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超高效液相色谱-串联质谱法同时测定水稻中氟酮磺草胺及其代谢物的残留

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农药科学与管理 2024年第3期45卷 22-29页

作者：陈国峰滕瑶刘峰张晓波董见南黄文功兰静黑龙江省农业科学院农产品质量安全研究所黑龙江哈尔滨150086

本文旨在建立利用超高效液相色谱-串联质谱(Ultra Performance Liquid Chromatogra‐phy Tandem Mass Spectrometry,UPLC-MS/MS)同时测定糙米、稻壳和秸秆样品中的氟酮磺草胺及其代谢物BCS AA10030和BCS-CS64946。样品经乙腈水溶液振荡提取,PSA、C_(18)或GCB净化,UPLC-MS/MS测定,外标法定量。氟酮磺草胺、BCS AA10030和BCS-CS64946在0.001~0.5 mg/L范围内线性关系较好,相关系数>0.997 0,检出限均为0.01 mg/kg,在0.01、0.05、0.1三个添加水平下,氟酮磺草胺及其代谢物BCS AA10030和BCS-CS64946在糙米、稻壳和秸秆中平均回收率均分别为88.4%~103.0%,相对标准偏差分别为0.9%~9.3%,3种化合物在糙米、稻壳和秸秆中的定量限均为0.01 mg/kg,。该方法能够满足水稻中氟酮磺草胺及其代谢物残留分析要求,适用于大量水稻样品中氟酮磺草胺及其代谢物的快速检测,为政府监管提供有效的检测分析手段。

关键词：氟酮磺草胺代谢物超高效液相色谱-串联质谱(UPLC-MS/MS) 水稻

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植物GYF结构域的进化和功能分析

激光生物学报 2024年第3期33卷 253-258页

作者：陆训鲁建华彭书明夏清柱彭勃李奔奔张小波湘西土家族苗族自治州农业科学研究院湘西416000 凯里学院大健康学院凯里556011 平江县农业农村局植保植检站岳阳414500

根据GYF结构域蛋白质分布的广泛性及功能的多样性,更深入地研究GYF结构域蛋白,并对其进行进化分析是十分必要的。因AtEXA1是植物里研究最为透彻的GYF结构域蛋白,因此,本研究主要聚焦于与AtEXA1类似的蛋白的研究。通过分析真核生物(范围... 详细信息

根据GYF结构域蛋白质分布的广泛性及功能的多样性,更深入地研究GYF结构域蛋白,并对其进行进化分析是十分必要的。因AtEXA1是植物里研究最为透彻的GYF结构域蛋白,因此,本研究主要聚焦于与AtEXA1类似的蛋白的研究。通过分析真核生物(范围从单细胞低等真菌到高等生物)中的8053个GYF结构域蛋白,研究发现类似AtEXA1的蛋白质主要存在于植物物种中,而来自动物的GYF蛋白质与AtEXA1的相似性较低。研究还发现,类似AtEXA1的蛋白质存在于几乎所有的农作物中。本研究展示了GYF结构域蛋白的保守性,初步解构了GYF结构域蛋白进化的历程,并为后续对GYF结构域蛋白功能特征的研究提供了启示。

关键词： GYF结构域保守性蛋白进化蛋白功能

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HIV阳转家庭双方的生命质量现况及影响因素

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中国艾滋病性病 2024年第1期30卷 29-33页

作者：郝晓宇韩瑜杨志敏霍俊丽张小波安晓静徐诺雅黎萍李烙施玉华马艳玲昆明医科大学昆明650500 云南省疾病预防控制中心昆明650022

目的调查HIV阳转家庭夫妻双方生命质量现况及影响因素。方法采用横断面调查方法,调查120个云南省HIV阳转家庭的先证方和阳转方各120人,采用自制问卷和健康调查简易问卷(SF-36),对夫妻双方进行生命质量调查,分析影响因素,并与常模进行比... 详细信息

