检索结果-南通市图书馆

Formulated nano-liposomes for reversal of cisplatin resistance in NSCLC with nucleus-targeting peptide

Nano Research 2023年第11期16卷 12864-12879页

作者： Minxian Li Mei Jiang Mengting Chen Lilusi ma xiaocui Fang Yanlian Yang Chen Wang Key Laboratory for Biological Effects of Nanomaterials and Nanosafety(Chinese Academy of Sciences) Key Laboratory of Standardization and Measurement for Nanotechnology(Chinese Academy of Sciences)and CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish Center for Education and Research Sino-Danish CollegeBeijing 101499China Central Laboratory Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing 100026China

Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability,offering an alternative for reversing drug resistance in cancer ***,a formulated nano-liposome that fabricated by hybridizing cisplatin-resistant A549 cell line(A549/cis)cancer cell membrane and phospholipids for co-delivery of cisplatin and nuclear protein zeste homolog 2(EZH2)-targeting peptide EIP103,referred to as cLCE,was *** vitro results indicated that the formulated nano-liposome can efficiently inhibit A549/cis cancer cell invasion and metastasis through the down-regulation of Ncadherin and vimentin *** studies demonstrated that the reduction of nerve growth factor receptor(NGFR)levels and the increase of peroxisome proliferator-activated receptorγ(PPARγ)levels achieved by EIP103 may contribute to the reversal of cisplatin *** vivo results demonstrated that the encapsulation of both cisplatin and EIP103 within cLCE leads to increased intratumoral accumulation and prolonged survival in A549/cis cancer-bearing mice as compared to the individual drugs *** can be attributed to the enhanced tumor homing capability of cLCE achieved through the presence of inherited membrane proteins derived from A549/cis *** together,this study may provide a highly promising therapeutic strategy to improve clinical treatments for cisplatin-resistance non-small-cell lung cancer(NSCLC)as well as other malignant cancers.

关键词： formulated liposome tumor homing cisplatin resistance nucleus-peptide cancer therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Advances in 0D Ni/Co-based Hollow Electrocatalysts for Electrochemical Water Splitting

引用

Chemical Research in Chinese Universities 2024年第3期40卷 437-450页

作者： GE Wenjing CHEN xiaocui ma Ruizhao ZHENG Siyuan SHANG Ningzhao ZHAO Xiaoxian Department of Chemistry College of ScienceHebei Agricultural UniversityBaoding 071001P.R.China

Electrochemical water splitting using renewable energy sources has been recognized as a sustainable way to produce hydrogen energy due to the characteristics of low-carbon and no ***,the slow hydrogen/oxygen evolution reactions(HER/OER)seriously hinder the practical application of large-scale water *** this paper,the 0D Ni/Co-based hollow material is discussed in detail because of adjustable morphology,low mass density and abundant active sites,which provides an effective solution for improving the HER/OER reaction *** synthesis methods of hollow materials,such as hard template,soft template and self-template are ***,catalysts with different structural designs of hollow structures are reviewed,including hollow single-shelled structure,hollow core-shelled structure,hollow double-shelled structure and hollow multi-shelled structure(HoMS)***,the research progress of the 0D Ni/Co-based HoMS electrocatalysts in recent years and their prominent performances in water splitting are ***,the challenges and development prospects of designing Ni/Co-based HoMS catalysts in water splitting in the future are discussed.

关键词： Electrochemical watersplitting Morphological regulation Hollow structure Hollow multi-shelled structure(HoMS)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高取向碳纳米管薄膜和碳纳米管束薄膜的场发射性质研究

引用

广东化工 2008年第10期35卷 12-15页

作者：曹培江朱德亮柳文军贾芳马晓翠吕有明深圳大学材料学院广东深圳518060

采用热解二茂铁/三聚氰氨混合物方法合成了高取向碳纳米管薄膜和碳纳米管束薄膜。二氧化硅基底上生长的碳纳米管具有一致的外部直径约22 nm和一致的长度约40μm;陶瓷基底上生长的碳纳米管具有变化的外部直径为10～90 nm和不同的长度约20... 详细信息

