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中国化学快报:英文版 2023年第8期34卷 227-231页

作者： Xiongbo Song Liling Gu Qiming Yang Jiarui Wu Junrong Chen xiaobin tian Li Sun Long Chen Medical College Guizhou UniversityGuiyang 550000China Department of Orthopedics Guizhou Provincial People’s HospitalGuiyang 550000China Department of Orthopaedics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000China

Current clinical treatments cannot effectively delay the progression of osteoarthritis(OA).Consequently,joint replacement surgery is required for late-stage OA when patients cannot tolerate pain and joint dysfunction.Therefore,the prevention of OA progression in the early and middle stages is an urgent clinical problem.In a previous study,we demonstrated that NDRG3-mediated hypoxic response might be closely related to the development and progression of OA.In this study,an injectable thermosensitive hydrogel was established by cross-linking Pluronic F-127 and hyaluronic acid(HA)for the sustained release of hypoxia-induced exosomes(HExos)derived from adipose-derived mesenchymal stem cells.We demonstrated that for OA at the early and middle stages,the HExos-loaded HP hydrogel could maintain the chondrocyte phenotype by enhancing chondrocyte autophagy,reducing chondrocyte apoptosis,and promoting chondrocyte activity and proliferation through the NDRG3-mediated hypoxic response.This novel composite hydrogel,which could activate the NDRG3-mediated hypoxic response,may provide new ideas and a theoretical basis for the treatment of early-and mid-stage OA.

关键词： Osteoarthritis Injectable thermosensitive hydrogel Exosomes Hypoxic response NDRG3

Biomaterial-induced macrophage polarization for bone regeneration

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Chinese Chemical Letters 2023年第6期34卷 164-171页

作者： Long Chen Zhicheng Yao Siqin Zhang Kuihan Tang Qiming Yang Yuanzheng Wang Bohan Li Yingjie Nie xiaobin tian Li Sun Department of Orthopedics Guizhou Provincial People’s HospitalGuiyang 550000China Medical College Guizhou UniversityGuiyang 550000China Department of Materials Science and Engineering Translational Tissue Engineering CenterJohns Hopkins UniversityBaltimoreMD 21218United States Department of Endocrinology and Metabolism Guizhou Provincial People’s HospitalGuiyang 550000China The Central Laboratory Guizhou Provincial People’s HospitalGuiyang 550000China Department of Orthopedics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000China

As the main target cells of immune regulation,macrophages play an important role in the bone regeneration process.Macrophages can be polarized into the M1 and M2 types under the stimulation of different factors.They have proinflammatory and anti-inflammatory effects,respectively,and play key roles in different stages of bone regeneration.The ratio of M1 to M2 macrophages can be regulated by immunomodulatory biomaterials to promote bone repair and regeneration.In this paper,we review the recent literature on the chemical,physical and biological properties of biomaterials and the regulation of macrophage polarization under the influence of other factors.We also cover new methods for preparing immunomodulatory biomaterials for bone regeneration.This paper will provide new design ideas for the development of biomaterials with immunological properties and will support the clinical translation of bone-related medical biomaterials.

关键词： Macrophage polarization Biomaterial Nano materials Bone regeneration Immune response

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考古新发现有“成都”字迹的秦汉文物

文史杂志 2024年第1期229卷 34-38页

作者：田小彬四川省对外文化研究中心

考古所得的云梦睡虎地秦简、荥经“成都”矛、青川吕不韦戈、蒲江“成都”矛这几件带有“成都”字迹的战国晚期文物,在关于“成都”得名的研究中,被反复作为证据,证明“成都”得名于秦统一巴蜀后。近年来,又在成都、西安发现了有“成都... 详细信息

考古所得的云梦睡虎地秦简、荥经“成都”矛、青川吕不韦戈、蒲江“成都”矛这几件带有“成都”字迹的战国晚期文物,在关于“成都”得名的研究中,被反复作为证据,证明“成都”得名于秦统一巴蜀后。近年来,又在成都、西安发现了有“成都”字迹的秦简、秦封泥,同样也是战国晚期的文物。这不仅佐证了“成都”确实得名于秦统一巴蜀后,还证明成都自从纳入全国统一战略后,确实迅速发展、繁荣,走向了成功。

关键词：成都秦简秦封泥战国晚期

Evaluation of 124I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1321-1330页

