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Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys

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General Psychiatry 2023年第5期36卷 410-416页

作者： Wenlei zhang Jiahui Zhou Hang Su xiaocheng zhang Weichen Song Zijing Wang Chengjie Tang Kadir Uludag Min Zhao Zhi-Qi Xiong Rongwei Zhai Haifeng Jiang Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Lingang Laboratory ShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of SciencesShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghaiChina

Background Brain-derived neurotrophic factor(BDNF)is known to prevent methamphetamine(METH)-induced neurotoxicity and plays a role in various stages of METH addiction.However,there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.Aims The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.Methods This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure.Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.Results Repeated METH exposure decreased plasma BDNF levels.Additionally,plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.Conclusions These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.

关键词： intake assessed exposure

On extended state based Kalman filter for nonlinear time-varying uncertain systems with measurement bias

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Control Theory and Technology 2021年第1期19卷 142-152页

作者： xiaocheng zhang Wenchao Xue Hai-Tao Fang LSC NCMISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijingChina Schoo of Mathematical Sciences University of Chinese Academy of SciencesBeijingChina

This paper addresses the state estimation for a class of nonlinear time-varying stochastic systems with both uncertain dynam-ics and unknown measurement bias.A novel extended state based Kalman filter(ESKF)algorithm is developed to estimate the original state,the uncertain dynamics and the measurement bias.It is shown that the estimation error of the proposed algorithm is bounded in the mean square sense.Also,the estimation of the measurement bias asymptotically converges to its true value,such that the infuence of measurement bias is eliminated.Furthermore,the asymptotic optimality of the estima-tion result is proved while the uncertain dynamics approaches to a constant vector.Finally,a simulation study for harmonic oscillator system model is provided to ilustrate the effectiveness of proposed method.

关键词： Extended state observer Kalman filter Uncertain dynamics Measurement bias

Repairable,Recyclable,and Regenerable Macrocycle Organic Polymer

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Chinese Journal of Chemistry 2023年第12期41卷 1497-1503页

作者： Yifan Liu Yuanyuan Chen Huacan Wu Xiaowei Chen Donghui Wang xiaocheng zhang Shiya Zheng Yao Ling Baoshuai Liang Jiamao Chen Yu Dong Weiguo Huang College of Chemistry and Materials Science Fujian Normal University Fuzhou Fujian 350007 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences 155 Yangqiao West Road Fuzhou Fujian 350002 China Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou Fujian 350002 China University of Chinese Academy of Sciences 19A Yuquan Road Beijing 100049 China

Covalent/metal organic frameworks are highly attractive due to their tunable structure and properties,and broad applications in multiple fields.However,they still suffer from numbers of drawbacks including low solubility,harsh synthesis and fabrication,and low mechanical flexibility.Herein,we report a new organic framework consisting of macrocycles and organic frames in its periodic structure,and denote it as macrocycle organic polymer(MOP).The size-tunable macrocycles containing peripheral furan units are synthesized by anionic ring-opening polymerization,which undergo a reversible Diels-Alde reaction with bismaleimide to generate/degrade MOPs at given temperatures.Relying on above features,MOPs exhibit excellent flexibility,healable ability and recycle ability.Interestingly,owing to the“living”nature of anionic ring-opening polymerization,MOPs can self-grow into bigger sizes in the presence of monomer and catalysis,analogs to the living creatures.Moreover,their high porosity and rich thioether structure enable them as good metal ion absorbers and promising applications in wearable electronics.

关键词： Macrocycle organic polymer Healable Recyclable Regenerable Wearable electronics Ring-opening polymerization Adsorption

Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

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National Science Review 2023年第11期10卷 34-44页

作者： Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei xiaocheng zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan zhang Yaqiu Tang Minghui Jin Yuxian zhang He Li Zhi Yang Guan Ning Lin Dan J.Stein Zhi-Qi Xiong Zhen Wang Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of Sciences Lingang Laboratory 4. Shanghai Center for Brain Science and Brain-Inspired Technology Translational Neuropsychiatry Unit(TNU) Department of Clinical MedicineAarhus University Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine

Obsessive-compulsive disorder(OCD) is a chronic and debilitating psychiatric disorder that affects ～2%–3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs) in individual-specific sequences that were repetitive, time-consuming and stable over prolonged periods. Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans. Brain imaging showed that monkeys with SMBs had larger gray matter(GM) volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum. The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs. Notably, exposure to a stressor(human presence) significantly increased SMBs. In addition, fluoxetine, a serotonergic medication commonly used for OCD, decreased SMBs in these monkeys. These findings provide a novel foundation for developing better understanding and treatment of OCD.

关键词： obsessive-compulsive disorder (OCD) primate ritualistic behavior model OCD risk genes caudate nucleus fluoxetine

New Inverse Method for Determining Uniaxial Flow Properties by Spherical Indentation Test

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 138-146页

作者： Guoyao Chen xiaocheng zhang Jiru Zhong Jin Shi Qiongqi Wang Kaishu Guan School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China

The spherical indentation test has been successfully applied to inversely derive the tensile properties of small regions in a non-destructive way.Current inverse methods mainly rely on extensive iterative calculations,which yield a considerable computational costs.In this paper,a database method is proposed to determine tensile flow properties from a single indentation force-depth curves to avoid iterative simulations.Firstly,a database that contain numerous indentation force-depth curves is established by inputting varied Ludwic material parameters into the indentation finite elements model.Secondly,for a given experimental indentation curve,a mean square error(MSE)is designated to evaluate the deviation between the experimental curve and each curve in the database.Finally,the true stresses at a series of plastic strain can be acquired by analyzing these deviations.To validate this new method,three different steels,i.e.A508,2.25Cr1 Mo and 316L are selected.Both simulated indentation curves and experimental indentation curves are used as inputs of the database to inversely acquire the flow properties.The result indicates that the pro-posed approach provides impressive accuracy when simulated indentation curves are used,but is less accurate when experimental curves are used.This new method can derive tensile properties in a much higher efficiency compared with traditional inverse method and are therefore more adaptive to engineering application.

