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Loss of Gn1a/OsCKX2 confers heavy-panicle rice with excellent lodging resistance

Journal of Integrative Plant Biology 2022年第1期64卷 23-38页

作者： Bin Tu Zhang Tao Shiguang Wang lei Zhou Ling Zheng Chun Zhang Xinzi Li Xiaoyu Zhang Junjie Yin xiaobo Zhu Hua Yuan Ting Li Weilan Chen Peng Qin Bingtian Ma Yuping Wang Shigui Li State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Chengdu 611130China Rice Research Institute Sichuan Agricultural UniversityChengdu 611130China Guangdong Key Laboratory of New Technology in Rice Breeding Rice Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China College of Agriculture and Horticulture Chengdu Agricultural CollegeChengdu 611130China Agriculture and Rural Affairs Bureau of Cuiping District Yibin 644000China

Significant achievements have been made in breeding programs for the heavy-panicle-type(HPT)rice(Oryza sativa) in Southwest China. The HPT varieties now exhibit excellent lodging resistance,allowing them to overcome the greater pressures caused by heavy panicles. However, the genetic mechanism of this lodging resistance remains elusive. Here, we isolated a major quantitative trait locus, Panicle Neck Diameter 1(PND1), andidentified the causal gene as GRAIN NUMBER 1 A/CYTOKININ OXIDASE 2(Gn1 A/Os CKX2). The null gn1 a allele from rice line R498(gn1 aR498) improved lodging resistance through increasing the culm diameter and promoting crown root ***-of-function of Gn1 a/Os CKX2 led to cytokinin accumulation in the crown root tip and accelerated the development of adventitious roots. Gene pyramiding between the null gn1 aR498 allele with two gain-of-function alleles, STRONG CULM 2(SCM2)and SCM3, further improved lodging ***, Gn1 a/Os CKX2 had minimal influence on overall rice quality. Our research thus highlights the distinct genetic components of lodging resistance of HPT varieties and provides a strategy for tailormade crop improvement of both yield and lodging resistance in rice.

关键词： culm strength crown root Gn1a/OsCKX2 heavy-panicle rice lodging resistance

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Small extracellular vesicles with nanomorphology memory promote osteogenesis

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Bioactive Materials 2022年第11期7卷 425-438页

作者： Liang Ma Wencan Ke Zhiwei Liao xiaobo Feng Jie lei Kun Wang Bingjin Wang Gaocai Li Rongjin Luo Yunsong Shi Weifeng Zhang Yu Song Weibin Sheng Cao Yang Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Spine Surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi830054China

Nanotopographical cues endow biomaterials the ability to guide cell adhesion, proliferation, and differentiation. Cellular mechanical memory can maintain the cell status by retaining cellular information obtained from past mechanical microenvironments. Here, we propose a new concept “morphology memory of small extracellular vesicles (sEV)” for bone regeneration. We performed nanotopography on titanium plates through alkali and heat (Ti8) treatment to promote human mesenchymal stem cell (hMSC) differentiation. Next, we extracted the sEVs from the hMSC, which were cultured on the nanotopographical Ti plates for 21 days (Ti8-21-sEV). We demonstrated that Ti8-21-sEV had superior pro-osteogenesis ability in vitro and in vivo. RNA sequencing further confirmed that Ti8-21-sEV promote bone regeneration through osteogenic-related pathways, including the PI3K-AKT signaling pathway, MAPK signaling pathway, focal adhesion, and extracellular matrix-receptor interaction. Finally, we decorated the Ti8-21-sEV on a 3D printed porous polyetheretherketone scaffold. The femoral condyle defect model of rabbits was used to demonstrate that Ti8-21-sEV had the best bone ingrowth. In summary, our study demonstrated that the Ti8-21-sEV have memory function by copying the pro-osteogenesis information from the nanotopography. We expect that our study will encourage the discovery of other sEV with morphology memory for tissue regeneration.