采用热解二茂铁/三聚氰氨混合物方法合成了高取向碳纳米管薄膜和碳纳米管束薄膜。二氧化硅基底上生长的碳纳米管具有一致的外部直径约22 nm和一致的长度约40μm;陶瓷基底上生长的碳纳米管具有变化的外部直径为10～90 nm和不同的长度约20～100μm;合成的纳米管为多壁纯碳管并存在大量的缺陷和石墨断层;高取向碳纳米管薄膜的开启电场为3.9 V/μm,场增强因子为3000;碳纳米管束薄膜的开启电场为2.9 V/μm,场增强因子为5200。

关键词：碳纳米管热解 FEE 增强因子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

黑龙江省改进中长期负荷预测方法及应用

引用

黑龙江电力 2013年第5期35卷 432-433,458页

作者：郝文波高宇峰陆莹张福忠马晓翠龙珠黑龙江省电力科学研究院哈尔滨150030 哈尔滨商业大学哈尔滨150028 国电哈尔滨热力有限公司哈尔滨150066 黑龙江省电力勘察设计研究院哈尔滨150078

针对传统的弹性系数法、时间序列法以及产业单耗法等在进行中长期负荷预测时预测时间以及预测精度上的不足,利用上述方法分别建立了黑龙江省"十二五"中长期负荷预测的数学模型,并根据黑龙江省的产业结构特点形成新的分产业弹性系数法,... 详细信息

针对传统的弹性系数法、时间序列法以及产业单耗法等在进行中长期负荷预测时预测时间以及预测精度上的不足,利用上述方法分别建立了黑龙江省"十二五"中长期负荷预测的数学模型,并根据黑龙江省的产业结构特点形成新的分产业弹性系数法,最后通过时变权综合预测方法将多种预测方法归一,使其优势互补。通过对历史数据的校核,表明了改进方法较原有方法在预测精度上有较大提高。

关键词：黑龙江省电网中长期负荷预测方法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

蓄电池智能在线维护监控管理系统在变电站中的应用

引用

黑龙江电力 2015年第6期37卷 547-550页

作者：殷晓红王中明周维宇王立杰唐晓博马晓翠黑龙江省电力科学研究院哈尔滨150030 鹤岗供电公司黑龙江鹤岗154101 哈尔滨供电公司哈尔滨150010 国电哈尔滨热电有限公司哈尔滨150066

在阐明铅酸蓄电池劣化及其修复技术的基础上,通过整合相关研究成果的特点,开发了集脉冲除硫→均衡充电→检测保护的三阶段蓄电池维护技术、多路输出分时循环除硫工作机制,以及集蓄电池网络化实时监控功能于一身的蓄电池智能在线维护监... 详细信息

在阐明铅酸蓄电池劣化及其修复技术的基础上,通过整合相关研究成果的特点,开发了集脉冲除硫→均衡充电→检测保护的三阶段蓄电池维护技术、多路输出分时循环除硫工作机制,以及集蓄电池网络化实时监控功能于一身的蓄电池智能在线维护监控管理系统。通过实际应用验证表明,该系统实现了蓄电池的网络化统一管理、电池性能准确甄别和蓄电池在线除硫维护等功能,其技术指标达到了预期的目标值,满足了现场运行需求。

关键词：直流电源蓄电池在线监测在线维护监控管理变电站

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-density SNP genetic linkage map construction and quantitative trait locus mapping for resistance to cucumber mosaic virus in tobacco(Nicotiana tabacum L.)

引用

The Crop Journal 2019年第4期7卷 539-547页

作者： Lirui Cheng xiaocui Chen Caihong Jiang Bing ma Min Ren Yazeng Cheng Dan Liu Ruimei Geng Aiguo Yang Key Laboratory of Tobacco Genetic Improvement and Biotechnology Tobacco Research Institute Chinese Academy of Agricultural Sciences Qingdao 266100 Shandong China Key Laboratory of Zunyi Crop Gene Resource and Germplasm Innovation Zunyi Academy of Agricultural Sciences Zunyi 563006 Guizhou China

