检索结果-南通市图书馆

阅读意义和审美价值的回归——论艺术家书的艺术语言

在线全文

学校读者我要写书评

暂无评论

美术观察 2024年第8期 31-36页

作者：徐小鼎清华大学美术学院

数字时代的到来使屏媒阅读成为人们信息传递和知识获取的重要手段,与此同时,纸质书籍的价值被激活和重塑,与数字媒介共同构建起当代的阅读生态。作为以书籍为载体的艺术形式,艺术家书在今天越发展现出新的活力和生命力。本文梳理和总结... 详细信息

数字时代的到来使屏媒阅读成为人们信息传递和知识获取的重要手段,与此同时,纸质书籍的价值被激活和重塑,与数字媒介共同构建起当代的阅读生态。作为以书籍为载体的艺术形式,艺术家书在今天越发展现出新的活力和生命力。本文梳理和总结艺术家书的艺术语言和审美价值,解析艺术家书在当代的定位,并延伸到对传统艺术与当代媒介关系的深层次思考.

关键词：艺术家书书籍设计数字阅读艺术语言

Nanoparticles(NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第8期13卷 3489-3502页

作者： Ke Yang Lei xu Ying xu Qian Shen Tao Qin Yunfang Yu Yan Nie Herui Yao xiaoding xu Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalFoshan 528200China Department of Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Pharmacology the Second Affiliated HospitalUniversity of South ChinaHengyang 421001China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Long non-coding RNAs(lncRNAs)play an important role in cancer *** metastasis-associated lncRNAs and developing effective strategy for targeted regulation of lncRNA function in vivo are of utmost importance for the treatment of metastatic cancer,which however remains a big ***,we identified a new functional lncRNA(denoted lncBCM A),which could stabilize the expression of eukaryotic translation elongation factor 1A1(eEF1A1)via antagonizing its ubiquitination to promote triple-negative breast cancer(TNBC)growth and *** on this regulatory mechanism,an endosomal pH-responsive nanoparticle(NP)platform was engineered for systemic lncBCMA siRNA(siBCMA)*** NPs-mediated siBCMA delivery could effectively silence lncBCMA expression and promote eEF1A1 ubiquitination,thereby leading to a significant inhibition of TNBC tumor growth and *** findings show that lncBCMA could be used as a potential biomarker to predict the prognosis of TNBC patients and NPs-mediated lncBCMA silencing could be an effective strategy for metastatic TNBC treatment.

关键词： Canermetastasis LncRNA Nanoparticles siRNA delivery Cancer therapy

Nanoparticles(NPs)-mediated systemic mRNA delivery to reverse trastuzumab resistance for effective breast cancer therapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第3期13卷 955-966页

作者： Zhihui Dong Zhuoshan Huang Senlin Li Ying Wang Yandan Yao Xianzhu Yang xiaoding xu Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China RNA Biomedical Institute Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Monoclonal antibody-based therapy has achieved great success and is now one of the most crucial therapeutic modalities for cancer *** first monoclonal antibody authorized for treating human epidermal growth receptor 2(HER2)-positive breast cancer is ***,resistance to trastuzumab therapy is frequently encountered and thus significantly restricts the therapeutic *** address this issue,tumor microenvironment(TME)pH-responsive nanoparticles(NPs)were herein developed for systemic mRNA delivery to reverse the trastuzumab resistance of breast cancer(BCa).This nanoplatform is comprised of a methoxyl-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid)copolymer with a TME pH-liable linker(Meo-PEG-Dlinkm-PLGA)and an amphiphilic cationic lipid that can complex PTEN mRNA via electrostatic *** the long-circulating mRNA-loaded NPs build up in the tumor after being delivered intravenously,they could be efficiently internalized by tumor cells due to the TME pH-triggered PEG detachment from the NP *** the intracellular mRNA release to up-regulate PTEN expression,the constantly activated PI3K/Akt signaling pathway could be blocked in the trastuzumab-resistant BCa cells,thereby resulting in the reversal of trastuzumab resistance and effectively suppress the development of BCa.

