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Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 434-442页

作者： xiaobo yang Haifeng Xu Bangyou Zuo Xu yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao Department of Liver Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College(CAMS&PUMC)BeijingChina

Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic *** this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been ***:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were ***:Nine patients with localized disease who received first-line systemic therapy were *** baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)*** patients achieved a pathological complete *** patients underwent laparoscopic surgery,and the other 3 patients underwent open *** a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour *** patients had any-grade AEs,and 55.6%of the patients experienced grade 3 *** was the most common AE,followed by elevated aminotransferase levels and ***:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become *** is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases.

关键词： Hepatocellular carcinoma(HCC) stereotactic therapy PD-1 systemic therapy conversion surgery

Pd^(0)-O v-Ce^(3+) Interfacial Sites with Charge Redistribution for Enhanced Hydrogenation of Methyl Oleate to Methyl Stearate

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Transactions of Tianjin University 2024年第4期30卷 359-368页

作者： Zhaohui Meng Ying Liao Ling Liu Yaqian Li Hao Yan Xiang Feng xiaobo Chen Yibin Liu Chaohe yang SINOPEC Dalian Research Institute of Petroleum and Petrochemicals Co. LtdDalianChina State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao 266580China

Improving the efficiency of metal/reducible metal oxide interfacial sites for hydrogenation reactions of unsaturated groups(e.g.,C=C and C=O)is a promising yet challenging *** our study,we developed a Pd/CeO_(2) catalyst by enhancing the oxygen vacancy(O V)concentration in CeO_(2) through high-temperature *** process led to the formation of an interface structure ideal for supporting the hydrogenation of methyl oleate to methyl *** cally,metal Pd^(0) atoms bonded to the O V in defective CeO_(2) formed Pd^(0)-O v-Ce^(3+)interfacial sites,enabling strong electron transfer from CeO_(2) to *** interfacial sites exhibit a synergistic adsorption eff ect on the reaction ***^(0) sites promote the adsorption and activation of C=C bonds,while O V preferably adsorbs C=O bonds,mitigating competition with C=C bonds for Pd^(0) adsorption *** synergy ensures rapid C=C bond activation and accelerates the attack of active H*species on the semi-hydrogenated *** a result,our Pd/CeO_(2)-500 catalyst,enriched with Pd^(0)-O v-Ce^(3+)interfacial sites,dem-onstrated excellent hydrogenation activity at just 30℃.The catalyst achieved a Cis-C18:1 conversion rate of 99.8% and a methyl stearate formation rate of 5.7 mol/(h·g metal).This work revealed the interfacial sites for enhanced hydrogenation reactions and provided ideas for designing highly active hydrogenation catalysts.

关键词： Hydrogenation Interfacial sites Oxygen vacancy C=C bond

Heat shock proteins in response to environmental carcinogens and lung cancer

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A novel mutation of glycogen synthase kinase-3β leads to a reduced level of GSK3βprotein in a patient with dilated cardiomyopathy

第七届全国医学生物化学与分子生物学和第四届全国临床应用生物化学与分子生物学联合学术研讨会暨医学生化分会会员代表大会

作者： Huan Guo Xiaomin Zhang xiaobo yang 邬堂春 MOE Key Lab of Environment and Health Tongji School of Public Health

The highly conserved proteins,called as heat shock proteins(HSPs) can be induced by such a lot of environmental stresses as physiological,physical,chemical factors,many of which are very common in the working and livi...

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Genes & Diseases 2024年第1期11卷 84-86页

作者： Ke Gong Zhiping Tan Haidan Liu xiaobo Liao Xinmin Zhou Bangliang Yin Shi Zeng Yao Yao Yifeng yang Li Xie Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan410011China Department of Ultrasound The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan 410011China Department of Blood Transfusion The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan 410011China

Dilated cardiomyopathy(DCM)is a frequently inherited heart condition.A familial transmission rate of 20%-35%has been documented,and most of these cases are autosomal *** condition has a high rate of morbidity and mort... 详细信息

关键词： GSK3β cardiomyopathy mortality

基于GMRF模型的统计特征畸变织物疵点识别

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纺织学报 2013年第4期34卷 137-142页

作者：杨晓波浙江财经学院信息分院浙江杭州310012

为提高纹理模型对统计特征畸变织物疵点的识别率,提出一种GMRF纹理模型自动识别不同种类的统计特征畸变织物疵点。介绍了GMRF模型的纹理合成。利用生成的GMRF纹理模型进行仿真实验,以验证参数估计算法和纹理合成算法的正确性。设计了织... 详细信息

为提高纹理模型对统计特征畸变织物疵点的识别率,提出一种GMRF纹理模型自动识别不同种类的统计特征畸变织物疵点。介绍了GMRF模型的纹理合成。利用生成的GMRF纹理模型进行仿真实验,以验证参数估计算法和纹理合成算法的正确性。设计了织物疵点的检测流程,并对实际疵布进行自动检测。结果证明:通过GMRF模型参数构造的距离统计量能够敏感地区分正常织物纹理和统计特征畸变疵点纹理,比较适用于统计特征畸变疵点的自动检测。

