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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang xiaofei Niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Boosting solar steam generation by structure enhanced energy management

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Science Bulletin 2020年第16期65卷 1380-1388,M0004页

作者： Yida Wang Xuan Wu Bo Shao xiaofei yang Gary Owens Haolan Xu Future Industries Institute University of South AustraliaMawson Lakes Campus AdelaideSA 5095Australia College of Science.Nanjing Forestry University Nanjing 210037China

Interfacial solar-steam generation is a promising and cost-effective technology for both desalination and wastewater *** process uses a photothermal evaporator to absorb sunlight and convert it into heat for water *** solar-steam generation can be somewhat inefficient due to energy losses via conduction,convection and ***,efficient energy management is crucial for optimizing the performance of solar-steam ***,via elaborate design of the configuration of photothermal materials,as well as warm and cold evaporation surfaces,performance in solar evaporation was significantly *** was achieved via a simultaneous reduction in energy loss with a net increase in energy gain from the environment,and recycling of the latent heat released from vapor condensation,diffusive reflectance,thermal radiation and convection from the evaporation ***,by using the new strategy,an evaporation rate of 2.94 kg m^-2 h^-1,with a corresponding energy efficiency of solar-steam generation beyond theoretical limit was achieved.

关键词： Solar-steam generation Photothermal Energy management Latent heat recycling Reduced graphene oxide Desalination

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磷酸银基光催化材料研究进展

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硅酸盐学报 2013年第10期41卷 1354-1365页

作者：严学华高庆侠杨小飞李扬唐华江苏大学新材料研究院江苏大学材料科学与工程学院镇江212013

开发新型的、高活性的光催化材料是未来光催化技术的发展方向。Ag3PO4由于具有高的量子效率、强的光氧化能力和高效光催化降解有机污染物的能力,已成为材料学、化学、能源和环境科学等领域研究的热点课题。从制备方法、形貌控制以及光... 详细信息

开发新型的、高活性的光催化材料是未来光催化技术的发展方向。Ag3PO4由于具有高的量子效率、强的光氧化能力和高效光催化降解有机污染物的能力,已成为材料学、化学、能源和环境科学等领域研究的热点课题。从制备方法、形貌控制以及光催化活性等方面综述Ag3PO4基光催化材料的研究进展与现状,对Ag3PO4基光催化材料面临的问题进行了讨论,并对该类光催化材料的未来发展方向提出了相应的建议。

关键词：光催化材料磷酸银复合材料可见光

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Hierarchical AgAu alloy nanostructures for highly efficient electrocatalytic ethanol oxidation

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Chinese Journal of Catalysis 2022年第3期43卷 851-861页

作者： Caiqin Wang Danil Bukhvalov M.Cynthia Goh Yukou Du xiaofei yang College of Science&Institute of Materials Physics and Chemistry Nanjing Forestry UniversityNanjing 210037JiangsuChina Department of Chemistry University of TorontoTorontoCanada College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123JiangsuChina

The ethanol oxidation reaction is a significant anodic reaction for direct alcohol fuel *** most commonly used catalysts for this reaction are Pt‐based materials;however,Pt‐based electrocatalysts cause carbon monoxide poisoning with intermediates before the complete transformation of alcohol to CO_(2).Herein,we present hierarchical AgAu bimetallic nanoarchitectures for ethanol electrooxidation,which were fabricated via a partial galvanic reduction reaction between Ag and HAuCl_(4).The ethanol electrooxidation performance of the optimal AgAu nanohybrid was increased to 1834 mA mg^(‒1),which is almost 10 times higher than that of the pristine Au catalyst(190 mA mg^(‒1))in alkaline *** was achieved by introducing Ag into the Au catalyst and controlling the time of the replacement *** heterostructure also presents a higher current density than that of commercial Pt/C(1574 mA mg^(‒1)).Density functional theory calculations revealed that the enhanced activity and stability may stem from unavoidable defects on the surface of the integrated AgAu *** oxidation reactions over these defects are more energetically favorable,which facilitates the oxidative removal of carbonaceous poison and boosts the combination with radicals on adjacent Au active sites.

