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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang xiao-Rui Pan Xin-xing Zeng zheng-zheng Li Bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

Efficacy and Safety of COX-2 Inhibitor Parecoxib for Rigid Cystoscopyrelated Pain Management in Male Patients:A Prospective,Randomized and Controlled Study

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Current Medical Science 2019年第1期39卷 94-98页

作者： Jia-yin SUN zheng-shuai SONG xiao-ping ZHANG xing-yuan xiao Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Using anesthetic gel may not sufficiently exclude pain perception during and after cystoscopy in male *** evaluate the analgesic efficacy and safety of intramuscular parecoxib(40 mg)for outpatient-based rigid cystoscopy,we performed a prospective,randomized and controlled *** male patients requiring diagnostic cystoscopy in our hospital were divided into group A(1%tetracaine gel,n=50)and group B(parecoxib,n^5l)at *** received intramuscular injections of either 2 mL sterile saline in group A or 40 mg parecoxib in group B 30 min before the *** gel was injected into the urethra 3 min before the procedure in group A,with patients receiving plain lubricant gel in group B at the same ***-associated pain levels were evaluated using the Visual Analog Score(VAS)during the ***-procedure urethral pain and complications were recorded and *** results showed that male patients experienced significantly less pain in group B than in group A(2.70±1.36 V5.3.56±1.74,P=0.008).The percentage of patients with dysuria pain was not significantly different between the two *** addition,24 h after cystoscopy,the patients with no previous experience of cystoscopy were more likely to declare urethral pain(59.2%vs.33.3%,P=0.012,relative risk=1.78).No difference was observed in analgesic-related complications between the two *** conclude that intramuscular injection of 40 mg parecoxib may improve comfort for male patients undergoing rigid cystoscopy.

关键词： cystoscopy parecoxib tetracaine gel analgesia

Changes of paired-pulse evoked responses during the development of epileptic activity in the hippocampus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 704-711页

作者： Zhou-yan FENG xiao-jing zheng Cong TIAN Yang WANG Hao-yu xing Ministry of Education Key Lab of Biomedical Engineering College of Biomedical Engineering & Instrument ScienceZhejiang UniversityHangzhou 310027China

Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons,thereby inducing epileptic *** aim of the paper is to investigate the effects of successive excitatory inputs on the epileptic activity induced in the absence of ***-pulse orthodromic and antidromic stimulations were used to test the changes in the evoked responses in the ***(PTX),γ-aminobutyric acid(GABA) type A(GABA A) receptor antagonist,was added to block the inhibitory synaptic transmission and to establish the epileptic *** evoked population spike(PS) was recorded in the CA1 region of the *** results showed that the application of PTX induced a biphasic change in the paired-pulse ratio of PS amplitude.A short latency increase of the second PS(PS2) was later followed by a reappearance of PS2 *** type of depression was observed in both orthodromic and antidromic paired-pulse responses,whereas the GABAergic PS2 depression [called paired-pulse depression(PPD)] during baseline recordings only appeared in orthodromic-evoked *** addition,the depression duration at approximately 100 ms was consistent with a relative silent period observed within spontaneous burst discharges induced by prolonged application of *** conclusion,the neurons may ignore the excitatory inputs and intrinsically generate bursts during epileptic *** depolarization block could be the mechanisms underlying the PPD in the absence of GABA A *** distinct neuronal responses to stimulations during different epileptic stages may implicate the different antiepileptic effects of electrical stimulation.

关键词： Epilepsy Paired-pulse depression γ-Aminobutyric acid(GABA) Picrotoxin(PTX) CA1 region In-vivo

Dynamic hydraulic jump and retrograde sedimentation in an open channel induced by sediment supply: experimental study and SPH simulation

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Journal of Mountain Science 2019年第8期16卷 1913-1927页

作者： zheng xiao-gang CHEN Ri-dong LUO Min KAZEMI Ehsan LIU xing-nian State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China Zienkiewicz Centre for Computational Engineering College of EngineeringSwansea UniversitySA1 8ENUK Department of Civil and Structural Engineering University of SheffieldSheffield S1 3JDUnited Kingdom

Mountainous torrents often carry large amounts of loose materials into the rivers, thus causing strong sediment transport. Experimentally it was found for the first time that when the intensive sediment motion occurs downstream over a gentle slope, the siltation of the riverbed is induced and the sediment particles can move upstream rapidly in the form of a retrograde sand wave, resulting in a higher water level along the river. To further study the complex mechanisms of this problem, a sediment mass model in the framework of the Smoothed Particle Hydrodynamics(SPH) method was presented to simulate the riverbed evolution, sediment particle motion, and the generation and development of dynamic hydraulic jump under the condition of sufficient sediment supply over a steep slope with varying angles. Because the sediment is not a continuous medium, the marker particle tracking approach was proposed to represent a piece of sediment with a marked sediment particle. The twophase SPH model realizes the interaction between the sediment and fluid by moving the bed boundary particles up and down, so it can reasonably treat the fluid-sediment interfaces with high CPU efficiency. The critical triggering condition of sediment motion, the propagation of the hydraulic jump and the initial siltation position were all systematically studied. The experimental and numerical results revealed the extra disastrous sediment effect in a mountainous flood. The findings will be useful references to the disaster prevention and mitigation in mountainous rivers.

