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Quantitative reconstruction of salinity and precipitation changes in Central Asia over the past 3200 years using diatom and pollen records of lacustrine sediment in Aibi Lake of SW Junggar Basin

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Journal of Earth Science 2025年

作者： Long Pan Guoqiang Li xiaoyan wang Ming Jin Xinrong He Luo Qin zhong wang Wenwei Zhao Chunzhu Chen Yuanlu Liu Jin Yang Lele Shu Key Laboratory of Western China's Environmental Systems (Ministry of Education)， College of Earth and Environmental Sciences， Lanzhou University College of Earth Sciences， Chengdu University of Technology School of Geographic Science， Nantong University Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions， Northwest Institute of Eco-Environment and Resources， Chinese Academy of Sciences

The response of lake environments in arid Central Asia to climate change during the Late Holocene over the centennial to millennial timescales remains contentious. The reason that primarily paleoenvironmental proxies interpreting diverse and the scarcity of accurate quantitative reconstruction records. In this study， we employed diatoms and pollen records from lacustrine sediment in the Aibi Lake of SW Junggar Basin to quantitatively reconstruct salinity and watershed precipitation amounts while exploring the associated forcing mechanism. The results indicate that Aibi Lake salinity varied between 2 g/L and 47 g/L during the Late Holocene period， indicating a generally brackish environment， and corresponding to prevailing Tryblionella granulata diatom in the lake basin. Westerly-dominated annual precipitation varied between 250 mm and 320 mm during the Late Holocene period in the basin， exhibiting a generally semi-arid environment and prevailing desert steppe vegetation. The Aibi Lake has a low salinity of average value of ～15 g/L. It exhibits elevated precipitation (average value of ～280 mm) during the periods of the Roman Warm Period (2900-1990 cal yr BP)， Dark Age Cold Period (1570-1140 cal yr BP)， and Little Ice Age (590-120 cal yr BP). The reconstructed precipitation and salinity exhibit a periodicity of ～200 years， which is consistent with the cycle of phase changes of the North Atlantic Oscillation (NAO) and Total Solar Irradiance (TSI). This correlation suggests that variations in NOA and TSI significantly influence the precipitation and salinity changes in Central Asia over centennial to millennial timescales.

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Mechanical properties and microstructures of Mg-6Si alloys fabricated using the tungsten-inert-gas arc additive manufacturing

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China Foundry 2025年

作者： Peng-cheng Zhou Guo-qiang You Jin-yu Feng Lei wang xiao Lin Bin Jiang College of Materials Science and Engineering Chongqing University National Engineering Research Center for Magnesium Alloys Chongqing University National Key Laboratory of Advanced Casting Technologies Chongqing University

Si-containing Mg alloys solidified at conventional rates often contain coarse and sharp Mg2Si phases,which can result in inferior material *** this study,Mg-6wt.%Si （Mg-6Si） alloy was prepared by wire arc additive manufacturing （WAAM）,employing the gas tungsten arc welding technique with rapid *** microstructures and mechanical properties of the WAAM alloy were investigated and compared with those of the as-cast samples produced using a metal *** results indicate that the WAAM Mg-6Si is harder and stronger than the as-cast *** microhardness of the WAAM Mg-6Si increases by 36.6%in comparison to that of as-cast Mg-6Si ***,the average tensile strengths at room temperature and 150°C increases by 63.4%and 21.3%,*** refines both the Mg2Si phase and the overall grains,resulting in a homogeneous morphology and improved mechanical *** granular Mg2Si phase,characterized by fine particles with a diffused distribution,shows a significant increase in *** acicular Mg2Si phase is distributed along the grain boundaries,and its concentration significantly *** average grain size of the Mg2Si phase is about 9.20μm,about 5 times *** refinement and distribution of the granular Mg2Si phase,as well as the reduction in the amount of needle-like Mg2Si particles,are the key factors for improving the mechanical properties of WAAM Mg-6Si alloy.