作者： Haifeng Huang Hua Zhu Quan Xie xiaobin tian Xianteng Yang Fan Feng Qiyu Jiang Xinan Sheng Zhi Yang Guizhou University School of Medicine Guizhou UniversityGuiyang 550025China Department of Orthopaedics Guizhou Provincial People’s HospitalGuiyang 550002China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing 100142China Research Center for Clinical and Translational Medicine the 302nd Hospital of Chinese PLABeijing 100039China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Renal Cancer and MelanomaPeking University Cancer Hospital&InstituteBeijing 100142China

JS001(toripalimab)is a humanized IgG monoclonal antibody which strongly inhibits programmed cell death protein 1(PD1).In this study,we used a different iodine isotype(nat/124/125I)to label JS001 probes to target the human PD1(hPD1)antigen.In vitro,the half maximal effective concentration(EC50)value of natI-JS001 did not significantly differ from that of JS001.The uptake of 125I-JS001 by activated T cells was 5.63 times higher than that by nonactivated T cells after 2 h of incubation.The binding affinity of 125I-JS001 to T cells of different lineages after phytohemagglutinin(PHA)stimulation reached 4.26 nmol/L.Humanized PD1 C57 BL/6 mice bearing mouse sarcoma S180 cell tumors were validated for immuno-positron emission tomography(immuno-PET)imaging.Pathological staining was used to assess the expression of PD1 in tumor tissues.The homologous 124I-human IgG(124I-hIgG)group or blocking group was used as a control group.Immuno-PET imaging showed that the uptake in the tumor area of the 124I-JS001 group at different time points was significantly higher than that of the blocking group or the 124I-hIgG group in the humanized PD1 mouse model.Taken together,these results suggest that this radiotracer has potential for noninvasive monitoring and directing tumor-specific personalized immunotherapy in PD1-positive tumors.

关键词： Immunotherapy JS001 Toripalimab Programmed cell death protein 1 Immuno-PET imaging Iodine isotopes

Facial paralysis in cerebral infarction:A case of misdiagnosis and literature review

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Journal of Otology 2014年第4期9卷 191-193页

作者： Xin Li Xiaoyan Zhang xiaobin tian Zigang Jiang Baohuan Li Department of Otorhinolaryngology Beijing Tsinghua Changgung Hospital Department of Otology the First People's Hospital of Qinhuangdao Department of Allergic Reactions the First People's Hospital of Qinhuangdao

Facial paralysis can be classified as central or peripheral facial paralysis based on the location of the underlying lesion,both of which demonstrate facial motor dysfunction.In the currently report,a patient admitted to the department of otology,First People’s Hospital of Qinhuangdao,presented with facial asymmetry as the initial symptom of a cerebral infarction and was first misdiagnosed as peripheral facial paralysis.The case is reported as follows.

关键词： Facial paralysis in cerebral infarction case

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光子带隙光纤背向散射次波建模及实验验证

光学精密工程 2024年第6期32卷 765-773页

作者：王晓阳滕飞徐小斌王琪伟周晓娜田亚男马官营李勇北京控制工程研究所北京100190 空间智能控制技术重点实验室北京100190 北京航空航天大学仪器科学与光电工程学院北京100191

光子带隙光纤有着独特的结构形式、传输介质和导光机制,这使其具有传统光纤无法比拟的优点,是未来光纤陀螺的理想选择。但光子带隙光纤粗糙的纤芯内壁导致其产生强烈的背向散射次波,会使光子带隙光纤陀螺产生额外的非互易误差。为了定... 详细信息

光子带隙光纤有着独特的结构形式、传输介质和导光机制,这使其具有传统光纤无法比拟的优点,是未来光纤陀螺的理想选择。但光子带隙光纤粗糙的纤芯内壁导致其产生强烈的背向散射次波,会使光子带隙光纤陀螺产生额外的非互易误差。为了定量分析光子带隙光纤背向散射次波强度大小,论文基于电偶极子辐射理论建立了一种简单的光子带隙光纤背向散射次波理论模型。通过聚焦离子束微纳加工法和原子力显微镜测量得到了准确的纤芯内壁表面形貌功率谱密度,进而计算得到HC-1550-02型光子带隙光纤背向散射系数理论值为2.61×10^(-9)/mm。通过光频域背向反射散射仪得到HC-1550-02型光子带隙光纤背向散射系数测量值为~1.82×10^(-9)/mm,初步验证了背向散射次波模型的正确性,为背向散射次波抑制技术研究奠定了基础。

