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一种混合算子改进帝王蝶优化算法

安阳师范学院学报 2024年第2期26卷 13-18页

作者：郭德龙周锦程罗晓宾黔南民族师范学院数学与统计学院贵州都匀558000 贵州省高等学校复杂系统与智能优化重点实验室贵州都匀558000

帝王蝶优化算法存在收敛速度慢、容易陷入局部最优、求解精度不高等问题,基于此提出一种基于柯西-高斯混合算子帝王蝶优化算法,该改进算法是在标准帝王蝶算法的迁移操作和调整操作中引入柯西-高斯混合算子,并发挥柯西算子全局搜索能力... 详细信息

帝王蝶优化算法存在收敛速度慢、容易陷入局部最优、求解精度不高等问题,基于此提出一种基于柯西-高斯混合算子帝王蝶优化算法,该改进算法是在标准帝王蝶算法的迁移操作和调整操作中引入柯西-高斯混合算子,并发挥柯西算子全局搜索能力强和高斯算子的局部搜索能力强来改善算法性能,同时也对调整操作中调整率做改进。最后通过数值仿真实验对4个单峰、多峰、混合、复合测函数进行测试,同时与其他算法进行对比,结果表明改进帝王蝶优化算法收敛性、求解精度等性能有所提高,该改进算法适应性、鲁棒性好于其他算法。

关键词：帝王蝶优化算法迁移操作调整操作柯西算子混合操作

An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Glioblastoma

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Journal of Biosciences and Medicines 2023年第8期11卷 95-113页

作者： xiaobin luo Department of Neurosurgery Zigong Fourth People’s Hospital Zigong China

To investigate the immunogenic Cell Death gene’s potential mechanism and prognostic value in glioblastoma. Information on GBM samples from The Cancer Genome Atlas database was downloaded, ICD genes were obtained, genotyping, integrated bioinformatics to verify the prognostic value of genotyping, and finally, prognostic model construction. Two subtypes associated with the ICD gene were obtained by consensus clustering, and the high ICD subtype (risk) group was associated with poor prognosis, high mutations in the PTEN gene, high stromal score, and high immune score. We also constructed a new classification system for GBM based on ICD characteristics. This study is the first to use immunogenic cell death genes for genotyping and successfully build a prognostic model.

关键词： Immunogenic Cell Death Prognostic Value Classification Immunotherapy Glioblastoma

昼夜节律和代谢途径在抑郁症中的角色:生物标志物的发现与新药物的预测

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华西医学 2024年第9期39卷 1457-1464页

作者：杨呈浩王伟罗小彬邹勇张明辉自贡市第四人民医院神经外科四川自贡643000 四川大学华西医院神经外科成都610041

目的探讨抑郁症相关的生物标志物及潜在的药物,以期改善抑郁症症状,提高患者生活质量。方法于2022年11月—2024年1月,下载并分析Gene Expression Omnibus数据库中抑郁症患者和健康志愿者的表达谱,对其进行差异表达分析后得到差异表达基... 详细信息

目的探讨抑郁症相关的生物标志物及潜在的药物,以期改善抑郁症症状,提高患者生活质量。方法于2022年11月—2024年1月,下载并分析Gene Expression Omnibus数据库中抑郁症患者和健康志愿者的表达谱,对其进行差异表达分析后得到差异表达基因,然后进行基因的富集分析,再进行蛋白质相互作用网络的构建,最后运行Cytoscape软件的插件Cytohubba找到其潜在的关键基因,并进行药物预测。结果通过差异表达分析,共找到110个差异表达基因(上调74个,下调36个)。蛋白质相互作用网络筛选出10个关键基因,差异表达分析显示其中8个基因(CPA3、HDC、IL3RA、ENPP3、PTGDR2、VTN、SPP1和SERPINE1)在健康志愿者和抑郁症患者之间的表达水平存在差异(P<0.05)。差异表达基因富集分析显示,上调基因显著富集于昼夜节律、烟酸和烟酰胺代谢、嘧啶代谢等通路,下调基因则主要富集在细胞外基质-受体相互作用、白细胞介素-17信号通路等通路。使用韦恩图获得了6个重叠验证基因(SALL2、AKAP12、GCSAML、CPA3、FCRL3和MS4A3),单细胞测序分析表明,这些基因在星形胶质细胞和神经细胞中表达显著。孟德尔随机化分析结果显示,FCRL3基因在抑郁症发生中可能具有重要作用。药物预测分析揭示了多种药物(如头孢替安、骆驼蓬醇、林可霉素、病毒唑等)具有潜在的抗抑郁作用。结论昼夜节律通路、烟酸和烟酰胺代谢通路、嘧啶代谢通路可能是抑郁症患者发病的潜在致病机制,骆驼蓬醇可能是抑郁症潜在的治疗药物。

