检索结果-南通市图书馆

Molecularly imprinted polymer/graphene oxide modified glassy carbon electrode for selective detection of sulfanilamide

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2017年第3期27卷 374-379页

作者： xiaobing wei Xinhua Xu Wen Qi Ying Wu Lihong Wang School of Materials Science and Engineering Tianjin University Analysis and Testing Center Shandong University of Technology Beijing Key Laboratory of Energy Nanomaterials Advance Technology & Materials CoLtdChina Iron & steel Research Institute Group School of Agricultural and Food Engineering Shandong University of Technology

A novel sensitive electrochemical sensor based on a glassy carbon electrode（GCE） modified with molecularly imprinted polymer（MIP） and grapheme oxide（GO） was *** MIP/GO material was prepared by precipitation polymerization in the presence of sulfanilamide as template *** MIP/GO based electrochemical sensor was characterized using scanning electron microscopy（SEM）,cyclic voltammetry（CV）,electrochemical impedance spectroscopy（EIS） and square wave voltammetry（SWV）.The results indicated that the sensor exhibited good affinity and excellent electrochemical response for *** optimized conditions,the oxidation peak current intensity of sulfanilamide showed two linear dynamic ranges from 10 to 1000 ng mL;,and the standard deviation was less than 5% using SWV *** sensor displays good stability,reproducibility,and high *** can be further applied to quantify sulfanilamide in milk.

关键词： Graphene oxide Sulfanilamide Molecularly imprinted polymer Electrochemical detection

Preparation of porous hollow silica spheres via a layer-by- layer process and the chromatographic performance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2017年第1期11卷 33-41页

作者： xiaobing wei Cairong GONG Xujuan CHEN Guoliang FAN Xinhua XU School of Materials Science and Engineering Tianjin University Tianjin 300350 China Analysis and Testing Center Shandong University of Technology Zibo 255000 China

Hollow silica spheres possessing excellent mechanical properties were successfully prepared through a layer-by-layer process using uniform polystyrene （PS） latex fabricated by dispersion polymerization as template. The formation of hollow SiO2 micro-spheres, structures and properties were observed in detail by zeta potential, SEM, TEM, FTIR, TGA and nitrogen sorption porosimetry. The results indicated that the hollow spheres were uniform with particle diameter of 1.6 μm and shell thickness of 150 nm. The surface area was 511 m2/g and the pore diameter was 8.36 nm. A new stationary phase for HPLC was obtained by using C18-derivatized hollow SiO2 micro-spheres as packing materials and the chromatographic properties were evaluated for the separation of some regular small molecules. The packed column showed low column pressure, high values of efficiency （up to about 43 000 plates/m） and appropriate asymmetry factors.

关键词： PS latex layer-by-layer hollow silica spheres packing materials

Simultaneous Prediction of Retention Times and Peak Shapes of Sulfonamides in Reversed-Phase High-Performance Liquid Chromatography

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Tianjin University 2018年第3期24卷 256-262页

作者： xiaobing wei Zhengji Pang Guoliang Fan Xinhua Xu Lihong Wang School of Materials Science and Engineering Tianjin University Department of Applied Chemical Engineering Ningbo Polytechnic School of Agricultural and Food Engineering Shandong University of Technology

In this paper, we propose a novelmethod based on the plate theory to simultaneously predict retention times and peak shapes under gradient elutions and different flow rates by reversed-phase high-performance liquid chromatography. The proposed method yielded excellent retention prediction results in experiments with 16 common sulfonamides under 18 gradient conditions and four different flow rates, including 0.7, 1.0, 1.3, and 1.5 mL/min. The mean absolute deviation was 0.70%, which indicates accurate prediction. Moreover, the proposed method predicts the change wellin peak shapes caused by the expansion or compression ofpeaks under different gradient conditions.

关键词： Retention time Peak shape Prediction RP-HPLC Sulfonamide

在线全文

学校读者我要写书评

暂无评论

山地城市生物滞留设施磷素富集与形态特征

环境影响评价 2024年第3期46卷 74-77页

作者：季晓晖何勇魏小兵魏泽军牛佳伟贵阳中节能水务有限公司贵州贵阳550001 重庆市合川区生态环境监测站重庆401520 重庆蓝洁环境技术有限公司重庆402465 重庆市科学技术研究院重庆401120

生物滞留设施是城市生态系统中重要的雨水管理设施,因其对雨水径流中污染物的净化作用而在全国海绵城市建设中普遍应用,以建成时间大于5年的生物滞留设施为对象,通过现场取样、检测、分析等方法,重点关注了生物滞留设施中磷污染物的富... 详细信息