关键词：光子带隙光纤背向散射次波功率谱密度

Unsupervised hyperspectral unmixing based on robust nonnegative dictionary learning

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Journal of Systems Engineering and Electronics 2022年第2期33卷 294-304页

作者： LI Yang JIANG Bitao LI xiaobin tian Jing SONG Xiaorui Department of Space Information Space Engineering UniversityBeijing 101400China Beijing Institute of Remote Sensing Information Beijing 100192China

Considering the sparsity of hyperspectral images(HSIs),dictionary learning frameworks have been widely used in the field of unsupervised spectral unmixing.However,it is worth mentioning here that existing dictionary learning method-based unmixing methods are found to be short of robustness in noisy contexts.To improve the performance,this study specifically puts forward a new unsupervised spectral unmixing solution.For the reason that the solution only functions in a condition that both endmembers and the abundances meet non-negative con-straints,a model is built to solve the unsupervised spectral un-mixing problem on the account of the dictionary learning me-thod.To raise the screening accuracy of final members,a new form of the target function is introduced into dictionary learning practice,which is conducive to the growing robustness of noisy HSI statistics.Then,by introducing the total variation(TV)terms into the proposed spectral unmixing based on robust nonnega-tive dictionary learning(RNDLSU),the context information under HSI space is to be cited as prior knowledge to compute the abundances when performing sparse unmixing operations.Ac-cording to the final results of the experiment,this method makes favorable performance under varying noise conditions,which is especially true under low signal to noise conditions.

关键词： hyperspectral image(HSI) nonnegative dictionary learning norm loss function unsupervised unmixing

Decomposition analysis of CO_(2) emissions of electricity and carbon-reduction policy implication: a study of a province in China based on the logarithmic mean Divisia index method

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Clean Energy 2023年第2期7卷 340-349页

作者： Fuyuan Yang xiaobin Yang Xueqin tian Xinlei Wang Tong Xu State Grid Economic and Technological Research Institute Co. LtdBeijing102209China State Grid Jiangxi Electric Power Research Institute State Grid Jiangxi Electric Power Co.LtdNanchangChina

As the proportion of electricity in final energy consumption gradually increases,CO_(2) emissions reduction actions in the power system will become the key to achieving China’s carbon-peak and carbon-neutrality goals.It is essential to analyse and quantify the driving forces of CO_(2) emissions from electricity generation in the fossil-rich area in China.This paper aims to identify the characteristics of CO_(2) emissions generated by electricity and provide a basis for formulating CO_(2)-reduction policies in power systems.First,we analyse the current state of CO_(2) emissions from electricity generation in Anhui Province that was dominated by fossil energy during the period 2010-19.Then,we apply the logarithmic mean Divisia index method to find the nature of the factors influencing the changes in CO_(2) emissions.Finally,we analyse the CO_(2)-reduction measures of each side of the source-network-load-storage of the power system in Anhui through a power-system carbon-reduction path analysis model proposed in this study and provide policy suggestions.The results showed the following.(i)CO_(2) emissions in Anhui Province continued to increase from 2010 to 2019 and the trend in the growth rate of CO_(2) emissions presented approximately a u-shaped curve.(ii)Economic activity has always been the dominant factor driving the growth of electricity CO_(2) emis-sions.The increase in the proportion of renewable energy in power generation,the improvement in thermal power-conversion efficiency and the decrease in the intensity of power consumption are the three major driving factors for the reduction in CO_(2) emissions from power generation in Anhui.(iii)The CO_(2)-reduction measures of the power system are provided in each link of the source-network-load-storage,such as developing the photovoltaic industry and building energy storage,upgrading and transforming coal-fired power stations,redu-cing the loss rate of transmission lines on the grid side and improving the efficiency of the utilization of electricity on the user s

关键词： CO_(2)emissions LMDI electricity generation carbon-reduction measures

川西地区沙溪庙组储层特征及双向物源条件下孔隙差异性演化

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矿物岩石 2024年第2期44卷 108-121页

作者：陈春宇梁庆韶田景春余瑜王旭丽林小兵成都理工大学沉积地质研究院四川成都610059 中国石油西南油气田公司川西北气矿四川江油621700

四川盆地侏罗系沙溪庙组是重要的致密气储层。通过对川西地区侏罗系沙溪庙组储层特征的研究,探究南北双向物源条件下沙溪庙组储层砂岩孔隙的演化过程,对指导致密砂岩气的高效勘探开发具有重要意义。根据岩心和薄片观察结果,使用X射线衍... 详细信息