关键词：抑郁症标志物生物信息学

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Optimization of mechanical properties of Sn-3.8Ag-0.7Cu alloys by the additions of Bi, In and Ti

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Progress in Natural Science:Materials International 2022年第5期32卷 643-654页

作者： Youyang Chen Kangdong You Shuting Yu Tixin Yang Ziqiang Dong Jincang Zhang Yandong Jia Gang Wang Jubo Peng Shanshan Cai xiaobin luo Jiajun Wang Chen Liu Institute of Materials Shanghai University Materials Genome Institute Shanghai University Yunnan Tin Group (Holding) Co.Ltd.

Bi, In and Ti were added to Sn-3.8Ag-0.7Cu(SAC387) solder alloy to optimize the mechanical performance. The alloying effects of Bi, In and Ti on the microstructure, thermal and mechanical properties of SAC387 based solder alloys were investigated. The results demonstrate that adding 3.5 wt % of Bi could refine the microstructure,optimize the thermal properties, and improve the tensile strength. Meanwhile, the ductility of the solder alloys reduced evidently. Adding 2.8 wt % of In into SAC387–3.5 wt %Bi alloy could increase both the strength and ductility, which is attributed to the beneficial effect of In addition, as adding In could improve the solubility of Bi in the β-Sn matrix. Meanwhile, the melting point was reduced, and the wettability improved with the addition of In. Introducing amounts of Ti into SAC387–3.5 wt % Bi-2.8 wt % In alloy could further increase the ***, the ductility was significantly reduced when 0.8 wt % of Ti was added due to the formation of the coarse Ti2Sn3phase. The undercooling was remarkably reduced with the addition of Ti. The nanoindentation tests demonstrate that the hardness increased mainly due to the hardening effect of the Bi addition. Among all the samples prepared, alloy SAC387–3.5 wt % Bi exhibited the highest creep resistance at the ambient *** adding In and Ti into SAC387–3.5 wt % Bi alloys reduced the creep resistance of the solder alloys. The mechanism associated with the different mechanical responses is also discussed in this study.

关键词： Sn–Ag–Cu solder Alloys Microstructure Tensile strength Nanoindentation

2023年慢性阻塞性肺疾病全球倡议更新评述

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西部医学 2024年第1期36卷 1-5页

作者：吴晓娟杜发旺罗晓斌李丽王小川王勤熊伟朱涛遂宁市中心医院呼吸与危重症医学科遂宁四川629000 重庆医科大学附属第二医院呼吸与危重症医学科重庆410000

慢性阻塞性肺病(COPD)发病机制复杂,是一种复杂累积和动态的基因-环境-时间相互作用的最终结果,这些相互作用会损害肺部和/或改变其正常的发育。COPD目前是全球范围内发病率和死亡率的主要原因,其经济和社会负担正在不断增加。本文根据2... 详细信息

慢性阻塞性肺病(COPD)发病机制复杂,是一种复杂累积和动态的基因-环境-时间相互作用的最终结果,这些相互作用会损害肺部和/或改变其正常的发育。COPD目前是全球范围内发病率和死亡率的主要原因,其经济和社会负担正在不断增加。本文根据2023年慢性阻塞性肺疾病全球倡议(GOLD)的更新,就COPD定义、诊断和治疗等关键问题进行评述,以期为临床医师诊断和治疗COPD患者提供参考和借鉴。

关键词：慢性阻塞性肺疾病 GOLD 气流阻塞药物治疗病情评估

MiR-183-5p promotes the progression of non-small cell lung cancer through targeted regulation of FOXO1

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Oncology and Translational Medicine 2023年第3期9卷 121-132页

