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Relationship between Expression of CEA,E-cadherin and Liver Metastasis in Colorectal Cancer

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Chinese Journal of Clinical Oncology 2008年第6期5卷 429-432页

作者： Ning Li xiaobing chen Xiangbin Wan Suxia Luo Lili Han Mengqiang Zhou Dengwen Yin Li Zhang Department of Oncologic Medicine Henan Tumor Hospital Zhengzhou 450003 Henan Province China Zhengzhou University Cancer Center Zhengzhou 450000 Henan Province China Department of Surgery Henan Tumor Hospital Zhengzhou 450003 Henan ProvinCe China Department of Oncologic Medicine Sun YatSen University Cancer Center Guangzhou 510000 Guangdong Province China

OBJECTIVE To investigate the expression of E-cadherin andCEA in serum in colorectal carcinoma and their relationship withliver *** CEA level was measured post-operativelyby radioimmunoassay of 60 patients with colorectal *** analysis was used to evaluate theexpression of *** In liver metastasis group,24 patients (24/26,92.3%)were high level of CEA,but only 9 patients in non-liver *** difference is significant (P=0.004).Expression ofE-cadherin significantly correlated with differentiation,but wasnot associated with Tstage or N *** metastatic rate innegative expression was higher than that in positive *** the survival analysis showed that time of liver metastasis wassignificant different in two groups (P<0.05).CONCLUSION The expression of CEA in serum can be usedto predict liver mestatasis of colorectal cancer after operation.E-cadherin,associated with tumor differentiation,is also a hopefulindicator for the prediction of liver metastasis in patients withcolorectal cancer.

关键词： colorectal cancer liver metastasis E-cadherin CEA.

Ferroelectric and Magnetic Properties of Co Doping Bi6Fe2Ti3O18 Ceramics

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Ferroelectric and Magnetic Properties of Co Doping Bi6Fe2Ti3...

Influence of longitudinal slope on the mechanical response of steel deck pavement

中国材料大会2012

作者： Chunyan chen Song Hou Xiangyu Mao xiaobing chen College of Physics Science and Technology Yangzhou University

ISBN: (纸本)9783037856079;3037856076

In this paper, for the purpose of enhancement in the magnetic behavior, the five-layer Aurivillius phase structure Bi6Fe2-xCoxTi3O18 （BFCT-x, x = 0.0～2.0） ceramics were synthesized using the solid-state reaction method from a mixture of Bi2O3 , Co2O3 , Fe2O3 , and TiO2 powders with different stoichiometric ratio. The microstructure, ferromagnetic and ferroelectric properties are investigated. The crystallographic structures of BFCT-x are determined to be the typical five-layer Aurivillius phase with a suggested structural transformation at heavy doping of Co ions. At room temperature, the remnant magnetization （2Mr ） of BFCT-0.0, BFCT-0.6, BFCT-1.0 and BFCT-2.0 samples are 0.043 memu/g, 0.59 emu/g, 0.81 emu/g and 1.75 memu/g, respectively. The 2Mr , at first, gradually enhance and reach a greatest value of 0.81 emu/g at x = 1.0 then degrade again with the increasing of the ratio x. At room temperature, the samples have ferroelectricity, which the remnant polarization （2Pr ） of the BFCT-0.0 , BFCT-0.6, BFCT-1.0 and BFCT-2.0 samples are 2.8 μC/cm2 , 8.0 μC/cm2 , 3.0 μC/cm2 and 7.2 μC/cm2 respectively. The 2Pr first increases, then decreases and increases again with Co doping. When x = 0.6, the 2Pr reaches a maximum value of 8.0 μC/cm2 .

关键词： Ceramic Aurivillius phase Ferroelectric Ferromagnetic

来源： cnki会议评论

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Journal of Southeast University(English Edition) 2018年第1期34卷 71-77页

作者： chen xiaobing　 Xu Libin Luo Ruilin Liu Han School of Transportation Southeast UniversityNanjing 210096China

In order to study the influence of longitudinal slope on the mechanical response of steel deck pavement,a method of slope-modulus transformation was proposed for the mechanical analysis of the steel deck pavement based on the time-temperature equivalence *** the mechanical action on a slope,a finite element model of the deck pavement was established to determine the critical load position of tensileand shear stress of the steel deck ***,the influence of longitudinal slope on the mechanical response of the deck pavement under the conditions of uniform speed and emergency braking was *** results indicate that the maximum transverse tensile stress at the pavement surface and the maximum transverse shear stress at the pavement bottom are always greater than their longitudinal counterparts under uniform *** emergency braking,however,the critical slope gradient of t e maximum transverse and longitudinal tensile stress at t e pavement surface is 6%.The maximum longitudinal shear stess at t e pavement bottom is always greater ta n t e maximum tansverse shear *** stidy is helpful in t e strctural design of large longitudinal slope steel deck pavements.