Genetic linkage maps are essential for studies of genetics, genomic structure, and genomic evolution, and for mapping quantitative trait loci (QTL). Identification of molecular markers and construction of genetic linkage maps in tobacco (Nicotiana tabacum L.), a classical model plant and important economic crop, have remained limited. In the present study we identified a large number of single nucleotide polymorphism (SNP) markers and constructed a high-density SNP genetic map for tobacco using restriction site-associated DNA sequencing. In 1216.30 Gb of clean sequence obtained using the Illumina HiSeq 2000 sequencing platform, 99,647,735 SNPs were identified that differed between 203 sequenced plant genomes and the tobacco reference genome. Finally, 13,273 SNP markers were mapped on 24 high-density tobacco genetic linkage groups. The entire linkage map spanned 3421.80 cM, with a mean distance of 0.26 cM between adjacent markers. Compared with genetic linkage maps published previously, this version represents a considerable improvement in the number and density of markers. Seven QTL for resistance to cucumber mosaic virus (CMV) in tobacco were mapped to groups 5 and 8. This high-density genetic map is a promising tool for elucidation of the genetic bases of QTL and for molecular breeding in tobacco.

关键词： Single nucleotide polymorphism Genetic linkage map Tobacco Cucumber mosaic virus Quantitative trait loci

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

补喂不同水平褪黑素对绵羊血浆中褪黑素含量、尿液中6-羟基褪黑素含量及抗氧化能力的影响

引用

中国草食动物科学 2024年第6期44卷 37-41页

作者：米热古丽·伊马木侯传祥孙硕梅莹莹马晓翠张文杰邓海峰赵国栋杨开伦新疆农业大学新疆肉乳用草食动物营养重点实验室乌鲁木齐830052

试验旨在探究补喂不同水平褪黑素(Melatonin,MT)对绵羊抗氧化能力、血浆中褪黑素含量及尿液中6-羟基褪黑素含量的影响。选择3月龄健康哈萨克公羊25只,随机分为5组,分别为对照组、试验Ⅰ组、试验Ⅱ组、试验Ⅲ组、试验Ⅳ组,每组5只,分别... 详细信息

试验旨在探究补喂不同水平褪黑素(Melatonin,MT)对绵羊抗氧化能力、血浆中褪黑素含量及尿液中6-羟基褪黑素含量的影响。选择3月龄健康哈萨克公羊25只,随机分为5组,分别为对照组、试验Ⅰ组、试验Ⅱ组、试验Ⅲ组、试验Ⅳ组,每组5只,分别对应补饲0、1、2、4和8 mg/d的褪黑素,为期19 d。在试验第13~16天采集试羊的尿样,第18天上午饲喂前0 h,饲喂后1、2、4 h通过颈静脉采集血样。结果显示,补喂褪黑素2 h后,试验Ⅳ组血浆中总抗氧化力(T-AOC)与试验Ⅰ组相比显著提高(P<0.05);试验Ⅲ、Ⅳ组过氧化氢酶(CAT)活性、超氧化物歧化酶(SOD)活性均显著高于对照组(P<0.05),血浆中丙二醛(MDA)含量显著低于对照组(P<0.05);试验Ⅳ组血浆中谷胱甘肽过氧化物酶(GSH-PX)活性显著高于对照组(P<0.05)。试验羊补喂褪黑素1 h时,对照组及试验组血浆中褪黑素含量均达到峰值,4 h时各试验组血浆中褪黑素含量均显著高于对照组(P<0.05);试验Ⅱ、Ⅲ、Ⅳ组尿液中6-羟基褪黑素排出量与对照组相比均显著提高(P<0.05)。综上所述,补喂褪黑素能够提高绵羊抗氧化能力,血浆和尿液中褪黑素代谢物含量也随着补喂量的增加而增加,综合比较,补喂量以4 mg/d剂量最佳。

关键词：绵羊褪黑素抗氧化能力 6-羟基褪黑素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice

引用

Neuroscience Bulletin 2022年第1期38卷 81-94页

作者： Lin ma Yanhua Du Xiangjie Xu Hexi Feng Yi Hui Nan Li Guanyu Jiang Xiaoqing Zhang xiaocui Li Ling Liu Translational Medical Center for Stem Cell Therapy Shanghai East HospitalSchool of MedicineTongji UniversityShanghai200120China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of the Ministry of Education Orthopaedic Department of Tongji HospitalShanghai200065China Brain and Spinal Cord Innovative Research Center School of MedicineTongji UniversityShanghai200092China Key Laboratory of Neuroregeneration of Shanghai Universities School of MedicineTongji UniversityShanghai200092China Tsingtao Advanced Research Institute Tongji UniversityQingdao266071China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai200120China Department of Pathology and Pathophysiology School of MedicineTongji UniversityShanghai200092China Department of Immunology and Microbiology Shanghai Institute of ImmunologyShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai First maternity and Infant Hospital School of MedicineTongji UniversityShanghai200092China