关键词： AgAu nanohybrids Hierarchical nanostructures Defected surface DFT calculation Ethanol electrooxidation

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基于北京串列加速器的若干核物理实验研究

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核技术 2023年第8期46卷 44-55页

作者：华辉叶沿林杨晓菲北京大学物理学院和核物理与核技术国家重点实验室北京100871

原子核是主要由短程相互作用制约的量子复杂多体系统,储存着宇宙间绝大部分可见的质量和能量。对原子核的研究,近百年来对人类的生存发展和国家的地位与安全产生了重大影响。过去几十年,短寿命放射性原子核的奇特结构现象不断被揭示,打... 详细信息

原子核是主要由短程相互作用制约的量子复杂多体系统,储存着宇宙间绝大部分可见的质量和能量。对原子核的研究,近百年来对人类的生存发展和国家的地位与安全产生了重大影响。过去几十年,短寿命放射性原子核的奇特结构现象不断被揭示,打破了人们对原子核结构的经典认知,开启了不稳定核(放射性核)结构研究的新领域。北京串列加速器核物理国家实验室在过去30多年为我国低能核物理实验提供了基础平台。北京大学实验核物理团队长期以来发展特色实验设备,在北京HI-13串列加速器上完成了系列核物理实验,在原子核奇特结构研究中取得了一批重要成果。本文将介绍团队基于北京HI-13串列加速器开展的几项代表性工作,如基于在束γ谱学的A=70质量区Ge同位素形状演化研究,基于直接核反应实验的轻丰中子核集团结构研究,以及基于北京放射性束装置发展的共线激光谱设备和首次在线激光核谱实验等。

关键词：不稳定原子核奇特结构核衰变核反应激光核谱

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基于无源性与势场法的四旋翼避障与位置控制

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航空学报 2023年第S1期44卷 225-235页

作者：王羿叶辉杨晓飞江苏科技大学电子信息学院镇江212003

针对四旋翼无人机位置控制与障碍避让问题,提出了一种无源控制理论和人工势场法相结合的控制策略。将整个控制系统分解为外环位置控制器和内环姿态控制器两部分。在外环控制器设计中,采用级联系统的无源性理论,并通过选取适当的势场函... 详细信息

针对四旋翼无人机位置控制与障碍避让问题,提出了一种无源控制理论和人工势场法相结合的控制策略。将整个控制系统分解为外环位置控制器和内环姿态控制器两部分。在外环控制器设计中,采用级联系统的无源性理论,并通过选取适当的势场函数作为存储函数,解决定点跟踪过程中的避障问题。在内环控制器设计中,采用四元数描述姿态动力学方程,并基于Lyapunov函数设计内环控制律。在此基础上,进一步构造无源位置子系统和姿态子系统的互联结构,保证了整个闭环系统的稳定性。最后,通过仿真结果验证了所提出控制策略的有效性与控制性能。

关键词：四旋翼无人机定点跟踪无源控制人工势场障碍避让

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Enhanced monopole transition strength from the cluster decay of ^(13)C

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Science China(Physics,Mechanics & Astronomy) 2019年第1期62卷 49-55页

作者： Jun Feng YanLin Ye Biao yang ChengJian Lin HuiMin Jia Danyang Pang ZhiHuan Li JianLing Lou QiTe Li xiaofei yang Jing Li HongLiang Zang Qiang Liu Wei Jiang ChenGuang Li yang Liu ZhiQiang Chen HongYi Wu ChunGuang Wang Wei Liu Xiang Wang JingJing Li DiWen Luo Ying Jiang ShiWei Bai JinYan Xu NanRu Ma LiJie Sun DongXi Wang School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University China Institute of Atomic Energy School of Physics and Nuclear Energy Engineering Beihang University Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University

The inelastic excitations and cluster decay of ^(13)C have been measured using the reaction,9Be(^(13)C, ^(13)C* →~9Be + α)~9Be. We observe strong excitation to the 14.3-MeV(1/2-) resonant state from the cluster-decay channel, leading to an enhanced monopole matrix element of(6.3 ± 0.6) fm^2. This large cluster-related monopole strength is a clear indication of the cluster-structure domination of this state and is consistent with the recent prediction of the orthogonality condition model(OCM). It would be interesting to further explore the three-center molecular rotational band that is initiated from the observed band-head.

