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Biological function of miRNA-145-5p in angiotensin II induced renal inflammation

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BIOCELL 2024年第4期48卷 601-611页

作者： BIN LI YUCHENG SHENG XIAOYING XU SHENGCUN WANG HONGYAN SONG JINGYUAN LI HAONAN JI QINGHUA WANG xiaodi zhou LONGJU QI Department of Pediatrics Affiliated Hospital of Nantong UniversityNantong226001China Department of Science and Education Affiliated Nantong Hospitalof Nantong UniversityNantong226001China Laboratory Animal Center Nantong UniversityNantong226001China Department of Gynecology and Obstetrics and Department of Oncology Hai’an Hospital Affiliated to Nantong UniversityNantong226600China

Objective:Chronic kidney disease(CKD)is a progressive disorder characterized by intricate structural and functional alterations in the kidneys,attributable to diverse causative ***,the therapeutic promise of miR-145-5p in addressing renal pathologies has been *** investigation seeks to elucidate the functional role of miR-145-5p in injured kidneys by subjecting human glomerular mesangial cells(HGMCs)to stimulation with Angiotensin II(AngII).Materials and Methods:Cellular viability and the levels of inﬂammatory mediators were evaluated utilizing Cell Counting Kit-8(CCK-8),quantitative real-time polymerase chain reaction(qRT-PCR),and western blot methodologies,both in the presence of AngII incubation and in scenarios of miR-145p overexpression and ***,the cell cycle dynamics were elucidated through Fluorescence-activated Cell Sorting(FACS)***:AngII incubation induced an upregulation of miR-145-5p and inﬂammatory factors including Intercellular Adhesion Molecule 1(ICAM-1),Interleukin 6(IL-6),Interleukin 8(IL-8),and Interleukin 1β(IL-1β).Additionally,it elevated the expression of Cyclin A2,Cyclin D1,and the G2/M cell cycle ***,inhibition of miR-145-5p heightened the levels of inﬂammatory factors and cell cycle regulators induced by AngII *** expression of miR-145-5p correlated with a downregulation of Interleukin 10(IL-10)expression,concurrently promoting HGMC proliferation under AngII ***,ectopic miR-145-5p expression demonstrated a reduction in inﬂammatory factors,cell cyclin regulators,G2/M cell cycle ratio,and overall ***:MiR-145-5p exhibited inhibitory effects on the inﬂammatory response and proliferation induced by Angiotensin II in HGMCs,showcasing its potential as a therapeutic avenue for the treatment of kidney injury.

关键词： miR-145-5p Kidney Angiotensin II Cell cycle Inflammation

Low-dimensional cobalt doped carbon composite towards wideband electromagnetic dissipation

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Nano Research 2023年第1期16卷 70-79页

作者： xiaodi zhou Biao Zhao Hualiang Lv School of Microelectronics Fudan UniversityShanghai 200433China Willian G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA

Composites composed of a carbon matrix decorated with a metal or metal oxide derived from zeolitic imidazolate frameworks(ZIFs)have been widely applied as suitable electromagnetic wave absorbers due to their high porosity and controllable ***,achieving ideal absorption performance remains a challenge owing to the inadequate conductivity and high density of the metal ***,a temperature-controlling treatment was employed for the bimetal ZIFs,and the corresponding derivatives exhibited an excellent dissipation ability with a minimum reflection loss value of−54.3 dB and an effective bandwidth of 7.0 GHz at a thickness of 2.4 mm,which resulted from the strong dipole polarization ***,after successfully controlling the Zn/Co ratio,the attenuation capability was greatly enhanced at a thickness of 1.4 mm,with bandwidths of 13.0–18.0 ***,this work provides an ameliorated strategy for microwave absorption performance of carbon-based materials.

关键词： microwave absorption bi-meta based absorber single-atom metal organic frameworks(MOFs)derived composite dielectric relaxation

Silicon-coated fibrous network of carbon nanotube/iron towards stable and wideband electromagnetic wave absorption

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Journal of Materials Science & Technology 2022年第26期121卷 199-206页

作者： xiaodi zhou He Han Yuchao Wang Cheng Zhang Hualiang Lv Zhichao Lou Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China Willian G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA School of Science Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China

Materials that can absorb electromagnetic(EM)wave have garnered increased attention in recent years due to their potential to mitigate the ever increasing environmental pollution by EM *** to recent advances in micro/nanofabrication,a variety of magnetic metal-based EM absorbers have been *** design and synthesis of EM absorbers that exhibit efficient and wide-band absorption at small thicknesses,however,remains *** we report the design of fibrous nanostructures consisting of magnetic iron(Fe)nanoparticles and carbon nanotubes(CNTs),which exhibits a wide-band EM absorption(3.8 GHz)while maintain the thickness at 1.2 *** our work,we created a novel core-shell structure by immersing the highly fibrous CNT-Fe structure into solid-state silicon(SiO)***,the SiO-coated CNT-Fe structures exhibit good stability against air-induced oxidation and acid corrosion while maintaining high EM ***,the results reported in this study present new avenues to absorb EM from ambient *** believe that our work elevates the utility of EM absorbers to real-world applications such as anti-acid and oxidation ability.

