检索结果-南通市图书馆

Low central venous pressure reduces blood loss in hepatectomy

World Journal of Gastroenterology 2006年第6期12卷 935-939页

作者： Wei-Dong Wang Li-Jian Liang Xiong-Qing Huang xiao-yu yin Department of General Surgery The FirstPeople's Hospital of Shun De Fuoshan 528300 GuangdongProvince China Department of Hepatobiliary Surgery The First Affiliated Hospital Sun Yat-Sen University Guangzhou510080 Guangdong Province China Department of Anaesthesia The FirstAffiliated Hospital Sun Yat-Sen University Guangzhou 510080Guangdong Province China

AIM： To investigate the effect of low central venous pressure （LCVP） on blood loss during hepatectomy for hepatocellular carcinoma （HCC）. METHODS： By the method of sealed envelope, 50 HCC patients were randomized into LCVP group （n=25） and control group （n=25）. In LCVP group, CVP was maintained at 2-4 mmHg and systolic blood pressure （SBP） above 90 mmHg by manipulation of the patient＇s posture and administration of drugs during hepatectomy, while in control group hepatectomy was performed routinely without lowering CVP. The patients＇ preoperative conditions, volume of blood loss during hepatectomy, volume of blood transfusion, length of hospital stay, changes in hepatic and renal functions were compared between the two groups. RESULTS： There were no significant differences in patients＇ preoperative conditions, maximal tumor dimension, pattern of hepatectomy, duration of vascular occlusion, operation time, weight of resected liver tissues, incidence of post-operative complications, hepatic and renal functions between the two groups. LCVP group had a markedly lower volume of total intraoperative blood loss and blood loss during hepatectomy than the control group, being 903.9 ± 180.8 mL vs 2 329.4 ±2 538.4 （W=495.5, P〈0.01） and 672.4±429.9 mL vs 1 662.6±1 932.1 （W=543.5, P〈0.01）. There were no remarkable differences in the pre-resection and post-resection blood losses between the two groups. The length of hospital stay was significantly shortened in LCVP group as compared with the control group, being 16.3±6.8 d vs 21.5 ± 8.6 d （W= 532.5, P〈0.05）.CONCLUSION： LCVP is easily achievable in technique. Maintenance of CVP ≤4 mmHg can help reduce blood loss during hepatectomy, shorten the length of hospital stay, and has no detrimental effects on hepatic or renal function.

关键词： Hepatectomy Hepatocellular carcinoma Central venous pressure Blood loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robotic-assisted hepatopancreatoduodenectomy and resection of pancreatic tail for one multiple endocrine neoplasia type 1 secreting multiple hormones

引用

Hepatobiliary Surgery and Nutrition 2023年第5期12卷 818-821页

作者： Xi-Tai Huang Jian-Peng Cai xiao-yu yin Department of Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

One 42-year-old female suffered from recurrent weakness and diarrhea for 2 *** had a history of thyroidectomy and patent foramen *** her local hospital,she was diagnosed and treated as transient ischemic attack,however her symptoms were not relieved and she was eventually referred to our *** test showed that the fasting serum gastrin(>1,000.0 ng/L;normal:28.1-106.5 ng/L),the insulin(7.54μU/mL;normal:1.9-23.0μU/mL),C-peptide(1.92 nmol/L;normal:0.4-1.7 nmol/L),and isolated parathyroid hormone(214.3 pg/mL;normal:12.0-88.0 pg/mL)were elevated,while the fasting serum glucose(2.0 mmol/L;normal:3.9-7.8 mmol/L)was decreased.

