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氮自由基化学新进展:光催化N—H键活化途径

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化学学报 2017年第12期75卷 1137-1149页

作者：宋颢刘小宇秦勇靶向药物与释药系统教育部重点实验室华西药学院四川大学成都610041

氮自由基作为一种高活性的中间体,为新型化学反应的设计及含氮化合物的合成提供了新的机遇.光催化条件活化N—H键直接产生氮自由基具有绿色、高效、经济等优点,相关方法学的研究在近年来取得了重要进展.本综述就2016年至今报道的几例最... 详细信息

氮自由基作为一种高活性的中间体,为新型化学反应的设计及含氮化合物的合成提供了新的机遇.光催化条件活化N—H键直接产生氮自由基具有绿色、高效、经济等优点,相关方法学的研究在近年来取得了重要进展.本综述就2016年至今报道的几例最新的研究成果进行亮点评述.

关键词：氮自由基可见光光催化剂单电子转移串联反应

Recent strategies to improve the electroactivity of metal-organic frameworks for advanced electrocatalysis

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Information ＆ Functional Materials 2024年第2期1卷 181-206页

作者： Runzhi Wei xiaoyu liu Aziz Bakhtiyarovich Ibragimov Junkuo Gao School of Materials Science and Engineering Zhejiang Sci‐Tech UniversityHangzhouChina Institute of General and Inorganic Chemistry Uzbekistan Academy of SciencesTashkentUzbekistan

Metal-organic frameworks(MOFs)have emerged as promising materials in the realm of electrocatalysis due to their high surface area,tunable porosity,and versatile chemical ***,their practical application has been hampered by inherent limitations such as low electrical conductivity and a limited number of active metal *** addressed these challenges through various strategies,including enhancing conductivity by incorporating conductive materials and metal nanoparticles,modifying the structure and composition of MOFs by replacing metal nodes and functionalizing linkers,and preparing MOFs catalysts through thermal processes such as decarburization and con-version into metal oxides,phosphides(MPs),and sulfides(MSs).This review provided a comprehensive summary of the strategies that were employed to enhance the electroactivity of MOFs for improved electrocatalytic performance in recent *** also explored future directions and potential innovations in the design and synthesis of MOF‐based electrocatalysts,offering valuable insights for advancing their application in sustainable energy technologies.

关键词： conductivity electroactivity electrocatalysis functional sites metal-organic frameworks porosity

The research of feet pressing energy collection and utilization device --based on piezoelectric ceramics

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International Journal of Technology Management 2015年第9期 107-109页

作者： Chen RUAN Dengjin WU Niu liu xiaoyu ZHAO North China Electric Power University Beijing 102206 China

After people or vehicles press, piezoelectric ceramics can send a weak and unstable alternating current. According to this characteristic, we made feet pressing energy collection and utilization device based on piezoelectric ceramics. The two parts of this device includes energy storage and utilization. In terms of storage, the energy collection module, can deposit AC sent by piezoelectric ceramics in the super capacitor after rectification. In terms of utilization of energy, the device achieve a variety of usage： through the USB interface, it can supply power for different equipments, replace the mobile station of train stations and realize the function of saving the electricity as the night corridor induction lamp, combined with vibration module design and programmable timer. The whole structure is supported by an acrylic plate, which saves cost and have good durability. This device implements the storage and usage of idle feet pressing energy. In conclusion, it is helpful to provide a new idea for people＇ s low carbon lives and has a quite broad application prospect.

关键词： piezoelectric ceramic acrylic plate energy collection module super capacitor vibration module timer.