目的调查HIV阳转家庭夫妻双方生命质量现况及影响因素。方法采用横断面调查方法,调查120个云南省HIV阳转家庭的先证方和阳转方各120人,采用自制问卷和健康调查简易问卷(SF-36),对夫妻双方进行生命质量调查,分析影响因素,并与常模进行比较。结果阳转家庭先证方生理健康(PSS)得分(65.61±19.00)分,心理健康(MSS)得分(60.70±18.44)分;阳转方PSS得分(72.67±16.85)分,MSS得分(67.13±18.89)分,在生理职能(RP)、躯体疼痛(BP)、情感职能(RE)、精神健康(MH)、PSS及MSS,HIV阳转家庭双方得分均低于常模,差异有统计学意义(P<0.05),在一般健康状况(GH)、精力(VT)、社会功能(SF)、MH、PSS及MSS领域,先证方得分低于阳转方,差异有统计学意义(P<0.05)。阳转家庭中先证方高收入和无HIV临床及合并症状是PSS得分的保护因素;高收入和有民政救助是MSS得分的保护因素。阳转家庭阳转方年轻和无HIV临床及合并症状是PSS得分的保护因素;有民政救助和无HIV临床及合并症状是MSS得分的保护因素。结论HIV阳转家庭双方多领域评分降低,生命质量评分明显低于常模,影响阳转家庭生命质量的因素有收入、有无HIV临床及合并症状和有无民政救助,建议做好阳转家庭双方的抗病毒治疗和定期随访,控制及减少HIV感染相关症状的产生,同时扩大收入途径,采取民政救助等措施,改善阳转家庭生命质量。

关键词：艾滋病病毒阳转家庭生命质量

Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy:a novel delivery system candidate for tumor vaccines

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Science China(Life Sciences) 2024年第4期67卷 680-697页

作者： Nan Li Yun zhang Miaomiao Han Tian Liu Jinjia Wu Yingxia Xiong Yikai Fan Fan Ye Bing Jin Yinghua zhang Guibo Sun xiaobo Sun Zhengqi Dong State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Chinese Academy of Medical Sciences&Peking Union Medical College(CAMS)Institute of Medicinal Plant Development(IMPLAD)Beijing 100193China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine)and Translational MedicineKey Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription from Chinese Academy of Medical SciencesCAMSIMPLADBeijing 100193China Department of Pharmaceutics School of Pharmaceutical SciencesHeilongjiang University of Chinese MedicineHarbin 150036China Jilin Academy of Chinese Medicine Sciences Changchun 130012China Joint Research Center for Chinese Medicinal Herbs IMPLADABRC&ACCLBeijing 100193China

The study of tumor nanovaccines(NVs)has gained interest because they specifically recognize and eliminate tumor cells.However,the poor recognition and internalization by dendritic cells(DCs)and insufficient immunogenicity restricted the vaccine efficacy.Herein,we extracted two molecular-weight Astragalus polysaccharides(APS,12.19 k D;APSHMw,135.67 k D)from Radix Astragali and made them self-assemble with OVA257–264directly forming OVA/APS integrated nanocomplexes through the microfluidic method.The nanocomplexes were wrapped with a sheddable calcium phosphate layer to improve stability.APS in the formed nanocomplexes served as drug carriers and immune adjuvants for potent tumor immunotherapy.The optimal APS-NVs were approximately 160 nm with uniform size distribution and could remain stable in physiological saline solution.The FITC-OVA in APS-NVs could be effectively taken up by DCs,and APS-NVs could stimulate the maturation of DCs,improving the antigen cross-presentation efficiency in vitro.The possible mechanism was that APS can induce DC activation via multiple receptors such as dectin-1 and Toll-like receptors 2 and 4.Enhanced accumulation of APS-NVs both in draining and distal lymph nodes were observed following s.***.injection.Smaller APS-NVs could easily access the lymph nodes.Furthermore,APS-NVs could markedly promote antigen delivery efficiency to DCs and activate cytotoxic T cells.In addition,APS-NVs achieve a better antitumor effect in established B16-OVA melanoma tumors compared with the OVA+Alum treatment group.The antitumor mechanism correlated with the increase in cytotoxic T cells in the tumor region.Subsequently,the poor tumor inhibitory effect of APS-NVs on the nude mouse model of melanoma also confirmed the participation of antitumor adaptive immune response induced by NVs.Therefore,this study developed a promising APS-based tumor NV that is an efficient tumor immunotherapy without systemic side effects.