关键词： longitudinal slope steel deck pavement stress critical load position time-temperature equivalence finite element method

Multiferroic Properties of Bi_(4.15)Nd_(0.85)Fe_(0.5)Co_(0.5)Ti_3O_(15) Ceramics

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Journal of the Chinese Ceramic Society 2016年第3期3卷 133-139页

作者： MOU Xiuju WANG Wei WU Yuying SUN Hui chen xiaobing College of Physical Science and Technology Yangzhou University

Bi_(4.15)Nd_(0.85)Fe_(0.5)Co_(0.5)Ti_3O_(15)(BNFCT) ceramics were prepared using the traditional solid state reaction method.X-ray diffraction patterns show that the Aurivillius phase was formed without any *** scattering was used to predicate the distribution of the Nd ions and the vibration of the phonon modes corresponding to A-site ions and B-site octahedra were *** ferroelectric hysteresis loops show the remanent polarization(2 P_r) of BNFCT is 16μC/cm^2,which is twice as high as that of non-doped *** is considered that the suppression of oxygen vacancies and the increased lattice distortion due to Nd modification contribute to the enhancement in *** remanent magnetization(2 M_r) is also apparently increased up to 0.66 emu/g.X-ray photoelectron spectra show that the amount of Fe^(2+) ions decreases while that of Co^(3+) ions increases,which contributes to the more probability of spin-canting of the Fe-based and Co-based sublattices via Dzyaloshinskii-Moriya interaction.

关键词： ceramics doping ferroelectricity magnetization

Discrimination of mitochondrial DNA 10400 locus by SNP-operated on/off Switch

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Journal of Nanjing Medical University 2008年第6期22卷 346-350页

作者： Mei Hong Enben Su Ziqing chen xiaobing Ju Qi chen Rong Zhou The expert evidence institute the First Affiliated Hospital of Nanjing Medical University Nanjing 210029Jiangsu Province China

Objective：To apply reformed AS-PCR, which combined phosphorothioate-modified primers with exo^＋ polymerase, in single nucleotide polymorphism discrimination of mitochondrial DNA 10400 locus. Methods： We used the mtDNA 10400 locus to design unrnodifled and 3 ＇ phosphorothioate-modified allele-specific primers for PCR, which was performed using polymerases with and without 3 ＇ exonuclease activities. The effects of these primers on primer-extension were evaluated by agarose gel electrophoresis. Results： The unmodified primers were extended by both exo and exo^＋ polymerase irrespective of whether the primers were matched or mismatched with the templates. However, the 3＇ phosphorothioate-modified primers with a terminal mismatch triggered an ＂off-switch＂ of exo~ polymerase when compared to exopolymerase. Conclusion： The＂ on/off＇switch constituted by the combination of 3 ＇ phosphorothioatemodified primers with exo^＋ polymerase is a cost-effective, high-throughput and reliable method for SNP typing, which will be of enormous application in association studies by single nucleotide polymorphism screening.

关键词： SNP exo^+ polymerase phosphorothioate-modification allele-specific PCR mitochondrial DNA

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经济学的方法论:纷争及其后果

经济学家 2008年第4期 13-21页

作者：陈孝兵湖北省社会科学院湖北武汉430077

经济学是一门动态的鲜活的社会科学,它从不同的侧面反映生产力与生产关系发展变革的基本特性,为我们昭示人类经济社会进步的固有规律与变化趋势。从狭义的角度看,传统的政治经济学与自然科学有本质差别,它与生俱来就具有鲜明的"人文"特... 详细信息

经济学是一门动态的鲜活的社会科学,它从不同的侧面反映生产力与生产关系发展变革的基本特性,为我们昭示人类经济社会进步的固有规律与变化趋势。从狭义的角度看,传统的政治经济学与自然科学有本质差别,它与生俱来就具有鲜明的"人文"特征,除了作为一小部分人"休身养性"的"艺术品"之外,它在很大程度上也担负着"经世致用"的使命。经济学的细分和日益规范化表明,经济学有没有充实完善的方法论,不仅是其成熟与否的重要标志,而且是它能否得以顺利发展的基本前提和必要条件。现代经济学的发展再也不可能回到古典的老路上去了,它的进步是一种方法论的进步。

