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Long-term outcomes of drusenoid pigment epithelium detachment in intermediate AMD treated with 577 nm subthreshold micropulse laser: a preliminary clinical study

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 474-482页

作者： zhen huang Kai-Yu Deng Yu-Meng Deng Yan-Nian Hui Yan-Ping Song The First School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Ophthalmology General Hospital of Central Theater CommandWuhan 430070Hubei ProvinceChina Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

AIM: To evaluate the long-term anatomical and visual outcomes of drusenoid pigment epithelial detachment(D-PED) in intermediate age-related macular degeneration(AMD) eyes treated with 577 nm yellow subthreshold micropulse laser(SML).METHODS: In this retrospective study, 21 eyes of 16 patients with D-PED in intermediate AMD were consecutively included and *** the eyes were treated with 577 nm SML in several sessions according to D-PED growth *** logarithm of the minimum angle of resolution(logMAR) best-corrected visual acuity(BCVA) were assessed at the initial visit and after ***-domain optical coherence tomography(SD-OCT) was performed to evaluate the D-PED lifecycle by volumetric *** analysis was used to determine the breakpoint, growth, and collapse rate of the D-PED *** progression to advanced AMD was also ***: All the eyes were treated with SML for 2.9±1.0 *** mean follow-up period was 25.3±12.6 *** BCVA was stable from the baseline to final *** the eyes were categorized into two groups according to the anatomical changes of the D-PED lesion: the collapse group(n=6, 28.6%) and non-collapse group(n=15, 71.4%).The change in logMAR BCVA did not differ significantly between the collapse group 0.00(-0.31, 0.85) and non-collapse group 0.00(0.00, 0.00;P=1).Regression analysis showed that the growth rate was significantly higher in the collapse group(0.090±0.095 mm;/mo) than in the non-collapse group(0.025±0.035 mm;/mo;P<0.001).One eye(4.8%) developed macular neovascularization at 11 mo after SML treatment in the non-collapse *** eyes(14.3%) developed geographic atrophy(GA) in the collapse ***: Compared to the natural course of D-PED reported by previous studies, our results preliminarily show that SML can alleviate visual loss and possibility of progression to advanced AMD in eyes with D-PED in intermediate AMD.A controlled clinical trial needs to further ve

关键词： age-related macular degeneration drusenoid pigment detachment optical coherence tomography retinal pigment epithelium subthreshold micropulse laser

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甘蔗种质材料田间抗螟性综合评价及筛选

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南方农业学报 2024年第6期55卷 1561-1572页

作者：李德伟罗亚伟黄慧文李涛梁菊菊宋修鹏覃振强广西农业科学院甘蔗研究所/农业农村部广西甘蔗生物技术与遗传改良重点实验室/广西甘蔗遗传改良重点实验室广西南宁530007

【目的】探索甘蔗种质材料田间抗螟性评价体系,并对163份不同甘蔗种质材料进行田间抗螟性评价,了解各材料对甘蔗螟虫的抗性表现,筛选优良的抗螟性甘蔗种质材料,为甘蔗抗螟种质创新、新品种选育及抗螟品种的推广应用提供参考。【方法】... 详细信息

【目的】探索甘蔗种质材料田间抗螟性评价体系,并对163份不同甘蔗种质材料进行田间抗螟性评价,了解各材料对甘蔗螟虫的抗性表现,筛选优良的抗螟性甘蔗种质材料,为甘蔗抗螟种质创新、新品种选育及抗螟品种的推广应用提供参考。【方法】通过田间甘蔗螟虫自然种群感虫法,跟踪调查163份甘蔗种质材料3年(1新2宿)田间的苗期螟害枯心率和生长中后期螟害节率,以新台糖22号(ROC22)作为抗螟性对照品种,计算各甘蔗种质材料的相对螟害减退率,并以相对螟害减退率及相应的甘蔗抗螟性分级评价体系对供试甘蔗种质材料进行抗螟性评价和筛选。【结果】163个甘蔗种质材料“1新2宿”的螟害枯心率在1.74%~21.75%、螟害节率在1.17%~9.74%;供试材料中3年均进入苗期螟害枯心率最重前20名的材料只有CP09-4707,均进入苗期螟害枯心率最轻前20名的材料为0份,均进入中后期螟害节率最轻或最重前20名的材料也为0份。抗螟性评价结果表明,在新植苗期、新植生长中后期、第1年宿根苗期、第1年宿根生长中后期、第2年宿根苗期和第2年宿根生长中后期的抗螟性表现为中抗以上的甘蔗种质材料数量分别有96、151、48、88、106和147份;以韦恩图分析方法筛选出GT03-571、GT03-1438、GT03-2887、YT96-86、GT02-467、Q200、T6、T5、ROC22、T8和GT42共11份甘蔗种质材料在6个生长时期的抗螟性表现均在中抗以上。【结论】建立了一种能有效结合甘蔗品种区域试验、对照品种明确易得、操作方法简单、可对甘蔗6个不同生长期抗螟性进行评价的评价体系。不同甘蔗种质材料间螟害率存在较大差异,抗螟性差异客观存在。筛选出11份在6个生长期抗螟性表现均在中抗以上的甘蔗种质材料,可用于抗螟新品种选育。

