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MiR-183-5p promotes the progression of non-small cell lung cancer through targeted regulation of FOXO1

Oncology and Translational Medicine 2023年第3期9卷 121-132页

作者： Yan Deng Zhengguang He xiaobin luo Rong Qiu Yong Zhao Wen luo Department of Respiratory and Critical Care Medicine Suining Central HospitalSuining 629000China

Objective To investigate miR-183-5p targeting to forkhead box protein O1(FOXO1)and its corresponding effect on the proliferation,migration,invasion,and epithelial-mesenchymal transition(EMT)of non-small cell lung cancer(NSCLC)*** NSCLC tissues and adjacent normal tissues from 60 patients with NSCLC adenocarcinoma were obtained via pathological biopsy or intraoperative *** cell lines were cultured in vitro,including the human normal lung epithelial cell line BEAS-2B and human NSCLC cell lines A549,SPCA-1,PC-9,and ***-183-5p and FOXO1 mRNA expression in tissues and cells were detected by qRT-PCR;the corresponding correlations in NSCLC tissues were analyzed using the Pearson test,and the relationship between miR-183-5p expression and clinicopathological parameters was *** miR-183-5p-mediated regulation of FOXO1 was verified by bioinformatics prediction alongside double luciferase,RNA-binding protein immunoprecipitation(RIP)assay,and pull-down experiments.A549 cells were divided into control,anti-miR-NC,anti-miR-183-5p,miR-NC,miR-183-5p,miR-183-5p+pcDNA3.1,and miR-183-5p+pcDNA3.1-FOXO1 *** proliferation,invasion,migration,apoptosis,and cell cycle distribution were detected using an MTT assay,clone formation assay,Transwell assay,scratch test,and flow cytometry,*** expression of EMT-related proteins in the cells was analyzed by western *** effect of miR-185-3p silencing on the development of transplanted tumors was detected by analyzing tumor formation in nude *** miR-183-5p expression was significantly higher in NSCLC tissues and cells than in adjacent normal tissues,whereas FOXO1 mRNA expression was significantly *** was a significant negative correlation between miR-183-5p and FOXO1 mRNA in NSCLC tissues(P<0.05).Additionally,the expression of miR-183-5p was significantly correlated with tumor size,tumor differentiation,and tumor-node-metastasis stage in patients with NSCLC(P<

关键词： non-small cell lung cancer miR-183-5p forkhead box protein O1 malignant biological behavior targeted regulation

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An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Glioblastoma

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Journal of Biosciences and Medicines 2023年第8期11卷 95-113页

作者： xiaobin luo Department of Neurosurgery Zigong Fourth People’s Hospital Zigong China

To investigate the immunogenic Cell Death gene’s potential mechanism and prognostic value in glioblastoma. Information on GBM samples from The Cancer Genome Atlas database was downloaded, ICD genes were obtained, genotyping, integrated bioinformatics to verify the prognostic value of genotyping, and finally, prognostic model construction. Two subtypes associated with the ICD gene were obtained by consensus clustering, and the high ICD subtype (risk) group was associated with poor prognosis, high mutations in the PTEN gene, high stromal score, and high immune score. We also constructed a new classification system for GBM based on ICD characteristics. This study is the first to use immunogenic cell death genes for genotyping and successfully build a prognostic model.

关键词： Immunogenic Cell Death Prognostic Value Classification Immunotherapy Glioblastoma

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Optimization of mechanical properties of Sn-3.8Ag-0.7Cu alloys by the additions of Bi, In and Ti

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Progress in Natural Science:Materials International 2022年第5期32卷 643-654页

作者： Youyang Chen Kangdong You Shuting Yu Tixin Yang Ziqiang Dong Jincang Zhang Yandong Jia Gang Wang Jubo Peng Shanshan Cai xiaobin luo Jiajun Wang Chen Liu Institute of Materials Shanghai University Materials Genome Institute Shanghai University Yunnan Tin Group (Holding) Co.Ltd.

Bi, In and Ti were added to Sn-3.8Ag-0.7Cu(SAC387) solder alloy to optimize the mechanical performance. The alloying effects of Bi, In and Ti on the microstructure, thermal and mechanical properties of SAC387 based solder alloys were investigated. The results demonstrate that adding 3.5 wt % of Bi could refine the microstructure,optimize the thermal properties, and improve the tensile strength. Meanwhile, the ductility of the solder alloys reduced evidently. Adding 2.8 wt % of In into SAC387–3.5 wt %Bi alloy could increase both the strength and ductility, which is attributed to the beneficial effect of In addition, as adding In could improve the solubility of Bi in the β-Sn matrix. Meanwhile, the melting point was reduced, and the wettability improved with the addition of In. Introducing amounts of Ti into SAC387–3.5 wt % Bi-2.8 wt % In alloy could further increase the ***, the ductility was significantly reduced when 0.8 wt % of Ti was added due to the formation of the coarse Ti2Sn3phase. The undercooling was remarkably reduced with the addition of Ti. The nanoindentation tests demonstrate that the hardness increased mainly due to the hardening effect of the Bi addition. Among all the samples prepared, alloy SAC387–3.5 wt % Bi exhibited the highest creep resistance at the ambient *** adding In and Ti into SAC387–3.5 wt % Bi alloys reduced the creep resistance of the solder alloys. The mechanism associated with the different mechanical responses is also discussed in this study.

