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Thiol-Disulfide Exchange Coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in Colitis

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Research 2024年第2期6卷 285-300页

作者： Junna Lu Tongfei Shi chengxin Shi Fangman chen Chao Yang xiaochun Xie Zheng Wang He Shen Jiaqi Xu Kam W.Leong Dan Shao School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong 510006China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangdong 510006China Department of Plastic and Aesthetic Center The First Affliated Hospital of Zhejiang UniversityHangzhou 310000China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA School of Medicine South China University of TechnologyGuangzhouGuangdong 510006China CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China CAS Key Laboratory for Biomedical Efects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

The cell-specific functions of nitric oxide(NO)in the intestinal microenvironment orchestrate its therapeutic effects in ulcerative *** most biomaterials show promise by eliciting the characteristics of NO,the insufficient storage,burst release,and pro-inflammatory side effects of NO remain as ***,we report the development of thiol-disulfide hybrid mesoporous organosilica nanoparticles(MONs)that improve the storage and sustained release of NO,broadening the therapeutic window of NO-based therapy against *** tailored NO-storing nanomaterials coordinated the release of NO and the immunoregulator dexamethasone(Dex)in the intestinal microenvironment,specifically integrating the alleviation of oxidative stress in enterocytes and the reversal of NO-exacerbated macrophage ***,such a synchronous operation was achieved by a self-motivated process wherein the thiyl radicals produced by NO release cleaved the disulfide bonds to degrade the matrix and release Dex via thiol-disulfide ***,the MON-mediated combination of NO and Dex greatly ameliorated intractable colitis compared with 5-aminosalicylic acid,even after delayed ***,our results reveal a key contribution of synergistic modulation of the intestinal microenvironment in NO-based colitis therapy and introduce thiol-disulfide hybrid nanotherapeutics for the management of inflammatory diseases and cancer.

关键词： sustained release disulfide

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A柱内饰件“一模两腔”注塑工艺参数优化

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中国塑料 2019年第6期33卷 112-116,126页

作者：陈晓春江阴职业技术学院

对A柱内饰件模型进行分析,得出浇口应选择潜伏式侧浇口,选择四点进料,模具设置成“一模两腔”结构。对熔体温度、保压压力、保压时间、冷却时间进行研究,得出在熔体温度232℃、保压压力105MPa、保压时间7s、冷却时间29s时,塑件平均体积... 详细信息

对A柱内饰件模型进行分析,得出浇口应选择潜伏式侧浇口,选择四点进料,模具设置成“一模两腔”结构。对熔体温度、保压压力、保压时间、冷却时间进行研究,得出在熔体温度232℃、保压压力105MPa、保压时间7s、冷却时间29s时,塑件平均体积收缩率为3.42%。对该组工艺参数试验验证后,得出A柱内饰件音响口特征成型完全,没有因为内流道细长而产生缺陷,整体轮廓与检具间隙在允许范围内。

关键词：熔体温度保压压力保压时间冷却时间正交试验

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基于特征空间切分建模的变形手势跟踪算法

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机器人 2018年第4期40卷 401-412页

作者：张彦彬陈晓春深圳清华大学研究院电子设计自动化实验室广东深圳518057 哈尔滨工业大学(深圳) 广东深圳518055

为解决人机交互中手势形变和无规律运动带来的跟踪难题,提出了一种基于特征空间切分建模的非参数核密度估计算法来实现手势跟踪.首先,在检测模块中利用AdaBoost分类器检测图像中手势的存在,将检测到的手势位置信息传送给跟踪模块,该模... 详细信息

为解决人机交互中手势形变和无规律运动带来的跟踪难题,提出了一种基于特征空间切分建模的非参数核密度估计算法来实现手势跟踪.首先,在检测模块中利用AdaBoost分类器检测图像中手势的存在,将检测到的手势位置信息传送给跟踪模块,该模块精确提取手势目标从而对其颜色建模.然后,利用目标的颜色模型对各帧图像进行后验概率密度估算,获取运动目标的概率密度图像,将其分解成手势运动区和同色干扰区.最后,对同色干扰区采用混合高斯建模来削弱同色目标的干扰,当目标丢失时启动再检测模块,并利用贝叶斯分类器与方差分类器实现手势目标重检.实验结果表明,该算法通过对特征空间切分建模以及不同分类器的级联解决了变形手势跟踪的同色干扰与再检测难题.该算法提高了跟踪的准确率(>81.5%),适合于非刚性物体做无规则运动的复杂场景.

关键词：非参数核密度估计变形手势运动跟踪概率密度图同色干扰区再检测模块

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CX3C-chemokine receptor 1 modulates cognitive dysfunction induced by sleep deprivation

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Chinese Medical Journal 2022年第2期135卷 205-215页

作者： Jiawei Xin Chao Wang Xiaojuan cheng Changfu Xie Qiuyang Zhang Yilang Ke Xuanyu Huang xiaochun chen Xiaodong Pan Department of Neurology Fujian Institute of GeriatricsFujian Medical University Union HospitalFuzhouFujian 350001China Fujian Key Laboratory of Molecular Neurology Fujian Medical UniversityFuzhouFujian 350001China Key Laboratory of Brain Aging and Neurodegenerative Diseases Fujian Medical UniversityFuzhouFujian 350001China School and Hospital of Stomatology Fujian Medical UniversityFuzhouFujian 350001China Department of Geriatrics Fujian Institute of GeriatricsFujian Medical University Union HospitalFuzhouFujian 350001China Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian 350001China.