关键词：甘蔗甘蔗螟虫种质材料抗虫性评价

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Genome-wide analysis of the invertase genes in strawberry(Fragaria×ananassa)

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Journal of Integrative Agriculture 2021年第10期20卷 2652-2665页

作者： YUAN Hua-zhao PANG Fu-hua CAI Wei-jian CHEN xiao-dong ZHAO Mi-zhen YU Hong-mei Institute of Pomology Jiangsu Academy of Agricultural Sciences/Jiangsu Key Laboratory for Horticultural Crop Genetic ImprovementNanjing 210014P.R.China

Sugar is an important material basis in fruit development,and strawberry fruit flavour and sweetness largely depend on the sugar content and ***(INVs)play an important role in the regulation of sugar accumulation because they irreversibly catalyse the hydrolysis of sucrose into the corresponding nucleoside diphosphate-glucose,glucose or fructose in *** this work,we provided a comprehensive analysis of the INV gene family in octoploid strawberry(Fragaria×ananassa),including the gene structure,chromosomal locations,conserved domains,and gene evolution and expression profiles during strawberry fruit *** study revealed that polyploid events resulted in the abundant amplification(almost three-or four-fold)of the INV gene in the F.×ananassa genome,and these amplified INV genes showed dominant expression in strawberry *** than half of the FaINVs transcripts with low expression had incomplete coding sequences by alternative *** studies have shown that cell wall invertases(CWINV)are involved in the regulation of phloem unloading and sink strength *** expression of FaCWINV1 was markedly upregulated during fruit development and strongly expressed in ripe ***,a significant correlation was observed between the total sugar content and the FaCWINV1 expression *** findings suggest that FaCWINV1 may be involved in sugar accumulation in strawberry *** together,the results of our study will be beneficial for further research into the functions of INVs in the regulation of fruit ripening.

关键词： strawberry sugar invertases fruit ripening

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Ce-Fe-Mn ternary mixed-oxide catalysts for catalytic decomposition of ozone at ambient temperatures

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Journal of Rare Earths 2020年第2期38卷 175-181页

作者： xiao Chen zhenglong Zhao Shuo Liu Jinxing huang Jing Xie Ying Zhou Zhiyan Pan Hanfeng Lu Institute of Environmental Chemicals and Resources College of EnvironmentZhejiang University of TechnologyHangzhou 310014China Innovation Team of Air Pollution Control Institute of Catalytic Reaction EngineeringCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China Hangzhou Runxing Technology Co. Ltd.Hangzhou 310014China

Ce-modified Mn-Fe mixed-oxide catalysts were prepared by a citric acid sol-gel method and characterized by X-ray diffraction,Raman,N2 adsorption-desorption,infrared spectra H2 temperature-programmed reduction and thermogravimetric *** catalytic properties were investigated in ozone(O3)decomposition *** show that the small amount of rare earth metal Ce added during Mn-Fe(FM) mixed-oxide synthesis greatly improves the catalytic performance in O3 *** the prepared *** C0.04(FM)0.96 mixed-oxide catalyst exhibits the highest catalytic activity and *** O3 conversion over C0.04(FM)0.96 is 98% after 24 h reaction at 25℃ under dry condition,and that over FM decreases to 90% after 16 h *** 0℃,the O3 conversion over C0.04(FM)0.96 is 95% after 7 h reaction under dry *** that over FM slows down to 70%.Under humid condition(RH 65%),the O3 conversion over C0.04(FM)0.96 is 63% after 6.5 h reaction at 25℃.while that over FM decreases to 55%.When Ce is doped into Mn-Fe mixed oxides,the small amount of Ce enters the crystal lattice of *** partial Fe is separated to form *** changes cause lattice distortion and increase defects and enable the as-synthesized Ce-Fe-Mn ternary mixed-oxide catalysts to acquire additional oxygen vacancies and increase their specific surface area,thereby increasing the number of reaction sites and enhancing the catalytic performance of the catalysts for O3 decomposition.

