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Stretchable and environment-resistant doubly crosslinked hydrogel for all-in-one supercapacitor and strain sensors

Journal of Materiomics 2024年第6期10卷 1186-1195页

作者： Chunlin Liu Le Jjiang Fenglin Zhao Qin Hu Yingge Zhang xiaodan sun Lianxin Peng School of Mechanical Engineering Chengdu UniversityChengdu 610106China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs Chengdu UniversityChengdu 610106China

Despite their importance as components for flexible electronics,most stretchable hydrogels suffer from incomplete recovery after deformation,are prone to failure upon long-term repeated stretching,and cannot be exploited at subzero temperatures because of the freezing of their constituent ***-quently,strategies for circumventing these drawbacks are highly sought *** study describes the synthesis of a doubly(chemically and physically)crosslinked hydrogel from gelatin and methacrylic acid and demonstrates the suitability of this material for the fabrication of high-performance stretchable and environment-resistant supercapacitors and strain *** performance of this supercapacitor(areal capacitance=1,210.2 mF/cm^(2) at a current density of 1 mA/cm^(2),maximum energy density=158.8μW.h/cm^(-1),maximum power density=659.5μW/cm^(2))was superior to that of most of integrated super-capacitors reported to date and was hardly affected by stretchable,low temperatures,bending,ice-cold water and strong acid/alkali solutions or long-term ***,a strain sensor based on the above hydrogel was capable of accurately capturing human body motions when affixed to skin and recognising mouse movement(even in humid environments)after implantation into mouse *** work may pave the way to high-performance stretchable and environment-resistant wearable electronics.

关键词： Doubly crosslinked hydrogel Stretchable Environment-resistant All-in-one supercapacitor Strain sensor

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Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats

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Regenerative Biomaterials 2019年第6期6卷 325-334页

作者： Jiaju Lu Fengyi Guan Fuzhai Cui xiaodan sun Lingyun Zhao Ying Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing Center of Neutral Regeneration and Repair Key Laboratory for Neurodegenerative Disease of the Ministry of EducationCapital Medical UniversityBeijing 100069China

Angiogenesis plays an important role in brain injury repair,which contributes to the reconstruction of regenerative neurovascular niche for promoting axonal regeneration in the lesion *** a major component of developing brain extracellular matrix,hyaluronic acid(HA)has attracted more attention as a supporting matrix for brain *** the present study,HA-KLT hydrogel was developed via modifying HA with a VEGF mimetic peptide of KLT(KLTWQELYQLKYKGI).The characterization of the hydrogel shows that it could provide a porous,three-dimensional scaffold structure,which has a large specific surface area available for cell adhesion and *** with the unmodified HA hydrogel,the HA-KLT hydrogel could effectively promote the attachment,spreading and proliferation of endothelial cells in ***,the pro-angiogenic ability of hydrogels in vivo was evaluated by implanting them into the lesion cavities in the injured rat *** results showed that the hydrogels could form a permissive interface with the host tissues at 4 weeks after ***,they could efficiently inhibit the formation of glial scars at the injured *** HA-KLT hydrogel could significantly increase the expression of endoglin/CD105 and promote the formation of blood vessels,suggesting that HA-KLT hydrogel promoted angiogenesis in ***,the HA-KLT hydrogel has the potential to repair brain defects by promoting angiogenesis and inhibiting the formation of glial-derived scar tissue.