关键词： Astragalus polysaccharides nanovaccines OVA immunotherapy self-adjuvant

Thermodynamic equilibrium theory-guided design and synthesis of Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4)/C cathode for lithium-ion batteries

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Journal of Energy Chemistry 2024年第4期91卷 619-627页

作者： Wei Lyu Wenlong Cai Tuan Wang xiaobo Sun Enhao Xu Jinxuan Chen Kaipeng Wu Yun zhang College of Materials Science and Engineering Sichuan UniversityChengdu 610064SichuanChina

Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibrium analysis of Mn^(2+)-Fe^(2+)-Mg^(2+)-C_(2)O_(4)^(2-)-H_(2)O system is used to guide the design and preparation of insitu Mg-doped(Fe_(0.4)Mn_(0.6))_(1-x)Mg_(x)C_(2)O_(4)intermediate,which is then employed as an innovative precursor to synthesize high-performance Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4).It indicates that the metal ions with a high precipitation efficiency and the stoichiometric precursors with uniform element distribution can be achieved under the optimized thermodynamic conditions.Meanwhile,accelerated Li+diffusivity and reduced charge transfer resistance originating from Mg doping are verified by various kinetic characterizations.Benefiting from the contributions of inherited homogeneous element distribution,small particle size,uniform carbon layer coating,enhanced Li+migration ability and structural stability induced by Mg doping,the Li(Fe_(0.4)Mn_(0.6))_(0.97)Mg_(0.03)PO_(4)/C exhibits splendid electrochemical performance.

关键词： (Fe_(0.4)Mn_(0.6))_(1-x)MgxC_(2)0_(4) precursors Thermodynami cequilibrium Co-precipitation Mg doping Lithium-ion batteries

Glycerol Electrooxidation over Precision-Synthesized Gold Nanocrystals with Different Surface Facets

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Precision Chemistry

Precision Chemistry 2024年第3期2卷 103-111页

作者： Hansen Mou Fang Lu Zechao Zhuang Qiaowan Chang Lihua zhang xiaobo Chen Yugang zhang Jingguang G.Chen Department of Chemical Engineering Columbia UniversityNew YorkNew York 10027United States School of Chemical Engineering and Bioengineering Washington State UniversityPullmanWashington 99164United States Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNew York 11973United States Materials Science and Engineering Program State University of New York at BinghamtonBinghamtonNew York 13902United States Chemistry Division Brookhaven National LaboratoryUptonNew York 11973United States

Electrochemical glycerol oxidation(EGO)emerges as a promising route to valorize glycerol,an underutilized byproduct from biodiesel production,into value-added chemicals.This study employed three types of gold(Au)nanocrystals with controlled shapes to elucidate the facet-dependent electrocatalytic behavior in EGO.Octahedral,rhombic dodecahedral,and cubic Au nanocrystals with{111},{110},and{100}facets,respectively,were precisely synthesized with uniform size and shape.Rhombic dodecahedra exhibited the lowest onset potential for EGO due to facile AuOH formation,while octahedra showed enhanced electrochemical activity for glycerol oxidation and resistance to poisoning.In-situ FTIR analysis revealed that Au{111}surfaces selectively favored C_(2) products,whereas Au{100}surfaces promoted C_(3) product formation,highlighting the significant effect of facet orientation on EGO performance and informing catalyst design.

