检索结果-南通市图书馆

Neuropeptide Y receptor Y8b(npy8br)regulates feeding and digestion in Japanese medaka(Oryzias latipes)larvae:evidence from gene knockout

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 605-616页

作者： xiaodan jia Ke LU Xufang LIANG College of Fisheries Chinese Perch Research CenterHuazhong Agricultural UniversityWuhan 430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt Ministry of EducationWuhan 430070China

Neuropeptide Y receptor Y8(NPY8R)is a fish-specific receptor with two subtypes,NPY8AR and *** in expression levels during physiological processes or in vivo regulation after ventricular injection suggest that NPY8BR plays an important role in feeding regulation;this has been found in only a few fish,at *** order to better understand the physiological function of npy8br,especially in digestion,we used clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology to generate npy8br-/-japanese medaka(Oryzias latipes).We found that the deletion of npy8br in medaka larvae affected their feeding and digestion ability,ultimately affecting their ***,npy8br deficiency in medaka larvae resulted in decreased feed intake and decreased expression levels of orexigenic genes(npy and agrp).npy8br-/-medaka larvae fed for 10 d(10th day of feeding)still had incompletely digested brine shrimp(Artemia nauplii)in the digestive tract 8 h after feeding,the messenger RNA(mRNA)expression levels of digestion-related genes(amy,lpl,ctra,and ctrb)were significantly decreased,and the activity of amylase,trypsin,and lipase also significantly *** deletion of npy8br in medaka larvae inhibited the growth and significantly decreased the expression of growth-related genes(gh and igf1).Hematoxylin and eosin(H&E)sections of intestinal tissue showed that npy8br-/-medaka larvae had damaged intestine,thinned intestinal wall,and shortened intestinal *** far,this is the first npy8br gene knockout model established in fish and the first demonstration that npy8br plays an important role in digestion.

关键词： Neuropeptide Y receptor Y8b(npy8br) Japanese medaka(Oryzias latipes) Knockout Feeding Digestion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

拦挡作用对黄土坡面泥流动力过程影响机制

引用

西北地质 2024年第3期57卷 285-292页

作者：华山贾晓丹张霞长安大学地球科学与资源学院陕西西安710054 中国地质调查局西安地质调查中心/西北地质科技创新中心陕西西安710119 西安理工大学西北旱区生态水利国家重点实验室陕西西安710048

泥石流运动过程中拦挡坝的拦挡作用是泥流防治研究中的一项重要议题。本研究引入侵蚀速率概念,建立了含有拦挡坝的泥流连续介质模型,阐明了拦挡坝拦挡作用对泥流运动行为和动力过程的影响。结果表明,泥流撞击拦挡坝发生漫坝时,拦挡坝遭... 详细信息

泥石流运动过程中拦挡坝的拦挡作用是泥流防治研究中的一项重要议题。本研究引入侵蚀速率概念,建立了含有拦挡坝的泥流连续介质模型,阐明了拦挡坝拦挡作用对泥流运动行为和动力过程的影响。结果表明,泥流撞击拦挡坝发生漫坝时,拦挡坝遭受了逐渐加速泥流巨大的影响。拦挡坝发挥出拦截和拦挡双重功效:一方面,使得泥流灾害体横向扩展增强,纵向延伸减弱,滑移距离减少,降低了泥流的致灾范围;另一方面,降低了泥流侵蚀夹带作用,减少了泥流灾害体质量,使得灾害体面积和体积分别下降2.48%和3.63%。同时,使泥流偏离流动方向,泥流运动的平均速度下降10.62%,缓解了泥流的冲击力,削减了灾害体16.17%的致灾能量,进一步降低了泥流的致灾强度和致灾规模。引入基底地形和侵蚀速率的数值模型为泥石流动力机制提供理论支持,也为泥流防治提供技术指导。

关键词：泥流拦挡坝动力机制致灾能量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

脑小血管病总负荷与急性脑梗死患者早期预后的相关性

引用

中国现代医生 2024年第3期62卷 26-29,64页

作者：贾小丹曲娟蚌埠医学院研究生院安徽蚌埠233030 嘉善县第一人民医院神经内科浙江嘉兴314000 嘉兴市第一医院神经内科浙江嘉兴314000

目的探讨脑小血管病(cerebral small vessel disease,CSVD)总负荷与急性脑梗死(acute cerebral infarction,ACI)患者早期预后的相关性。方法选取2020年10月至2022年6月嘉兴市第一医院神经内科收治的150例ACI患者,根据改良Rankin评分量... 详细信息