关键词： Fibrous network Silicon-coated nanostructure Electromagnetic pollution Magnetic-dielectric loss

Characteristics of the site selection and the layout of the Great Wall of the Ming dynasty from a military perspective:Xiaohekou section as an example

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Frontiers of Architectural Research 2020年第3期9卷 541-555页

作者： Yang Shen Qingshang Su Tingli Jia xiaodi zhou School of Architecture Southeast UniversityNanjingChina Key Scientific Research Base of Traditional Wooden Architecture(Southeast University) State Administration for Cultural Heritaget NanjingChina Architecture Et Engineers Co. Ltd.of Southeast UniversityNonjinsChina

As a great engineering work for the purpose of military defense in the time of Cold Weapon,the Great Wall’s military function is of the most *** study takes the Xiaohekou section of the Great Wall in *** constructed in the Ming Dynasty in Liaoning Province as the research *** addition,this study discusses the relationship between the terrain and its site selection and layout from the military *** research analyzes the trend and the grade of the terrain,the distance,the view range,and the effective firing range between the main body and the subsidiary establishments through GIS *** GPS data collected in the on-site investigation were used,applying the theories of military ***,this study concludes the characteristics of the site selection and the layouts of the city walls,the hollow watchtowers,the M a ria n s,and the signal towers on different terrains and the reasons behind.

关键词： Military function Xiaohekou section of the great wall of the ming dynasty Site selection and layout Terrain

越城区坡塘小流域水土流失治理及施工技术应用

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浙江水利水电学院学报 2024年第3期36卷 45-48页

作者：张清彪张坚瑶周枭迪陈颖绍兴市水利水电勘测设计院有限公司浙江绍兴312000 绍兴市水利水电建设投资有限公司浙江绍兴312000 杭州余杭交通建设有限公司浙江杭州311100 浙江智慧云环境科技有限公司浙江杭州311100

绍兴市越城区坡塘小流域存在水土流失问题。通过分析该区域的综合生态治理项目,评估水土流失、生态退化和生产条件等制约因素对当地生态环境稳定及区域可持续发展的影响,采用了土地封育、水土保持和生态恢复等多元化治理策略,以期优化... 详细信息

绍兴市越城区坡塘小流域存在水土流失问题。通过分析该区域的综合生态治理项目,评估水土流失、生态退化和生产条件等制约因素对当地生态环境稳定及区域可持续发展的影响,采用了土地封育、水土保持和生态恢复等多元化治理策略,以期优化生态环境,减缓水土流失,增强区域水源涵养能力。通过实地调研与数据分析,精准实施上述水土流失治理措施。结果表明,综合治理能有效改善小流域生态,增强农业生产能力,推动区域共同富裕,促进人与自然和谐共生。

关键词：小流域水土保持综合治理

Hierarchical porous hollow graphitized carbon@MoS_(2)with wideband EM dissipation capability

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Journal of Materials Science & Technology 2021年第24期83卷 239-247页

作者： Lieji Yang Tianwei Deng Zirui Jia xiaodi zhou Hualiang Lv Yutao Zhu Juncen Liu Zhihong Yang College of Material Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China William G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOHUSA Fu Foundation School of Engineering and Applied Science Columbia UniversityNew York10027USA State Key Laboratory of Biofibers and Eco-textiles College of Chemistry and Chemical EngineeringQingdao UniversityQingdao266071China

Core-shell materials are promising broadband electromagnetic(EM)absorption materials since the highly component manipulation performance,interfacial effect ***,a well-defined core-shell shaped structure constructed by 2-dimensional Mo S_(2)nanosheets-coated porous hollow carbon has been successfully designed with controlled pore-sizes of the core,adjustable shell content,and *** effectively optimizing the parameters for these factors,the as-prepared hierarchical porous hollow C@Mo S_(2)sample enables an ultra-width EM absorption ability(covering 11.4-18.0 GHz)at a thickness of only 2.0 *** detailed contributions of each component and structure on the excellent EM absorption capability have been *** encouraging results indicate that the development of core-shell composites with multiple controllable physical factors is of great significance for the future ultra-wideband electromagnetic absorbers.