关键词： Electrochemical glycerol oxidation Precision synthesis Shaped nanocrystals Au nanocrystals SAXS In-situ FTIR

An In-Memory-Computing Design of Multiplier Based on Multilevel-Cell of Resistance Switching Random Access Memory

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Chinese Journal of Electronics 2018年第6期27卷 1151-1157页

作者： DAI Lan GUO Hong LIN Qipeng XIA Yongxin zhang xiaobo zhang Feng FAN Dongyu North China University of Technology Institute of Microelectronics of Chinese Academy of Sciences

Due to the Von Neumann bottleneck,in-memory-computing, as a new architecture, has drawn considerable attention and is becoming an candidate of next generation electronics system. It presents an inmemory-computing approach for multiplier design based on Multilevel-cell(MLC) of Resistive random access memories(RRAMs). The paper proposes a Look-up-table(LUT) operations to optimize the speed, area and power of the multiplier circuits. The proposed MLC function of RRAM revealed that RRAM could have a multilevel stable resistance by adjusting the operating voltage. The simulation results show that, taking a 16-bits multiplier as an example, the circuits of this paper has a calculation speed that is increased by 35.7 percent and an area that is decreased by 14 percent under the similar power consumption conditions when compared with other traditional 16-bits multiplier.

关键词： Resistive random access memory(RRAM) Multilevel-cell(MLC) storage Look-up-table(LUT) In-momery-computing

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长窄型薄壁叶片的套料电解加工

中国机械工程 2022年第7期33卷 797-803,810页

作者：张晓博朱栋南京航空航天大学机电学院南京210016

为实现长窄型薄壁叶片的套料电解加工,设计了电解液沿叶片轮廓四周进液的流动方式,开展了导流式出液和开放式出液的仿真对比分析,结果表明,导流式出液可以明显改善加工区域内流场的均匀性。开展了薄壁叶片套料电解加工试验研究,在进给速... 详细信息

为实现长窄型薄壁叶片的套料电解加工,设计了电解液沿叶片轮廓四周进液的流动方式,开展了导流式出液和开放式出液的仿真对比分析,结果表明,导流式出液可以明显改善加工区域内流场的均匀性。开展了薄壁叶片套料电解加工试验研究,在进给速度1.4 mm/min下实现了薄壁叶片的套型加工,轮毂表面粗糙度从0.532μm降低至0.307μm,叶片型面粗糙度从0.816μm降低至0.583μm。

关键词：薄壁叶片套料电解加工流场仿真表面粗糙度

Effect of Enhanced Plasma Density on the Properties of Aluminium Doped Zinc Oxide Thin Films Produced by DC Magnetron Sputtering

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Journal of Materials Science & Technology 2011年第5期27卷 393-397页

作者： Jun Gong xiaobo zhang Zhiliang Pei Chao Sun Lishi Wen Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Aluminum doped zinc oxide （AZO） thin films were prepared by DC magnetron sputtering at low substrate temperature. A coaxial solenoid coil was placed near the magnetron target to enhance the plasma density （Ji）. The enhanced plasma density improved significantly the bulk resistivity （p） and its homogeneity in spatial distribution of AZO films. X-ray diffraction （XRD） analysis revealed that the increased Ji had influenced the crystallinity, stress relaxation and other material properties. The AZO films deposited in low plasma density （LPD） mode showed marked variation in p （ranging from -6.5x10-2 to 1.9x10-3 Ω.cm）, whereas those deposited in high plasma density （HPD） mode showed a better homogeneity of films resistivity （ranging from ~1.3x10-3 to 3.3x10-3 ~.cm） at different substrate positions. The average visible transmittance in the wavelength range of 500-800 nm was over 80%, irrespective of the deposition conditions. The atomic force microscopy （AFM） surface morphology showed that AZO films deposited in HPD mode were smoother than that in LPD mode. The high plasma density produced by the coaxial solenoid coil improved the electrical property, surface morphology and the homogeneity in spatial distribution of AZO films deposited at low substrate temperature.

关键词： Sputtering Electronic conductivity Ion bombardmentPlasma density