生物滞留设施是城市生态系统中重要的雨水管理设施,因其对雨水径流中污染物的净化作用而在全国海绵城市建设中普遍应用,以建成时间大于5年的生物滞留设施为对象,通过现场取样、检测、分析等方法,重点关注了生物滞留设施中磷污染物的富集与形态,以掌握其积累分布、形态转化。结果表明,生物滞留带总磷素在0.36~0.76 g/kg之间,城市不同用地类型道路生物滞留带污染物含量相差较大,在建区域和城市交通道路生物滞留带中磷污染物主要富集在土壤深度为0~10 cm的表层处,含量分别为0.81 g/kg和0.49 g/kg。在建区域、居住区、商业区道路磷素积累显著高于城市交通道路,磷素纵向分布主要在生物滞留带0~10 cm深度富集;在生物滞留设施内部形态以钙磷(Ca-P)与有机磷形态为主;其形态转化路径则是以有机磷向无机磷,特别是交换态磷转化,不同区域内的磷素具有相似的富集、转化规律。

关键词：生物滞留设施磷污染物分布特征

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第1期14卷 67-86页

作者： Chunhao Zhu xiaobing Lan Zhiqiang wei Jianqiang Yu Jian Zhang School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Basic Medical Science Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Ocean University of ChinaQingdao 266100China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical ***,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse *** G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining *** research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse *** review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this *** will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased *** is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.

关键词： Neuropathic pain Allosteric modulators G protein-coupled receptors Analgesia

Protective Graphite Coating for Two-Dimensional Carbon/Carbon Composites

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第1期20卷 97-108页

作者： wei Shi Zhengyi Li xiaobing Xu Yingshui Yu Xiaofei Ding Heng Ju School of Mechanical and Power Engineering Dalian Ocean UniversityDalian116023China School of Mechanical and Electrical Engineering Gongqing Institute of Science and TechnologyJiujiang332020China

Two-dimensional carbon/carbon(2D C/C)composites are a special class of carbon/carbon composites,generally obtained by combining resin-impregnated carbon fiber clothes,which are then cured and *** study deals with the preparation of a protective coating for these *** coating,based on graphite,was prepared by the slurry *** effect of graphite and phenolic resin powders with different weight ratios was *** results have shown that the coating slurry can fill the pores and cracks of the composite surface,thereby densifying the surface layer of the *** the increase of the graphite powder/phenolic resin weight ratio,the coating density is enhanced while the coating surface flatness decreases;moreover,the protective ability of coating against erosion first increases(from 1:3 to 2:2)and then decreases(from 2:2 to 3:1).When the weight ratio is about 1:1,the coating for 2D C/C composites exhibits the best erosion resistance,which greatly aids these materials during gas *** this case,the erosion rate is decreased by approximately 41.5%at the impact angle of 30°and 52.3%at normal impact,*** can be attributed to the ability of the coating slurry to infiltrate into the substrate,thereby bonding the fibers together and increasing the compactness of the 2D C/C composites.

关键词： Carbon/carbon composites graphite coating microstructure erosion resistance

Traditional Chinese medicines derived natural inhibitors of ferroptosis on ischemic stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第8期22卷 746-755页

作者： WANG Yongliang LAN xiaobing LIU Ning MA Lin DU Juan wei wei HAI Dongmei WU Jing YU Jianqiang LIU Yue School of Pharmacy Ningxia Medical UniversityYinchuan 750000China Ningxia Key Laboratory of Drug Development and Generic Drug Research Ningxia Medical UniversityYinchuan 750000China Ningxia Characteristic Traditional Chinese Medicine Modern Engineering Research Center Ningxia Medical UniversityYinchuan 750000China College of Basic Medical Sciences Ningxia Medical UniversityYinchuan 750000China

Ischemic stroke(IS)is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion,leading to significant morbidity and *** intricate pathological mechanisms underlying IS complicate the development of effective therapeutic ***,a form of programmed cell death(PCD)characterized by iron overload and accumulation of lipid peroxidation products,has been increasingly recognized as a key contributor to IS *** Chinese medicines(TCMs)have long been utilized in the management of IS,prompting extensive research into their potential as sources of natural ferroptosis *** review investigates the critical role of ferroptosis in IS and provides a comprehensive analysis of current research on natural ferroptosis inhibitors identified in TCMs,aiming to lay a theoretical groundwork for the development of innovative anti-IS therapies.

关键词： Ischemic stroke Traditional Chinese medicines Natural inhibitors Ferroptosis