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Chinese Medical Journal 2024年第8期137卷 883-886页

作者： xiaoshuang wang Jing wang Tao Cheng Institute of Basic Medical Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

The Institute of Basic Medical Sciences(IBMS)is a global leader in biomedical research and advanced medical *** year(2023)marks the 65^(th)anniversary of its foundation at the Chinese Academy of Medical Sciences(CAMS)and School of Basic Medicine(SBM)of the Peking Union Medical College(PUMC).In the beginning,the IBMS and SBM incorporated the premedical departments of the PUMC,which was established by the Rockefeller Foundation in *** then,these departments have been committed to undertakingrstrate medical science research in China.

关键词： Basic IBMS foundation

Internal m^(6)A and m^(7)G RNA modifications in hematopoietic system and acute myeloid leukemia

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Chinese Medical Journal 2024年第9期137卷 1033-1043页

作者： Xiaoxu Zhang Yanni Ma Jia Yu Rui Su xiaoshuang wang State Key Laboratory of Common Mechanism Research for Major Diseases State Key Laboratory for ComplexSevereand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100005China Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA The Institute of Blood Transfusion Chinese Academy of Medical Sciences/Peking Union Medical CollegeChengduSichuan 610052China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry and Molecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Epitranscriptomics focuses on the RNA-modification-mediated post-transcriptional regulation of gene *** past decade has witnessed tremendous progress in our understanding of the landscapes and biological functions of RNA modifications,as prompted by the emergence of potent analytical *** hematopoietic system provides a lifelong supply of blood cells,and gene expression is tightly controlled during the differentiation of hematopoietic stem cells(HSCs).The dysregulation of gene expression during hematopoiesis may lead to severe disorders,including acute myeloid leukemia(AML).Emerging evidence supports the involvement of the mRNA modification system in normal hematopoiesis and AML pathogenesis,which has led to the development of small-molecule inhibitors that target N6-methyladenosine(m^(6)A)modification machinery as ***,we summarize the latest findings and our most up-to-date information on the roles of m^(6)A and N7-methylguanine in both physiological and pathological conditions in the hematopoietic ***,we will discuss the therapeutic potential and limitations of cancer treatments targeting m^(6)A.

关键词： N6-methyladenosine N7-methylguanine Hematopoiesis Acute myeloid leukemia Therapeutic target RNA modifications

REDH:A database of RNA editome in hematopoietic differentiation and malignancy

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Chinese Medical Journal 2024年第3期137卷 283-293页

作者： Jiayue Xu Jiahuan He Jiabin Yang Fengjiao wang Yue Huo Yuehong Guo Yanmin Si Yufeng Gao Fang wang Hui Cheng Tao Cheng Jia Yu xiaoshuang wang Yanni Ma State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry and Molecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Institute of Blood Transfusion Chinese Academy of Medical SciencesChengduSichuan 610052China

Background:The conversion of adenosine(A)to inosine(I)through deamination is the prevailing form of RNA editing,impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic *** of high-confidence RNA editing sites have been identified and integrated into various RNA databases,providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic ***,the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still ***:We downloaded RNA sequencing(RNA-seq)data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information(NCBI)Gene Expression Omnibus(GEO)database,and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also *** performed sequence alignment,identified RNA editing sites,and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic ***:We established a new database,"REDH",represents RNA editome in hematopoietic differentiation and *** is a curated database of associations between RNA editome and *** integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts(human).Through the Differentiation,Disease,Enrichment,and knowledge modules,each A-to-I editing site is systematically integrated,including its distribution throughout the genome,its clinical information(human sample),and functional editing sites under physiological and pathological ***,REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy ***:REDH is accessible at http://***/.This user-friendly database

关键词： RNA editing Hematopoietic differentiation Hematopoietic malignancy Database management systems

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红黑着色的相场两相流并行投影算法

重庆大学学报 2024年第6期47卷 75-85页

作者：王小双张良奇肖姚曾忠重庆大学航空航天学院重庆400044

提出一种交错并行的有限体积投影算法求解基于相场法的两相流控制方程组。该算法的实施主要依赖于压力泊松方程的显式推进设计,从而突破投影算法求解不可压Navier-Stokes方程的效率瓶颈。同时,提出了一种交错扫描策略来更新节点上的变量... 详细信息

提出一种交错并行的有限体积投影算法求解基于相场法的两相流控制方程组。该算法的实施主要依赖于压力泊松方程的显式推进设计,从而突破投影算法求解不可压Navier-Stokes方程的效率瓶颈。同时,提出了一种交错扫描策略来更新节点上的变量,以实现更紧凑的时空耦合。本算法与相场模型相结合,能够高效、准确地捕获相界面的动态拓扑变化。测试算例结果表明:网格量为131 072,采用8线程CPU并行时,新提出并行算法的效率达到串行标准投影算法的80倍以上。

