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胡家河冲击地压防治及爆破卸压效果分析

科学技术创新 2024年第15期 46-49页

作者：雷小博李效鹏陕西彬长胡家河矿业有限公司陕西咸阳山西省煤炭地质一一四勘查院有限公司山西长治

胡家河作为强冲击地压矿井,危险指数高,采取科学的防治技术,能够预防矿井冲击地压灾害发生。论文对401111工作面冲击危险区域进行划分,提出冲击地压危险防治体系,对爆破卸压效果进行考察。结果表明,胡家河矿共划分8处强冲击危险区和7处... 详细信息

胡家河作为强冲击地压矿井,危险指数高,采取科学的防治技术,能够预防矿井冲击地压灾害发生。论文对401111工作面冲击危险区域进行划分,提出冲击地压危险防治体系,对爆破卸压效果进行考察。结果表明,胡家河矿共划分8处强冲击危险区和7处中等冲击危险区域;401111回采工作面采用大直径钻孔卸压、煤层注水、顶板预裂爆破等方案对冲击危险区域进行主动解危;401111工作面回风巷爆破后,相邻孔孔壁上出现比较明显的裂隙。

关键词：冲击地压危险区域爆破卸压煤层注水

High thermoelectric performance at room temperature of n-type Mg_(3)Bi_(2)-based materials by Se doping

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Journal of Magnesium and Alloys 2022年第4期10卷 1024-1032页

作者： xiaobo Mo Jiansong Liao Guocai Yuan Sha Zhu xiaobo lei Lihong Huang Qinyong Zhang Chao Wang Zhifeng Ren Key Laboratory of Fluid and Power Machinery of Ministry of Education School of Materials Science&EngineeringXihua UniversityChengdu 610039China Clean Energy Materials and Engineering Center State Key Laboratory of Electronic Thin Film and Integrated DeviceSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Physics and TcSUH University of HoustonHoustonTX 77204United States

Bi_(2)Te_(3) based alloys have been the most widely used thermoelectric material at low temperature for many *** we report Se doped n-type Mg_(3)Bi_(2) based materials with a thermoelectric figure-of-merit ZT of 0.82 at 300 K and a peak ZT of 1.24 at 498 K,which is comparable to the n-type Bi_(2)Te_(3) and Te doped Mg_(3)Bi_(1.4)Sb_(0.6).The improved thermoelectric performance is benefited from the high carrier concentration and mobility as well as the thermal conductivity *** reduced resistivity increased the power factor at all measured temperatures,leading to a higher engineering ZT(ZTeng)and engineering power factor(PFeng)for n-type Mg_(3)Bi_(2).The n-type Mg_(3)Bi_(1.4)Sb_(0.6) materials are promising for thermoelectric power generation and cooling applications near room temperature.

关键词： Mg_(3)Bi_(2) Zintl compound Thermoelectric Se-doping

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胶带燃烧特征及火灾危险性研究

陕西煤炭 2024年第9期43卷 38-42页

作者：贺涛冯加宇雷小博洲宇设计集团股份有限公司西安分公司陕西西安710000 陕西彬长大佛寺矿业有限公司陕西咸阳713500 陕西彬长胡家河矿业有限公司陕西咸阳713600

工业生产过程中胶带输送是一种常用的运输方式,但是胶带火灾时有发生,会严重威胁企业安全生产。为了研究胶带燃烧特性,使用锥形量热仪研究胶带在不同辐射强度条件下的燃烧过程。研究结果发现,热辐射强度逐渐增加从而导致胶带的点燃时间(... 详细信息

工业生产过程中胶带输送是一种常用的运输方式,但是胶带火灾时有发生,会严重威胁企业安全生产。为了研究胶带燃烧特性,使用锥形量热仪研究胶带在不同辐射强度条件下的燃烧过程。研究结果发现,热辐射强度逐渐增加从而导致胶带的点燃时间(TTI)大幅缩短;总放热量(THR)和放热速率峰值(PHRR)也随着热辐射强度的增加,显著增大。35 kW/m^(2)时的THR值为121.28 MJ/m^(2),比25 kW/m^(2)时增加了22.36 MJ/m^(2)。3种不同热辐射强度实验条件下胶带样品质量均显著降低,质量降低速率和产烟气量随实验辐射功率的降低而降低。通过火灾蔓延指数(FGI)、火灾性能指数(FPI)、放热指数(THRI_(6 min))和烟气生成速率(SP)分析表明,胶带燃烧时的火灾危险性均与热辐射强度成正比,热辐射强度越大,胶带试样在燃烧时从外界引火源能量越大,着火时的危险性也就越大。

