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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-xiao Yi Hui Ren Woon Genevieve Saw Li zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao Ming Li Xi Chen mei-Ze Xu Tian Ding xiao-Ping Gong Zhuo-mei Li Xue-Yuan Liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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[Advances in molecular networking technology for discovering emerging contaminants and transformation products]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 33-42页

作者： xiao.mei Tan Yu-Wei Zhang Zhao-Yu Jiao Nan-Yang Yu Si Wei State Key Laboratory of Pollution Control & Resource Reuse School of Environment Nanjing University Nanjing 210046 China.

Emerging contaminants and their transformation products are widely distributed in the environment. These pollutants carry unknown risks owing to their persistence, migration, and toxicity. The wide variety and complex structures of these substances render them difficult to identify using only target analysis. Suspect screening analysis can identify more substances than target analysis in a single run. However, this analysis method is based on limited data and cannot meet the growing demand for compound identification, especially for emerging contaminants and their transformation products with unknown information. The development of high-resolution mass spectrometry technology has promoted the applications of nontarget analysis in the environmental field, especially for identifying unknown transformation products. At present, the challenges of nontarget analysis include the difficulty of finding compounds of interest and their transformation products from complex data. Molecular networking calculates the similarity between mass spectra based on an improved cosine similarity algorithm. This method can cluster molecular families with similar structures, achieve visualization and a collection of massive mass spectral datasets, and promote the annotation of pollutants through networks and communities. Molecular networking can globally organize and systematically interpret complex tandem mass spectral datasets, providing a new direction for nontarget analysis. This technology was first used in proteomics and gradually introduced into metabolomics for the discovery of new natural products. Recently, it has been introduced into the environmental field for the study of various man-made chemicals, particularly for the discovery of emerging contaminants and their transformation products. In this paper, we introduce a molecular networking analysis method based on high-resolution tandem mass spectrometry and describe its applications in the nontargeted screening of emerging cont

关键词： emerging contaminants high-resolution tandem mass spectrometry molecular networking transformation products

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Applications of nanomaterials in COVID-19 pandemic

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Rare Metals 2022年第1期41卷 1-13页

作者： mei-Fang xiao Chang zeng Shao-Hui Li Fu-Lai Yuan Health Management Center Xiangya HospitalCentral South UniversityChangsha 410008China

The novel coronavirus 2019(COVID-19)pandemic represents one of the biggest global health threats in the last two decades,so researchers around the world are searching for solutions and treatments for *** the time of writing,there are no specific drugs that have demonstrated suitable effectiveness in treating *** current challenge involves designing tools for the prevention,rapid and accurate diagnosis,drug delivery,and effective treatment of this novel *** this short review,we discuss how nanotechnology offers new ways to combat COVID-19,and how nanomaterials can be applied to control the COVID-19 *** also summarize relevant studies regarding the use of nanomaterials for preventing viral spread,preparing vaccines,and diagnosing coronavirus,as well as studies that show how nanoparticles can be used as drug delivery systems for the treatment of viral *** on nanotechnology-based diagnosis,drug delivery,and antiviral therapy is currently in the early ***,the unique chemical properties of some nanomaterials highlight the broad prospect of nanomaterials in the future,and we propose that they will play an important role in the fight against COVID-19.

关键词： Coronaviruses COVID-19 Nanomaterials Viral control

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Tricyclic Sesquiterpene from Laurencia Majuscula

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Chemical Research in Chinese Universities 1997年第2期13卷 84-86页

作者： XU xiao Hua zeng Long mei SU Jing Yu Department of Chemistry Zhongshan UniversityGuangzhou510275

ＴｒｉｃｙｃｌｉｃＳｅｓｑｕｉｔｅｒｐｅｎｅｆｒｏｍＬａｕｒｅｎｃｉａＭａｊｕｓｃｕｌａ＊ＸＵＸｉａｏ－Ｈｕａ，ＺＥＮＧＬｏｎｇ－ＭｅｉａｎｄＳＵＪｉｎｇ－Ｙｕ＊＊（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，Ｚｈｏ... 详细信息

ＴｒｉｃｙｃｌｉｃＳｅｓｑｕｉｔｅｒｐｅｎｅｆｒｏｍＬａｕｒｅｎｃｉａＭａｊｕｓｃｕｌａ＊ＸＵＸｉａｏ－Ｈｕａ，ＺＥＮＧＬｏｎｇ－ＭｅｉａｎｄＳＵＪｉｎｇ－Ｙｕ＊＊（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＺｈｏｎｇｓｈａｎＵｎｉｖｅｒｓｉｔｙ，...

关键词： Tricyclic sesquiterpene Laurencia majuscula Terpenoid Majusin

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Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期 268-282页

作者： ZHENG Weilin WANG Qijiao xiao Huahua CHEN xiaoxiao XIE Fan zeng Wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

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Novel Cylinder Movement Modeling Method Based on Aerodynamics

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1193-1202页

作者： Jian-Qing Zhang xiao.mei Hu Jin-Sheng Kang Feng Xiong Ning zeng School of Mechatronic Engineering and Automation Key Laboratory of Intelligent Manufacturing and RoboticsShanghai University College of Engineering Design and Physical SciencesBrunel University London

The cylinder movement is affected by multiple factors and it is difficult to establish the accurate movement model of the cylinder. In order to improve the reliability of the production line design and to speed up the production line debugging, a novel cylinder movement modeling method based on aerodynamics is proposed. The kinetic theory, thermodynamic theory and kinematics knowledge are applied and integrated various factors which affect the movement characteristics of the cylinder are considered. According to the proposed mathematical model of cylinder movement, thecombined simulation software of cylinder movement based on Visual Studio and Visual Component （3D Create） is developed to calculate thevelocity, accel- eration and movement time of the cylinders during the running of the assembly line. Comparison results of cylinder＇s movement time under different intake air and displacement show that the mathematical model of cylinder movement based on aerodynamic is more accurate and the degree of fittingis 0.9846, which proves the effectiveness of the combined simulation software of cylinder movement. By the cylinder movement modeling method based on aerodynamic, accurate value of takt and the debug parameters can be calculated as a reference for the designers and debuggers of the cylinder-driven assembly lines.

关键词： Aerodynamics Thermodynamics Cylindercharacteristic Combined simulation

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Development of rapid advice guideline and standard and continuous updating guideline:experiences and practice

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Military Medical Research 2021年第4期8卷 581-583页

作者： Ying-Hui Jin xiao.mei Yao Xian-Tao zeng Center for Evidence-Based and Translational Medicine ZhongnanHospital of Wuhan UniversityWuhan 430071China. Department ofHealth Research Evidence and ImpactMcMaster UniversityHamiltonOntario L8S 4L8Canada. Department of Urology Zhongnan Hospitalof Wuhan University169 Donghu RoadWuchang DistrictWuhan430071China.

We published rapid advice guidelines and updated guidelines for coronavirus disease 2019(COVID-19)management on February 6,2020,and September 4,2020,*** two guidelines vary widely in their developmental background,type of evidence,grade of recommendation and so *** shared our experience for the development of these two guidelines to help clinical practitioners better understand and implement guidelines and to help guideline developers facilitate communication and discussion for guideline development during the pandemic.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Rapid advice guideline Clinical practice guideline Evidence-based medicine

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