目的探讨脑小血管病(cerebral small vessel disease,CSVD)总负荷与急性脑梗死(acute cerebral infarction,ACI)患者早期预后的相关性。方法选取2020年10月至2022年6月嘉兴市第一医院神经内科收治的150例ACI患者,根据改良Rankin评分量表(modified Rankin scale,m Rs)评分分为预后良好组(m Rs≤2分)和预后不良组(m Rs≥3分),对比两组患者的基线资料及临床特征,并通过头颅MRI评估CSVD总负荷。采用Logistic模型进行单因素及多因素分析,Pearson法分析CSVD总负荷与早期预后相关性。结果单因素分析显示,预后不良组患者的年龄、住院天数、入院美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)、超敏C反应蛋白、三酰甘油、同型半胱氨酸均高于预后良好组,差异有统计学意义(P<0.05),预后不良组患者的腔隙、脑微出血、白质高信号及CSVD总负荷高于预后良好组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,住院天数(OR=1.278,95%CI=1.054~1.548,P=0.012)、入院NIHSS评分(OR=1.354,95%CI=1.113~1.647,P=0.002)、CSVD总负荷(OR=2.494,95%CI=1.666~3.735,P<0.001)是ACI患者早期预后不良的独立危险因素。结论 CSVD总负荷与ACI患者早期预后不良相关。

关键词：急性脑梗死脑小血管病总负荷评分早期预后磁共振成像

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

超薄超小镍铁水滑石的声悬浮制备

引用

洁净煤技术 2024年第4期30卷 120-129页

作者：加晓丹李金龙张绍炳贾金鑫赵顺省杨再文杨征刘向荣西安科技大学化学与化工学院陕西西安710054 自然资源部煤炭资源勘查与综合利用重点实验室陕西西安710021

开发高效、低成本的清洁能源,有助于降低CO_(2)排放。电催化分解水产氢产氧或许可实现未来对清洁能源的需求。在诸多纳米材料中,超薄二维纳米材料因其可暴露更多的活性位点、具有更高的比表面积等特点,在电催化反应中表现出优异的性能... 详细信息

开发高效、低成本的清洁能源,有助于降低CO_(2)排放。电催化分解水产氢产氧或许可实现未来对清洁能源的需求。在诸多纳米材料中,超薄二维纳米材料因其可暴露更多的活性位点、具有更高的比表面积等特点,在电催化反应中表现出优异的性能。镍铁水滑石(NiFe-LDH)是非常有前景的过渡金属电催化分解水产氧反应(OER)催化剂。采用水热法制备Ni_(x)Fe_(1)-LDH(x=1,2,3)前体,利用超声悬浮剥离法实现超薄超小镍铁水滑石纳米片的快速制备。声悬浮法利用超声波发射端和反射端间产生的高强度声辐射力来抵消样品的重力,进而使样品被悬浮。超声波反复叠加形成的高声强驻波,更易实现超薄超小纳米材料的快速制备。研究发现,通过超声悬浮技术可实现仅用20μL甲酰胺在20 min内成功将Ni_(1)Fe_(1)-LDH前体从横向尺寸为1500 nm、厚度为25.66 nm剥离为分散较为均匀、横向尺寸约10 nm、厚度低至0.649 nm的超薄超小镍铁水滑石纳米片,并具有优异的OER性能。不同物质的量比的镍铁水滑石随超声悬浮时间逐渐增加,OER性能逐渐提高。其中,当电流密度达10 mA/cm^(2)时,Ni_(1)Fe_(1)-LDH-20 min的过电位低至309 mV,相比于Ni_(1)Fe_(1)-LDH前体的过电位673 mV,降低了364 mV,其塔菲尔斜率也相应从137 mV/dec降至67 mV/dec,电化学活性表面积增大了2.4倍。与其他过渡金属基催化剂相比,在OER中表现出优异的性能。