作者： Yan Deng Zhengguang He xiaobin luo Rong Qiu Yong Zhao Wen luo Department of Respiratory and Critical Care Medicine Suining Central HospitalSuining 629000China

Objective To investigate miR-183-5p targeting to forkhead box protein O1(FOXO1)and its corresponding effect on the proliferation,migration,invasion,and epithelial-mesenchymal transition(EMT)of non-small cell lung cancer(NSCLC)*** NSCLC tissues and adjacent normal tissues from 60 patients with NSCLC adenocarcinoma were obtained via pathological biopsy or intraoperative *** cell lines were cultured in vitro,including the human normal lung epithelial cell line BEAS-2B and human NSCLC cell lines A549,SPCA-1,PC-9,and ***-183-5p and FOXO1 mRNA expression in tissues and cells were detected by qRT-PCR;the corresponding correlations in NSCLC tissues were analyzed using the Pearson test,and the relationship between miR-183-5p expression and clinicopathological parameters was *** miR-183-5p-mediated regulation of FOXO1 was verified by bioinformatics prediction alongside double luciferase,RNA-binding protein immunoprecipitation(RIP)assay,and pull-down experiments.A549 cells were divided into control,anti-miR-NC,anti-miR-183-5p,miR-NC,miR-183-5p,miR-183-5p+pcDNA3.1,and miR-183-5p+pcDNA3.1-FOXO1 *** proliferation,invasion,migration,apoptosis,and cell cycle distribution were detected using an MTT assay,clone formation assay,Transwell assay,scratch test,and flow cytometry,*** expression of EMT-related proteins in the cells was analyzed by western *** effect of miR-185-3p silencing on the development of transplanted tumors was detected by analyzing tumor formation in nude *** miR-183-5p expression was significantly higher in NSCLC tissues and cells than in adjacent normal tissues,whereas FOXO1 mRNA expression was significantly *** was a significant negative correlation between miR-183-5p and FOXO1 mRNA in NSCLC tissues(P<0.05).Additionally,the expression of miR-183-5p was significantly correlated with tumor size,tumor differentiation,and tumor-node-metastasis stage in patients with NSCLC(P<

关键词： non-small cell lung cancer miR-183-5p forkhead box protein O1 malignant biological behavior targeted regulation

探究加减生肌玉红膏联合超声波治疗Ⅱ~Ⅲ期压力性损伤的效果

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世界复合医学 2024年第2期10卷 127-129,141页

作者：罗小斌龚细礼刘向东杨小梅涂琴蓉陈自勇龙小娴湖南师范大学附属湘东医院中医科湖南株洲412200

目的探究加减生肌玉红膏联合超声波治疗Ⅱ~Ⅲ期压力性损伤的效果。方法选择2022年1月—2023年12月湖南师范大学附属湘东医院收治的40例Ⅱ~Ⅲ期压力性损伤患者,依据奇偶数法,分为两组,均20例,对照组进行单纯超声波治疗,研究组进行加减生... 详细信息

目的探究加减生肌玉红膏联合超声波治疗Ⅱ~Ⅲ期压力性损伤的效果。方法选择2022年1月—2023年12月湖南师范大学附属湘东医院收治的40例Ⅱ~Ⅲ期压力性损伤患者,依据奇偶数法,分为两组,均20例,对照组进行单纯超声波治疗,研究组进行加减生肌玉红膏+超声波治疗,比较两组压力性损伤渗出物pH值、压力性损伤愈合情况[压力性损伤愈合计分量表(Pressure Ulcer Scale for Healing,PUSH)]。结果治疗前,两组渗出物pH值比较,差异无统计学意义(P>0.05),组间对比治疗7 d后、治疗14 d后、治疗21 d后、治疗28 d后研究组pH比对照组低,差异有统计学意义(t=10.000、15.811、15.811、15.811,P均0.05),组间对比治疗7 d后、治疗14 d后、治疗21 d后、治疗28 d后研究组PUSH评分(13.32±1.57)分、(12.19±1.96)分、(10.59±2.67)分、(8.59±3.14)分比对照组(15.03±0.75)分、(14.26±1.01)分、(13.61±1.10)分、(12.40±1.40)分低,差异有统计学意义(t=4.395、4.198、4.677、4.956,P均<0.05)。结论Ⅱ~Ⅲ期压力性损伤患者使用加减生肌玉红膏联合超声波治疗能够改善压疮渗出物pH值、促进患者伤口愈合,效果理想。