Congenital hydrocephalus is a major neurological disorder with high rates of morbidity and mortality;however,the underlying cellular and molecular mechanisms remain largely *** animal models mirroring both embryonic and postnatal hydrocephalus are also ***,we describe a new mouse model of congenital hydrocephalus through knockout ofβ-catenin in Nkx2.1-expressing regional neural *** ventriculomegaly and an enlarged brain were consistently observed in knockout mice from embryonic day 12.5 through to *** profiling revealed severe dysfunctions in progenitor maintenance in the ventricular zone and therefore in cilium biogenesis afterβ-catenin *** analyses also revealed an aberrant neuronal layout in both the ventral and dorsal telencephalon in hydrocephalic mice at both embryonic and postnatal ***,knockout ofβ-catenin in regional neural progenitors leads to congenital hydrocephalus and provides a reproducible animal model for studying pathological changes and developing therapeutic interventions for this devastating disease.

关键词： Congenital hydrocephalus β-Catenin Ependymal cells Nkx2.1 Neural development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

First-principles calculations of structural transition and elastic properties of Si4Ge4 alloy under high pressure

First-principles calculations of structural transition and e...

引用

第十八届中国高压科学学术会议

作者： xiaocui Yang Hongyuan ma Junping Xiao Zhuo Yu Department of Physics Baicheng Normal University

An investigation on the structure stability and elastic properties of Si4Ge4under high pressure was conducted using first-principles *** calculations were performed using the plane-wave pseudopotential DFT method as implemented in the CASTEP 7.0 simulation package,using norm-conserving pseudopotentials within the local density approximation(LDA)as parameterized by Perdew and *** convergence criteria for structure optimization and energy calculation were set to ultrafine quality with a kinetic energy cutoff of 390 e V and Monkhorst k-point meshes of 4×4×*** self-consistent convergence accuracy was set to be5.0×10-6 e V/*** convergence criterion for the maximal force between atoms was 0.01 e V/?.The maximum displacement was 5.0×10-4?,and the stress was set to be 0.02 GPa.

关键词： first-principles calculations structural transition elastic property high pressure

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Short-term Effects of Nitrogen Deposition on Soil Respiration of Cinnamomum camphora Plantation

引用

Chinese Forestry Science and Technology 2012年第3期11卷 37-38页

作者： Zhang Xuyuan Yan Wende ma Xiuhong Zheng Wei Wang Guangjun Liang xiaocui School of Life Science & Technology Central South University of Forestry & Technology National Engineering Laboratory for Applied Technology of Forestry & Ecology in South China Tianzhu Nursery Garden

The nitrogen deposition experiments on Cinnamomum camphora plantation of Hunan provincial botanical garden were simulated from June the 7th to October the 7th,2010,the nitrogen deposition levels was respectively as control(CK, 0 g·m-2 a-1),low nitrogen(LN,5 g·m-2 a-1),medium nitrogen(MN,15 g·m-2 a-1) and high nitrogen(HN, 30 g·m -2 a-1).The soil respiration speed and soil surface temperature and the surface water content of the soil were determined by LI-8100 measuring *** results show that the average values of soil respiration speed were CK (4.09±0.66μmol·m-2 s-1),LN(2.39±029μmol·m-2 s-1), MN(2.18±0.19μmol·m-2s-1),HN (2.28±0.25μmol·m-2 s-1),and the treatment of the CK was obviously higher than the other three treatments（P10 （temperature sensitivity coefficients） for soil respiration of CK,LN,MN and HN treatments were 1.84,1.71,1.83 and *** was positive correlation between the respiration speed and the surface（≤10 cm） temperature of tested *** was negative correlation between the respiration speed and the surface（≤5 cm） water content of tested soil（P>0.05）.Volumetric water content of 5-cm soil was between 0.266 6-0.294 4(m3·m-3), and the monthly content did not vary too much during the research period（1.8%-9.4%）.The findings suggest that the initial stage of nitrogen deposition obviously influenced the soil respiration of *** plantation.

关键词： soil respiration nitrogen deposition Q10value Cinnamomum camphora plantation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：