关键词： Rare earths modified Ce-Fe-Mn mixed oxide Oxygen vacancy Ozone Catalytic decomposition

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Quantum computation and simulation with superconducting qubits

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Chinese Physics B 2021年第8期30卷 1-17页

作者： Kaiyong He xiao Geng Rutian huang Jianshe Liu Wei Chen School of Integrated Circuits Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Beijing 100084China Tsinghua University Future Chip Technology Advanced Innovation Center Beijing 100084China

Superconducting circuits based on Josephson junctions are regarded as one of the most promising technologies for the implementation of scalable quantum *** review presents the basic principles of superconducting qubits and shows the progress of quantum computing and quantum simulation based on superconducting qubits in recent *** experimental realization of gate operations,readout,error correction codes,as well as some quantum algorithms are summarized,followed by an introduction of quantum *** then some important applications in fields including condensed matter physics,quantum annealing,and quantum chemistry are discussed.

关键词： quantum computation quantum simulation superconducting qubit

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Temperature and Composition Dependence of GaN_(x)As_(1−x)(0

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Chinese Physics Letters 2011年第12期28卷 263-266页

作者： ZHAO Chuan-zhen LI Na-Na WEI Tong TANG Chun-xiao School of Electronics and Information Engineering Tianjin Polytechnics UniversityTianjin 300160 School of Textiles Tianjin Polytechnic UniversityTianjin 300160 College of Science Civil Aviation University of ChinaTianjin 300300

The parameters in the band-anticrossing model for GaN_(x)As_(1−x)(0 详细信息

The parameters in the band-anticrossing model for GaN_(x)As_(1−x)(0

关键词： effect annealing

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2019—2022年河南省肾综合征出血热宿主动物监测情况分析

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中华预防医学杂志 2024年第1期58卷 18-24页

作者：李东晓范威朱琳胡晓李懿马红霞王海峰叶莹苏佳黄学勇河南省疾病预防控制中心传染病预防控制所郑州450016

目的分析2019—2022年河南省肾综合征出血热(HFRS)宿主动物分布及携带汉坦病毒(HV)情况。方法在河南省HFRS监测点开展宿主动物监测,采用实时荧光定量PCR法检测鼠肺HV,分析河南省鼠类动物携带HV型别,对阳性样本进行测序,分析核苷酸序列... 详细信息

目的分析2019—2022年河南省肾综合征出血热(HFRS)宿主动物分布及携带汉坦病毒(HV)情况。方法在河南省HFRS监测点开展宿主动物监测,采用实时荧光定量PCR法检测鼠肺HV,分析河南省鼠类动物携带HV型别,对阳性样本进行测序,分析核苷酸序列的同源性及变异情况。结果2019—2022年共捕鼠1308只,16份鼠肺HV核酸阳性,鼠HV阳性率为1.22%(16/1308)。按种类,黑线姬鼠HV阳性率最高(68.75%,11/16)。按分布地,野外鼠HV阳性率最高(2.50%,12/480),居民区鼠HV阳性率为0.53%(4/759)。16份阳性样本分型结果显示,所携带的病毒均属于Ⅰ型汉滩病毒。阳性样本测序后获得8条S基因片段(OQ681444~OQ681451)和6条M基因片段(OQ681438~OQ681443);S和M基因片段与陕西84FLi株、四川SN7株相似性较高。S和M基因片段系统进化分析显示,均为汉滩病毒H5基因亚型。氨基酸序列分析显示,与汉滩病毒疫苗株84FLi相比,8条S片段编码氨基酸第74位由天冬酰胺替换为丝氨酸;XC2022047株在Gn区第14位由色氨酸替换为甘氨酸,XC2022022和XC2022024第359位由异亮氨酸替换为丙氨酸。结论2019—2022年河南省宿主动物携带HV属于Ⅰ型汉滩病毒,黑线姬鼠仍然是汉滩病毒的优势宿主。同疫苗株比较,S和M基因片段的免疫表位区均有氨基酸位点替换。

关键词：肾综合征出血热监测汉坦病毒黑线姬鼠汉滩病毒

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Mechanisms of aid-leaching reagent calcium fluoride in the extracting vanadium processes from stone coal

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Rare Metals 2013年第1期32卷 57-62页

作者： Fei Wang Yi-Min Zhang Jing huang Tao Liu Yi Wang xiao Yang Jie Zhao College of Resources and Environmental Engineering Wuhan University of Science and Technology