关键词：镍铁水滑石析氧反应声悬浮剥离超薄超小纳米片

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

典型燃煤电厂大气污染物沉降对周边水源地的影响及贡献研究

引用

西北地质 2024年第1期57卷 64-72页

作者：蔡春霞贾晓丹鲍国臣曹竞心黄博雅王忠臣北京国寰环境技术有限责任公司北京100012 中国地质调查局西安地质调查中心/西北地质科技创新中心陕西西安710119

为揭示燃煤电厂大气污染物排放对周边水环境的影响,以典型燃煤电厂为研究对象,分析了2008~2020年电厂大气污染物(烟尘、SO_(2)、NO_(x)、NH_(3)和颗粒物重金属)及电厂周边典型水库的水质,并估算了电厂大气污染物排放与水库水质的相关性... 详细信息

为揭示燃煤电厂大气污染物排放对周边水环境的影响,以典型燃煤电厂为研究对象,分析了2008~2020年电厂大气污染物(烟尘、SO_(2)、NO_(x)、NH_(3)和颗粒物重金属)及电厂周边典型水库的水质,并估算了电厂大气污染物排放与水库水质的相关性及其对水库水体中硫化物、氮氧化物和重金属的贡献。结果显示,2008~2020年电厂烟尘、SO_(2)、NO_(x)和重金属(Hg、Cu、Zn、As、Cd、Cr和Pb)的排放量整体呈下降趋势,2015~2020年NH_(3)的排放量呈波动状态;2008~2020年黄壁庄水库入口和中心处的水质均达到《地表水环境质量标准》(GB 3838-2002)Ⅱ类水质标准以上,水库入口和中心处水体中的重金属含量与电厂烟尘重金属排放量呈显著相关。CALPUFF模型结果显示,该燃煤电厂排放的SO_(2)、SO_(4)^(2-)、NO_(x)、HNO_(3)、NH_(3)、Hg、As、Cd、Cr、Cu、Pb、Zn沉降到黄壁庄水库水面进入水中转化生成的水污染物SO_(4)^(2-)、HNO_(3)、NH_(3)-N、Hg、As、Cd、Cr^(6+)、Cu、Pb和Zn贡献浓度分别为3.35×10^(-3)mg/L、5.86×10^(-3)mg/L、5.88×10^(-4)mg/L、3.73×10^(-7)mg/L、1.32×10^(-5)mg/L、7.46×10^(10)mg/L、7.56×10^(-7)mg/L、2.16×10^(-7)mg/L、9.48×10^(-8)mg/L和8.66×10^(-6)mg/L,各项污染物的占标率的大小排序为Hg>NH_(3)-N>HNO_(3)>As>Cr^(6+)>SO_(4)^(2-)>Pb>Zn>Cu>Cd。

关键词：燃煤电厂大气污染物重金属元素污染贡献

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multifunctional N,S-doped and methionine functionalized carbon dots for on−off−on Fe^(3+)and ascorbic acid sensing,cell imaging,and fluorescent ink applying

引用

Nano Research 2023年第4期16卷 5401-5411页

作者： Zheng Yang Tiantian Xu Shaobing Zhang Hui Li Yali Ji xiaodan jia jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China College of Chemistry and Chemical Engineering Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Coal Resources Exploration and Comprehensive Utilization Ministry of Land and ResourcesXi’an 710012China

Fluorescent carbon dots(CDs)have been identified as potential nanosensors and attracted tremendous research interests in wide areas including anti-counterfeiting,environmental and biological sensing and imaging in considering of the attractive optical *** this work,we present a CDs based fluorescent sensor from polyvinylpyrrolidone,citric acid,and methionine as precursors by hydrothermal *** selective quantifying of Fe^(3+)and ascorbic acid(AA)are based on the fluorescent on-off-on process,in which the fluorescent quenching is induced by the coordination of the Fe^(3+)on the surface of the CDs,while the fluorescence recovery is mainly attributed to redox reaction between Fe^(3+)and AA,breaking the coordination and bringing the fluorescence *** by the good water solubility and biocompatibility,significant photostability,superior photobleaching resistance as well as high selectivity,sensitivity,and interference immunity,which are constructed mainly from the N,S-doping and methionine surface functionalization,the CDs have not only been employed as fluorescence ink in multiple anticounterfeiting printing and confidential document writing or transmitting,but also been developed as promising fluorescence sensors in solution and solid by CDs doped test strips and hydrogels for effectively monitoring and removing of Fe^(3+)and AA in environmental aqueous *** CDs have been also implemented as effective diagnostic candidates for imaging and tracking of Fe^(3+)and AA in living cells,accelerating the understanding of their function and importance in related biological processes for the prevention and treatment specific diseases.