关键词：胶带输送胶带燃烧火灾危险性放热

Construction of Non-infectious SARS-CoV-2 Replicons and Their Application in Drug Evaluation

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Virologica Sinica 2021年第5期36卷 890-900页

作者： Bei Wang Chongyang Zhang xiaobo lei Lili Ren He Huang Jianwei Wang Zhendong Zhao NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176China NHC Key Laboratory of Systems Biology of Pathogens and Christophe Me´rieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a devastating pandemic *** and antiviral drugs are the most promising candidates for combating this global epidemic,and scientists all over the world have made great efforts to this ***,manipulation of the SARS-CoV-2 should be performed in the biosafety level3 *** makes experiments complicated and ***,a safer system for working with this virus is urgently ***,we report the construction of plasmid-based,non-infectious SARS-CoV-2 replicons with turbo-green fluorescent protein and/or firefly luciferase reporters by reverse genetics using transformation-associated recombination cloning in Saccharomyces *** of these replicons was achieved simply by direct transfection of cells with the replicon plasmids as evident by the expression of reporter *** SARS-CoV-2 replicons,the inhibitory effects of E64-D and remdesivir on SARS-CoV-2 replication were confirmed,and the halfmaximal effective concentration(EC50)value of remdesivir and E64-D was estimated by different quantification methods respectively,indicating that these SARS-CoV-2 replicons are useful tools for antiviral drug evaluation.

关键词： SARS-CoV-2 Reverse genetics Replicon Antiviral drugs Drug evaluation

Aircraft Observation and Simulation of the Supercooled Liquid Water Layer in a Warm Conveyor Belt over North China

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Advances in Atmospheric Sciences 2024年第3期41卷 529-544页

作者： Jiefan YANG Fei YAN Hengchi lei Shuo JIA xiaobo DONG Xiangfeng HU Key Laboratory of Cloud Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Weather modification office of Hebei Province Hebei Meteorology AdministrationShijiazhuang 050000China

This paper studied a snow event over North China on 21 February 2017,using aircraft in-situ data,a Lagrangian analysis tool,and WRF simulations with different microphysical schemes to investigate the supercooled layer of warm conveyor belts(WCBs).Based on the aircraft data,we found a fine vertical structure within clouds in the WCB and highlighted a 1-2 km thin supercooled liquid water layer with a maximum Liquid Water Content(LWC) exceeding0.5 g kg^(-1) during the vertical aircraft *** the main features of thermodynamic profiles were essentially captured by both modeling schemes,the microphysical quantities exhibited large diversity with different microphysics *** conventional Morrison two-moment scheme showed remarkable agreement with in-situ observations,both in terms of the thermodynamic structure and the supercooled liquid water ***,the microphysical structure of the WCB clouds,in terms of LWC and IWC,was not apparent in HUJI fast bin *** reduce such uncertainty,future work may focus on improving the representation of microphysics in bin schemes with in-situ data and using similar assumptions for all schemes to isolate the impact of physics.

关键词： warm conveyor belt Microphysical properties supercooled liquid water microphysics schemes

Electrical property enhancement and lattice thermal conductivity reduction of n-type Mg_(3)Sb_(1.5)Bi_(0.5)-based Zintl compound by In&Se co-doping

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Journal of Materiomics 2023年第3期9卷 431-437页

作者： Tong Liu Jiansong Liao Hang Liu Runyu Wang Guocai Yuan Jing Jiang Yi Niu xiaobo lei Lihong Huang Chao Wang Qinyong Zhang Key Laboratory of Fluid and Power Machinery of Ministry of Education School of Materials Science&EngineeringXihua UniversityChengdu610039China Clean Energy Materials and Engineering Center State Key Laboratory of Electronic Thin Film and Integrated DeviceSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu611731China

Mg_(3)Sb_(1.5)Bi_(0.5)-based Zintl compounds have attracted extensive attention as potential thermoelectric materials due to their earth-abundant ***,pure and intrinsic Mg_(3)Sb_(1.5)Bi_(0.5)manifests a poor thermoelectric performance because of its low electrical conductivity of about 3×10^(2)S/m at room *** this work,In and Se co-doping was carried out to optimize the thermoelectric perfor-mance of n-type Mg_(3)Sb_(1.5)Bi_(0.5)-based *** experimental results revealed that the carrier con-centration and mobility of Mg_(3)Sb_(1.5)Bi_(0.5)significantly increased after In and Se co-doping,leading to an improvement of power ***,lattice thermal conductivity was significantly reduced due to the large mass difference between In and Mg.A maximum zT of 1.64 at 723 K was obtained for the Mg_(3.17)In_(0.03)Sb_(1.5)Bi_(0.49)Se_(0.01)*** an average zT value of about 1.1 between 300 and 723 K was achieved,which insures its possible application at medium temperature range as a non-toxic and low-cost TE material.

