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Osteochondral scaffolds for early treatment of cartilage defects in osteoarthritic joints:from bench to clinic

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Biomaterials Translational 2020年第1期1卷 3-17页

作者： Maryam Tamaddon Helena Gilja Ling Wang JMiguel Oliveira xiaodan sun Rongwei Tan Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAveparkPortugal School of Materials Science and Engineering Tsinghua UniversityBeijingChina Shenzhen Lando Biomaterials Co.Ltd.Merchants Guangming Science Park ShenzhenGuangdong ProvinceChina

Osteoarthritis is a degenerative joint disease,typified by the loss in the quality of cartilage and bone at the interface of a synovial joint,resulting in pain,stiffness and reduced *** current surgical treatment for advanced stages of the disease is joint replacement,where the non-surgical therapeutic options or less invasive surgical treatments are no longer *** are major surgical procedures which have a substantial impact on patients’quality of life and lifetime risk of requiring revision *** using regenerative methods such as tissue engineering methods have been established and are promising for the early treatment of cartilage degeneration in osteoarthritis *** this approach,3-dimensional scaffolds(with or without cells)are employed to provide support for tissue ***,none of the currently available tissue engineering and regenerative medicine products promotes satisfactory durable regeneration of large cartilage ***,we discuss the current regenerative treatment options for cartilage and osteochondral(cartilage and underlying subchondral bone)defects in the articulating *** further identify the main hurdles in osteochondral scaffold development for achieving satisfactory and durable regeneration of osteochondral *** evolution of the osteochondral scaffolds–from monophasic to multiphasic constructs–is overviewed and the osteochondral scaffolds that have progressed to clinical trials are examined with respect to their clinical performances and their potential impact on the clinical *** of an osteochondral scaffold which bridges the gap between small defect treatment and joint replacement is still a grand *** scaffold could be used for early treatment of cartilage and osteochondral defects at early stage of osteoarthritis and could either negate or delay the need for joint replacements.

关键词： cartilage injury osteoarthritis osteochondral scaffold regenerative medicine subchondral defect tissue engineering

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震源机制参数对模拟地震动场速度脉冲的影响

地球物理学进展 2022年第4期37卷 1484-1491页

作者：孙晓丹任康万珂羽西南交通大学土木工程学院成都610031 陆地交通地质灾害防治技术国家工程研究中心成都610031

近断层区域脉冲型地震动对于大跨度工程结构地震响应具有重要影响,然而大震近场记录的匮乏使得探究脉冲型地震动的特征较为困难.本文借助基于运动学震源模型的地震动合成方法,合成不同震源机制参数情况下的近场地震动场.采取基于能量的... 详细信息

近断层区域脉冲型地震动对于大跨度工程结构地震响应具有重要影响,然而大震近场记录的匮乏使得探究脉冲型地震动的特征较为困难.本文借助基于运动学震源模型的地震动合成方法,合成不同震源机制参数情况下的近场地震动场.采取基于能量的速度脉冲识别方法,提取合成地震动场中的速度脉冲并计算脉冲周期和幅值,分析震源机制参数对速度脉冲空间分布及脉冲特征参数的影响规律.研究表明:断层走向变化主要影响脉冲型地震动的方位;倾角和滑动角主要影响脉冲型地震动的数量和分布方位;脉冲型地震动更易出现在与断层走向斜交的方向上,在垂直断层走向方向上脉冲型地震动分布相对较少;走向对脉冲特征参数影响很大;相对于脉冲周期,断层倾角对脉冲幅值影响更显著;倾滑断层引起的垂直分量脉冲周期明显大于其他震源机制情况.

关键词：速度脉冲地震动模拟震源机制脉冲周期脉冲幅值

White matter regeneration induced by aligned fibrin nanofiber hydrogel contributes to motor functional recovery in canine T12 spinal cord injury

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Regenerative Biomaterials 2022年第1期9卷 260-270页

作者： Zheng Cao Weitao Man Yuhui Xiong Yi Guo Shuhui Yang Dongkang Liu He Zhao Yongdong Yang Shenglian Yao Chuzhong Li Lingyun Zhao xiaodan sun Hua Guo Guihuai Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced MaterialsSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Center for Biomedical Imaging Research Tsinghua UniversityBeijing 100084China Department of Orthopedics Dongzhimen HospitalBeijing 100007China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Neurosurgical Institute Beijing Tiantan HospitalBeijing 100070China

A hierarchically aligned fibrin hydrogel(AFG)that possesses soft stiffness and aligned nanofiber structure has been successfully proven to facilitate neuroregeneration in vitro and in ***,its potential in promoting nerve regeneration in large animal models that is critical for clinical translation has not been sufficiently ***,the effects of AFG on directing neuroregeneration in canine hemisected T12 spinal cord injuries were *** obvious white matter regeneration consisting of a large area of consecutive,compact and aligned nerve fibers is induced by AFG,leading to a significant motor functional *** canines with AFG implantation start to stand well with their defective legs from 3 to 4 weeks postoperatively and even effortlessly climb the steps from 7 to 8 ***,high-resolution multi-shot diffusion tensor imaging illustrates the spatiotemporal dynamics of nerve regeneration rapidly crossing the lesion within 4 weeks in the AFG *** findings indicate that AFG could be a potential therapeutic vehicle for spinal cord injury by inducing rapid white matter regeneration and restoring locomotion,pointing out its promising prospect in clinic practice.