关键词： Monoclonal antibody therapy Trastuzumab resistance Nanoparticlem RNA delivery Cancer therapy

Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第12期13卷 5048-5059页

作者： Xiaodi Liu Qi Zhang Yixia Liang Shiyu Xiong Yan Cai Jincheng Cao Yanni xu Xiaolin xu Ye Wu Qiang Lu xiaoding xu Baoming Luo Department of Ultrasound Laboratory of Ultrasound Imaging and DrugWest China HospitalSichuan UniversityChengdu 610041China Department of Ultrasound Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Ultrasound Central People's Hospital of ZhanjiangZhanjiang 524045China

cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer *** evidence has shown that interferon-gamma(IFN)could enhance CXCL9 secretion from macrophages to recruit T cells,but Siglec15 expressed on TAMs can attenuate T cell ***,targeted regulation of macrophage function could be a promising strategy to enhance cancer immunotherapy via concurrently promoting the infiltration and proliferation of T cells in tumor *** herein developed reductionresponsive nanoparticles(NPs)made with poly(disulfide amide)(PDSA)and lipid-poly(ethylene glycol)(lipid-PEG)for systemic delivery of Siglec15 siRNA(siSiglec15)and IFN for enhanced cancer *** intravenous administration,these cargo-loaded could highly accumulate in the tumor tissues and be efficiently internalized by tumor-associated macrophages(TAMs).With the highly concentrated glutathione(GSH)in the cytoplasm to destroy the nanostructure,the loaded IFN and si-Siglec15 could be rapidly released,which could respectively repolarize macrophage phenotype to enhance CXCL9 secretion for T cell infiltration and silence Siglec15 expression to promote T cell proliferation,leading to significant inhibition of hepatocellular carcinoma(HCC)growth when combining with the immune checkpoint *** strategy developed herein could be used as an effective tool to enhance cancer immunotherapy.

关键词： Nanoparticles Tumor-associated macrophages Macrophage repolarization T cell infiltration T cell proliferation Cancer immunotherapy Siglec15 Hepatocellular carcinoma

A Study on Dual-Load-Zone Model of Overlying Strata andEvolution Law of Mining Stress

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2019年第2期58卷 391-407页

作者： Yuejin Zhou Mingpeng Li xiaoding xu Meng Li State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining&TechnologyXuzhou221116China

The changeable structure and movement law of overlying strata are the maincontributor to the change of mining *** from the relevant theory of keystratum and particularly based on the theory of mine ground pressure and strata control,this research proposed a new solution to mining stress problems by establishing adual-load-zone stratum structural *** foundation beam theory was used tosolve the stress of overlying strata of the dual-load-zones with superposition method,which revised the traditional calculation method of mining *** abnormal increaseof lead abutment pressure in the mining area was explained effectively,through which theevolution law of mining stress in the case of hard rock was *** results indicatethat mining stress experiences a drastic change within the range of 50 m ahead of the coalwall due to the collapse of main roof;under the influence of main key stratum andinferior key strata,the influence range of lead abutment pressure is extended up toapproximately 120 m in the working face;this remarkable increase can be attributed tothe excessive length of sagging *** from both the dual-load-zone modelexperiment and field measurement demonstrate high *** model can predictthe influence range of abutment pressure effectively and thus guide the safety productionof mining.

关键词： Overlying strata structure dual-load-zone mining stress evolution law

Non-coding RNAs:the new central dogma of cancer biology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2021年第1期64卷 22-50页

作者： Phei Er Saw xiaoding xu Jianing Chen Er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The central dogma of molecular biology states that the functions of RNA revolve around protein *** the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed *** discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being"junk"transcriptional products to"yet to be elucidated"—and potentially monumentally important—*** ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and *** major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ***,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics.

关键词： non-coding RNAs anti-cancer therapeutics personalized intervention miRNA lncRNA circRNA

基于“三铰拱-弹簧”模型的复合底板巷道非对称底鼓机制及卸压控制

在线全文

学校读者我要写书评

暂无评论

岩石力学与工程学报 2023年第6期42卷 1421-1433页

作者：徐晓鼎周跃进高玉兵付强魏兴见中国矿业大学深部岩石力学与地下工程国家重点实验室江苏徐州221008 中国矿业大学(北京)深部岩石力学与地下工程国家重点实验室(北京) 北京100083

为解决动压巷道非对称底鼓变形难题和诱发动力学事件的隐患,基于巷道非对称变形几何形态和受力特征建立“三铰拱-弹簧支撑”模型,分析系统能量的耗散特征和系统总势能函数的尖点突变失稳的充要判别条件,研究表明底板在平衡曲线变形为两... 详细信息