关键词： Spherical indentation test Database method Uniaxial stress-strain relationship

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Processing and valorization of cellulose,lignin and lignocellulose using ionic liquids

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Journal of Bioresources and Bioproducts 2020年第2期5卷 79-95页

作者： Zhenghao Xia Jinyang Li Jinming zhang xiaocheng zhang Xuejing Zheng Jun zhang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Cellulose,lignin and lignocellulose are important bioresources in the nature.Their effective and environmentally friendly utilization not only reduces dependence on fossil resources but also protects the environment.Recently,a class of novel eco-friendly solvents,ionic liquids,is employed to dissolve and process these bioresources.In this mini-review,we summarized the recent advances of processing and valorization of cellulose,lignin and lignocellulose in ionic liquids.It is expected that this up-to-date survey provides a comprehensive information of this field,and accelerates the development and utilization of the renewable plant biomass resources.

关键词： Lignocellulose Cellulose Lignin High-performance material Ionic liquid

计及共享储能与光伏的园区多用户综合收益优化

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电力工程技术 2024年第1期43卷 60-67页

作者：马佳伊刘海涛仲聪袁宇波张效诚南京工程学院电力工程学院江苏南京211167 江苏省配电网智能技术与装备协同创新中心江苏南京211167 国网江苏省电力有限公司电力科学研究院江苏南京211103

针对含共享储能与户用光伏的园区场景,文中提出一种用户侧综合收益双层优化方法,充分挖掘共享储能灵活性及用户用电需求差异性,在实现用户整体经济效益最优的同时提升光伏消纳能力。模型上层为月前优化阶段,以用户月度用电成本最低为目... 详细信息

针对含共享储能与户用光伏的园区场景,文中提出一种用户侧综合收益双层优化方法,充分挖掘共享储能灵活性及用户用电需求差异性,在实现用户整体经济效益最优的同时提升光伏消纳能力。模型上层为月前优化阶段,以用户月度用电成本最低为目标,考虑系统能量平衡、储能充放电约束以及储能荷电状态约束,优化工业用户最大用电功率,降低需量电费;模型下层为日前优化阶段,综合考虑用户综合收益及光伏消纳能力,以上层优化结果为约束条件,兼顾功率、储能等约束,提出共享储能充放电功率及用户与电网交互功率等日前优化策略,在用户月度整体经济性最优的前提下,实现用户侧每日经济效益的优化。最后,以南方某实际园区作为算例验证了文中所提方法的有效性。

关键词：共享储能户用光伏双层优化用户综合收益光伏消纳能力需量电费

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Simultaneous Strain and Temperature Measurement Based on Chaotic Brillouin Optical Correlation-Domain Analysis in Large-Effective-Area Fibers

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Photonic Sensors 2021年第4期11卷 377-386页

作者： xiaocheng zhang Shuangshuang LIU Jianzhong zhang Lijun QIAO Tao WANG Shaohua GAO Mingjiang zhang Key Laboratory of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China College of Physics and Optoelectronics Institute of Optoelectronic EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Chaotic Brillouin optical correlation domain analysis(BOCDA)has been proposed and experimentally demonstrated with the advantage of high spatial resolution.However,it faces the same issue of the temperature and strain cross-sensitivity.In this paper,the simultaneous measurement of temperature and strain can be preliminarily achieved by analyzing the two Brillouin frequencies of the chaotic laser in a large-effective-area fiber(LEAF).A temperature resolution of 1℃ and a strain resolution of 20μξ can be obtained with a spatial resolution of 3.9cm.The actual temperature and strain measurement errors are 0.37℃ and 10μξ,respectively,which are within the maximum measurement errors.

关键词： Brillouin scattering simultaneous strain and temperature measurement chaotic laser BOCDA LEAF

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地浸采铀工艺中电潜泵内流场数值模拟研究

湿法冶金 2024年第3期43卷 333-340页

作者：张翀贾皓朱建军李沁慈张晓程李学忠余卓华核工业北京化工冶金研究院北京101149 中核矿业科技集团有限公司北京101149 中国石油大学(北京)机械与储运工程学院北京102249 南方泵业股份有限公司杭州311100

电潜泵是我国地浸采铀工艺中实现浸出液有效提升的主要装备,但目前针对介质举升状态下电潜泵水力部件内部流场作用机制的研究较少。试验以叶轮-导叶内部结构为研究对象,应用CFD方法对介质流动特性开展非定常分析,研究了叶轮和叶轮出口... 详细信息

电潜泵是我国地浸采铀工艺中实现浸出液有效提升的主要装备,但目前针对介质举升状态下电潜泵水力部件内部流场作用机制的研究较少。试验以叶轮-导叶内部结构为研究对象,应用CFD方法对介质流动特性开展非定常分析,研究了叶轮和叶轮出口段内部的压力脉动变化规律,并利用瞬态流场数据对叶轮截面压力流场进行动模态分解(DMD)与压力流场重构,揭示了介质举升状态下由动静干涉引起的压力脉动周期性变化规律与动静部件距离对动静干涉强度的影响规律。结果表明,叶片通过频率值与快速傅里叶变换(FFT)频率值基本一致。试验结果可对减少由压力脉动引发的泵体无效震动、优化电潜泵水力部件结构参数和提升系统效率提供一定理论参考。

关键词：地浸采铀电潜泵动模态分解流场重构数据分析

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