关键词： elevated diarrhea fasting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Values of a novel pyroptosis-related genetic signature in predicting outcome and immune status of pancreatic ductal adenocarcinoma

引用

Gastroenterology Report 2022年第1期10卷 476-489页

作者： Xiang Xu Jia-Hua Liang Jian-Hui Li Qiong-Cong Xu xiao-yu yin Department of Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background Pyroptosis is an emerging form of programmed cell death associated with progression in ***,there are few studies reporting on the association between pancreatic ductal adenocarcinoma(PDAC)and ***,we aimed to construct a pyroptosis-related genetic signature to predict the clinical outcome and immune status in PDAC *** RNA-seq data of 176 PDAC patients from The Cancer Genome Atlas(TCGA)and 167 PDAC patients from the Genotype-Tissue Expression Project were analysed for pyroptosis-related differentially expressed genes(DEGs)between PDAC and normal *** risk signature of DEGs was analysed using the least absolute shrinkage and selection operator(LASSO)Cox regression analysis and its accuracy was validated in the Gene Expression Omnibus(GEO)cohort(n=190).Functional enrichment analyses were performed to explore the mechanisms of the *** immune characteristics were evaluated using single-sample gene set enrichment analysis and ESTIMATE algorithms for each *** A nine-gene risk signature was generated from LASSO Cox regression analysis and classified PDAC patients into either a high-or low-risk group according to the median risk *** high-risk group had significantly shorter overall survival than the low-risk group and it was verified in the external GEO database.A nomogrambased on the risk signature was constructed and showed an ideal prediction *** enrichment analyses revealed that pyroptosis might regulate the tumor immune microenvironment in *** infiltration evaluation suggested that immune status was more activated in the low-risk group than in the high-risk *** The risk signature encompassing nine pyroptosis-related genes may be a prognostic marker for *** might affect the prognosis of PDAC patients via regulating the tumor immune microenvironment.

关键词： pancreatic ductal adenocarcinoma pyroptosis prognosis immune

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Conjugated organic component-functionalized hourglass-type phosphomolybdates for visible-light photocatalytic Cr(VI)reduction in wide pH range

引用

Rare Metals 2023年第11期42卷 3638-3650页

作者： Hao-Xue Bi xiao-yu yin Jing-Yan He Hao Song Shi-Jia Lu yuan-yuan Ma Zhan-Gang Han College of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang050024China Hebei Key Laboratory of Organic Functional Molecules Hebei Key Laboratory of Inorganic NanomaterialsNational Demonstration Center for Experimental Chemistry EducationHebei Normal UniversityShijiazhuang050024China

Abstra ct Utilizing efficient and durable photocatalysts for the removal of carcinogen Cr(Ⅵ)in wide pH water environment is of great significance for environment ***,three conjugated organic component-functionalized hourglass-type phosphomolybdate hybrids with the formulas(H_(2)DBQ)[Fe(-H_(2)O)_(3)]_(2){Fe[P_(4)Mo_(6)0_(31)H_(7)]_(2)}·7H_(2)O(1),(H_(2)DBQ)_(2)(H_(2)DBP)[Fe(H_(2)O)_(4)]{Fe[P_(4)Mo_(6)O_(31)H_(7)]_(2)}·4H_(2)O(2),(H_(2)DBP)_(2){Fe[P_(4-)Mo_(6)O_(31)H_(9)]_(2)}·10H_(2)O(3)(DBQ=2,2'-dimehyl-6,6'-biquinoline;DBP=4,4'-diaminobiphenyl)were synthesized via hydrothermal method as photocatalysts for reducing Cr(Ⅵ)under visible light *** analysis showed that hybrids 1-3 consist of hourglass-type[Fe(P_(4)Mo_(6)O_(31)H_(6))_(2)]^(10)-(***{P_(4)Mo_(6)}_(2))poly anionic clusters functionalized with different proportional of conjugated organic components(DBQ and DBP)effectively regulated their visible-light absorption capabilities and electron structures,which could be employed to reflect the structure-activity relationship of *** used as catalysts for reducing Cr(Ⅵ),hybrids 1-3 displayed distinct photocatalytic activities with Cr(Ⅵ)removal efficiencies of 91%,86%and 81%with only 10 W of white light being used as illumination,which are superior to that of pristine Fe{P_(4)Mo_(6)}_(2) salt(62%).Moreover,hybrid 1 also maintained high Cr(Ⅵ)removal efficiencies above~85%and high structural stabilities in solutions with wide pH ranges *** investigation showed that the higher organic component conjugation levels could promote the optic al absorption and facilitate the electron transfer between Fe{P_(4)Mo_(6)}_(2) and org anic components,thus resulting in effective Cr(Ⅵ)reduction photocatalytic *** work provides a viable way to design the photocatalysts based on polyoxometalates for removing wastewater pollutants.