Background:Microglia plays an indispensable role in the pathological process of sleep deprivation(SD).Here,the potential role of microglial CX3C-chemokine receptor 1(CX3CR1)in modulating the cognition decline during SD was evaluated in terms of microglial neuroinflammation and synaptic *** this study,we aimed to investigat whether the interference in the microglial function by the CX3CR1 knockout affects the CNS's response to ***:Middle-aged wild-type(WT)C57BL/6 and CX3CR1^(−/−)mice were either subjected to SD or allowed normal sleep(S)for 8 h to mimic the pathophysiological changes of middle-aged people after staying up all *** which,behavioral and histological tests were used to explore their different ***:CX3CR1 deficiency prevented SD-induced cognitive impairments,unlike WT *** with the CX3CR1^(−/−)S group,the CX3CR1^(−/−)SD mice reported a markedly decreased microglia and cellular oncogene fos density in the dentate gyrus(DG),decreased expression of pro-inflammatory cytokines,and decreased microglial phagocytosis-related factors,whereas increased levels of anti-inflammatory cytokines in the hippocampus and a significant increase in the density of spines of the DG were also ***:These findings suggest that CX3CR1 deficiency leads to different cerebral behaviors and responses to *** inflammation-attenuating activity and the related modification of synaptic pruning are possible mechanism candidates,which indicate CX3CR1 as a candidate therapeutic target for the prevention of the sleep loss-induced cognitive impairments.

关键词： Sleep deprivation Cognitive dysfunction Microglia CX3CR1 deficiency

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The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease

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Translational Neurodegeneration 2016年第1期5卷 95-106页

作者： Shengdi chen Piu Chan Shenggang Sun Haibo chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan cheng Ming Shao Zhenguo Liu Zhenfu Wang xiaochun chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen chen Xingyue Hu Anmu Xie Qin Xiao Department of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Xuanwu Hospital affiliated to Capital Medical University BeijingChina Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina Beijing Hospital BeijingChina The Second Hospital affiliated to Zhejiang University School of Medicine HangzhouChina The First Hospital affiliated to Dalian Medical University DalianChina The Second Affiliated Hospital of Soochow University SuzhouChina The First Hospital affiliated to Chongqing Medical University ChongqingChina Xiangya Hospital Central South UniversityChangshaChina Guangdong General Hospital GuangzhouChina General Hospital affiliated to Tianjin Medical University TianjinChina Sichuan Rehabilitation Hospital ChengduChina Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine ShanghaiChina Chinese PLA General Hospital BeijingChina Fujian Medical University Union Hospital FuzhouChina The First Hospital affiliated to Hebei Medical University ShijiazhuangChina Peking Union Medical College Hospital BeijingChina West China Hospital affiliated to Sichuan University ChengduChina Qilu Hospital affiliated to Shandong University JinanChina The First Hospital affiliated to Guangzhou Medical University GuangzhouChina Huashan Hospital affiliated to Fudan University ShanghaiChina Tiantan Hospital affiliated to Capital Medical University BeijingChina The First Hospital affiliated to Anhui Medical University HefeiChina Sir Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine HangzhouChina The Affiliated Hospital Qingdao University School of MedicineQingdaoChina

Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in *** is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural *** the disease progresses,additional complications can arise such as non-motor and neurobehavioral *** treatment and surgical intervention for PD have been implemented in *** 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different *** then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,***,the overall level of treatment for PD in China ***:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of ***:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the *** principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor ***,different treatment strategies should be considered at different stages of the ***,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China.

关键词： Parkinson’s disease Treatment guideline optimal therapeutic options China

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互动·创新·多元——2006年中国电视文艺创作报告

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中国广播电视学刊 2007年第1期 16-17页

作者：陈笑春四川大学新闻传播研究所

2006年，中国电视文艺节目的种类．数量和市场份额进一步扩大。主要由多家电视台举行的舞台”选秀”节目成为本年度文艺节目的绝对主角，体现出全方位的互动性和参与性；并且，”选秀”作为一种节目元素还被不少综艺栏目借鉴，成为其创... 详细信息

2006年，中国电视文艺节目的种类．数量和市场份额进一步扩大。主要由多家电视台举行的舞台”选秀”节目成为本年度文艺节目的绝对主角，体现出全方位的互动性和参与性；并且，”选秀”作为一种节目元素还被不少综艺栏目借鉴，成为其创新的重要手段。不仅如此，各种节目之间的渗透融合继续加强，节目形态呈现出相互溶合的特征。尽管平民化、大众化是大部分文艺节目的诉求，但一些具有较高文化品位的文艺节目仍坚守着自己的观众群体。