关键词： carbon dots fluorescent sensors Fe^(3+) ascorbic acid fluorescent ink message encryption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hybrid ZnO@Au Nanorod Array for Fast and Repeatable Bacteria Inactivation

引用

Chinese Journal of Chemistry 2023年第17期41卷 2132-2142页

作者： Yu Liu Xiaoyu Zhao Xiaosa Zhang xiaodan jia Lie Wu Xiue jiang College of Science Shenyang University of Chemical TechnologyShenyangLiaoning 110142China Shenyang National Laboratoryfor Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyangLiaoning 110016China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of Scienc ChangchunJilin 130022China

Comprehensive Summary,The worldwide abuse of antibiotics and resultant antimicrobial resistance made the development of new antibacterial materials an urgent and significant ***,a hybrid ZnO@Au nanorod array with fast bacterial inactivation and excellent recyclability was reported.93%bacteria could be inactivated within 5 min ultra-sonication under indoor daylight,and the killing rate maintains above 90%after seven repeated using *** mechanism involves extracellular reactive oxygen species(ROS)generated from photocatalysis and piezoelectricity of nanorod array,intracellular ROS generation and decrease of adenosine-triphosphate(ATP)originated from electron transfer(ET)from bacteria to nanorod array,as well as mechanical effect from the nanorod,among which ET mechanism plays a major *** Schottky barrier from the hybrid interface not only enhances the ROS generation by promoting the charge transfer and carrier separation as well as light utilization,but also enables one-direction electron transfer from bacteria to nanorod *** resultant continuous electron loss breaks the energy metabolism and disturbs the redox equilibrium,leading to bacterial *** study demonstrates the great potential of hybrid structure in antibacterial applications and indicates ET as a novel effective antibacterial mechanism for semiconductor materials,which provides insights into the design of next-generation antibacterial materials.

关键词： Antibacterial Hybrid structure Zinc oxide nanorod Electron transfer Reactive oxygen species Microarrays Nanocomposites Semiconductors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

青藏高原东北部地区城市PM_(2.5)和PM_(10)时空分布特征及气象因素的影响

引用

西北地质 2024年第4期57卷 285-296页

作者：梁明武李慧婷李魏龙贾晓丹汪铭媛冯朝晖中国诚通生态有限公司北京100070 中国长江电力股份有限公司湖北武汉430071 中国地质调查局西安地质调查中心/西北地质科技创新中心陕西西安710119 中国科学院地理科学与资源研究所北京100101

随着工业化进程的迅速发展,大气污染问题已不容忽视,青藏高原东北部作为中国重要的生态安全战略地区,由于其常年多风的地理特点导致土地荒漠化,而土地荒漠化会带来颗粒物污染的问题。笔者以青藏高原东北部地区逐月可吸入颗粒物(PM_(10)... 详细信息

随着工业化进程的迅速发展,大气污染问题已不容忽视,青藏高原东北部作为中国重要的生态安全战略地区,由于其常年多风的地理特点导致土地荒漠化,而土地荒漠化会带来颗粒物污染的问题。笔者以青藏高原东北部地区逐月可吸入颗粒物(PM_(10))和细颗粒物(PM_(2.5))浓度为基础,分析了大气颗粒物PM_(2.5)和PM_(10)时空分布特征,与气象因素(降水量、气温和风速)之间的相关性及受气象因素的影响程度。结果表明:①东部人口密集和经济发达的西宁市、海东市和黄南州PM_(2.5)和PM_(10)较高,以上3个市州的PM_(2.5)平均水平分别为44.2μg/m^(3),44.7μg/m^(3)和36.5μg/m^(3),PM_(10)平均水平分别为99.1μg/m^(3),99.7μg/m^(3)和72.2μg/m^(3);2015~2019年的时间分布上各地区颗粒物浓度呈现逐年下降的趋势;空间分布表明PM_(2.5)呈现从西到东逐渐升高的趋势,PM_(10)则呈东高西低分布。②各地区气温和降水量的峰值均出现在夏季,呈现出“Λ”型的分布规律;而各地区的PM_(2.5)、PM_(10)逐月浓度变化整体呈现出“V”型的分布规律,非采暖季颗粒物浓度最低、采暖季颗粒物浓度最高。③各种气象因素的影响中,PM_(2.5)和PM_(10)与降水量、气温、风速均呈负相关,并且PM_(2.5)浓度受到风速的负向影响,而PM_(10)浓度受到风速的显著正向影响,表明风起扬尘对该区域大气污染贡献突出但风速与污染物浓度的作用机制复杂。本研究可为典型地区空气质量的改善与预测提供理论基础与参考依据。