关键词： traumatic brain injury hyaluronic acid angiogenesis VEGF mimetic peptide

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Organic mulching promotes soil organic carbon accumulation to deep soil layer in an urban plantation forest

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Forest Ecosystems 2021年第1期8卷 11-21页

作者： xiaodan sun Gang Wang Qingxu Ma Jiahui Liao Dong Wang Qingwei Guan Davey L.Jones College of Biology and Environment Nanjing Forestry UniversityNanjing 210037China Co-Innovation Center of Sustainable Forestry in Southern China Nanjing 210037China School of Natural Sciences Bangor UniversityGwynedd LL572UWUK College of Environmental Science and Engineering China West Normal UniversityNanchong 637000China UWA School of Agriculture and Environment The University of Western AustraliaPerthWA 6009Australia

Background:Soil organic carbon(SOC)is important for soil quality and fertility in forest *** SOC fractions are sensitive to environmental changes,which reflect the impact of short-term internal and external management measures on the soil carbon *** mulching(OM)alters the soil environment and promotes plant ***,little is known about the responses of SOC fractions in rhizosphere or bulk soil to OM in urban forests and its correlation with carbon composition in ***:A one-year field experiment with four treatments(OM at 0,5,10,and 20 cm thicknesses)was conducted in a 15-year-old Ligustrum lucidum *** in the SOC fractions in the rhizosphere and bulk soil;the carbon content in the plant fine roots,leaves,and organic mulch;and several soil physicochemical properties were *** relationships between SOC fractions and the measured variables were ***:The OM treatments had no significant effect on the SOC fractions,except for the dissolved organic carbon(DOC).OM promoted the movement of SOC to deeper soil because of the increased carbon content in fine roots of *** were significant correlations between DOC and microbial biomass carbon and SOC and easily oxidised organic *** OM had a greater effect on organic carbon fractions in the bulk soil than in the *** thinnest(5 cm)mulching layers showed the most rapid carbon decomposition over *** time after OM had the greatest effect on the SOC fractions,followed by soil ***:The frequent addition of small amounts of organic mulch increased SOC accumulation in the present *** is a potential management model to enhance soil organic matter storage for maintaining urban forest productivity.

关键词： Soil organic carbon Labile organic carbon fractions Rhizosphere Urban plantation forest Organic mulching

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A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration

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Nano Research 2018年第9期11卷 4599-4613页

作者： Jiaju Lu Xun sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue sun Lingyun Zhao xiaodan sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China Institute of Orthopedics Chinese PLA General Hospital Beijing 100853 China School of Medicine Nankai University Tianjin 300071 China Experimental Surgery and Regenerative Medicine Department of Surgery Ludwig-Maximilians-University Munich 80336 Germany Department of Ultrasound Beijing Hospital Beijing 100730 China CenterofBiomedicalAnalysis Tsinghua University Beijing 100084 China Department of Bioengineering Bioscience Research Collaborative Rice University Texas 77030 USA Co-innovation Center of Neuroregeneration Nantong University Nantong 226007 China

Nerve guidance conduit （NGC） is a potential alternative to autologous nerve for peripheral nerve regeneration. A promising therapeutic strategy is to modify the nerve guidance conduit intraluminal microenvironment using physical and/or chemical guidance cues. In this study, a neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel that could promote PC12 cell adhesion, proliferation, and neuronal differentiation in vitro was prefilled in the lumen of a hollow chitosan tube （hCST） to accelerate axonal regeneration in a rat sciatic nerve defect model. The functionalized self-assembling peptide was developed by introducing a neurotrophic peptide （RGI, RGIDKRHWNSQ） derived from brain-derived neurotrophic factor （BDNF） to the C-terminus of the self-assembling peptide RADA16-I （Ac-（RADA）4-CONH2）. Morphological, histological, electrophysiological, and functional analyses demonstrated that the RGI-functionalized, self-assembling, peptide nanofiber hydrogel RAD/RGI could produce a neurotrophic microenvironment that markedly improved axonal regeneration with enhanced re-myelination and motor functional recovery.

