution law

Non-coding RNAs:the new central dogma of cancer biology

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Science China(Life Sciences) 2021年第1期64卷 22-50页

作者： Phei Er Saw xiaoding xu Jianing Chen Er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The central dogma of molecular biology states that the functions of RNA revolve around protein *** the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed *** discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being"junk"transcriptional products to"yet to be elucidated"—and potentially monumentally important—*** ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and *** major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ***,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics.

关键词： non-coding RNAs anti-cancer therapeutics personalized intervention miRNA lncRNA circRNA

Nanoparticles(NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3489-3502页

作者： Ke Yang Lei xu Ying xu Qian Shen Tao Qin Yunfang Yu Yan Nie Herui Yao xiaoding xu Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalFoshan 528200China Department of Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Pharmacology the Second Affiliated HospitalUniversity of South ChinaHengyang 421001China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Long non-coding RNAs(lncRNAs)play an important role in cancer *** metastasis-associated lncRNAs and developing effective strategy for targeted regulation of lncRNA function in vivo are of utmost importance for the treatment of metastatic cancer,which however remains a big ***,we identified a new functional lncRNA(denoted lncBCM A),which could stabilize the expression of eukaryotic translation elongation factor 1A1(eEF1A1)via antagonizing its ubiquitination to promote triple-negative breast cancer(TNBC)growth and *** on this regulatory mechanism,an endosomal pH-responsive nanoparticle(NP)platform was engineered for systemic lncBCMA siRNA(siBCMA)*** NPs-mediated siBCMA delivery could effectively silence lncBCMA expression and promote eEF1A1 ubiquitination,thereby leading to a significant inhibition of TNBC tumor growth and *** findings show that lncBCMA could be used as a potential biomarker to predict the prognosis of TNBC patients and NPs-mediated lncBCMA silencing could be an effective strategy for metastatic TNBC treatment.

关键词： Canermetastasis LncRNA Nanoparticles siRNA delivery Cancer therapy

Nanoparticles(NPs)-mediated systemic mRNA delivery to reverse trastuzumab resistance for effective breast cancer therapy

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Acta Pharmaceutica Sinica B 2023年第3期13卷 955-966页

作者： Zhihui Dong Zhuoshan Huang Senlin Li Ying Wang Yandan Yao Xianzhu Yang xiaoding xu Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China RNA Biomedical Institute Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Monoclonal antibody-based therapy has achieved great success and is now one of the most crucial therapeutic modalities for cancer *** first monoclonal antibody authorized for treating human epidermal growth receptor 2(HER2)-positive breast cancer is ***,resistance to trastuzumab therapy is frequently encountered and thus significantly restricts the therapeutic *** address this issue,tumor microenvironment(TME)pH-responsive nanoparticles(NPs)were herein developed for systemic mRNA delivery to reverse the trastuzumab resistance of breast cancer(BCa).This nanoplatform is comprised of a methoxyl-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid)copolymer with a TME pH-liable linker(Meo-PEG-Dlinkm-PLGA)and an amphiphilic cationic lipid that can complex PTEN mRNA via electrostatic *** the long-circulating mRNA-loaded NPs build up in the tumor after being delivered intravenously,they could be efficiently internalized by tumor cells due to the TME pH-triggered PEG detachment from the NP *** the intracellular mRNA release to up-regulate PTEN expression,the constantly activated PI3K/Akt signaling pathway could be blocked in the trastuzumab-resistant BCa cells,thereby resulting in the reversal of trastuzumab resistance and effectively suppress the development of BCa.

关键词： Monoclonal antibody therapy Trastuzumab resistance Nanoparticlem RNA delivery Cancer therapy

Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5048-5059页

作者： Xiaodi Liu Qi Zhang Yixia Liang Shiyu Xiong Yan Cai Jincheng Cao Yanni xu Xiaolin xu Ye Wu Qiang Lu xiaoding xu Baoming Luo Department of Ultrasound Laboratory of Ultrasound Imaging and DrugWest China HospitalSichuan UniversityChengdu 610041China Department of Ultrasound Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Ultrasound Central People's Hospital of ZhanjiangZhanjiang 524045China

cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer *** evidence has shown that interferon-gamma(IFN)could enhance CXCL9 secretion from macrophages to recruit T cells,but Siglec15 expressed on TAMs can attenuate T cell ***,targeted regulation of macrophage function could be a promising strategy to enhance cancer immunotherapy via concurrently promoting the infiltration and proliferation of T cells in tumor *** herein developed reductionresponsive nanoparticles(NPs)made with poly(disulfide amide)(PDSA)and lipid-poly(ethylene glycol)(lipid-PEG)for systemic delivery of Siglec15 siRNA(siSiglec15)and IFN for enhanced cancer *** intravenous administration,these cargo-loaded could highly accumulate in the tumor tissues and be efficiently internalized by tumor-associated macrophages(TAMs).With the highly concentrated glutathione(GSH)in the cytoplasm to destroy the nanostructure,the loaded IFN and si-Siglec15 could be rapidly released,which could respectively repolarize macrophage phenotype to enhance CXCL9 secretion for T cell infiltration and silence Siglec15 expression to promote T cell proliferation,leading to significant inhibition of hepatocellular carcinoma(HCC)growth when combining with the immune checkpoint *** strategy developed herein could be used as an effective tool to enhance cancer immunotherapy.