关键词： Polyoxometalate Phosphomolybdate Photocatalyst Conjugated organic component Cr(VI)reduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

引用

Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG yu-xia ZHAO Yan-na yu xiao-ling yin Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EYA4 gene functions as a prognostic marker and inhibits the growth of intrahepatic cholangiocarcinoma

引用

Chinese Journal of Cancer 2016年第8期35卷 421-429页

作者： xiao-Yi Hao Jian-Peng Cai Xin Liu Wei Chen Xun Hou Dong Chen Jia-ming Lai Li-jian Liang xiao-yu yin Departments of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-sen UniversityZhongshan 2nd RoadGuangzhou 510080GuangdongPR.China

Background:The molecular prognostic markers and carcinogenesis of intrahepatic cholangiocarcinoma(ICC) have not been well *** purpose of this study was to investigate the prognostic value of the eyes absent homolog 4(EYA4) gene in ICC and its biological effects on ICC growth in vitro and in ***:One hundred twelve patients with ICC who underwent hepatectomy were enrolled in the ***4 mRNA and EYA4 protein levels in ICC and adjacent non-tumoral tissues were evaluated using real-time quantitative polymerase chain reaction and immunohistochemical staining,***4 protein levels in ICC cells were determined using western blot *** associations between EYA4 expression and clinicopathologic features of ICC were *** identify independent prognostic factors,univariate and multivariate analyses were *** biological effects of EYA4 on ICC cells were evaluated by establishing stable EYA4-overexpressing transfectants in vitro,and EYA4's effects on tumor growth were evaluated by intra-tumoral injection of EVA4-expressing plasmids in a NOD/SCID murine model of xenograft ***:ICC tissues had significantly lower EYA4 mRNA and protein levels compared with adjacent non-tumoral tissues(both P < 0.001).Univariate and multivariate analyses showed that EYA4 protein level,tumor number,adjacent organ invasion,lymph node metastasis,and tumor differentiation were independent prognostic factors for diseasefree survival and overall survival(all P < 0.05).In vitro,EYA4 overexpression inhibited tumor cell growth,foci formation,and cell *** vivo,intra-tumoral injection of EYA4-expressing plasmids significantly inhibited ICC growth in the murine xenograft model compared with the control group(P < 0.05).Conclusion:EYA4 gene functioned as a molecular prognostic marker in ICC,and its overexpression inhibited tumor growth in vitro and in vivo.

关键词： EYA4 gene Intrahepatic cholangiocarcinoma Prognostic factor Surgical resection Tumor suppressor gene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation

引用

Cancer Communications 2018年第1期38卷 105-119页

作者： Shi-Jing Mo Xun Hou xiao-Yi Hao Jian-Peng Cai Xin Liu Wei Chen Dong Chen xiao-yu yin Department of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-sen UniversityNo.58Zhongshan Er RoadGuangzhou 510080GuangdongP.R.China