关键词：电视文艺创作中国电视文艺节目市场份额综艺栏目节目形态观众群体文化品位

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基于UEFI的固件级硬盘安全保护机制

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武汉大学学报（理学版） 2019年第2期65卷 223-228页

作者：孙亮陈小春中电科技(北京)有限公司北京100083

为提高硬盘的安全性和可靠性,提出一种基于统一可扩展固件接口(unified extensible firmware interface,UEFI)的固件级硬盘安全保护机制。该机制可以由硬盘厂商在硬盘的受保护空间内预置固件级安全运行环境和硬盘安全保护功能模块,实现... 详细信息

为提高硬盘的安全性和可靠性,提出一种基于统一可扩展固件接口(unified extensible firmware interface,UEFI)的固件级硬盘安全保护机制。该机制可以由硬盘厂商在硬盘的受保护空间内预置固件级安全运行环境和硬盘安全保护功能模块,实现身份认证、全盘加密、硬盘固件度量等安全功能。基于该机制,设计并实现了原型系统,并利用该原型系统进行芯片密码算法接口调用实验和硬盘读写效率测试。实验结果表明,在硬盘保护区内预置固件级安全模块,能够在操作系统启动前对用户身份进行认证,实现全盘加解密,提升了硬盘的安全性,且不影响加密硬盘的算法性能。

关键词： UEFI 固件安全硬盘安全保护机制数据加密

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在多种语言中寻求突破和生存的德语——谈德语在欧盟和世界范围内的现状

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德国研究 2010年第4期25卷 65-69+80页

作者：陈晓春上海外国语大学德语系

德语虽然目前是欧盟的工作语言之一,但随着英语的不断普及和欧盟的东扩,有着被弱化的可能。另外,欧盟成员国里学习德语的人数也在大幅度下降,这对德国在欧盟的地位构成了严峻的挑战。本文试对此作探讨。

关键词：欧盟工作语言欧盟多语言格局德语语言地位

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Clinical management and associated costs for moderate and severe Alzheimer’s disease in urban China: a Delphi panel study

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Translational Neurodegeneration 2015年第1期4卷 111-119页

作者： Xin Yu Shengdi chen xiaochun chen Jianjun Jia Chunhou Li Cong Liu Mondher Toumi Dominique Milea Institute of Mental Health Peking University Sixth HospitalHuayuanbeilu 51Haidian DistrictBeijing 100191China Department of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Fujian Institute of Geriatrics Union Hospital of Fujian Medical UniversityFuzhouChina Department of Geriatric Neurology Chinese PLA General HospitalBeijingChina Medical Services Department Peking Union Medical College HospitalBeijingChina Beijing Tongren Hospital Capital Medical UniversityBeijingChina University of Aix-Marseille MarseilleFrance Lundbeck Singapore SingaporeSingapore

Background:Healthcare resource utilisation for Alzheimer’s disease(AD)in China is not well *** Delphi panel study aimed to describe the clinical management pathways for moderate and severe AD patients in urban China and to define the amount and cost of healthcare resources ***:A panel of 11 experts was recruited from urban China to participate in two rounds of preparatory *** the first round,9 physicians specialised in dementia gave a qualitative description of the clinical management of AD *** the second round,2 hospital administrators were asked about the cost of AD management and *** from the interviews were discussed by the experts in a Delphi panel meeting,where consensus was reached on quantitative aspects of AD management,including the rate of healthcare resource utilisation,the respective unit costs and caregiving ***:Interviewees reported that mild AD is under-recognised in China;most patients are diagnosed with moderate to severe *** of independence and agitation/aggression are the main drivers for healthcare resource utilisation and contribute to a heavier caregiver *** was estimated that 70%moderate AD patients are independent/non-aggressive at the time of diagnosis,15%are independent/aggressive,10%are dependent/non-aggressive,and 5%are dependent/***/aggressive AD patients are more likely to be hospitalised(70–90%)than accepted in a nursing home(0–20%),while the opposite is true for dependent/non-aggressive patients(5–35%for hospitalisation vs.80%for nursing home).Independent AD patients require 1–3 hours/day of caregiver time,while dependent patients can require up to 12–15 hours/*** agreed that AD complicates the management of age-related comorbidities,found in 70–80%of all AD patients,increasing the frequency and cost of ***:The Delphi panel approach was an efficient method of gathering data about the amount of healthcare resources used

关键词： Delphi gathering panel

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流向变换强制周期操作合成甲醇

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现代化工 2000年第7期20卷 43-45页

作者：陈晓春李成岳北京化工大学化学工程学院 100029

该技术分段填充MK 1 0 1型合成甲醇催化剂和α Al2 O3 填料的固定反应床 ,用CO、CO2 、H2 、N2 的混合气体为原料 ,使反应自发地进行。原料浓度比传统定态过程低一个数量级 ,反应器对进料的浓度、温度。

关键词：周期操作流向变换甲醇合成

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