四川盆地侏罗系沙溪庙组是重要的致密气储层。通过对川西地区侏罗系沙溪庙组储层特征的研究,探究南北双向物源条件下沙溪庙组储层砂岩孔隙的演化过程,对指导致密砂岩气的高效勘探开发具有重要意义。根据岩心和薄片观察结果,使用X射线衍射、阴极发光、扫描电镜、电子探针等实验技术手段对储层特征进行研究,从储层演化和储层成因机理方面讨论优质储层成因。研究发现:受物源方向影响,川西南在南向物源影响下,主要发育长石砂岩和岩屑砂岩,川西北地区受北向物源影响,主要为长石岩屑砂岩和岩屑长石砂岩;川西南地区平均孔隙度为10.52%,平均渗透率为0.1334×10^(-3)μm^(2),川西北地区,平均孔隙度9.74%,平均渗透率为0.5262×10^(-3)μm^(2);川西地区储集空间主要为原生粒间孔和次生粒内溶孔;压实作用在孔隙减少中占主导地位,导致川西北地区孔隙度减少了23.94%。相比之下,由于绿泥石包膜的保护作用,川西南地区孔隙度减少了22.75%;胶结作用在孔隙减少中发挥次要作用,川西北和川西南地区的孔隙度分别减少了9.2%和11.3%;与此相反,溶蚀作用在孔隙增加方面起到积极作用,分别使川西北和川西南地区的孔隙度增加了5.26%和4.32%。综合分析显示,川西地区沙溪庙组储层的现今孔隙特征是多种成岩作用共同作用的结果。

关键词：四川盆地侏罗系沙溪庙组储层特征主控因素成岩作用

孕早期外泌体miR-876-3p与妊娠糖尿病和胰岛素抵抗、脂联素水平的关系

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中国优生与遗传杂志 2024年第2期32卷 305-310页

作者：王亚玲赵宏王小斌田丽丽西北妇女儿童医院产科陕西西安710061 西安航天总医院妇科陕西西安710100

目的探讨孕早期外泌体微小RNA(miR)-876-3p与妊娠糖尿病(GDM)和胰岛素抵抗(IR)、脂联素(ADP)水平的关系。方法选取2021年1月1日—12月31日期间在西北妇女儿童医院产科接受常规产前检查并分娩的150例孕产妇作为研究对象,包括50例GDM孕... 详细信息

目的探讨孕早期外泌体微小RNA(miR)-876-3p与妊娠糖尿病(GDM)和胰岛素抵抗(IR)、脂联素(ADP)水平的关系。方法选取2021年1月1日—12月31日期间在西北妇女儿童医院产科接受常规产前检查并分娩的150例孕产妇作为研究对象,包括50例GDM孕妇(GDM组)和100例无GDM的正常孕妇(非GDM组)。提取并纯化受试者循环外泌体,通过实时荧光定量PCR法检测受试者孕早期循环外泌体miR-876-3p表达水平。结果 GDM组孕早期循环外泌体miR-876-3p、糖化血红蛋白(HbA1c)、空腹胰岛素(Fins)、稳态模型-胰岛素抵抗指数(HOMA-IR)、瘦素(LEP)水平均显著高于非GDM组,ADP显著低于非GDM组(P<0.05)。ROC曲线分析循环外泌体miR-876-3p表达预测GDM的曲线下面积(AUC)为0.806(95%CI:0.734~0.878)。在将循环外泌体miR-876-3p添加到经典的GDM风险因素模型中后,可显著增加经典预测模型的预测效能。经Spearman秩相关性分析,循环外泌体miR-876-3p表达与HbA1c、Fins、HOMA-IR、LEP呈正相关,与ADP呈负相关(P<0.05)。结论孕早期循环外泌体miR-876-3p水平高表达与GDM高风险以及IR加重和ADP水平降低有关。循环外泌体miR-876-3p有希望成为孕早期GDM临床筛查的生物标志物以及潜在的治疗靶点。

关键词：孕早期循环外泌体miR-876-3p 妊娠糖尿病胰岛素抵抗脂联素