关键词：经济学科学性方法论

利用特征刀位点的三角网格表面NURBS刀轨生成

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计算机辅助设计与图形学学报 2010年第9期22卷 1587-1592页

作者：陈晓兵廖文和南京航空航天大学机电学院南京210016 淮阴工学院计算机工程学院淮安223003

为了提高数控加工的加工效率和精度,提出一种利用特征刀位点的NURBS刀轨生成算法.采用截平面和三角网格模型的等距模型求交来计算直线刀轨的刀位点,由等距模型的顶点曲率估算刀位点处沿刀轨和刀轨间隔方向的曲率半径,并根据残留高度确... 详细信息

为了提高数控加工的加工效率和精度,提出一种利用特征刀位点的NURBS刀轨生成算法.采用截平面和三角网格模型的等距模型求交来计算直线刀轨的刀位点,由等距模型的顶点曲率估算刀位点处沿刀轨和刀轨间隔方向的曲率半径,并根据残留高度确定刀轨行距;对基于特征刀位点的NURBS曲线拟合算法进行改进,采用阈值分割的方法选取初始特征刀位点,采用相邻直线段夹角最大原则确定新特征点,并用刀位点的投影点参数对特征点参数进行修正.采用文中算法对直线刀轨的刀位点进行NURBS曲线拟合,并在刀轨行间采用NURBS曲线过渡,以减小数控程序量并提高刀轨光顺性.实验结果表明,文中算法效率高,采用其生成的刀轨具有较少的控制顶点、较高的拟合精度以及较好的光顺性.

关键词：三角网格模型曲率半径估算特征刀位点选取特征刀位点参数修正 NURBS曲线拟合

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现代货币主义没落的方法论桎梏

江海学刊 2010年第4期 66-72页

作者：陈孝兵湖北省社会科学院江汉论坛杂志社

现代货币主义经济学是"二战"后由芝加哥大学的密尔顿.弗里德曼及其众多追随者们发展起来的,其理论基础是现代货币数量论。20世纪七八十年代,货币主义的实践在减缓美国经济增长压力、降低通货膨胀率方面取得了明显的成功。近年来伴随着... 详细信息

现代货币主义经济学是"二战"后由芝加哥大学的密尔顿.弗里德曼及其众多追随者们发展起来的,其理论基础是现代货币数量论。20世纪七八十年代,货币主义的实践在减缓美国经济增长压力、降低通货膨胀率方面取得了明显的成功。近年来伴随着金融创新工具的不断涌现,货币的周转率变得不再稳定,使得消费者行为方式的转变从根本上动摇了货币主义的方法论基础,货币主义开始走向衰落。实际上,现代市场经济的发展变化千姿百态,其复杂程度极高,而影响经济波动和社会就业变化的因素远不止货币这一种,因而采用单一规则的货币政策是无法长期维系经济的正常增长秩序的,现代货币主义的货币万能主张实际上是一种空想。

关键词：货币数量论货币主义自然失业率方法论

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论企业的经济自由及其限度

江淮论坛 2005年第5期 5-11页

作者：陈孝兵湖北省社会科学院武汉430077

作为一种最现实的微观经济组织,企业有自己的内部运行机理和利益预期。企业对市场的甄别、侵润和调整的能力在很大程度上决定了它同政府互动博弈的经济水平和实际效果,也决定了企业自身在多大程度上自主经营、自由选择的成本。市场的经... 详细信息

作为一种最现实的微观经济组织,企业有自己的内部运行机理和利益预期。企业对市场的甄别、侵润和调整的能力在很大程度上决定了它同政府互动博弈的经济水平和实际效果,也决定了企业自身在多大程度上自主经营、自由选择的成本。市场的经济自由是从个体主义出发,从私有财产出发,强调个体对财产的权利、市场的自发作用、自由企业制度以及国家对宏观经济的较少干预和控制。企业的经济自由可以为现代企业制度的建设打开另一扇成功的大门,提高企业的市场竞争能力;而必要的合理的政府宏观调控及其相应的经济规制形式上是对企业经济自由的反动,事实上却是经济自由的伴侣。因为纯粹的绝对的经济自由从来就不曾有过,而有限度的相对的企业的经济自由倒是高效率地促进经济社会协调发展的引擎。

关键词：企业政府经济自由经济规制