关键词：两相流相场法有限体积法投影算法并行计算

基于OBE理念的社会体育指导与管理专业教学体系改革研究

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体育科学进展 2024年第4期12卷 698-703页

作者：赵永兴王小双池州学院体育学院安徽池州

本研究对社会体育指导与管理专业传统教学体系存在的不足进行分析,在此基础上,以OBE理念为指导,从课程设置、教学方法、实践教学等方面进行了深入探讨,提出了相应的改革思路,以助力社会体育指导与管理专业学生综合能力的培养,实现人才... 详细信息

本研究对社会体育指导与管理专业传统教学体系存在的不足进行分析,在此基础上,以OBE理念为指导,从课程设置、教学方法、实践教学等方面进行了深入探讨,提出了相应的改革思路,以助力社会体育指导与管理专业学生综合能力的培养,实现人才培养与社会需求有效对接,为提高毕业生的就业能力和社会适应能力为其他相关专业的教学体系改革提供参考。

关键词： OBE理念应用型本科体育专业教学体系改革

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肥胖模型小鼠肝脏的病理变化及代谢组分析

基础医学与临床 2024年第5期44卷 699-704页

作者：丁宝锋王小爽王芳余佳中国医学科学院基础医学研究所、北京协和医学院基础学院重大疾病共性机制研究全国重点实验室北京100005

目的检测肥胖模型小鼠的肝脏病理变化,并探究肥胖对肝脏代谢的影响。方法通过24周的持续高脂饮食(HFD)喂养,建立肥胖模型小鼠,对照组为正常饮食(CD)喂养。24周后,解剖观察肝脏病变,利用苏木精-伊红(HE)染色和天狼猩红染色观察肝脏组织... 详细信息

目的检测肥胖模型小鼠的肝脏病理变化,并探究肥胖对肝脏代谢的影响。方法通过24周的持续高脂饮食(HFD)喂养,建立肥胖模型小鼠,对照组为正常饮食(CD)喂养。24周后,解剖观察肝脏病变,利用苏木精-伊红(HE)染色和天狼猩红染色观察肝脏组织病理特点。取适量肝脏组织于80%甲醇中萃取后,利用超高效液相色谱-质谱(UPLC-MS)进行代谢组检测;并对所获得的代谢组数据进行主成分分析(PCA)、差异代谢物分析以及KEGG通路富集分析,探究肥胖小鼠肝脏的代谢改变。结果高脂饮食24周后,HFD组小鼠的体质量和肝脏质量均显著高于正常饮食的CD组;HFD组小鼠肝脏脂肪变性程度严重,出现轻微纤维化;两组小鼠肝脏代谢物具有明显差异,且HFD组小鼠肝脏的代谢改变主要集中在苯丙氨酸代谢、柠檬酸循环(TCA循环)、鞘脂类代谢、精氨酸生物合成、初级胆汁酸的生物合成等代谢通路。结论成功构建肥胖模型小鼠,阐明了肥胖小鼠肝脏的病理特征;对肥胖小鼠肝脏进行代谢组学分析,揭示了肥胖小鼠肝脏的主要代谢通路改变。

关键词：肥胖肝脏代谢组饮食诱导

Boosting bidirectional conversion of polysulfide driven by the built-in electric field of MoS_(2)/MoP Mott–Schottky heterostructures in lithium–sulfur batteries

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Journal of Advanced Ceramics 2023年第10期12卷 1872-1888页

作者： Meixiu Song Yanan Liu Jingzhe Hong xiaoshuang wang Xiaoxiao Huang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China MIIT Key Laboratory of Advanced Structural–Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China

Heterostructure engineering for sulfur hosts is an effective way to achieve interfacial synergistic effects on suppressing the“shuttle effect”of polysulfides and thus improve electrochemical performance of lithium–sulfur(Li–S)*** selection and design of different components into heterostructures is vital to enhance the synergistic ***,MoS_(2)/MoP Mott–Schottky heterostructure nanoparticles decorated on reduced graphene oxide(MoS_(2)/MoP@rGO)are fabricated and used as sulfur host *** calculation and experiment results reveal that the in-situ introduction of MoP could tune the electronic structure,activate the basal plane of MoS_(2),and achieve the interfacial synergistic effects between adsorption(MoS_(2))and fast conversion(MoP).Such synergistic effects enable MoS_(2)/MoP@rGO to not only remarkably facilitate Li_(2)S deposition during the discharging process but also significantly accelerate the Li_(2)S dissolution during the charging process,demonstrating bidirectional promotion ***,the designed cathode delivers initial capacity of 919.5 mA·h·g^(−1)with capacity of 502.3 mA·h·g^(−1)remaining after 700 cycles at 0.5 *** under higher sulfur loading of 4.31 mg·cm^(−2)and lower electrolyte to sulfur(E/S)ratio of 8.21μL·mg^(−1),the MoS_(2)/MoP@rGO@S cathode could still achieve good capacity and cycle *** work provides a novel and efficient structural design strategy of sulfur hosts for high-performance Li–S energy storage systems.