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肿瘤中lncRNAs和circRNAs关系的研究进展

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中国药理学通报 2018年第9期34卷 1203-1205页

作者：高元峰刘昭前李珊肖望重欧阳荣湖南中医药大学第一附属医院药学部湖南长沙410007 中南大学湘雅医院临床药理研究所湖南长沙410008

随着基因测序技术的发展,越来越多的长链非编码RNAs(lncRNAs)和环状RNAs(circRNAs)在肿瘤的研究中被发现,并引起学者对它们持续的关注。lncRNAs和circRNAs同属非编码RNA,在起源和功能上两者存在着密切关系,现均被证实在肿瘤发生、发展... 详细信息

随着基因测序技术的发展,越来越多的长链非编码RNAs(lncRNAs)和环状RNAs(circRNAs)在肿瘤的研究中被发现,并引起学者对它们持续的关注。lncRNAs和circRNAs同属非编码RNA,在起源和功能上两者存在着密切关系,现均被证实在肿瘤发生、发展中发挥重要作用。该文总结了lncRNAs和circRNAs国内外的最新研究进展,专注于它们之间的关系,进一步了解与区分,以期更好识别肿瘤生物标志物。

关键词：肿瘤长链非编码RNA 环状RNA 非编码RNA 生物靶标药理作用

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong xiao Chen Chen Shuo wang Zi-Yin Dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

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Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing Weng Zhao-Ying Ding Ying-Chao Li Yuan-Feng Wu Yuan-Yang Xu Rui Chen xiao-Lei Zhao Hai-Yong wang Da-Lei Zhang Yu-Long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin xiao Fangqing Zhao Jing-Dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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有机硅耐高温涂料防腐蚀性能分析

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涂料工业 2004年第5期34卷 48-50页

作者：沈孝忠王兆安田育廉山东乐化漆业股份有限公司潍坊262411 青岛海建制漆股份有限公司 266043

通过试验探讨了漆膜厚度、防锈颜料对耐高温涂料防腐蚀性能的影响 ,并模拟自然环境设计了防腐蚀性能的检测。

关键词：有机硅耐高温涂料防腐蚀性能检测评价方法

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A dry-electrode enabled ECG-on-Chip with arrhythmia-aware data transmission

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Science China(Information Sciences) 2025年

作者： Xinzi XU Yanxing SUO Yang ZHAO Peiyi ZHOU xiao HAN Qiao CAI Min wang Jiajun YUAN Liebin ZHAO Yongfu LI Guoxing wang Yong LIAN Department of Micro-Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Pediatric AI Clinical Application and Research Center Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Child Health Advocacy Institute Shanghai Children's Medical Center School of MedicineShanghai Jiao Tong University Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Xin Hua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine

Early detection and treatment of cardiovascular diseases (CVDs) can be significantly enhanced through the use of flexible wearable electrocardiogram (ECG) sensors, potentially reducing CVD-related mortality. This paper introduces an ECG-on-Chip (EoC) solution tailored for flexible ECG sensors, incorporating novel features to address common challenges in wearable ECG technology. The EoC integrates a chopper-stabilized capacitively-coupled instrumentation amplifier (CS-CCIA),ensuring a high common-mode rejection ratio (CMRR) and low noise performance. Performance is further boosted via a positive feedback loop (PFL) and a programmable gain amplifier (PGA) with shared on-chip calibration logic, which enhances input impedance and minimizes gain variability to ensure consistent algorithm performance. Additionally, a secondary chopping technique is employed to further reduce noise, achieving an input-referred noise level of 454 nVrms. The embedded algorithm within the EoC is designed to extract clinically meaningful features, facilitating robust real-time arrhythmia analysis. Fabricated using a 0.18μm CMOS process, the EoC consumes 14.9μW with a supply voltage of 1.2 V. The algorithm’s efficacy has been validated over 0.4 million heartbeats, demonstrating a sensitivity of over 99.7%for R-peak detection and 98.3%for arrhythmia analysis. To demonstrate practical application, the EoC has been integrated with a commercial Bluetooth low energy (BLE)transceiver, forming a wireless arrhythmia monitoring sensor equipped with dry electrodes. This system consumes 292.04μW in arrhythmia-aware transmission mode, supporting 13 days of operation with a 30 mAh thin-film battery.