关键词： peripheral nerve regeneration,self-assembling peptide,hydrogel,neurotrophic peptide,intraluminal microenvironment

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Snow disaster characteristics in Palongzangbu River Basinand mitigation countermeasures for road engineering

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Research in Cold and Arid Regions 2016年第2期8卷 95-102页

作者： ShuSu Duan LingKan Yao xiaodan sun Qiang Cai School of Civil Engineering Southwest Jiaotong UniversityChengduSichuan 610031China Road and Railway Engineering Research Institute Sichuan Key Laboratory of Seismic Engineering and TechnologyChengduSichuan 610031China MOE Key Laboratory of High-speed Railway Engineering ChengduSichuan 610031China

The Palongzangbu River Basin contains the highest number of maritime province glaciers in China. There are 130 glacial lakes, 64 snow avalanche sites and 28 glacial debris flow gullies distributed within the basin. Snow disasters play a controlling role in the Sichuan-Tibet Highway construction, due to the terrain’s special characteristics of high altitude and large height differential. Segmentation mitigation countermeasures for the Sichuan-Tibet Highway are presented based on snow disaster severity level and damage mode of the road. In the Ranwu to Midui section, snow avalanches are regional disasters, so the line should be placed in sunny slopes. In the Midui Gully to Yupu section, the line should be placed in shady slopes and at higher elevations to reduce the risk of glacial lake outburst. In the Yupu to Guxiang section, all three snow disasters are minimal. In the Guxiang to Tongmai section, glacier debris flows are the major threat, thus the road should be placed in shady slopes.

关键词： Palongzangbu River Basin glacial lake outburst snow avalanche glacial debris flow line engineering

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Construction of a mineralized collagen nerve conduit for peripheral nerve injury repair

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Regenerative Biomaterials 2023年第1期10卷 81-96页

作者： Guman Duan Chengli Li Xiaoqing Yan Shuhui Yang Shuo Wang xiaodan sun Lingyun Zhao Tianxi Song Yongwei Pan Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Orthopedics Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Orthopedics Beijing Changping District HospitalBeijing 102202China Beijing Allgens Medical Science and Technology Co. LtdBeijing 100176China

A new nerve guidance conduits(NGCs)named MC@Col containing Type I collagen(Col)and mineralized collagen(MC)was developed,enhancing mechanical and degradation *** physicochemical properties,the mechanical properties and in vitro degradation behavior were all *** adhesion and proliferation of Schwann cells(SCs)were *** the in vivo experiment,MC@Col NGC and other conduits including Col,chitosan(CST)and polycaprolactone(PCL)conduit were implanted to repair a 10-mm-long Sprague-Dawley rat’s sciatic nerve *** analyses,morphological analyses,electrophysiological analyses and further gait analyses were all evaluated after implantation in 12 *** strength and degradation performance of the MC@Col NGC were improved by the addition of MC in comparison with pure Col *** vitro cytocompatibility evaluation revealed that the SCs had good viability,attachment and proliferation in the MC@*** in vivo results,the regenerative outcomes of MC@Col NGC were close to those by an autologous nerve graft in some respects,but superior to those by Col,CST and PCL *** MC@Col NGC exhibited good mechanical performance as well as biocompatibility to bridge nerve gap and guide nerve regeneration,thus showing great promising potential as a new type of conduit in clinical applications.

关键词： nerve guidance conduit collagen mineralized collagen peripheral nerve regeneration

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General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics

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Nano Research 2017年第2期10卷 704-717页

作者： Hao Yan Lingyun Zhao Wenting Shang Zhongqun Liu Wensheng Xie Cai Qiang Zhiyuan Xiong Ranran Zhang Baohua Li xiaodan sun Feiyu Kang State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China Key Laboratory of Advanced Materials of Ministry of Education of China Tsinghua University Beijing 100084 China Engineering Laboratory for Functionalized Carbon Materials Graduate School at Shenzhen Tsinghua University Shenzhen 518055 China Key Laboratory of Molecular Imaging Institute of Automation Chinese Academy of Sciences Beijing 100190 China