Geometric origin of intrinsic dark counts in superconducting nanowire single-photon detectors

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Superconductivity 2022年第1期1卷 45-51页

作者： Xingyu Zhang Xiaofu Zhang Jia Huang Can Yang Lixing You xiaoyu liu Peng Hu You Xiao Wenying Zhang Yongliang Wang Lingyun Li Zhen Wang Hao Li State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences(CAS)865 Changning Rd.Shanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China CAS Center for Excellence in Superconducting Electronics 865 Changning Rd.Shanghai 200050People’s Republic of China

The dark count is one of the key physical issues for superconducting nanowire single-photon detectors(SNSPDs)that limits various applications for optical quantum information and classical *** the bias current approaches the switching current of SNSPDs,the dark count is actually dominated by the intrinsic dark counts(iDCs).However,the origin of iDCs and its relation to constrictions remains unclear for practical *** herein systematically characterize the iDCs of the SNSPDs with and without artificial geometric constrictions by applying the differential readout *** these devices with constrictions,we have observed distinct Gaussian distributions in the temporal distribution of iDCs,in which the time difference between the distributions is consistent with the geometric distance between constrictions,and the rates of iDCs produced by each constriction are in good agreement with constrictions'*** respect to practical SNSPDs,surprisingly,we also observe several Gaussian distributions in the temporal domain and it shows no significant dependence on the devices’sizes,demonstrating that the iDCs of SNSPDs are mainly dominated by a few specific constrictions.

关键词： Superconducting nanowire Single-photon detector Dark count Differential readout

Distributed Generation Application in the Rural Areas of West China

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Energy and Power Engineering 2013年第4期5卷 167-170页

作者： Yanfei Su Chenxu Zhao Long Xu xiaoyu liu The Bayannur power Bureau of Inner Mongolia Electric Power Group Co. Ltd. Hohhot China

In this paper, at first the appearance background electricity grid in the rural areas of west China, and its meaning as well as the concept and structure of DG technologies are resented, and a DG technologies mode of development in the rural areas of west China is given. The development ideas and the future development direction of DG in are compared and summarized. At last, the significance of DG in future development of the rural areas of west China is prospected and some problems to be especially considered in the domestic research on DG technologies are put forward.

关键词： Distributed Generation Technologies Rural West China Application

Improving antibody affinity through in vitro mutagenesis in complementarity determining regions

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The Journal of Biomedical Research 2022年第3期36卷 155-166页

作者： Wei Ye xiaoyu liu Ruiting He Liming Gou Ming Lu Gang Yang Jiaqi Wen Xufei Wang Fang liu Sujuan Ma Weifeng Qian Shaochang Jia Tong Ding Luan Sun Wei Gao Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineKey Laboratory of Human Functional Genomics of Jiangsu ProvinceNational Health Commission Key Laboratory of Antibody TechniquesSchool of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215001China Department of Biotherapy Nanjing Jinling HospitalNanjingJiangsu 210002China.

High-affinity antibodies are widely used in diagnostics and for the treatment of human ***,most antibodies are isolated from semi-synthetic libraries by phage display and do not possess in vivo affinity maturation,which is triggered by antigen *** is therefore necessary to engineer the affinity of these antibodies by way of in vitro *** this study,we optimized the affinity of two human monoclonal antibodies which were isolated by phage display in a previous related *** the 42A1 antibody,which targets the liver cancer antigen glypican-3,the variant T57H in the second complementarity-determining region of the heavy chain(CDR-H2)exhibited a 2.6-fold improvement in affinity,as well as enhanced cell-binding *** the I4A3 antibody to severe acute respiratory syndrome coronavirus 2,beneficial single mutations in CDR-H2 and CDR-H3 were randomly combined to select the best synergistic *** these,the mutation S53P-S98T improved binding affinity(about 3.7 fold)and the neutralizing activity(about 12 fold)compared to the parent *** together,single mutations of key residues in antibody CDRs were enough to increase binding affinity with improved antibody *** mutagenic combination of key residues in different CDRs creates additive ***,this study provides a safe and effective in vitro strategy for optimizing antibody affinity.

关键词： antibody engineering phage display affinity maturation

Transcription-independent phosphorylation of RNAP Ⅱ CTD is associated with chromosome separation in mouse oocytes during meiosis

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Transcription-independent phosphorylation of RNAP Ⅱ CTD is ...

Formation and emission of geraniol in tea(Camellia sinensis) leaves exposed to tea green leafhopper(Empoasca(Matsumurasca) onukii Matsuda) attack

中国解剖学会2015年年会

作者： liu xiaoyu Wei Haojie Ma Wei Department of Histology and Embryology School of Basic Medical SciencesCapital Medical University

＜正＞The RNA polymeraseⅡ（RNAPⅡ）largest subunit（RPB1）contains a unique C-terminal domain（CTD）,in which Ser,Thr and Tyr residues can all be phosphorylated,which is required for transcription initiation,elongation and RNA *** far,information about CTD phosphorylation status and function is extremely scarce when transcription activity is

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Formation and emission of geraniol in tea(Camellia sinensis)...