关键词： Porous hollow carbon@MoS_(2) Dielectric dissipation Pore-controllable core Wideband electromagnetic absorption

Biomass-Derived Carbon Heterostructures Enable Environmentally Adaptive Wideband Electromagnetic Wave Absorbers

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Nano-Micro Letters 2022年第1期14卷 210-225页

作者： Zhichao Lou Qiuyi Wang Ufuoma IKara Rajdeep SMamtani xiaodi zhou Huiyang Bian Zhihong Yang Yanjun Li Hualiang Lv Solomon Adera Xiaoguang Wang Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037People’s Republic of China Willian G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA Institute of Materials Research and Engineering Agency for SciencesTechnology and ResearchSingaporeSingapore Sustainability Institute The Ohio State UniversityColumbusOH 43210USA Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA

Although advances in wireless technologies such as miniature and wearable electronics have improved the quality of our lives,the ubiquitous use of electronics comes at the expense of increased exposure to electromagnetic(EM)*** to date,extensive efforts have been made to develop high-performance EM absorbers based on synthetic ***,the design of an EM absorber with both exceptional EM dissipation ability and good environmental adaptability remains a substantial ***,we report the design of a class of carbon heterostructures via hierarchical assembly of graphitized lignocellulose derived from ***,the assemblies of nanofibers and nanosheets behave as a nanometer-sized antenna,which results in an enhancement of the conductive *** addition,we show that the composition of cellulose and lignin in the precursor significantly influences the shape of the assembly and the formation of covalent bonds,which affect the dielectric response-ability and the surface hydrophobicity(the apparent contact angle of water can reach 135°).Finally,we demonstrate that the obtained carbon heterostructure maintains its wideband EM absorption with an effective absorption frequency ranging from 12.5 to 16.7 GHz under conditions that simulate the real-world environment,including exposure to rainwater with slightly acidic/alkaline pH ***,the advances reported in this work provide new design principles for the synthesis of high-performance EM absorbers that can find practical applications in real-world environments.

关键词： Electromagnetic dissipation Carbon heterostructure Environment adaptability Bamboo Lignocellulose

Dihydroartemisinin ameliorates palmitate-induced apoptosis in cardiomyocytes via regulation on miR-133b/Sirt1 axis

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BIOCELL 2022年第4期46卷 989-998页

作者： LONGJU QI XIAOYING XU BIN LI BO CHANG SHENGCUN WANG CHUN LIU LIUCHENG WU xiaodi zhou QINGHUA WANG Affiliated Nantong Hospital 3 of Nantong University Nantong UniversityNantong226001China Comparative Medicine Institution of Nantong University Nantong UniversityNantong226001China Department of Gynecology and Obstetrics Hai’an Hospital Affiliated to Nantong UniversityNantong UniversityNantong226001China Department of Paediatric Affiliated Hospital of Nantong UniversityNantong UniversityNantong226001China Department of Internal Cardiovascular Medicine the 6th People’s Hospital of Nantong CityNantong226001China

Excessive fat ectopically deposited in the non-adipose tissues is considered as one of the leading causes of *** aim of this study was to investigate the role of Dihydroartemisinin(DHA)in palmitate(PAL)-incubated H9c2 cells(lipotoxicity-induced cell injury model).Cell viability of PAL-treated cells was determined by MTT assay,and apoptotic regulators were examined by qRT-PCR and western blot analysis,in the absence or in the presence of DHA,*** levels of miR-133b and Sirt1 were also evaluated by qRT-PCR and western blotting *** decreased the viability of H9c2 cells and enhanced the expression of apoptotic *** reversed the effect of PAL on cell viability and lowed the level of Caspase3 and *** also lowered the expression of miR-133b,while enhanced the expression of ***1 was revealed as target of miR-133b through transcriptional regulation and the process was affected by *** partially protected against the PAL-induced lipotoxicity by influencing the expression of miR-133b that hindered the activity of *** may be used as a potential treatment in clinical management for lipotoxicity induced heart complications.

关键词： microRNA-133b Palmitate acid Cardiomyocytes Sirt1 Dihydroaretemisinin

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基于超声波传感器的AGV模糊避障设计

自动化应用 2024年第15期65卷 24-27页

作者：白自强邢希达李敏商宝富周晓迪王兴宾山东北方光学电子有限公司山东泰安271000

根据工业现场实际生产状况,设计了一款用于避障的AGV小车。四传感器融合的模糊控制系统用于AGV避障,通过远程API控制AGV在CoppeliaSim中进行避障仿真,实现了MATLAB(客户端)和CoppeliaSim(服务器)跨越两平台联合实时仿真,论证了该四传感... 详细信息

根据工业现场实际生产状况,设计了一款用于避障的AGV小车。四传感器融合的模糊控制系统用于AGV避障,通过远程API控制AGV在CoppeliaSim中进行避障仿真,实现了MATLAB(客户端)和CoppeliaSim(服务器)跨越两平台联合实时仿真,论证了该四传感器融合模糊控制可用于行进过程中躲避障碍物,为后期的控制系统优化提供了一定依据。

关键词：四传感器融合模糊逻辑控制器远程 API 避障