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AGS细胞系中12-LOX的表达及其抑制剂对细胞增殖的影响

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世界华人消化杂志 2005年第14期13卷 1652-1657页

作者：黄彩云陈丰霖李建英陈治新王小众福建医科大学附属协和医院消化内科福建省福州市350001

目的:探讨人胃癌细胞系AGS中12-脂肪氧化酶(12- lipoxygenase,12-LOX)的表达情况及其抑制剂黄芩甙元(baicalein)对AGS细胞增殖的影响. 方法:AGS在含100 mL/L小牛血清+100 kU/L青、链霉素的RPMI1640培养基中常规培养.用RT-PCR 检测12-LOX... 详细信息

目的:探讨人胃癌细胞系AGS中12-脂肪氧化酶(12- lipoxygenase,12-LOX)的表达情况及其抑制剂黄芩甙元(baicalein)对AGS细胞增殖的影响. 方法:AGS在含100 mL/L小牛血清+100 kU/L青、链霉素的RPMI1640培养基中常规培养.用RT-PCR 检测12-LOX在AGS中的表达情况,分别以20,40, 80 μmol/L baicalein干预细胞,用四氮唑蓝(thiazolyl blue tetrazolium bromide,MTT)法在24,48,72 h 测量细胞吸光度,检测baicalein对细胞增殖的影响:用倒置显微镜和电子显微镜进行形态观察;通过脱氧核糖核酸末端转移酶介导的dUTP缺口末端标记法(TUNEL)和吖啶橙-溴化乙锭(AO-EB)染色法检测细胞凋亡指数. 结果:AGS细胞中存在12-LOXmRNA表达;MTT显示baicalein大致呈时间、剂量依赖性抑制细胞增殖(各组间P0.05),其余各干预组细胞凋亡指数均有显著差异(P<0.01);TUNEL染色法显示48 h时,baicalein 80μmol/L细胞调亡指数为38.37±0.36%而0 μmol/L组细胞调亡指数为7.27±0.21%,两组间存在显著差异(P<0.01). 结论:人胃癌细胞AGS中存在12-LOXmRNA表达,其特异性抑制剂baicalein能抑制AGS细胞增殖并促进其凋亡.

关键词： AGS细胞系 12-LOX 表达抑制剂细胞增殖胃癌

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Design high-performance narrowband emitters for blue light-emitting diodes through manipulating resonance structure of aromatic heterocycles

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Science China Chemistry 2025年

作者： Yue Yu Lei Xu Wenle Tan Yuyu Pan Jiyin xiao Bohan wang Guangjun Tian Yuguang Ma Lei Ying Institute of Polymer Optoelectronic Materials and Devices Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology School of Petrochemical Engineering Shenyang University of Technology Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University

Narrowband light-emitting materials play critical roles in improving the color gamut and energy consumption of electroluminescence. Herein we demonstrated that by regulating the ground state resonance structure form of emitters with polycyclic aromatic heterocycles, the high-energy vibration of the C–C bond can be effectively suppressed, resulting in narrow emission like classical cyanine dyes. The designed compounds consist of twist and planar conformation, while having differences in the orientation of the positioning electron-donating(nitrogen) and electron-accepting(carbonyl) groups in the polycyclic aromatic hydrocarbon skeleton. The resulting compound Ac-Ph-Ac with a dominated zwitterionic resonance structure exhibits a relatively wide electroluminescent profile with the full width at half maximum(FWHM) of 42 nm and moderate device performance. In contrast, the “soliton transition” of 2AcPh based on the cyanine limit character effectively suppresses C–C stretching vibration in the polycyclic aromatic heterocycle skeleton, leading to a narrow electroluminescent profile with FWHM of 30 nm(0.16 eV)associated with an impressively high external quantum efficiency of 28.52%, which is among the highest efficiencies of so far reported non-sensitized organic light-emitting diodes.

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