心血管外科术后非计划性二次开胸探查术后患者住院死亡的预后因素分析

2018全国植物生物学大会

作者： Ying Zhou xiaoyu liu Ziyin Yang Guangdong Provincial Key Laboratory of Applied Botany & Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement South China Botanical GardenChinese Academy of Sciences University of Chinese Academy of Sciences

When insects attack plants,insect-derived elicitors and mechanical damage induce the formation and emission of plant volatiles that have important ecological functions and flavor *** events have mainly been studied in model plants,rather than crop *** evaluated the production and emission of volatiles from tea(Camellia sinensis)leaves after attack by the tea green leafhopper(Empoasca(Matsumurasca) onukii Matsuda),a major insect infesting tea.E.(M.) onukii attack significantly induced the emission of geraniol from tea leaves,but did not affect the enzyme activity of geraniol synthase in tea *** automatic machine was used to simulate continuous wounding from E.(M.) onukii attack on tea *** contrast to a single mechanical damage event,continuous mechanical damage increased geraniol emission and geraniol synthase activity in tea ***,an enzyme extract of E.(M.) onukii specifically produced geraniol from geraniol diphosphate,suggesting that E.(M.)onukii has its own geraniol ***,an EoTPS was isolated from E.(M.)onukii and functionally *** coli-expressed EoTPS was able to convert geraniol diphosphate to ***,both E.(M.) onukii-derived geraniol synthase and continuous wounding-induced geraniol synthase in tea leaves contributed to the formation and emission of geraniol from tea *** information advances our understanding of the roles of plant volatiles in the interaction between crops and insects,and illustrates that elicitors from piercing-sucking insects can induce the emission of volatiles from crop plants.

关键词： aroma Camellia sinensis geraniol insect tea volatile

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中华外科杂志 2020年第4期58卷 310-314页

作者：刘晓雨刘楠首都医科大学附属北京安贞医院心脏外科危重症中心 100029

目的探讨心血管外科术后行非计划性二次开胸探查术后患者住院死亡的预后因素。方法回顾性分析2015年3月至2019年3月于首都医科大学附属北京安贞医院行心血管手术,术后滞留于ICU并行非计划性二次开胸探查手术的311例患者的资料。男性24... 详细信息

目的探讨心血管外科术后行非计划性二次开胸探查术后患者住院死亡的预后因素。方法回顾性分析2015年3月至2019年3月于首都医科大学附属北京安贞医院行心血管手术,术后滞留于ICU并行非计划性二次开胸探查手术的311例患者的资料。男性241例,女性70例,年龄(58.3±12.5)岁(范围:20~85岁)。采用Logistics回归进行多因素分析确定患者住院死亡的预后因素。构建患者住院死亡的评估模型,计算该模型的受试者工作特征曲线下面积,采用拟合优度检验进一步评价该模型的评估效能。结果 311例患者中,81例患者死亡。Logistics回归分析结果显示,二次开胸探查手术时间、探查前48 h内最差血肌酐值、探查后24 h内最差乳酸值,以及二次开胸前后发生心功能不全、呼吸功能不全、急性肾损伤是心血管外科术后二次开胸患者住院死亡的独立预后因素(P值均<0.05)。由这些预后因素构成的评估模型的曲线下面积为0.910,评估效能良好(χ2=4.243,P=0.835)。结论二次开胸探查手术时间、探查前48 h内最差血肌酐值、探查后24 h内最差乳酸值,二次开胸前后发生心功能不全、呼吸功能不全、急性肾损伤是心血管外科术后二次开胸患者住院死亡的预后因素。明确二次开胸患者住院死亡的预后因素,能够有效指导临床医师对术后危重患者进行筛查,及时调整临床治疗策略,改善患者预后。

关键词：心血管外科手术再手术死亡因素分析,统计学