关键词： inelastic excitation monopole transition cluster decay

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Anchoring Co3O4 nanoparticles on MXene for efficient electrocatalytic oxygen evolution

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Science Bulletin 2020年第6期65卷 460-466,M0003页

作者： Yi Lu Deqi Fan Zupeng Chen Weiping Xiao Cancan Cao xiaofei yang Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of ScienceNanjing Forestry UniversityNanjing 210037China Institute for Chemical and Bioengineering Department of Chemistry and Applied BiosciencesETH ZiirichCH-8093 ZurichSwitzerland Key Laboratory for Photonic and Electronic Band Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin J 50025China

Rational design and controllable synthesis of efficient electrocatalysts for water oxidation is of significant importance for the development of promising energy conversion systems, in particular integrated photoelectrochemical water splitting devices. Cobalt oxide(Co3O4) nanostructures with mixed valences(Ⅱ,Ⅲ)have been regarded as promising electrocatalysts for the oxygen evolution reaction(OER). They are able to promote catalytic support of OER but with only modest activity. Here, we demonstrate that the OER performance of cubic Co3O4 electrocatalyst is obviously improved when they are anchored on delaminated two-dimensional(2D) Ti3C2 MXene nanosheets. Upon activation the overpotential of the hybrid catalyst delivers 300 m V at a current density of 10 m A cm(2) in basic solutions, which is remarkably lower than those of Ti3C2 MXene and Co3O4 nanocubes. The strong interfacial electrostatic interactions between two components contribute to the exceptional catalytic performance and stability. The enhanced OER activity and facile synthesis make these Co3O4 nanocubes-decorated ultrathin 2D Ti3C2 MXene nanosheets useful for constructing efficient and stable electrodes for high-performance electrochemical water splitting.

关键词： Oxygen evolution reaction CO3O4 MXene Heterojunctions Electrocatalysis Water splitting

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Green synthesis of ZnO@G hybrids toward a full lithium-ion battery

Green synthesis of ZnO@G hybrids toward a full lithium-ion b...

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第33届全国化学与物理电源学术年会

作者： xiaofei yang huiling Chen Tingting Zhang Hai Ming College of Chemical Engineering Beijing University of Chemical Technology Research Institute of Chemical Defence

ZnO,generally known as an abundant,low cost and high safety inorganic materials,yet has a high theoretical capacity (978 mAh/g) for lithium-ion ***,the commercialized applications of ZnO-based anodes are still limited...

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RNA G-quadruplex structure contributes to cold adaptation in plants

RNA G-quadruplex structure contributes to cold adaptation in...

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首届植物科学前沿学术大会

作者： xiaofei yang Haopeng Yu Huakun Zhang Yiliang Ding CAS Center for Excellence in Molecular Plant Sciences CAS-JIC Centre of Excellence for Plant and Microbial Science John Innes Centre Colney Lane Key Laboratory of Molecular Epigenetics of Ministry of Education Northeast Normal University

Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct ***,the underlying biological function of nucleotide composition dictating environmental adaptations is largely *** this study,we systematically analyzed the nucleotide compositions of transcriptomes across 1000 plants(1 KP) and their corresponding ***,we found that plants growing in cold climates have guanine(G)-enriched transcriptomes,which are prone to forming RNA G-quadruplex *** immunofluorescence detection and in vivo structure profiling revealed that RNA G-quadruplex formation in plants was globally enhanced in response to ***-responsive RNA G-quadruplexes strongly enhanced mRNA stability,rather than affecting *** of individual RNA G-quadruplex promoted mRNA decay in the cold,leading to impaired plant cold ***,we propose that plants adopted RNA G-quadruplex structure as a molecular marker to facilitate their adaptation to the cold during evolution.

关键词： RNA G-quadruplex structure structure profiling cold temperature mRNA decay adaptation

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