关键词： Nanotopographic PEEK hMSCs Small extracellular vesicles Osteogenesis

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根霉功能曲制曲工艺条件优化研究

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酿酒科技 2024年第1期 24-29页

作者：蒲升惠秦辉徐琼张宿义杨艳蔡小波黄孟阳雷雨刘静王品翔付鑫泸州老窖股份有限公司四川泸州646000 国家固态酿造工程技术研究中心四川泸州646000

利用中高温大曲中筛选出的高产糖化酶根霉Rhizopus sp.菌株制备功能曲,通过单因素试验及响应面优化设计得出最佳工艺条件为:原料配比小麦粉∶熟糠∶麸皮(36∶10∶5)、接种量2.36%、料水比1∶0.6(g∶mL)、培养温度29.42℃和培养时间54.6... 详细信息

利用中高温大曲中筛选出的高产糖化酶根霉Rhizopus sp.菌株制备功能曲,通过单因素试验及响应面优化设计得出最佳工艺条件为:原料配比小麦粉∶熟糠∶麸皮(36∶10∶5)、接种量2.36%、料水比1∶0.6(g∶mL)、培养温度29.42℃和培养时间54.69 h。在此最佳工艺条件下制备的根霉功能曲糖化力为896 mg/g·h、液化力为1.5 g/g·h、试饭试验还原糖含量为37.5 g/100 g。

关键词：根霉糖化酶功能曲工艺优化

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Laser powder bed fusion additive manufacturing of NiTi shape memory alloys: a review

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International Journal of Extreme Manufacturing 2023年第3期5卷 1-29页

作者： Shuaishuai Wei Jinliang Zhang lei Zhang Yuanjie Zhang Bo Song xiaobo Wang Junxiang Fan Qi Liu Yusheng Shi State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China Department of Mechanical Engineering City University of Hong KongTat Chee AvenueKowloonHong KongPeople’s Republic of China Science and Technology on Power Beam Processes Laboratory Beijing Key Laboratory of High Power Beam Additive Manufacturing Technology and EquipmentAeronautical Key Laboratory for Additive Manufacturing TechnologiesAVIC Manufacturing Technology InstituteBeijing 100024People’s Republic of China

NiTi alloys have drawn significant attentions in biomedical and aerospace fields due to their unique shape memory effect(SME),superelasticity(SE),damping characteristics,high corrosion resistance,and good *** of the unsatisfying processabilities and manufacturing requirements of complex NiTi components,additive manufacturing technology,especially laser powder bed fusion(LPBF),is appropriate for fabricating NiTi *** paper comprehensively summarizes recent research on the NiTi alloys fabricated by LPBF,including printability,microstructural characteristics,phase transformation behaviors,lattice structures,and *** parameters and microstructural features mainly influence the printability of LPBF-processed NiTi *** phase transformation behaviors between austenite and martensite phases,phase transformation temperatures,and an overview of the influencing factors are summarized in this *** paper provides a comprehensive review of the mechanical properties with unique strain-stress responses,which comprise tensile mechanical properties,thermomechanical properties(*** stress to induce martensitic transformation,thermo-recoverable strain,and SE strain),damping properties and ***,several common structures(e.g.a negative Poisson’s ratio structure and a diamond-like structure)are considered,and the corresponding studies are *** illustrates the various fields of application,including biological scaffolds,shock absorbers,and driving *** the end,the paper concludes with the main achievements from the recent studies and puts forward the limitations and development tendencies in the future.

关键词： NiTi shape memory alloys laser powder bed fusion transformation behavior thermomechanical response lattice structures

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采用单次快拍数据实现信源DOA估计

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数据采集与处理 2013年第1期28卷 58-63页

作者：梁浩李小波王磊电子工程学院305教研室合肥230037

针对均匀线性阵列DOA估计中的实时性和解相干问题,提出了一种基于单次快拍数据的估计算法,通过对阵列接收的单次快拍数据进行相关处理后重构Toeplitz矩阵,并证明该矩阵的秩不受信号相干性的影响。通过特征值分解,得到对应的信号子空间... 详细信息

针对均匀线性阵列DOA估计中的实时性和解相干问题,提出了一种基于单次快拍数据的估计算法,通过对阵列接收的单次快拍数据进行相关处理后重构Toeplitz矩阵,并证明该矩阵的秩不受信号相干性的影响。通过特征值分解,得到对应的信号子空间和噪声子空间,结合MUSIC,ESPRIT等子空间类算法实现了对相干和非相干信号的DOA估计。算法不损失阵列孔径,具有更好的实时性和抗噪声干扰的能力;在低信噪比条件下,仍具有较好的估计性能。最后计算机仿真结果证实了算法的有效性和可行性。