关键词： Sn–Ag–Cu solder Alloys Microstructure Tensile strength Nanoindentation

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The difference of clinical characteristics of patients with COVID-19 in Fourth-tier city and Wuhan

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Infectious Diseases Research 2021年第3期2卷 1-11页

作者： Xiaojuan Wu Chaoping Wang Gaoyan He Baolin Jia Li luo xiaobin luo Department of Respiratory Respiratory and Critical Care Medicine Suining Central HospitalAn Affiliated Hospital of Chongqing Medical UniversitySichuan629000SuiningChina Department of Oral and Maxillofacial Surgery Suining Central HospitalAn Affiliated Hospital of Chongqing Medical UniversitySichuan629000SuiningChina

Objective:This study mainly analyzed the clinical characteristics of patients with COVID-19 in Suining,one of China’s fourth-tier cities,and Wuhan and compared data between the 2 ***:A retrospective analysis of the clinical data of 68 patients with COVID-19 diagnosed at Wuhan Red Cross Hospital and 17 patients diagnosed at Suining Central Hospital,was ***:Among the 68 patients with COVID-19 in Wuhan,30(44.1%)had hypertension,and 25(36.8%)had *** out of the 17 patients in Suining(17.6%)had hypertension,and 2 patients(11.8%)had *** the clinical classification,there were 1(5.9%)and 23(33.8%)patients with severe COVID-19 in Suining and Wuhan,*** CT showed that lung consolidation occurred in 2(11.8%)and 26(38.2%)patients with COVID-19 in Suining and Wuhan,*** proportion of patients with diabetes or hypertension,severe COVID-19,lung consolidation in Wuhan was significantly higher than that in *** laboratory tests suggested that percentage of elevated C-reactive protein(CRP)(58.8%),ALT(33.8%),blood glucose(45.6%),creatine kinase(CK)(33.8%)or D-dimer(47.1%)of patients in Wuhan were significantly increased than those in Suining(29.4%,5.9%,17.6%,5.9%,and 17.7%,respectively).Conclusion:The incidence of COVID-19 in fourth-tier city and the disease severity were significantly lower than that in Wuhan.

关键词： Coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 China’s fourthtier cities Wuhan

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基于ANSYS优化分析的导管架损伤识别

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北京化工大学学报（自然科学版） 2013年第4期40卷 109-113页

作者：罗潇斌张杨北京化工大学机电工程学院北京100029

采用有限元软件ANSYS自带的APDL语言和可以考虑水影响的PIPE59单元,建立了管架平台的参数化有限元模型,通过改变有限元模型中的单元几何参数和物理参数的方法,描述导管架在作业中常见的腐蚀、弯曲等损伤情况。选择和测取导管架上部远离... 详细信息

采用有限元软件ANSYS自带的APDL语言和可以考虑水影响的PIPE59单元,建立了管架平台的参数化有限元模型,通过改变有限元模型中的单元几何参数和物理参数的方法,描述导管架在作业中常见的腐蚀、弯曲等损伤情况。选择和测取导管架上部远离损伤位置节点处的模态位移,创建目标函数;利用ANSYS的优化功能寻找某种对原完好导管架有限元模型进行修改后的模型,使其在测试节点的数据与预先建立的存在损伤的模型对应节点的数据趋于一致,从而实现识别导管架的损伤类型和损伤位置。计算结果表明当计算步数达到20000时,对于单处损伤的情况,损伤位置以及损伤程度识别准确率平均可达到90%以上;对于两处损伤同时存在的情况,损伤位置以及损伤程度识别准确率平均可达到70%以上。

关键词：损伤识别海洋平台导管架有限元

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The Effect of Magnetic Field-Tuned Resonance on the Capacitance of Laminate Composites

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Journal of Sensor Technology 2011年第3期1卷 81-85页

作者： Lijie Yang Jianguo Tang Wei Wang xiaobin luo Ning Zhang 不详

The magneto-electric coupling and magneto-capacitance effect of a layer composite ferromagnet/ piezoelectric/ferromagnet was investigated. Several resonant peaks were observed on the curves of the capacitance versus frequency. The resonant peaks were found to shift under an applied magnetic field, and the impedance of the sample can be changed from capacitive to inductive ones with changing the field. Thus, giant negative and positive magneto-capacitance effects can be observed simultaneously under a magnetic field less than 1 k Oe near the resonant points. Experimental and theoretical analysis showed that such magnetically tuned variation in impedance originates from the magnetic field-induced change of the compliances of the magnetic phase of the composite.