关键词： GMRF模型纹理合成算法特征提取疵点检测

长期干扰对海南热带雨林国家公园森林群落木本植物特征的影响

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国家公园（中英文） 2024年第4期2卷 235-245页

作者：黄耀梁彩群莫燕妮刘畅张翔郝杰威李东海戚春林张顺卫李婧涵杨小波海南大学生态学院海南省热带生态环境修复工程研究中心海口570228 海南省林业局生态保护修复处海口570203

海南热带雨林国家公园成立于2021年,但仍有局部区域的植被因历史原因存在人为干扰。以海南热带雨林国家公园中霸王岭、吊罗山、尖峰岭3个片区的热带雨林为例,采用时空替代法,调查并分析了3个国家公园受不同程度长期干扰群落物种丰富度... 详细信息

海南热带雨林国家公园成立于2021年,但仍有局部区域的植被因历史原因存在人为干扰。以海南热带雨林国家公园中霸王岭、吊罗山、尖峰岭3个片区的热带雨林为例,采用时空替代法,调查并分析了3个国家公园受不同程度长期干扰群落物种丰富度、多样性和物种组成及其受地形和生物因子的综合影响。结果表明,长期干扰降低了3个国家公园群落的α多样性,增加了β多样性。物种组成的相似性沿长期干扰的梯度递减。长期干扰与木本植物物种组成呈负相关关系。长期干扰削弱了木本植物丰富度与地形、生物因子关系,直接影响木本植物丰富度。需要重点监测公园内受干扰严重的森林群落以维持海南国家公园生物多样性。

关键词：人类干扰濒危植物国家公园物种组成

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试析美国州级高等教育管理机制

高教探索 2007年第6期 57-63页

作者：杨晓波国家教育行政学院国际教育教研部

如何构建州高等教育管理机制,如何在政府部门和高校之间分配权利和责任,领导和影响着美国各州高等教育事业的发展。当前美国州高等教育系统的管理结构可分为分割式、统一式和联邦式三大类型。不同的高教系统管理模式均有其优缺点,每个... 详细信息

如何构建州高等教育管理机制,如何在政府部门和高校之间分配权利和责任,领导和影响着美国各州高等教育事业的发展。当前美国州高等教育系统的管理结构可分为分割式、统一式和联邦式三大类型。不同的高教系统管理模式均有其优缺点,每个州的高教管理系统都是政府与高等教育在其政治、经济、历史、文化环境作用下的结果。

关键词：州高等教育管理机制州政府管理美国高等教育

Controllable Rh(Ⅲ)-Catalyzed C-H Arylation and Dealcoholization:Access to Biphenyl-2-carbonitriles and Biphenyl-2-carbimidates

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Controllable Rh(Ⅲ)-Catalyzed C-H Arylation and Dealcoholiza...

中国化学会·第十六届全国有机合成化学学术研讨会

作者：蒋博 Songxiao Wu Jing Zeng xiaobo yang 沈阳师范大学 Institute of Catalysis for Energy and Environment College of Chemistry & Chemical EngineeringShenyang Normal University

Over the past decades,Rhodium(Ⅲ)-catalyzed direct C-H functionalization has been established as a powerful and versatile tool for the synthesis of valuable molecules. Among them,readily available benzimidates,which act as both directing groups and synthons for cyclization,are always employed as the reaction partners. However,in these transformations,the directing groups generally disappear,which deprives the chance for further functionalization based on N-unsubstituted ***,the rational utilization of directing groups is still *** this context,a controllable Rh(Ⅲ)-catalyzed C-H arylation and dealcoholization of benzimidates with arylboronic esters was developed,delivering various biphenyl-2-carbonitriles and biphenyl-2-carbimidates by simply tuning the reaction *** approach features high efficiency,good functional group tolerance,and easy ***,it provides an alternative pathway to thoroughly exploit the directing group in transition-metal-catalyzed C-H activations.

关键词： Controllable Rhodium C-H Arylation Dealcoholization Benzimidates

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圆形口径平面天线阵列的多约束稀布优化方法

电波科学学报 2013年第1期28卷 21-27页

作者：唐斌陈客松杨晓波电子科技大学电子工程学院四川成都610054 成都航空职业技术学院航空电子工程系四川成都610100

针对圆形口径平面稀布阵列的多约束优化设计问题,以均匀同心圆环阵列的阵元位置分布特性为基础,构造了稀布圆阵的满足多个优化约束的可行初始解.提出了一种个体元素的间接表示法,设计了一种新的交叉算子和变异算子,运用改进的实数遗传... 详细信息

针对圆形口径平面稀布阵列的多约束优化设计问题,以均匀同心圆环阵列的阵元位置分布特性为基础,构造了稀布圆阵的满足多个优化约束的可行初始解.提出了一种个体元素的间接表示法,设计了一种新的交叉算子和变异算子,运用改进的实数遗传算法优化设计天线阵的阵元位置.优化约束包括阵元数约束、口径约束和最小阵元间距约束,优化目标是使阵列响应的峰值旁瓣电平最小.运用这种改进实数遗传算法可以充分利用阵元布阵的自由度,同时能减小搜索空间,提高计算效率.仿真试验证实了算法的稳健性和有效性.

关键词：阵列天线稀布阵遗传算法(GA) 旁瓣电平优化布阵