关键词： DOA估计单次快拍矩阵重构 Toeplitz矩阵

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Heterogeneous oxidization of graphene nanosheets damages membrane

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Science China(Physics,Mechanics & Astronomy) 2019年第6期62卷 45-54页

作者： QianChun Wang xiaobo Zhai Michael Crowe Lu Gou YinFeng Li DeChang Li lei Zhang JiaJie Diao BaoHua Ji Biomechanics and Biomaterials Laboratory Department of Applied Mechanics Beijing Institute of Technology College of Science Xi'an University of Science and Technology Department of Cancer Biology University of Cincinnati College of Medicine MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of Science Xi'an Jiaotong University Department of Engineering Mechanics School of Naval Architecture Ocean and Civil Engineering and Key Laboratory of HydrodynamicsShanghai Jiao Tong University Institute of Applied Mechanics Department of Engineering Mechanics Zhejiang University

Graphene-based materials exhibit unique properties that have been sought to utilize for various potential applications. Many studies suggest that graphene-based materials can be cytotoxic, which may be attributed to destructive effects on cell ***, there still are conflicting results regarding interactions between graphene-based materials and lipid membranes. Here,through cryo-electron microscopy(Cryo-EM) and dye-leakage experiments along with in silico methods, we found that graphene oxide nanosheets induce significant membrane damage, while the effect of pristine graphene is negligible. We revealed the importance of heterogeneous oxidization of graphene-based nanosheets in damaging vesicle membranes. Moreover, that not only the oxidization degree but also the oxidization loci and membrane tension play important roles in the cytotoxicity of the graphene-based nanosheets.

关键词： graphene graphene oxide heterogeneous oxidization cytotoxicity lipid membrane

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Cryo-EM structures of a prokaryotic heme transporter CydDC

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Protein & Cell 2023年第12期14卷 919-923页

作者： Chen Zhu Yanfeng Shi Jing Yu Wenhao Zhao Lingqiao Li Jingxi Liang Xiaolin Yang Bing Zhang Yao Zhao Yan Gao xiaobo Chen Xiuna Yang Lu Zhang Luke W.Guddat lei Liu Haitao Yang Zihe Rao Jun Li Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China Laboratory of Structural Biology Tsinghua UniversityBeijing 100084China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300353China Innovative Centerfor Pathogen Research Guangzhou LaboratoryGuangzhou 510005China School of Chemistry and Molecular Biosciences The University of QueenslandBrisbaneQLD 4072Australia

DearEditor,Heme is an essential cofactor required across all kingdoms of life utilized in numerous biological processes,including cellular *** is a prokaryotic ATP-binding cassette(ABC)transporter required for heme assembling in respiratory cytochrome bd oxidase(Georgiou et al.,1987;Poole et al.,1989),a promising target for drug discovery(Borisov et al.,2011).CydDC is thought to play a role in maintaining an optimum periplasmic redox poise that is required for the incorporation of heme cofactors(Yamashita et al.,2014).It also suggested that CydDC is involved in heme processing by mediating glutathione/cysteine translocation(Cook and Poole,2000;Cook et al.,2002),although a role in heme translocation seems unlikely(Yamashita et al.,2014).To date,CydDC has been shown to be important for disulfide bond formation,motility,respiration,and tolerance to nitric oxide and antibiotics(Poole et al.,2019).

