检索结果-南通市图书馆

Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques

Signal Transduction and Targeted Therapy 2022年第8期7卷 2687-2689页

作者： xiaolei liu Yi liu Xuemin Jin Zhanlong He Zhen Huang Shumin Sun Yuwei Gao Jingyu Li Qin Ning Zhongping Xie Ningyi Jin Mingyuan liu State Key Laboratory for Zoonotic Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationInstitute of Zoonosisand College of Veterinary MedicineJilin University130062 ChangchunChina Institute of Medical Biology Chinese Academy of Medicine Sciences&Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases650118 KunmingChina Walvax Biotechnology Co. Ltd650106 KunmingChina College of Animal Science and Technology Inner Mongolia University for Nationalities028000 TongliaoChina Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchunChina Yuxi JOZO Biotechnology co. LTD653199 YuxiChina National Medical Center for Major Public Health Events State Key Laboratory for Zoonotic DiseasesDepartment and Institute of Infectious DiseaseTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Dear Editor,The unprecedented COVID-19 pandemic caused by SARS-CoV-2 remains ongoing,but there is a lack of fully effective *** plasma-derived hyperimmune globulins have been a safe and effective treatment but restricted by the difficulties in obtaining sufficient plasma with high antibody titers from a large number of recovered *** antibodies,particularly equine antibodies,have been widely used for decades as the therapeutics against some viral infections or as antivenoms.1 Equine antibodies could be rapidly developed and manufactured into therapeutic antibodies in large quantities under WHO standardized *** we explored the development of equine antibody-derived F(ab′)2 as an option to treat COVID-19 by targeting the receptor-binding domain(RBD)of the viral spike protein that is essential for the viral entry into the host cells.2 We observed excellent neutralization titers of the F(ab′)2 in vitro and high potency against SARS-CoV-2 infection in the nonhuman primate rhesus macaques.

关键词： quantities restricted treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tissue-resident macrophages exacerbate lung injury after remote sterile damage

引用

Cellular & Molecular Immunology 2024年第4期21卷 332-348页

作者： Hanhui Zhong Jingjing Ji Jinling Zhuang Ziying Xiong Pengyun Xie xiaolei liu Jundi Zheng Wangli Tian Xiaoyang Hong Jing Tang The Department of Anesthesiology Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdongChina The Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhouChina The Department of Respiratory Medicine Guangdong Provincial Hospital of Integrated Chinese and Western MedicineFoshanChina Pediatric Intensive Care Unit Senior Department of Pediatricsthe Seventh Medical Center of PLA General HospitalBeijingChina

Remote organ injury,which is a common secondary complication of sterile tissue damage,is a major cause of poor prognosis and is difficult to ***,we report the critical role of tissue-resident macrophages in lung injury after trauma or stroke through the inflammatory *** found that depleting tissue-resident macrophages rather than disrupting the recruitment of monocyte-derived macrophages attenuated lung injury after trauma or *** findings revealed that the release of circulating alarmins from sites of distant sterile tissue damage triggered an inflammatory response in lung-resident macrophages by binding to receptor for advanced glycation end products(RAGE)on the membrane,which activated epidermal growth factor receptor(EGFR).Mechanistically,ligand-activated RAGE triggered EGFR activation through an interaction,leading to Rab5-mediated RAGE internalization and EGFR phosphorylation,which subsequently recruited and activated P38;this,in turn,promoted RAGE translation and trafficking to the plasma membrane to increase the cellular response to RAGE ligands,consequently exacerbating *** study also showed that the loss of RAGE or EGFR expression by adoptive transfer of macrophages,blocking the function of RAGE with a neutralizing antibody,or pharmacological inhibition of EGFR activation in macrophages could protect against trauma-or stroke-induced remote lung ***,our study revealed that targeting the RAGE-EGFR signaling pathway in tissue-resident macrophages is a potential therapeutic approach for treating secondary complications of sterile damage.

关键词： tissue-resident macrophage RAGE remote sterile damage

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging Concepts of Pathogenesis and Comprehensive Therapeutic Strategies for Spinocerebellar Ataxia Type 3

引用

Neuroscience & Medicine 2021年第1期12卷 22-43页

作者： Sagor Kumar Roy xiaolei liu Department of Neurology Xiangya Hospital Central South University Changsha China State Key Lab of Medical Genetics Central South University Changsha China