关键词： Dynamic hydraulic jump Retrograde sedimentation Sediment supply Mountainous river Smoothed Particle Hydrodynamics Marked sediment particle

Downregulation of cold-inducible RNA-binding protein activates mitogen-activated protein kinases and impairs spermatoRenic function in mouse testes

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Asian Journal of Andrology 2012年第6期14卷 884-889页

作者： Zhi-Ping Xia Xin-Min zheng Hang zheng xiao-Jun Liu Gui-Yong Liu xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China Department of Urology Qianjiang Central Hospital Qianjiang 433100 China

Cold-inducible RNA-binding protein （CIRP） is an RNA-binding protein that is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures. The purpose of this study was to investigate the functions of CIRP in the testes. We employed RNAi technique to knock down the expression of CIRP in the testes, and performed haematoxylin and eosin staining to evaluate morphological changes following knockdown. Germ cell apoptosis was examined by terminal deoxynucleotidal transferase-mediated dUTP nick end labelling （TUNEL） assay, and mitogen-activated protein kinase （MAPK） signalling pathways were investigated by Western blotting to determine the possible mechanism of apoptosis. We found that using siRNA is a feasible and reliable method for knocking down gene expression in the testes. Compared to controls, the mean seminiferous tubule diameter （MSTD） and the thickness of the germ cell layers decreased following siRNA treatment, whereas the percentage of apoptotic seminiferous tubules increased. The p44/p42, p38 and SAPK/JNK MAPK pathways were activated after downregulation of CIRP. In conclusion, we discovered that downregulation of CIRP resulted in increased germ cell apoptosis, possibly viathe activation of the p44/p42, p38 and SAPK/JNK MAPK pathways.

关键词： cold-inducible RNA-binding protein (CIRP) mitogen-activated protein kinase (MAPK) siRNA in vivo spermatogenesis heat stress male infertility

Nonlinear dynamical systems and bistability in linearly forced isotropic turbulence

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Acta Mechanica Sinica 2013年第6期29卷 823-826页

作者： zheng Ran xing-Jie Yuan Shanghai Institute of Applied Mathematics and Mechanics Shanghai University

In this paper, we present an extensive study of the linearly forced isotropic turbulence. By using analytical method, we identify two parametric choices, of which they seem to be new as far as our knowledge goes. We prove that the underlying nonlinear dynamical system for linearly forced isotropic turbulence is the general case of a cubic Lienard equation with linear damping. We also discuss a FokkerPlanck approach to this new dynamical system, which is bistable and exhibits two asymmetric and asymptotically stable stationary probability densities.

关键词： Isotropic turbulence Nonlinear dynamical system Karman-Howarth equation

基于拉曼光谱的转炉烟气中多组分气体在线分析方法研究

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光谱学与光谱分析 2025年第1期45卷 146-151页

作者：郑传新刘晓萌李泉孟征王恩宁司星宇王健年李振林王红球鞍钢集团本钢板材股份有限公司炼钢厂厂部辽宁本溪117021 中国计量科学研究院计量科学研究所北京100029 大连艾尔科技发展有限公司技术部辽宁大连116021 北京鉴知技术有限公司技术开发部北京100083

冶金行业中,转炉烟气的在线分析普遍采用激光吸收光谱法等单组分气体分析技术,实践中需使用多传感器的组合以同时监测CO、CO_(2)、O_(2)、H_(2)等多组分,分析系统整体的复杂程度和成本高,响应速度慢,逐个传感器的日常校正维护工作量大... 详细信息