关键词： utilized disulfide Poole

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超越追赶:范式转变期的创新战略

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管理工程学报 2020年第1期34卷 1-8页

作者：吴晓波余璐雷李楠浙江大学管理学院浙江杭州310058

基于对技术追赶路径经典理论研究的梳理,本文回顾了与西方创新管理领域中著名的“U-A模型”所不同的“二次创新动态模型”。同时,通过对传统战略管理理论置于“范式转变期”的环境中重新审视,本文开拓性地提出了非线性混沌过程中的“超... 详细信息

基于对技术追赶路径经典理论研究的梳理,本文回顾了与西方创新管理领域中著名的“U-A模型”所不同的“二次创新动态模型”。同时,通过对传统战略管理理论置于“范式转变期”的环境中重新审视,本文开拓性地提出了非线性混沌过程中的“超越追赶”创新战略。结合中国领先企业从跟跑、并跑到领跑的发展实践,本文总结了超越追赶的主要模式,为后发企业把握机会窗口实现技术追赶提供有效指导。

关键词：超越追赶后发企业范式转变期机会窗口二次创新

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Doped, conductive SiO_(2) nanoparticles for large microwave absorption

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Light(Science & Applications) 2018年第1期7卷 211-219页

作者： Michael Green Zhanqiang Liu Peng Xiang Yan Liu Minjie Zhou Xinyu Tan Fuqiang Huang lei Liu xiaobo Chen Department of Chemistry University of MissouriKansas CityMO 64110USA State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China College of Materials and Chemical Engineering Hubei Provincial Collaborative Innovation Center for New Energy MicrogridChina Three Gorges UniversityYichang 443002China College of Environment Sichuan Agricultural UniversityChengduSichuan 611130China School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang 414000China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Although many materials have been studied for the purpose of microwave absorption,SiO_(2) has never been reported as a good *** this study,we present for the first time that doped,microwave conductive SiO_(2) nanoparticles can possess an excellent microwave absorbing performance.A large microwave reflection loss(RL)of−55.09 dB can be *** large microwave absorption originates mainly from electrical relaxation rather than the magnetic relaxation of the incoming microwave *** electrical relaxation is attributed to a large electrical conductivity that is enabled by the incorporation of heterogeneous(N,C and Cl)*** removal of the magnetic susceptibility only results in a negligible influence of the microwave *** contrast,the removal of the heterogeneous atoms leads to a large decrease in the electrical conductivity and microwave absorption ***,the microwave absorption characteristics can be largely adjusted with a change of the thickness,which provides large flexibility for various microwave absorption applications.

关键词： nanoparticles microwave absorption

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Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy

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Protein & Cell 2022年第1期13卷 65-71页

作者： Bin Li Yongkun Zhan Qianqian Liang Chen Xu Xinyan Zhou Huanhuan Cai Yufan Zheng Yifan Guo lei Wang Wenqing Qiu Baiping Cui Chao Lu Ruizhe Qian Ping Zhou Haiyan Chen Yun Liu Sifeng Chen xiaobo Li Ning Sun Department of Physiology and Pathophysiology State Key Laboratory of Medical NeurobiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Shanghai Institute of Precision Medicine Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Lab of Birth Defect Children's Hospital of Fudan UniversityShanghai 201102China Shanghai Key Laboratory of Clinical Geriatric Medicine Research Center on Aging and MedicineFudan UniversityShanghai 200032China Department of Echocardiography Zhongshan HospitalFudan UniversityShanghai 200032China Department of Biochemistry School of Basic Medical SciencesFudan UniversityShanghai 200032China

Dear Editor,Dilated cardiomyopathy(DCM)is a common form of inherited *** the past decades,single mutations in various genes encoding sarcomeric,cytoskeletal,and channel proteins *** been found to be associated with DCM(Hershberger et al.,2013;McNally and Mestroni,2017).However,the mechanisms how single mutations in sarcomeric or structural genes lead to the disease remain *** interesting phenomenon often seen in familial cardiomyopathy is that different single mutations on the same gene can cause either DCM or hypertrophic cardiomyopathy(HCM)(Kathiresan and Srivastava,2012),which exhibit almost opposite disease *** is characterized by thinned myocardium and septum,ventricular chamber dilation,and systolic dysfunction(Jefferies and Towbin,2010;McNally and Mestroni,2017),while HCM exhibits thickened myocardium and septum,reduced ventricular chamber,and diastolic dysfunction(Richard et al.,2003).At the cellular level,HCM cardiomyocytes exhibit concentric hypertrophy characterized by assembly of myofilaments in parallel and widening of the *** contrast,DCM cardiomyocytes show eccentric hypertrophy,with assembly of the myofilaments in series and myocyte elongation(Kehat and Molkentin,2010).

关键词： cardiomyopathy familial

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