Recently, increasing attention has been paid to magneto-conjugated polymer core-shell nanoparticles （NPs） as theranostic platforms. However, the utilization of surfactants and extra oxidizing agents with potential toxicity in synthesis, the lack of general methods for the controlled synthesis of various kinds of magnetic NP （MNP）@conjugated polymer NPs, and the difficulty of obtaining balanced magneto-optical properties have greatly limited the applications of magneto-conjugated polymers in theranostics. We developed an in situ surface polymerization method free of extra surfactants and oxidizing agents to synthesize MNP@polypyrrole （PPy） NPs with balanced, prominent magneto-optical properties. MNP@PPy NPs with an adjustable size, different shapes, and a controlled shell thickness were obtained using this method. The method was extended to synthesize other MNP-conjugated polymer core-shell NPs, such as MNP@polyaniline and MNP@poly（3,4-ethylenedioxythiophene）：poly（4- styrenesulfonate）（PEDOT：PSS）. We discuss the formation mechanism of the proposed method according to our experimental results. Finally, using the optical and magnetic properties of the obtained MNP@PEDOT：PSS NPs, in vivo multimodal imaging-guided hyperthermia was induced in mice, achieving an excellent tumor-ablation therapeutic effect. Our work is beneficial for extending the application of MNP-conjugated polymer core-shell NPs in the biomedical field.

关键词： iron oxide polypyrrole photothermal magnetic hyperthermal poly(3 4-ethylenedioxythiophene):poly(4-styrenesulfonate)(PEDOT:PSS)

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Doxorubicin-Ioaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging- guided chemo-photothermal therapy of breast cancer

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Nano Research 2018年第5期11卷 2470-2487页

作者： Wensheng Xie Qin Gao Dan Wang Zhenhu Guo Fei Gao Xiumei Wang Qiang Cai Si-shen Feng Haiming Fan xiaodan sun Lingyun Zhao State Key Laboratory of New Ceramics and Fine Processing School of Materials Science & Engineering Tsinghua University Beijing 100084 China Key Laboratory of Advanced Materials Ministry of Education of China School of Materials Science & Engineering Tsinghua University Beijing 100084 China School of Chemical and Biomolecular Engineering Notional University of Singapore 119077 Singapore College of Chemistry and Materials Science Northwest University Xi'an 710069 China

Molybdenum disulfide （MoS2）, a typical transition-metal dichalcogenide, has attracted increasing attention in the field of nanomedicine because of its preeminent properties. In this study, magnetic resonance imaging （MRI）-guided chemo-photothermal therapy of human breast cancer xenograft in nude mice was demonstrated using a novel core/shell structure of Fe3O4@MoS2 nanocubes （IOMS NCs） via the integration of MoS2 （MS） film onto iron oxide （IO） nanocubes through a facile hydrothermal method. After the necessary PEGylation modification of the NCs for long-circulation purposes, such PEGylated NCs were further capped by 2-deoxy-D-glucose （2-DG）, a non-metabolizable glucose analogue to increase the accumulation of the as-prepared NCs at the tumor site, as 2-DG molecules could be particularly attractive to resource-hungry cancer cells. Such 2-DG- modified PEGylated NCs （IOMS-PEG-2DG NCs） acted as drug-carriers for doxorubicin （DOX）, which could be easily loaded within the NCs. The obtained IOMS-PEG（DOX）-2DG NCs exhibited a 3？2 relaxivity coefficient of 48.86 （mM）^-1·s^-1 and excellent photothermal performance. 24 h after intravenous injection of IOMS-PEG（DOX）-2DG NCs, the tumor site was clearly detected by enhanced T2-weighted MRI signal. Upon exposure to an NIR 808-nm laser for 5 rain at a low power density of 0.5 W·cm^-2 a marked temperature increase was noticed within the tumor site, and the tumor growth was efficiently inhibited by the chemo-photothermal effect. Therefore, our study highlights an excellent theranostic platform with great potential for targeted MRI-guided precise chemo-photothermal therapy of breast cancer.