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease (MJD), is an autosomal dominant neurodegenerative disorder that predominantly involves the cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems. SCA3 presents strong phenotypic heterogeneity and its causative mutation of SCA3 consists of an expansion of a CAG tract in exon 10 of the ATXN3 gene, situated at 14q32.1. The ATXN3 gene is ubiquitously expressed in neuronal and non-neuronal tissues, and also participates in cellular protein quality control pathways. Mutated ATXN3 alleles present about 45 to 87CAG repeats, which result in an expanded polyglutamine tract in ataxin-3. After mutation, the polyQ tract reaches the pathological threshold (about 50 glutamine residues);the protein is considered that it might gain a neurotoxic function through some unclear mechanisms. We reviewed the literature on the pathogenesis and therapeutic strategies of spinocerebellar ataxia type 3 patients. Conversion of the expanded protein is possible by enhancing protein refolding and degradation or preventing proteolytic cleavage and prevents the protein to reach the site of toxicity by altering its ability to translocate between the nucleus and cytoplasm. Proteasomal degradation and enhancing autophagic aggregate clearance are currently proposed remarkable therapy. In spite of extensive research, the molecular mechanisms of cellular toxicity resulting from mutant ataxin-3 remain no preventive treatment is currently available. These therapeutic strategies might be able to improve sign symptoms of SCA3 as well as slow the disease progression.

关键词： Spinocerebellar Ataxia Type 3 Machado-Joseph Disease Polyglutamine Disease Ataxin-3 Therapeutic Strategies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study

引用

Genomics, Proteomics & Bioinformatics 2021年第4期19卷 619-628页

作者： Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li xiaolei liu Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionMinistry of Education&College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Key Laboratory of Swine Genetics and Breeding Ministry of AgricultureHuazhong Agricultural UniversityWuhan 430070China School of Computer Science and Technology Wuhan University of TechnologyWuhan 430070China Department of Crop and Soil Sciences Washington State UniversityPullmanWA 99164USA

Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ***,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated *** by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at https://***/xiaolei-lab/r MVP.

关键词： Memory-efficient Visualization-enhanced Parallel-accelerated rMVP GWAS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel case of Hyper IgE syndrome combined with natural killer cell deficiency

引用

Chinese Medical Journal 2014年第5期127卷 982-983页

作者： Zhang xiaolei liu Yangang liu Yan Dai Huaping Department of Pulmonary and Critical Care Beijing Institute of Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

The Hyper IgE syndrome （HIES） is a rare,complex primary *** we report a case of HIES combined with natural killer cell deficiency,which has not been previously documented in the *** informed consent was obtained fro... 详细信息

关键词： hyper IgE Syndrome natural killer cell deficiency infection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Precision intervention for sarcopenia

引用

Precision Clinical Medicine 2022年第2期5卷 137-138页

作者： xiaolei liu Jirong Yue National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengdu 610041China

Dear Editor,Sarcopenia is an aging-related disease characterized by progressive muscle mass loss,decreasing muscle strength,and physiological muscle function *** is associated with multiple adverse outcomes,including falls,fractures,physical disability,and *** new code in ICD-10-CM(M62.84)in 2016 signifies its being recognized as a disease and drawing attention to the condition in this ever-aging *** prevalence of sarcopenia in the elderly is∼6.8%–25.7%for Asia1 and,in particular,8.9%–38.8%for China.2 The mechanism of sarcopenia is complex and includes hormonal changes,nutritional deficiencies,chronic inflammation,neuromuscular function decline,and decreased physical *** no specific drugs have been approved to treat sarcopenia,ten pharmacological interventions have been identified to ameliorate the condition in the elderly,including growth hormone,growth hormone-releasing hormone,vitamin D,dehydroepiandrosterone,combined estrogen–progesterone,testosterone-growth hormone,pioglitazone,testosterone,insulin-like growth factor-1,and angiotensin-converting enzyme inhibitors.3 Possible drugs for sarcopenia are under development(Table 1).4 As a result,understanding the mechanisms of sarcopenia is critical for drug development.

关键词： drugs vitamin inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of Earth Art in Landscape Reconstruction of Urban Industrial Wasteland

引用

Journal of Landscape Research 2023年第2期15卷 77-81页

作者： liu xiaolei MENG Jin Tianjin Chengjian University Tianjin 300384China

The ecological environment of industrial wasteland has been severely damaged,and problems such as environmental pollution,sharp decline in biodiversity,and ecological damage frequently ***,reasonable renovation of industrial wasteland has become an urgent issue to be *** art originates from nature and integrates with industrial wasteland,which plays a guiding role in promoting the upgrading and transformation of industrial wasteland landscapes,and is of great significance for the healthy development of urban environment,improving urban human settlements,and other *** combination of land art and urban industrial wasteland landscape transformation can guide the healthy development of urban environment.