关键词： Nanoparticles Tumor-associated macrophages Macrophage repolarization T cell infiltration T cell proliferation Cancer immunotherapy Siglec15 Hepatocellular carcinoma

阅读意义和审美价值的回归——论艺术家书的艺术语言

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美术观察 2024年第8期 31-36页

作者：徐小鼎清华大学美术学院

数字时代的到来使屏媒阅读成为人们信息传递和知识获取的重要手段,与此同时,纸质书籍的价值被激活和重塑,与数字媒介共同构建起当代的阅读生态。作为以书籍为载体的艺术形式,艺术家书在今天越发展现出新的活力和生命力。本文梳理和总结... 详细信息

数字时代的到来使屏媒阅读成为人们信息传递和知识获取的重要手段,与此同时,纸质书籍的价值被激活和重塑,与数字媒介共同构建起当代的阅读生态。作为以书籍为载体的艺术形式,艺术家书在今天越发展现出新的活力和生命力。本文梳理和总结艺术家书的艺术语言和审美价值,解析艺术家书在当代的定位,并延伸到对传统艺术与当代媒介关系的深层次思考.

关键词：艺术家书书籍设计数字阅读艺术语言

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石膏矿老采空区塑性支撑系统的突变失稳分析

岩石力学与工程学报 2018年第11期37卷 2548-2555页

作者：徐晓鼎周跃进庞顺中国矿业大学力学与土木工程学院江苏徐州221008 中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221008 中国矿业大学矿业工程学院江苏徐州221008

采空区支撑系统稳定性研究是保证石膏矿区安全生产的关键,为此构建塑性区的矿柱–岩梁支撑系统,将岩梁和矿柱分别视为能量释放体和能量耗散体,并运用能量理论构建支撑系统尖点突变模型,得出支撑体系相关的失稳判别条件。研究结果表明:... 详细信息

采空区支撑系统稳定性研究是保证石膏矿区安全生产的关键,为此构建塑性区的矿柱–岩梁支撑系统,将岩梁和矿柱分别视为能量释放体和能量耗散体,并运用能量理论构建支撑系统尖点突变模型,得出支撑体系相关的失稳判别条件。研究结果表明:支撑系统失稳是能量释放、耗散与支撑系统变形不协调的结果,当α>0时,系统能量释放与系统变形协调,支撑系统按路径I由下叶稳态渐进过度到上叶稳态的准静态过程;当α塑性区宽度>矿房跨度>矿柱宽度>矿柱高度矿。结合工程实例,根据各区开采几何参数不同对采空区进行分类,并运用突变理论对各类采空区支撑系统稳定性进行分析,得出D类区域为危险采区,与现场调研结果一致。

关键词：采矿工程塑性区突变理论敏感性

基于局部对称重加权惩罚最小二乘的拉曼基线校正

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中国激光 2018年第12期45卷 274-285页

作者：赵恒陈娱欣续小丁胡波西安电子科技大学生命科学技术学院陕西西安710126 西安电子科技大学通信工程学院陕西西安710071

拉曼光谱分析技术具有快速响应、非接触、检测限制小、灵敏度高的优点,广泛应用于生产生活的众多领域。然而实际测得的原始拉曼光谱总会有不同程度的基线漂移,严重影响光谱分析的有效性和准确性。针对现有基线校正方法容易造成估计基线... 详细信息

拉曼光谱分析技术具有快速响应、非接触、检测限制小、灵敏度高的优点,广泛应用于生产生活的众多领域。然而实际测得的原始拉曼光谱总会有不同程度的基线漂移,严重影响光谱分析的有效性和准确性。针对现有基线校正方法容易造成估计基线偏低、校正后光谱抬升的问题,提出了一种基于局部对称重加权惩罚最小二乘(LSRPLS)的基线校正算法,该算法在非对称惩罚最小二乘的基础上,使用softsign函数引入局部对称加权的思想,对光谱中无谱峰的基线区域赋予相近的权重,并通过迭代调整估计基线的权重。在模拟和实际拉曼光谱上分别进行了验证。实验结果表明:LSRPLS基线校正算法不仅能对不同类型的光谱基线进行校正,而且与现有的基线校正方法相比,具有更高的准确度和稳定性。基线校正后的光谱在主成分空间上的聚集度得到提升,模型的分类准确性明显提高,说明LSRPLS算法在去除基线的同时,能够保留光谱的有效信息,为拉曼光谱的进一步分析提供了依据。

关键词：光谱学基线校正惩罚最小二乘拉曼光谱 softsign函数

A Novel Targeting Drug Delivery System Based on Self-Assembled Peptide Hydrogel

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Journal of Biomaterials and Nanobiotechnology 2011年第5期2卷 622-625页

作者： Liang Liang Jun Yang Qinghua Li Ming Huo Fagang Jiang xiaoding xu Xianzheng Zhang 不详

In the last two decades, 5-fluorouracil (5-FU) is widely used in clinical practice to inhibit the fibroblasts to proliferate and improve the success rate of glaucoma-filtering surgery, but 5-FU has many toxic effects to normal ocular tissues. The self-assembled peptide hydrogels may serve as a new class of biomaterials for applications including tissue engineering and drug delivery. How to deliver 5-FU quickly and precisely to the target sites of ocular tissue by a self-assembled peptide hydrogel remains unexplored. RGD (arginine-glycine-aspartic acid) sequence is cell attachment site in extracellular matrix (ECM). Thus, If the self-assembled peptide hydrogel containing the RGD sequence that act as a specific attachment site for the proliferated fibroblasts adhesion could be designed, after integrated 5-FU, a novel targeting drug delivery system will be put into practice in the future.

关键词： Drug Delivery System Self-Assembly Filtering Surgery