冶金行业中,转炉烟气的在线分析普遍采用激光吸收光谱法等单组分气体分析技术,实践中需使用多传感器的组合以同时监测CO、CO_(2)、O_(2)、H_(2)等多组分,分析系统整体的复杂程度和成本高,响应速度慢,逐个传感器的日常校正维护工作量大。为简化在线分析系统的复杂度,提高分析效率,实现炼钢流程的降本增效,首创性的建立了一种转炉烟气中多组分气体实时在线分析的拉曼光谱方法,并首次研制了专用于炉气检测的多组分气体分析系统。通过检测CO、CO_(2)、N_(2)、O_(2)、H_(2)五组分的拉曼光谱特征峰强,对五组分含量进行同时定量分析。检测范围0.1%~100%,检测精密度RSD值均≤0.1%。分析系统中,样气处理模块采用耐高温探头和大功率抽气泵,快速、有效去除进入分析仪的样气中水分和灰尘,保证测试条件稳定;分析模块采用窄线宽532 nm激光器和透射式光谱仪,并通过空间光路设计以提高检测灵敏度,满足气体检测需求。相比于现有的单组分在线分析技术,所提出的多组分检测方法可同时给出五组分的定量结果,不受样气压力、测试条件变化影响,样气前处理难度低,检测准确度高,系统维护简单。N_(2)标准气体的拉曼散射信号特征峰强在24 h内波动≤0.48%。经标准样品验证,该方法检测误差≤0.3%,达到转炉烟气实时检测的需求。该方法不仅在冶金行业有广阔应用前景,还可通过模型扩展以拓展到其他多组分气体实时在线分析监测领域。

关键词：拉曼光谱在线气体分析转炉烟气多元标准曲线模型冶金

P_(53) Codon72多态性与新疆维吾尔族、汉族宫颈癌发生的相关性研究

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石河子大学学报（自然科学版） 2004年第4期22卷 340-344页

作者：王晓凌潘晓琳高志斌郑兴征李洪安蒋金芳石河子大学医学院基础医学系新疆石河子832002

采用限制性酶切片段多态性分析技术检测73例维吾尔族宫颈癌组织及26例正常宫颈组织、38例汉族宫颈癌及34例正常宫颈石蜡包埋组织中P53基因多态性的分布,探讨P53基因第四外显子第72位密码子多态性与新疆维吾尔族、汉族人群宫颈癌发生的... 详细信息

采用限制性酶切片段多态性分析技术检测73例维吾尔族宫颈癌组织及26例正常宫颈组织、38例汉族宫颈癌及34例正常宫颈石蜡包埋组织中P53基因多态性的分布,探讨P53基因第四外显子第72位密码子多态性与新疆维吾尔族、汉族人群宫颈癌发生的遗传易感性方面的关系,及其分布是否存在种族差异。结果发现,P53的3种基因型Arg Arg、Pro Pro、Pro Arg在维吾尔族宫颈癌中所占比例分别是47.9%、20.6%、31.5%,相对于对照组的30.8%、19.2%、50.0%,总构成比未见显著性差异(χ2=3.12,P>0.05),但可见Arg Arg所占比例高于对照组,且高于其它二型;在汉族宫颈癌中所占比例分别为21.0%、39.5%、39.5%,与对照组38.2%、14.7%、47.1%相比,存在显著性差异(χ2=6.01,P<0.05),Pro Pro在宫颈癌中所占比例高于对照组。结果表明,P53Pro Pro基因型可能是新疆汉族人群宫颈癌发生的一个主要遗传易感因素,P53codon72多态性是否与新疆维吾尔族宫颈癌的发生相关,尚需进一步研究。

关键词：宫颈癌 P53 多态性维吾尔族

The bar and spiral arms in the Milky Way: structure and kinematics

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Research in Astronomy and Astrophysics 2020年第10期20卷 173-190页

作者： Juntai Shen xing-Wu zheng Department of Astronomy School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai 200240China Department of Astronomy Nanjing UniversityNanjing 210093China

The Milky Way is a spiral galaxy with the Schechter characteristic luminosity L*,thus an important anchor point of the Hubble sequence of all spiral *** the true appearance of the Milky Way has remained elusive for *** review the current best understanding of the structure and kinematics of our home galaxy,and present an updated scientifically accurate visualization of the Milky Way structure with almost all components of the spiral arms,along with the COBE image in the solar *** Milky Way contains a strong bar,four major spiral arms,and an additional arm segment(the Local arm)that may be longer than previously *** Galactic boxy bulge that we observe is mostly the peanut-shaped central bar viewed nearly end-on with a bar angle of^25°-30°from the SunGalactic center *** bar transitions smoothly from a central peanut-shaped structure to an extended thin part that ends around R^5 *** Galactic bulge/bar contains^30%-40%of the total stellar mass in the *** modelling of both the stellar and gas kinematics yields a bar pattern rotation speed of^35-40 km s-1 kpc-1,corresponding to a bar rotation period of^160-180 *** a galaxy formation point of view,our Milky Way is probably a pure-disk galaxy with little room for a significant merger-made,"classical"spheroidal bulge,and we give a number of reasons why this is the case.

关键词： Galaxy:structure Galaxy:bulge Galaxy:kinematics and dynamics galaxies:spiral galaxies:structure