关键词： Earth art Industrial wasteland Landscape renovation Urban environment Ecological restoration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Whole genome variants across 57 pig breeds enable comprehensive identification of genetic signatures that underlie breed features

引用

Journal of Animal Science and Biotechnology 2021年第2期12卷 492-507页

作者： Jingya Xu Yuhua Fu Yan Hu Lilin Yin Zhenshuang Tang Dong Yin Mengjin Zhu Mei Yu Xinyun Li Yang Zhou Shuhong Zhao xiaolei liu Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionMinistry of Education&Key Laboratory of Swine Genetics and BreedingMinistry of Agriculture&College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiPR China

Background:A large number of pig breeds are distributed around the world,their features and characteristics vary among breeds,and they are valuable *** the underlying genetic mechanisms that explain across-breed variation can help breeders develop improved pig ***:In this study,we performed GWAS using a standard mixed linear model with three types of genome variants(SNP,InDel,and CNV)that were identified from public,whole-genome,sequencing data *** used 469 pigs of 57 breeds,and we identified and analyzed approximately 19 million SNPs,1.8 million InDels,and 18,016 *** defined six biological phenotypes by the characteristics of breed features to identify the associated genome variants and candidate genes,which included coat color,ear shape,gradient zone,body weight,body length,and body height.A total of 37 candidate genes was identified,which included 27 that were reported previously(e.g.,PLAG1 for body weight),but the other 10 were newly detected candidate genes(e.g.,ADAMTS9 for coat color).Conclusion:Our study indicated that using GWAS across a modest number of breeds with high density genome variants provided efficient mapping of complex traits.

关键词： Breed feature CNV GWAS InDel Pig SNP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

退行性和峡部裂性腰椎滑脱患者椎旁肌肉组织退变的影像学比较

引用

中国组织工程研究 2025年第27期29卷 5869-5875页

作者：王守康梁钢刘晓垒洪春波辛兵徐州医科大学江苏省徐州市221000 徐州医科大学附属医院江苏省徐州市221000

背景:现有研究已对退行性腰椎滑脱患者与健康人群椎旁肌肉退变程度的差异进行了比较,但还缺乏不同腰椎滑脱症种类之间影像参数差异的比较研究。目的:探讨峡部裂性腰椎滑脱与退行性腰椎滑脱患者在椎旁肌肉组织退变方面的差异,以及与腰背... 详细信息

背景:现有研究已对退行性腰椎滑脱患者与健康人群椎旁肌肉退变程度的差异进行了比较,但还缺乏不同腰椎滑脱症种类之间影像参数差异的比较研究。目的:探讨峡部裂性腰椎滑脱与退行性腰椎滑脱患者在椎旁肌肉组织退变方面的差异,以及与腰背痛症状的相关性。方法:对2019年2月至2023年8月在徐州医科大学附属医院治疗的107例腰椎滑脱患者进行回顾性分析,根据滑脱类型将患者分为2组,峡部裂性腰椎滑脱组39例,退行性腰椎滑脱组68例。对比分析两组患者椎旁肌组织影像学参数情况以及腰背痛目测类比评分,依据目测类比评分,将两组患者分别分为目测类比评分≤45 mm和>45 mm两个亚组,分析目测类比评分差异与椎旁肌肉组织退变参数的关系。结果与结论:①退行性腰椎滑脱组患者多裂肌的脂肪浸润百分比高于峡部裂性腰椎滑脱组(P=0.003);②两组腰背痛目测类比评分≤45 mm的患者多裂肌脂肪浸润百分比低于腰背痛目测类比评分>45 mm患者(P=0.021,P45 mm患者(P=0.002);④结果显示,峡部裂性腰椎滑脱患者和退行性腰椎滑脱患者在椎旁肌肉组织退化方面存在显著差异,且退行性腰椎滑脱患者相比峡部裂性腰椎滑脱患者展现出更为严重的椎旁肌退化;此外,两组腰椎滑脱患者中,疼痛较严重者的多裂肌脂肪浸润程度相对较高。

关键词：退变性腰椎滑脱峡部裂性腰椎滑脱椎旁肌肉组织多裂肌竖脊肌腰大肌相对横截面积脂肪浸润百分比

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

从传入途径与方式看中国电影早期发展格局

引用

电影艺术 2007年第2期313卷 73-79页

作者：刘小磊北京电影学院文学系

关于电影在中国的传入,以往均沿用《中国电影发展史》的说法,认为电影最先传入到上海,然后陆续在各地流行开来。对电影在各地的具体传入方式和途径关注的人相对较少。尽管上海是中国电影早期发展的产业中心,但是其他各个省份也都有不同... 详细信息

关于电影在中国的传入,以往均沿用《中国电影发展史》的说法,认为电影最先传入到上海,然后陆续在各地流行开来。对电影在各地的具体传入方式和途径关注的人相对较少。尽管上海是中国电影早期发展的产业中心,但是其他各个省份也都有不同程度的制片业存在。电影传入途径和方式的不同对各地制片业的形成与发展也产生了不同的影响……

关键词：《中国电影发展史》早期发展发展格局制片业上海

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：