关键词： MoS_(2)/MoP Mott-Schottky heterostructures synergistic effect bidirectional polysulfide conversion shuttle effect lithium-sulfur(Li-S)batteries

Catalytic combustion of ethyl acetate over CeMnO_x and CeMnZrO_x compounds synthesized by coprecipitation method

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Journal of Natural Gas Chemistry 2011年第6期20卷 623-628页

作者： xiaoshuang Li Jianli wang Chuanwen Liao Hongyan Cao Yaoqiang Chen Maochu Gong Key Laboratory of Green Chemistry ＆ Technology of Ministry of Education College of Chemistry Sichuan University Chengdu 610064 Sichuan China

Ce0.6Mn0.4O2 catalysts with different sources of manganese and Ce0.6-xZrxMn0.4O2 mixed oxide catalysts were prepared by coprecipitation method and were characterized by N2 adsorption-desorption,TPR,XRD,and XPS *** activities of the prepared catalysts for ethyl acetate combustion,and the effects of calcination temperature and space velocity on catalytic activity were *** results showed that partial replacement of Mn（NO3）2 with KMnO4 as sources of manganese could improve activities of ***0.45Zr0.15Mn0.4O2 catalyst exhibited the best catalytic activity and high thermal stability,e.g.,T90 could be still below 210℃ even if space velocity was up to 20000h-1.

关键词： ethyl acetate catalytic combustion volatile organic compound CeMnZrOx catalysts

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融合角点检测的点云配准研究

组合机床与自动化加工技术 2024年第5期 17-20页

作者：宋庆军高义强姜海燕来庆昱王晓双山东科技大学智能装备学院泰安271000

为提高点云配准效率,提出一种基于点云曲率信息的Harris角点提取算法,通过引入曲率约束,对传统Harris角点提取做出改进;计算每个点的曲率值并与整幅点云的平均曲率作比较,保留曲率值大于平均曲率的点云,实现对配准价值较低的点的剔除,... 详细信息

为提高点云配准效率,提出一种基于点云曲率信息的Harris角点提取算法,通过引入曲率约束,对传统Harris角点提取做出改进;计算每个点的曲率值并与整幅点云的平均曲率作比较,保留曲率值大于平均曲率的点云,实现对配准价值较低的点的剔除,为后续点云配准减少计算量;构建所提取角点之间的特征匹配,结合采样一致性(sample consensus initial alignment, SAC-IA)粗配准和正态分布变换(normal distributions transform, NDT)精配准,寻找最优的变换矩阵,实现源点云和目标点云的重合。通过比较不同算法在公开数据集上进行实验验证,结果表明该方法对复杂点云、多拐点点云都有较好的表现,对初始位置相差较大的点云也有良好的适用性。

关键词：机器人视觉曲率约束角点检测矩阵变换点云配准

青霉菌导致腹膜透析相关性腹膜炎1例并文献复习

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新发传染病电子杂志 2024年第3期9卷 69-72页

作者：王毓琦胡明亮王丽梁彩星王晓双广东医科大学深圳龙华临床医学院(深圳市龙华区人民医院)肾内科广东深圳518109

腹膜透析相关性腹膜炎是腹膜透析治疗的严重并发症,可导致多种不良临床结局。因此,预防及治疗腹膜透析相关性腹膜炎是改善患者预后的重要环节。临床上大多数腹膜透析相关性腹膜炎是由革兰氏阳性球菌引起的,青霉菌属较为罕见。本文报道1... 详细信息

腹膜透析相关性腹膜炎是腹膜透析治疗的严重并发症,可导致多种不良临床结局。因此,预防及治疗腹膜透析相关性腹膜炎是改善患者预后的重要环节。临床上大多数腹膜透析相关性腹膜炎是由革兰氏阳性球菌引起的,青霉菌属较为罕见。本文报道1例45岁女性腹膜透析相关性腹膜炎患者,既往行电子结肠镜检查提示结直肠炎。入院后先后使用左氧氟沙星、亚胺培南西司他丁、氟康唑等抗感染治疗,后续腹膜透析管微生物培养结果提示青霉菌感染,予拔除腹膜透析管并使用伏立康唑抗真菌治疗后腹膜炎治愈。本例患者在诊治过程中发现其临床表现及常规实验室检查无特异性,对于治疗效果不佳或病原体培养阴性的腹膜炎患者,需警惕青霉菌感染的可能。在及时、规范治疗腹膜炎的同时应注意识别并处理腹膜透析相关性腹膜炎的易感因素。

关键词：腹膜透析腹膜炎真菌感染青霉菌属肾脏疾病