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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou lixia Qin lingyan liang Yichen Wei Qingping Zhang xiaocheng li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Spontaneous regression of solid-pseudopapillary neoplasms with hepatic metastases

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 169-170页

作者： xiaocheng li Yahui liu Department of Hepatobiliary and Pancreatic Surgery the First Hospital of Jilin UniversityChangchunChina

A 42-year-old female patient was presented to our hospital due to abdominal distension for 3 *** scan showed a huge mass(16 cm diameter)in the pancreatic tail and irregular low-density shadows(0.4-5.6 cm diameter)in the liver with left outer lobe atrophy(Panel A).These lesions have increased radioactive uptake in PET/CT(Panel B).The patient underwent distal pancreatectomy,splenectomy,left lateral hepatectomy and pathological examination confirmed the diagnosis of solid-pseudopapillary neoplasms(Panel C;staining method HE,magnification×20).

关键词： neoplasms diagnosis PET/CT

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Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 485-498页

作者： xiaocheng li Yaqing XIAO Pengfei li Yayun ZHU Yonghong GUO Huijie BIAN Zheng li Laboratory for Functional Glycomics College of Life SciencesNorthwest UniversityXi’an 710069China National Translational Science Center for Molecular Medicine Department of Cell BiologyFourth Military Medical UniversityXi’an 710032China Medical Experiment Center Shaanxi University of Chinese MedicineXianyang 712046China The Infectious Disease Department Gongli HospitalPudong New AreaShanghai 200135China

End-stage liver diseases,such as cirrhosis and liver cancer caused by hepatitis B,are often combined with hepatic encephalopathy(HE);ammonia poisoning is posited as one of its main pathogenesis *** is closely related to autophagy,but the molecular mechanism of ammonia’s regulatory effect on autophagy in HE remains *** is an essential form of *** the nervous system,abnormal sialylation affects various physiological processes,such as neural development and synapse ***3 β-galactoside α2,3-sialyltransferase 6(ST3GAL6)is one of the significant glycosyltransferases responsible for addingα2,3-linked sialic acid to substrates and generating glycan *** found that the expression of ST3GAL6 was upregulated in the brains of mice with HE and in astrocytes after ammonia induction,and the expression levels of α2,3-sialylated glycans and autophagy-related proteins microtubule-associated protein light chain 3(LC3)and Beclin-1 were upregulated in ammonia-induced *** findings suggest that ST3GAL6 is related to autophagy in ***,we aimed to determine the regulatory relationship between ST3GAL6 and *** found that silencing ST3GAL6 and blocking or degrading α2,3-sialylated glycans by way of Maackia amurensis lectin-II(MAL-II)and neuraminidase can inhibit *** addition,silencing the expression of ST3GAL6 can downregulate the expression of heat shock proteinβ8(HSPB8)and Bcl2-associated athanogene 3(BAG3).Notably,the overexpression of HSPB8 partially restored the reduced autophagy levels caused by silencing ST3GAL6 *** results indicate that ST3GAL6 regulates autophagy through the HSPB8-BAG3 complex.

关键词： Hepatic encephalopathy Hyperammonemia Autophagy ST3β-galactosideα2,3-sialyltransferase 6(ST3GAL6) Heat shock proteinβ8(HSPB8)

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Layout Optimization of Large-scale Urban Water Supply Network Pressure Measuring Point Distribution Using Genetic Algorithm 36

Layout Optimization of Large-scale Urban Water Supply Networ...

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第36届中国控制会议

作者： Huayi Luo Jingcheng Wang xiaocheng li Jiayu Zhu Department of Automation Shanghai JiaoTong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of China Autonomous Systems and Intelligent Control International Joint Research Center Xi'an Technological University

ISBN: (纸本)9781538629185

In the urban water supply system, the location and quantity of the pressure monitoring nodes play a significant role for the monitoring effect and the response warning of the pipe burst. However, most installation of pressure monitoring nodes are based on human experience, which cannot totally present the whole water supply system condition. In view of the unreasonable layout of pressure monitoring nodes, this paper presents a solution Integrating sensitivity analysis, genetic algorithm, hydraulic model calculation and pipe network topology. Then optimize the number of pressure monitoring nodes by considering the amount of water covered and the number of associated nodes. This solution offers a relatively accurate and reasonable way to optimize the layout of pressure monitoring nodes in large-scale site selection, presenting better comprehensive effect compared with previous layout. To a certain extent, this optimized layout of pressure monitoring nodes reduce the impact of human factors and improve the monitoring of water supply network operation results.

关键词： pressure measuring point layout optimization genetic algorithm urban water supply network

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Robustness of the complex networks by statistical physics method 36

Robustness of the complex networks by statistical physics me...