关键词： iron oxide nanocubes molybdenum disulfide multimodality therapy photothermal therapy nanotheranostics

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Ultrasound-driven BaTiO_(3) nanorobots patching immunologic barrier to cure chronic rheumatoid arthritis

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Journal of Advanced Ceramics 2023年第5期12卷 1105-1117页

作者： Le Jiang Yifan Wang Chunlin Liu Nan Xu Wenshuo Li Lei Wang Yixian Wu Jingyun Wang Zhijun He Fengbo sun Lingyun Zhao Qiong Wu Xiumei Wang Huihui Yuan Xiaohui Wang xiaodan sun State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China MOE Key Lab.Bioinformatics School of Life SciencesTsinghua UniversityBeijing 100084China Department of Immunology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which engender the prediction of this immunologic barrier as a potential driver for the achievement of"cure"in ***,strategies to promote the reconstruction of this barrier have not been reported,and the effect of patching this barrier remains *** the other hand,appropriate piezoelectric stimulation can reprogram macrophages,which has never been exerted on this barrier TRM ***,we design piezoelectric tetragonal BaTiO_(3)(BTO)ultrasound-driven nanorobots(USNRs)by the solvothermal synthesis method,which demonstrates satisfactory electro-mechanical conversion effects,paving the way to generate controllable electrical stimulation under ultrasound to reprogram the barrier TRM by minimally invasive injection into joint *** is demonstrated that the immunologic barrier could be patched by this USNR effectively,thereby eliminating the hyperplasia of vessels and nerves(HVN)and ***,TREM2 deficiency serum-transfected arthritis(STA)mice models are applied and proved the indispensable role of TREM2 in RA curing mediated by *** all,our work is an interesting and important exploration to expand the classical tetragonal BTO nanoparticles in the treatment of autoimmune diseases,providing a new idea and direction for the biomedical application of piezoelectric ceramics.

关键词： ultrasound-driven BaTiO_(3)nanorobots(BTO NRs) immunologic barrier upstream driver rheumatoid arthritis(RA)

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Osteochondral scaffolds for early treatment of cartilage defects in osteoarthritic joints:from bench to clinic

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Biomaterials Translational 2020年第1期1卷 3-17页

作者： Maryam Tamaddon Helena Gilja Ling Wang JMiguel Oliveira xiaodan sun Rongwei Tan Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAveparkPortugal School of Materials Science and Engineering Tsinghua UniversityBeijingChina Shenzhen Lando Biomaterials Co.Ltd.Merchants Guangming Science Park ShenzhenGuangdong ProvinceChina

Osteoarthritis is a degenerative joint disease,typified by the loss in the quality of cartilage and bone at the interface of a synovial joint,resulting in pain,stiffness and reduced *** current surgical treatment for advanced stages of the disease is joint replacement,where the non-surgical therapeutic options or less invasive surgical treatments are no longer *** are major surgical procedures which have a substantial impact on patients’quality of life and lifetime risk of requiring revision *** using regenerative methods such as tissue engineering methods have been established and are promising for the early treatment of cartilage degeneration in osteoarthritis *** this approach,3-dimensional scaffolds(with or without cells)are employed to provide support for tissue ***,none of the currently available tissue engineering and regenerative medicine products promotes satisfactory durable regeneration of large cartilage ***,we discuss the current regenerative treatment options for cartilage and osteochondral(cartilage and underlying subchondral bone)defects in the articulating *** further identify the main hurdles in osteochondral scaffold development for achieving satisfactory and durable regeneration of osteochondral *** evolution of the osteochondral scaffolds–from monophasic to multiphasic constructs–is overviewed and the osteochondral scaffolds that have progressed to clinical trials are examined with respect to their clinical performances and their potential impact on the clinical *** of an osteochondral scaffold which bridges the gap between small defect treatment and joint replacement is still a grand *** scaffold could be used for early treatment of cartilage and osteochondral defects at early stage of osteoarthritis and could either negate or delay the need for joint replacements.

关键词： cartilage injury osteoarthritis osteochondral scaffold regenerative medicine subchondral defect tissue engineering

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