关键词： aligned fibrin hydrogel spinal cord injury white matter regeneration diffusion tensor imaging canine

Eularian wall film model for predicting dynamic cell culture process to evaluate scaffold design in a perfusion bioreactor

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Medicine in Novel Technology and Devices 2022年第1期13卷 12-21页

作者： Ziyu Liu Chunjing Tao Shanshan Yuan Wei Wang Maryam Tamaddon Liqi Ng Hao Huang xiaodan sun Chaozong Liu Division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalStanmore HA74LPUK School of Medical Science and Engineering Beihang UniversityChina Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijingChina Department of Cardiology Qingdao Municipal HospitalShandongChina School of Science and Engineering The Chinese University of Hong KongShenzhenChina

In tissue engineering field,it is important to develop a suitable numerical model to evaluate scaffold geometry *** experimental evaluation of the effect of each specific scaffold parameter on tissue regeneration requires large cost and long time *** cell culture is commonly used for generating tissues which could replace damaged tissues.A perfusion bioreactor model is developed which is able to simulate dynamic cell culture,to evaluate scaffold *** wall-film model is used to simulate cell attachment with the assumption that cells could be seen as liquid *** the process of cell attachment,the cells could impinge to a solid surface and form a liquid film which were considered as cell attached on the scaffold *** types of cell-scaffold interactions were involved in numerical models including trap model and Stanton-Rutland(Cell impinge model—CIM)*** trap model,all cells impinged the scaffold are seen as *** Stanton-Rutland model,four regimes of cell-scaffold interaction are involved in the cell attachment,including stick,rebound,spread,and splash,and only stick and spread are seen as *** comparison with two different numerical methods,the results showed that CIM model result is more related to the experimental results than trap model,which indicated that four regimes of cell-scaffold interaction occurred in cell attachment *** evaluating two different geometry scaffold's cells seeding by these two models,the results further indicated that this model are able to use for assessing the scaffold design.

关键词： Scaffold structure Computational fluid dynamics Cell attachment Cell impinge model

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农用地遥感影像信息的角提取方法

农业工程学报 2009年第10期25卷 135-141,I0002页

作者：孙小丹徐涵秋福州大学环境与资源学院福州350108 福州职业技术学院福州350108

在高分辨率影像中,耕地和坑塘具有显著的角特征点,该文根据此特点准确地实现这两类地物信息的提取。在角提取时,针对TK(Tomasi-Kanade)角检测法对角方位的变化较为敏感这一缺陷,结合双向分析技术对传统的角检测算法加以改进,并提出鲁棒... 详细信息

在高分辨率影像中,耕地和坑塘具有显著的角特征点,该文根据此特点准确地实现这两类地物信息的提取。在角提取时,针对TK(Tomasi-Kanade)角检测法对角方位的变化较为敏感这一缺陷,结合双向分析技术对传统的角检测算法加以改进,并提出鲁棒性更高的双向TK角检测;利用COVPEX(corner validation based on corner property extraction)算法对角检测结果进行验证,发现验证结果中不仅存在一些对于影像分析来说几乎无利用价值的伪角,而且还存在"角簇"现象,前者降低了验证结果的合理性,而后者破坏了角的唯一性。针对这两个问题,该文联合多尺度分析技术对COVPEX算法进行改进,提出了多尺度COVPEX算法和"去角簇"操作,角提取的精度和合理性均得到了明显地提高。

关键词：遥感图像识别信息提取农用地

Acceleration of experimental cerebral malaria by aspirin via elevating the pro-inflammatory response

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Acceleration of experimental cerebral malaria by aspirin via...

COVID-19 transmission and control in land public transport:A literature review

第八届全国免疫学学术大会

作者： xiaodan sun Jun Liu Yaming Cao Department of Immunology College of Basic Medical Sciences China Medical University

Background and Objective:As a severe life-threatening complication caused by malaria infection, cerebral malaria(CM) still cannot be effectively prevented and cured through current *** is a famous anti-platelet drug whose roles in CM and the mechanism concerned are still *** using the Plasmodium berghei model of CM, we further investigated these ***:The proinflammatory molecules IFN-γ/TNF-α/NO by splenocytes in control and aspirin treated mice were detected by ***:We found that aspirin could not improve the survival of infected mice, but instead accelerate their *** with the control mice, the productions of proinflammatory molecules IFN-γ/TNF-α/NO by splenocytes were significantly increased in the aspirin treated mice at 3/5/8 days postinfection(p.i.), detected by *** the permeability of blood-brain barrier at 8 day *** no remarkable difference between the control and aspirin treated ***:Our results demonstrate that aspirin can decrease the survival of experiment cerebral malaria in mice, which is closely related to the induction of the elevation in proinflammatory molecule *** findings hold great realistic significance in the prevention and treatment on malaria.