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第36届中国控制会议

作者： Hai lin Jincheng Wang xiaocheng li Hongyuan Wang Bin Ma Department of Automation Shanghai Jiao Tong University and Key Laboratory of System Control and Information ProcessingMinistry of Education of China Autonomous Systems and Intelligent Control nternational Joint Research Center Xian Technological University

ISBN: (纸本)9781538629185

In this study,we present a novel analytical approach for robustness on Erdos-Renyi（ER） networks by introducing statistical physics *** establish an exact mapping relation between ER networks and Ising *** on the mapping relation,we obtain the partition function of the ER networks and use it to determine the size of the giant component and the value of the critical edge present probability in ER *** extend the approach to investigate the size of remaining giant component and the critical fraction of the nodes removed in the ER networks whose nodes under the randomly attack.

关键词： Percolation Erdos-Renyi(ER) networks Ising model mapping relation

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Sinopec Focuses on Sustainable Business Development

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China Oil & Gas 2013年第1期20卷 9-12页

作者： li xiaocheng Sinopec Shengli Oilfield Company

Sinopec Corp., China’s largest oil refiner, saw its oil and gas output rise 4.83 percent year-on-year in 2012 to 427.62 million barrels of oil equivalent, according to preliminary data released recently by the oil gi... 详细信息

关键词：企业可持续发展中石化天然气产量中国石化原油产量炼油企业同比增长生产国

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Chinese Oil Giants on Overseas Acquisition Spree

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China Oil & Gas 2012年第3期19卷 61-62页

作者： li xiaocheng Sinopec Shengli Oilfield

Energy security is a priority and concern for *** recent years,China's big three oil companies China National Petroleum Corporation(CNPC),China Petroleum & Chemical Corporation(Sinopec)and China National Off shore Oil... 详细信息

关键词：中国石油天然气集团公司收购海外能源安全 CNPC 石油公司

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Sinopec Commits to Cleaner Production and Fuels

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China Oil & Gas 2012年第4期19卷 50-51页

作者： li xiaocheng Sinopec Shengli Oilfield

China Petrochemical Corporation,or Sinopec,has issued a report on its efforts at environmental protection a first for a Chinese *** report cites strategies of China’s biggest oil refiner by capacity to reduce environmental impact,as well as implementation of lower-carbon fuels and less-polluting production methods."The18th CPC National Congress created a blueprint for a better tomorrow of promoting ecological progress and building a beautiful China,"said li Ganjie,vice minister of environmental protection."Chinese industrial companies should play a leading role in

关键词：中石化中国石油化工集团公司清洁生产燃料生产方法碳含量

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Look,That’s You Lagos, Nigeria

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ChinAfrica 2018年第12期10卷 4-5页

作者： li xiaocheng

Two young Nigerian football players are delighted to see themselves on the camera screen of a visiting Chinese photographer, at the local Police College sports grounds. The photographer was part of a media contingent ...

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Tb_(0.3)Dy_(0.7)Fe_(1.95-x)Nb_x(x=0,0.03,0.06,0.09)合金的组织与磁致伸缩性能

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稀有金属材料与工程 2012年第11期41卷 2045-2048页

作者：李晓诚丁雨田胡勇兰州理工大学甘肃省有色金属新材料省部共建国家重点实验室甘肃兰州730050 兰州理工大学温州泵阀工程研究院浙江温州325105

采用高真空电弧炉制备了Tb0.3Dy0.7Fe1.95-xNbx(x=0,0.03,0.06,0.09)合金,研究了该系列合金的晶体结构、微观组织及磁致伸缩性能。结果表明:添加Nb元素后的Tb0.3Dy0.7Fe1.95-xNbx(x=0.03,0.06,0.09)合金基体相结构仍保持为MgCu2(C15型)立方Laves相,添加Nb后Tb0.3Dy0.7Fe1.95-xNbx合金基体相晶格常数几乎不变。Nb在基体相RFe2中和富Re相中都不溶,但在x=0.03时的RFe3相中微溶而形成Re(Nb,Fe)3相。初生相NbFe2(C14型)相的形成使凝固液体富稀土从而抑制了RFe3有害相形成。六方结构的NbFe2在与自身结构不同的RFe2(C15型)中不溶而单独成为一相存在于RFe2基体上。Nb的添加量x对磁致伸缩的影响很大,微量(x=0.03)Nb的添加有效抑制了RFe3有害相的生成而使得磁致伸缩性能提高最大,但当Nb含量继续增大时,由于顺磁相NbFe2和富Re相的析出影响了基体磁-弹性交互作用而使磁效伸缩性能下降。但相对于Tb0.3Dy0.7Fe1.95母合金都有少量提高。

关键词： Tb-Dy-Fe合金磁致伸缩 Nb元素添加显微组织 Laves相

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