关键词： Zintl compound Thermoelectric property n-type Mg_(3)Sb_(1.5)Bi_(0.5) In&Se co-doping

650℃超超临界镍基高温合金超高压内缸铸造技术研究

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大型铸锻件 2024年第1期 1-6页

作者：李遥杨晓兵肖章玉林平岳磊吕友清邓琴方迁张川雷小波二重(德阳)重型装备有限公司四川德阳618013

介绍了高参数燃煤发电机组用镍基高温合金12 t级超高压内缸铸造技术研究工作及相关生产经验。结合镍基高温合金的材料特性、超高压内缸铸件的结构特点,应用MAGMA软件进行充型、凝固、应力多场耦合的模拟计算,并结合多年生产制造经验,制... 详细信息

介绍了高参数燃煤发电机组用镍基高温合金12 t级超高压内缸铸造技术研究工作及相关生产经验。结合镍基高温合金的材料特性、超高压内缸铸件的结构特点,应用MAGMA软件进行充型、凝固、应力多场耦合的模拟计算,并结合多年生产制造经验,制定合理的铸造工艺方案。目前,铸件已经完成毛坯制作,经对铸件化学成分、表观质量、尺寸进行检测,满足相关要求,为后续的工程化制造提供了经验。

关键词： 650℃超超临界超高压内缸铸造镍基高温合金数值模拟

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SARS-CoV-2 nsp12 attenuates type Ⅰ interferon production by inhibiting IRF3 nuclear translocation

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Cellular & Molecular Immunology 2021年第4期18卷 945-953页

作者： Wenjing Wang Zhuo Zhou Xia Xiao Zhongqin Tian Xiaojing Dong Conghui Wang Li Li Lili Ren xiaobo lei Zichun Xiang Jianwei Wang NHC Key Laboratory of System Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730PR China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730PR China Christophe Merieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730PR China Biomedical Pioneering Innovation Center Beijing Advanced Innovation Center for GenomicsPeking University Genome Editing Research CenterSchool of Life SciencesPeking UniversityBeijing 100871China

SARS-CoV-2 is the pathogenic agent of COVID-19,which has evolved into a global *** with some other respiratory RNA viruses,SARS-CoV-2 is a poor inducer of type Ⅰ interferon(IFN).Here,we report that SARS-CoV-2 nsp12,the viral RNA-dependent RNA polymerase(RdRp),suppresses host antiviral ***-CoV-2 nsp12 attenuated Sendai virus(SeV)-or poly(I:C)-induced IFN-β promoter activation in a dose-dependent *** also inhibited IFN promoter activation triggered by RIG-I,MDA5,MAVS,and IRF3 ***12 did not impair IRF3 phosphorylation but suppressed the nuclear translocation of *** analyses suggested that this suppression was not dependent on the polymerase activity of *** these findings,our study reveals that SARS-CoV-2 RdRp can antagonize host antiviral innate immunity and thus provides insights into viral pathogenesis.

关键词： SARS-CoV-2 COVID-19 Nsp12 Antiviral immunity

Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection

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Signal Transduction and Targeted Therapy 2023年第2期8卷 361-364页

作者： Zhuanchang Wu xiaobo lei Xin Wang Zhaoying Zhang Yuming Li Lifen Gao Xiaohong Liang Peihui Wang Jianwei Wang Chunhong Ma Key Laboratory for Experimental Teratology of Ministry of Education Key Laboratory of Infection and Immunity of Shandong Province and Dept.ImmunologySchool of Basic Medical SciencesCheeloo Medical CollegeShandong University250012JinanShandongChina NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical College100730BeijingChina College of Agriculture and Forestry Linyi UniversityLinyiShandongChina School of Public Health Shandong First Medical University&Shandong Academy of Medical Sciences271016Tai’anChina Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute Shandong University250012JinanShandongChina

Dear Editor,To date,seven human coronaviruses(HCoVs)have been identified,among which the highly pathogenic severe acute respiratory syndrome-associated coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have caused public health disasters worldwide.

关键词： respiratory acute Ezrin