关键词： Experimental cerebral malaria aspirin proinflammatory cytokines blood-brain barrier

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Fundamental Research 2024年第3期4卷 417-429页

作者： Qiqi Luo Wenbing Liu Jiayuan Liao Zhongli Gu xiaodan Fan Zhiwen Luo Xuelin Zhang Jian Hang Cuiyun Ou School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong LaboratoryZhuhai 519082China Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089China China Meteorological Administration Xiong'an Atmospheric Boundary Layer Key Laboratory Xiong'an 070001China Key Laboratory of Tropical Atmosphere-Ocean System(sun Yat-sen University) Ministry of EducationZhuhai 519000China Guangdong Fans-tech Agro Co. LtdYunfu 527300China Welsh School of Architecture Cardiff UniversityCardiff CF103XQUnited Kingdom

Land public transport is an important link within and between cities,and how to control the transmission of COVID-19 in land public transport is a critical issue in our daily ***,there are still many inconsistent opinions and views about the spread of SARS-CoV-2 in land public transport,which limits our ability to implement effective *** purpose of this review is to overview the literature on transmission characteristics and routes of the epidemic in land public transport,as well as to investigate factors affecting its spread and provide feasible measures to mitigate the infection risk of *** obtained 898 papers by searching the Web of Science,Pubmed,and WHO global COVID database by keywords,and finally selected 45 papers that can address the purpose of this *** public transport is a high outbreak area for COVID-19 due to characteristics like crowding,inadequate ventilation,long exposure time,and environmental *** from surface touch transmission and drop spray transmission,aerosol inhalation transmission can occur not only in short distances but also in long *** ventilation is the most important factor influencing long-distance aerosol *** transmission factors(e.g.,interpersonal distance,relative orientation,and ambient conditions)should be noticed as well,which have been summarized in this *** address various influencing factors,it is essential to suggest practical and efficient preventive *** these,increased ventilation,particularly the fresh air(i.e.,natural ventilation),has proven to effectively reduce indoor infection *** preventive measures are also effective,such as enlarging social distance,avoiding face-to-face orientation,setting up physical partitions,disinfection,avoiding talking,and so *** research on the epidemic has intensified,people have broken down many perceived barriers,but more comprehensive studies on monitoring systems and preventi

关键词： Land transportation Infection risk Transmission route Mitigation measures COVID-19

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光催化涂层净化室内VOCs研究进展

精细化工 2023年第8期40卷 1679-1687页

作者：宋晶璟孙晓丹陕西科技大学轻工科学与工程学院陕西西安710021 轻化工程国家级实验教学示范中心陕西科技大学陕西西安710021 西安市绿色化学品与功能材料重点实验室陕西西安710021

挥发性有机物(VOCs)是造成室内空气污染的主要来源。光催化涂层作为一种新型VOCs净化技术,可以在太阳光下自发将VOCs降解为水和CO_(2),高效节能,不会产生二次污染,引起研究者的广泛关注和深入研究。该文介绍了用于室内VOCs净化的光催化... 详细信息

挥发性有机物(VOCs)是造成室内空气污染的主要来源。光催化涂层作为一种新型VOCs净化技术,可以在太阳光下自发将VOCs降解为水和CO_(2),高效节能,不会产生二次污染,引起研究者的广泛关注和深入研究。该文介绍了用于室内VOCs净化的光催化涂层的制备方法以及涂层光催化性能和稳定性的影响因素;阐述了VOCs的光催化净化机理和影响因素;综述了不同光催化涂层种类的研究进展及应用现状;最后,提出了光催化涂层目前存在的问题,展望了其未来的发展方向。

关键词：挥发性有机化合物光催化涂层制备净化机理影响因素研究现状

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山东“非遗”舞蹈大祁庄地秧歌的调查与研究

德州学院学报 2023年第3期39卷 61-64页

作者：韩晗孙晓丹德州学院音乐学院山东德州253023

大祁庄地秧歌起源于德州市武城县郝王庄镇大祁庄村,距今已有650多年的历史。德州学院师生从传统民俗文化、非物质文化遗产保护及艺术形态学等角度对大祁庄地秧歌展开了调查,发现大祁庄地秧歌具有独特的艺术形态、社会价值,但后继乏人,... 详细信息

大祁庄地秧歌起源于德州市武城县郝王庄镇大祁庄村,距今已有650多年的历史。德州学院师生从传统民俗文化、非物质文化遗产保护及艺术形态学等角度对大祁庄地秧歌展开了调查,发现大祁庄地秧歌具有独特的艺术形态、社会价值,但后继乏人,传承堪忧,需要政府扶持、社会参与、校地合作以及借助“互联网+”等多方资源助力这一市级非物质文化遗产的传承与发展。

关键词：大祁庄地秧歌 “非遗”舞蹈传承发展对策