为解决动压巷道非对称底鼓变形难题和诱发动力学事件的隐患,基于巷道非对称变形几何形态和受力特征建立“三铰拱-弹簧支撑”模型,分析系统能量的耗散特征和系统总势能函数的尖点突变失稳的充要判别条件,研究表明底板在平衡曲线变形为两种形式,当沿路径I时变形是线性渐进的,不会发生大能量释放的动力学事件;当沿II路径时,变形是非线性的突发式底鼓,其中巷道底板的岩性、尺寸及侧应力是影响系统失稳的关键因素,可通过卸消压力方式来防治底板动力学事件发生。因此,提出切顶卸压底鼓控制技术,分析卸压机制,并在曹家滩煤矿开展卸压试验。研究表明,切顶是通过改变悬顶板支座形式来缩短顶板的垮落步距,进而来实现采场横、纵向压力卸载和集聚能量的释放,且横向压力卸压较纵向更为明显,进而有效控制了巷道底鼓变形。

关键词：采矿工程突变理论复合底板巷道非对称底鼓能量耗散切顶卸压

特厚煤层综放开采邻空动压巷道围岩变形机理及卸压控制

在线全文

学校读者我要写书评

暂无评论

煤炭科学技术 2023年第2期51卷 83-94页

作者：高玉兵王琦杨军丁维波付强徐晓鼎中国矿业大学(北京)深部岩土力学与地下工程国家重点实验室北京100083 中国矿业大学(北京)力学与建筑工程学院北京100083 陕西陕煤曹家滩矿业有限公司陕西榆林719000 中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116

受工作面采动叠加影响,特厚煤层综放开采邻空动压巷道极易发生冲击地压、巷道大变形等强矿压显现现象,是采掘过程中的重点防控区域。以榆神矿区曹家滩矿井特厚煤层综放开采为工程背景,分析了邻空动压巷道强矿压显现机理,研究了邻空巷道... 详细信息

受工作面采动叠加影响,特厚煤层综放开采邻空动压巷道极易发生冲击地压、巷道大变形等强矿压显现现象,是采掘过程中的重点防控区域。以榆神矿区曹家滩矿井特厚煤层综放开采为工程背景,分析了邻空动压巷道强矿压显现机理,研究了邻空巷道围岩倾向和走向支承压力分布力学机制,提出于邻空巷道进行定向张拉爆破切顶卸压巷道围岩控制,并运用数值模拟及现场试验等方法对该技术的作用效果进行了综合研究。结果表明,特厚煤层综放开采条件下,工作面开采大空间采空区长悬臂结构断裂后形成台阶岩梁块体长度较大,其滑落失稳或关键层失稳均会引发强动压,该动压作用在煤柱上并进一步传递至超前区邻空巷道围岩是造成底鼓大变形的主要原因。于邻空巷道内进行定向切顶卸压后,可减弱本工作面后方采空区顶板与煤柱间的承压,邻空巷道围岩应力向远离巷道方向转移,应力峰值降低,应力范围减小。现场开展了不同切顶方式下的现场工程试验,基于定向张拉爆破的深孔切顶卸压技术可有效减小特厚煤层工作面端头区邻空动压巷道的围岩压力,定向切顶后邻空动压巷道超前支架平均荷载降低11%,巷旁煤柱体应力峰值降低10%,巷内底鼓严重段平均变形减小65%,有效提高了巷道稳定性,为特厚煤层综放开采邻空动压巷道强矿压大变形控制提供了一种有效手段。

关键词：特厚煤层综放开采邻空动压巷道切顶卸压围岩控制

在线全文

学校读者我要写书评

暂无评论

核酸药物研究进展及挑战

实用医学杂志 2022年第11期38卷 1305-1308页

作者：董志辉许小丁中山大学孙逸仙纪念医院基础医学与转化中心广州510120

核酸药物是一种可在基因水平上发挥作用的核苷酸类药物,在癌症、病毒感染等疾病治疗中具有很大的潜力。传统治疗的效果通常是短暂的,因为其目标是蛋白质而不是潜在的基因。相比之下,核酸疗法通过基因抑制、添加、替换或编辑可以达到长... 详细信息

核酸药物是一种可在基因水平上发挥作用的核苷酸类药物,在癌症、病毒感染等疾病治疗中具有很大的潜力。传统治疗的效果通常是短暂的,因为其目标是蛋白质而不是潜在的基因。相比之下,核酸疗法通过基因抑制、添加、替换或编辑可以达到长期的疗效。目前应用较多的核酸药物主要包括DNA药物、m RNA药物以及siRNA药物等。本文综述核酸药物的工作原理以及核酸药物在目前所面临的挑战及解决办法等。

关键词：核酸药物基因调控疾病治疗