关键词：生肌玉红膏超声波 Ⅱ~Ⅲ期压力性损伤创面愈合

Non-radical activation of persulfate with Bi_(2)O_(3)/BiO_(1.3)I_(0.4)for efficient degradation of propranolol under visible light

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Journal of Environmental Sciences 2024年第8期142卷 57-68页

作者： Yuehua Deng Qianqian Che Yani Li Jiating luo Xiang Gao Yan He Yiling Liu Tong Liu Xiaolong Zhao xiaobin Hu Wei Zhao College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation Xi’an 710054China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Life Science Huzhou UniversityHuzhou 313000China School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China

Non-radical activation of persulfate(PS)by photocatalysts is an effective approach for removing organic pollutants from aqueous *** this study,a novel Bi_(2)O_(3)/BiO_(1.3)I_(0.4)heterojunction was synthesized using a facile solvothermal approach and used for the first time for non-radical activation of PS to degrade propranolol(PRO)in the presence of visible *** findings found that the degradation rate of PRO in the Bi_(2)O_(3)/BiO_(1.3)I_(0.4)/PS system was significantly increased from 19%to more than 90%within 90 min compared to the Bi_(2)O_(3)/BiO_(1.3)I_(0.4)*** indicated that the composite system exerted an excellent synergistic effect between the photocatalyst and the persulfate-based *** tests and electron paramagnetic resonance demonstrated that the non-radical pathway with singlet oxygen as the active species played a major role in the photocatalytic *** existence of photo-generated holes during the reaction could also be directly involved in the oxidation of ***,a possible PRO degradation pathway was also ***,the impacts of pH,humic acid and common anions on the PRO degradation by the Bi_(2)O_(3)/BiO_(1.3)I_(0.4)/PS were explored,and the system’s stability and reusability were also *** study exhibits a highly productive catalyst for PS activation via a non-radical pathway and provides a new idea for the degradation of PRO.

关键词： Iodine deficiency Heterojunction Persulfate(PS) Propranolol(PRO) Photocatalytic degradation

Examining the pathway and mechanism of comprehensive land consolidation through the lens of rural neo-endogenous development

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Journal of Geographical Sciences 2024年第9期34卷 1739-1760页

作者： luo Xiuli JIN xiaobin LIU Xiaojie HONG Buting ZHOU Yinkang School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Key Laboratory of Coastal Zone Exploitation and Protection Ministry of Natural ResourcesNanjing 210023China Key Laboratory of Carbon Neutrality and Territory Optimization Ministry of Natural ResourcesNanjing 210023China Jiangsu Province Land Consolidation and Ecological Restoration Research Center Nanjing 210023China

Land consolidation(LC) stands as a globally recognized strategy for rural development. In China, it has evolved towards comprehensive land consolidation(CLC) to support the rural revitalization initiative. However, there are ongoing challenges in understanding CLC's specific pathway and mechanism, particularly its role in stimulating rural endogenous development. This study aims to investigate the localization process of international experiences, examine the pathway of CLC, and scrutinize its mechanism in rural development from a novel perspective of neo-endogenous development. Field research and semi-structured interviews were conducted in Nanzhanglou village, renowned for its early adoption of CLC practices inspired by German experiences since 1988. Overall, key findings underscore the advantages of CLC in spatial restructuring, industrial development, and human capital enhancement in rural areas. Additionally, international experiences emerge as crucial exogenous forces, primarily by knowledge embedding, which catalyzes rural neo-endogenous development via the “resource-engagement-identity-endogenous” mechanism. Collectively, by introducing a neo-endogenous theoretical framework, this study offers valuable insights into the CLC implementation in China and beyond, and emphasizes the positive impact of knowledge embedding as an exogenous force in promoting rural neo-endogenous development to address existing research gaps. Recommendations for sustainable rural development involve enhancing rural planning practicality, governance capacity, and local leadership, while prioritizing agricultural modernization and increasing investments in education and vocational training to ensure that villagers benefit from industrial development.

关键词： comprehensive land consolidation international experience localization rural neo-endogenous development mechanism