关键词： PM_(2.5) PM_(10) 空气污染气象因素成因分析青藏高原东北部

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrafine monolayer Co-containing layered double hydroxide nanosheets for water oxidation

引用

Journal of Energy Chemistry 2019年第7期28卷 57-63页

作者： xiaodan jia Xin Zhang jiaqing Zhao Yufei Zhao Yunxuan Zhao Geoffrey I.N.Waterhouse Run Shi Li-Zhu Wu Chen-Ho Tung Tierui Zhang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences.Beijing 100049 China School of Chemistry and Chemical Engineering Xi'an University of Science and TechnologyXi'an 710054ShaanxiChina School of Chemical Sciences The University of AucklandAuckland 1142New Zealand

For many two-dimensional(2D)materials,low coordination edges and corner sites offer greatly enhanced catalytic performance compared to basal sites,motivating the search for new synthetic approaches towards ultrathin and ultrafine 2D nanomaterials with high specific surface *** date,the synthesis of catalysts that are both ultrathin(monolayer)and ultrafine(lateral size<10nm)has proven extremely ***,using a facile ultrasonic exfoliation procedure,we describe the successful synthesis of ultrafine ZnCo-LDH nanosheets(denoted as ZnCo-UF)with a size^3.5 nm and thickness^0.5 *** single layer ZnCo-UF nanosheets possess an abundance of oxygen vacancies(Vo)and unsaturated coordination s让es,thereby affording outstanding electrocatalytic water oxidation *** calculations confirmed that Vo on the surface of ZnCo-UF enhanced H20 adsorption via increasing the electropositivity of the nanosheets.

关键词： Layered double hydroxides Ultrafine nanosheets Oxidation evolution reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distributionally robust optimization configuration method for island microgrid considering extreme scenarios

引用

Energy and AI 2024年第3期17卷 179-194页

作者： Qingzhu Zhang Yunfei Mu Hongjie jia xiaodan Yu Kai Hou Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin300072China Key Laboratory of Smart Energy&Information Technology of Tianjin Municipality Tianjin UniversityTianjin300072China

The marine climate conditions are intricate and variable. In scenarios characterized by high proportions of wind and solar energy access, the uncertainty regarding the energy sources for island microgrid is significantly exacerbated, presenting challenges to both the economic viability and reliability of the capacity configuration for island microgrids. To address this issue, this paper proposes a distributionally robust optimization (DRO) method for island microgrids, considering extreme scenarios of wind and solar conditions. Firstly, to address the challenge of determining the probability distribution functions of wind and solar in complex island climates, a conditional generative adversarial network (CGAN) is employed to generate a scenario set for wind and solar conditions. Then, by combining k-means clustering with an extreme scenario selection method, typical scenarios and extreme scenarios are selected from the generated scenario set, forming the scenario set for the DRO model of island microgrids. On this basis, a DRO model based on multiple discrete scenarios is constructed with the objective of minimizing the sum of investment costs, operation and maintenance costs, fuel purchase costs, penalty costs of wind and solar curtailment, and penalty costs of load loss. The model is subjected to equipment operation and power balance constraints, and solved using the columns and constraints generation (CCG) algorithm. Finally, through typical examples, the effectiveness of this paper’s method in balancing the economic viability and robustness of the configuration scheme for the island microgrid, as well as reducing wind and solar curtailment and load loss, is verified.

关键词： Island microgrid Extreme scenario Distributionally robust optimization Conditi onal generative adversarial network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：