关键词： Composite Materials Laminates Functional Magnetoelectric Coupling Magneto-Capacitance Effects

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Deficient expression of miR-125a contributes to elevated RANTES by targeting KLF13 in lupus

Deficient expression of miR-125a contributes to elevated RAN...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Xia Zhao Yuanjia Tang Nan Shen Bo Qu Huijuan Cui xiaobin luo Renji Hospital JiaoTong University School of Medicine Institute of Health Sciences Shanghai Institutes for Biological SciencesChinese Academy of Sciences and Shanghai JiaoTong University School of Medicine Renji Hospital Institute of Health SciencesShanghai Institutes for Biological SciencesChinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine

Background:Inflammatory chemokines are fundamental regulators that direct immune cells to sites of inflammation and play a pivotal role in the tissue and organ inflammatory damage of *** studies have implicated that microRNAs(miRNAs) contribute to the regulation of inflammatory process as posttranscriptional *** reported previously that aberrant expression of miR-146a negatively regulated typeⅠIFN induction and contributed to the pathogenesis of *** this study,we further investigate how aberrant expression of miRNAs contributes to the dysregulation of inflammatory chemokines in SLE. Methods:Expression of the 156 miRNAs included in the Taqman microRNA Assays was *** the Bio-Plex system,we simultaneously analyze 27 inflammatory cytokines and chemokines in serum samples of SLE patients.

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电子束曝光中低能电子散射的模拟

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微纳电子技术 2009年第1期46卷 55-59页

作者：罗晓斌于肇贤北京信息科技大学理学院北京100101

介绍了Pendry弹性散射截面,描述了电子在固体中的散射过程,包括散射步长、散射角、方位角和散射点处能量的确定,并将Pendry截面和Monte Carlo计算方法应用到电子散射过程中。分别改变入射电子束能量、抗蚀剂厚度和衬底材料,模拟了能量... 详细信息

介绍了Pendry弹性散射截面,描述了电子在固体中的散射过程,包括散射步长、散射角、方位角和散射点处能量的确定,并将Pendry截面和Monte Carlo计算方法应用到电子散射过程中。分别改变入射电子束能量、抗蚀剂厚度和衬底材料,模拟了能量不超过5keV的低能电子束在PMMA抗蚀剂中的散射轨迹。模拟结果表明,低能电子束曝光同样可应用于较高分辨率的表面成像技术工艺。通过对模拟结果和电子束曝光实验比较分析,可以进一步完善散射模型,为更深入开展电子束曝光技术的应用研究创造有利条件,同时也为开发低成本的低能电子束曝光系统提供了理论依据。

关键词：电子束光刻 Pendry截面低能电子束散射轨迹分辨率

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传统楼阁式木结构塔振动台试验研究

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建筑结构学报 2017年第9期38卷 10-19页

作者：宋晓滨吴亚杰罗烈顾祥林同济大学土木工程学院上海200092

以7层传统楼阁式木结构塔为研究对象,对一个缩尺比例为1/5的木塔模型进行了振动台试验。试验中考虑了7度多遇至8度罕遇烈度水平,得到了不同水准地震作用下结构的加速度响应、位移响应和层间剪力分布等,并运用模态分析和系统识别理论识... 详细信息

以7层传统楼阁式木结构塔为研究对象,对一个缩尺比例为1/5的木塔模型进行了振动台试验。试验中考虑了7度多遇至8度罕遇烈度水平,得到了不同水准地震作用下结构的加速度响应、位移响应和层间剪力分布等,并运用模态分析和系统识别理论识别了结构的动力特性。研究结果表明:模型结构1阶模态阻尼比大于10%,加速度放大系数在0.5~1.0之间;模型结构最大位移角发生在柱架层,7度基本地震作用下结构最大层间位移角为1/52,震后结构自振频率没有明显降低;7度和8度罕遇地震作用下最大层间位移角分别为1/24、4/91,震后结构1阶频率下降了17%,模型仅在局部散斗和栌斗处发生横纹劈裂和梁柱榫卯节点轻微拔榫,其余构件未发现明显破坏,说明传统木结构具有良好的抗震性能。

关键词：传统木结构楼阁式木塔振动台试验模态分析抗震性能

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河南广播电视发射塔外筒桉叶糖形钢柱吊装技术

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施工技术(中英文) 2011年第22期40卷 8-10页

作者：闫祥梅罗晓滨郑州航空工业管理学院土木建筑工程学院中建八局第二建设有限公司郑州公司

河南广播电视发射塔桉叶糖形钢柱结构体形截面大,单个构件质量较大,每根钢柱在空间呈双向倾斜,施工时需超高空、悬空安装就位、连接,故安装难度大,钢柱的临时定位与校正均十分复杂。针对以上问题,对钢柱的施工顺序、吊装技术、施工测量... 详细信息

河南广播电视发射塔桉叶糖形钢柱结构体形截面大,单个构件质量较大,每根钢柱在空间呈双向倾斜,施工时需超高空、悬空安装就位、连接,故安装难度大,钢柱的临时定位与校正均十分复杂。针对以上问题,对钢柱的施工顺序、吊装技术、施工测量以及钢柱吊点的设置及强度验算进行了详细的技术分析和研究。

关键词：钢结构电视塔钢柱吊装安装顺序测量

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