The mechanisms of aid-leaching reagent calcium fluoride in the extracting vanadium processes were researched by comparing the blank extraction with the extraction with calcium fluoride as aid-leaching reagent. The leaching experiments were carried out under the conditions of 95 ~C, 6 h, 1.5 ml.g-1, 15 vol % H2SO4, and 5 % calcium fluoride （mass ratio of CaF2 to stone coal）. The concentrations of hydrogen ion were adjusted from initial 1.82 and 4.79 mol.L-1 to the pH of 1.80 4- 0.05 by 200 g.L-1 lime milk, respectively. The solvent extraction experiments were carded out under the organic phase using 15 vol% D2EHPA, 5 vol% TBP, and 80 vol% sulfonated kerosene and O/A phase ratio of 1/4. The leaching rate of vanadium and six-stage countercurrent solvent extraction rate of vanadium can be remarkably improved from 66.71 to 92.97 % and 81.15 to 98.81%, respectively, when calcium fluoride was added as aid-leaching reagent. In the leaching process, fluorine can enhance the breakage of the structure of vanadium-bearing minerals. Meanwhile, fluoride ion can combine with iron ion to generate acid-insoluble iron fluoride hydrate （Fe2Fs.7H20） and consume all ferric ions and a portion of ferrous ions. In adjusting pH value process, the massive impurities are decreased to form KA1SO4 and FeA1Fs. In solvent extraction process, fluorine can prevent the formation of ferric hydroxide colloids and eliminate the formed unstable ferric hydroxide colloids and the silicon-containing colloids to promote the sufficient contact between the aqueous phase and the organic phase and the sufficient reaction.

关键词： Vanadium Stone coal Aid-leaching reagent Calcium fluoride Mechanisms

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浅谈绿色矿山建设的推广与应用

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价值工程 2024年第9期43卷 133-135页

作者：黄铜玲杜显峰袁汝安王振亭山东能源枣庄矿业集团公司柴里煤矿滕州277519

建设绿色矿山,发展绿色矿业,是践行习近平总书记“绿水青山就是金山银山”重要思想,促进生态文明建设,落实新发展理念的重要举措。为坚持科学发展观,切实履行企业社会责任,不断构建资源节约型、环境友好型企业,圆满完成柴里煤矿绿色矿... 详细信息

建设绿色矿山,发展绿色矿业,是践行习近平总书记“绿水青山就是金山银山”重要思想,促进生态文明建设,落实新发展理念的重要举措。为坚持科学发展观,切实履行企业社会责任,不断构建资源节约型、环境友好型企业,圆满完成柴里煤矿绿色矿山建设工作。

关键词：绿色矿山科学发展资源节约企业

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Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer

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World Journal of Gastroenterology 2014年第14期20卷 4085-4092页

作者： Yun-Feng Wang Fei-Ling Feng Xu-Hong Zhao zhen-Xiong Ye He-Ping Zeng zhen Li xiao-Qing Jiang Zhi-Hai Peng Department of Hepatobiliary Surgery Qianfoshan HospitalShandong University Department of General Surgery Yangpu HospitalTongji University School of Medicine The First Department of Biliary Surgery Eastern Hepatobiliary Surgery Hospital of the Second Military Medical University Central Experiment Laboratory Yangpu HospitalTongji University School of Medicine

AIM: To clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis. METHODS: Serum cancer antigens (CA) 199, CA242, carcinoembryonic antigen (CEA), and CA125 levels were measured in 78 patients with gallbladder cancer (GBC), 78 patients with benign gallbladder diseases, and 78 healthy controls using electrochemiluminescence. CA199, CA242, CEA, and CA125 levels and positive rates were analyzed and evaluated pre-and post-operatively. Receiver operator characteristic curves were used to determine diagnostic sensitivity and specificity of GBC. Survival time analysis, including survival curves, and multivariate survival analysis of a Cox proportional hazards model was performed to evaluate independent prognostic factors. RESULTS: Serum CA242, CA125, and CA199 levels in the GBC group were significantly higher when compared with those in the benign gallbladder disease and healthy control groups (P < 0.01). With a single tumor marker for GBC diagnosis, the sensitivity of CA199 was the highest (71.7%), with the highest specificity being in CA242 (98.7%). Diagnostic accuracy was highest with a combination of CA199, CA242, and CA125 (69.2%). CA242 could be regarded as a tumor marker of GBC infiltration in the early stage. The sensitivity of CA199 and CA242 increased with progression of GBC and advanced lymph node metastasis (P < 0.05). The 78 GBC patients were followed up for 6-12 mo (mean: 8 mo), during which time serum CA199, CA125, and CA242 levels in the recurrence group were significantly higher than in patients without recurrence (P < 0.01). The post-operative serum CA199, CA125, and CA242 levels in the non- recurrence group were significantly lower than those in the GBC group (P < 0.01). Multivariate survival analysis using a Cox proportional hazards model showed that cancer of the gallbladder neck and CA199 expression level were independent prognostic factors. CONCLUSION: CA242 is a marker of GBC infiltration in

关键词： Gallbladder cancer Tumor marker Combined detection Diagnosis Prognosis

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