Background:Our previous studies demonstrated that eyes absent homolog 4(EYA4),a member of the eye devel-opment-related EYA family in Drosophila,is frequently methylated and silenced in hepatocellular carcinoma(HCC)specimens and associated with shorter *** current work aimed to explore the mechanisms through which EYA4 functions as a tumor suppressor in ***:Stable EYA4-expressing plasmid(pEYA4)transfectants of the human HCC cell lines Huh-7 and PLC/PRF/5(PLC)were *** tumors were established via subcutaneous injection of the stable transfectants into BALB/c nude *** samples were obtained from 75 pathologically diagnosed HCC *** real-time polymerase chain reaction,Western blotting and immunohistochemistry were performed to determine the expression of EYA4 in cell lines,xenografts and clinical *** cell proliferation,colony formation,invasiveness and tumor formation of stable transfectants were studied.A gene expression microarray was utilized to screen genes regulated by EYA4 *** effect of EYA4 on nuclear factor-κB(NF-κB)/RAS-related protein 1(RAP1)signaling was demonstrated through the co-transfection of pEYA4 and Flag-tagged RAS-related protein 1A gene-expressing plasmid(Flag-RAP1A),functional studies,chromatin immunoprecipitation,immunofluorescence staining and cellular ubiquitination ***:The restoration of EYA4 expression in HCC cell lines suppressed cell proliferation,inhibited clonogenic outgrowth,reduced cell invasion and restrained xenograft tumor growth,and Flag-RAP1A reversed the suppressive effects of pEYA4 in *** of NF-κB with tumor necrosis factor-α(TNF-α)increased the binding of p65 to the RAP1A gene promoter and up-regulated RAP1 protein *** inhibition of NF-κB with BAY 11-7085 and p65 siRNA successfully blocked TNF-α-induced RAP1 ***4 antagonized the TNF-α-induced phosphoryla-tion and ubiquitination of inhibitor of NF-κBα(IκB

关键词： Eyes absent homolog 4(EYA4) RAS-related protein 1(RAP1) Nuclear factor-κB(NF-κB) Transactivation Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver synthetic function in predicting the prognosis of pregnancy complicating fulminant hepatitis

引用

Chinese Medical Journal 2007年第24期120卷 2311-2313页

作者： LI xiao-mao DENG Liu-zhi SHEN Hui-min YANG yue-bo LI Meng-xiong CHEN xiao-wei yin yu-zhu ZHOU Shui-sheng Department of Obstetrics and Gynecology Third Affiated Hospital of Sun Yat-sen University Guangzhou 510630 China

Pregnancy complicating fulminant hepatitis is characterized by rapid progress, complicated clinical symptoms, and association with blood coagulation dysfunction, hepatic encephalopathy, hepatorenal syndrome, toxic enteroparalysis and infection. Late pregnancy complicating fulminant hepatitis, which has a high fatality rate, is one of the maior causes of death of gravida and puerperant in China. Searching for exact objective indexes and correct judgement of the prognosis is extremely important to clinical work. The indexes of liver function mainly include （1） indexes for the damage of hepatic cells and its degree such as alanine transaminase （ALT）, etc; （2） indexes for the synthesis function of hepatic cells such as albumin （ALB）, total cholesterol （CHOL）, prothrombin time （PT）, prothrombin activity （PTA）, etc; （3） indexes for the function of liver excretion, metabolism and detoxication such as total bilirubin （TBIL）, total bile acid （TBA）, blood ammonia （NH3）, etc.

关键词： pregnancy fulminant hepatitis liver function prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of the short-term outcomes of robotic-assisted radical resection for perihilar cholangiocarcinoma:a propensity-scored matching analysis

引用

Gastroenterology Report 2023年第1期11卷 254-259页

作者： Xi-Tai Huang Jin-Zhao Xie Jian-Peng Cai Wei Chen Liu-Hua Chen Li-Jian Liang xiao-yu yin Department of Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:The application of robotic-assisted radical resection in perihilar cholangiocarcinoma(pCCA)remains poorly *** study aimed to evaluate the safety and efficacy of robotic-assisted radical resection for pCCA in our ***:Between July 2017 and July 2022,pCCA patients undergoing robotic-assisted and open radical resection at First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)were *** short-term outcomes were compared by using propensity-scored matching(PSM)***:Eighty-six pCCA patients were *** PSM at a ratio of 1:2,10 and 20 patients were assigned to the roboticassisted and open groups,*** were no significant disparities in the clinicopathological features between the two *** robotic-assisted group had significantly longer operation time(median:548 vs 353 min,P=0.004)and larger total number of lymph nodes examined(median:11 vs 5,P=0.010)than the open *** robotic-assisted group tended to have a lower intraoperative blood loss(median:125 vs 350 mL,P=0.067),blood transfusion rates(30.0%vs 70.0%,P=0.056),and post-operative overall morbidities(30.0%vs 70.0%,P=0.056)than the open group,even though the differences were not statistically *** were no significant differences in the negative resection margin,post-operative major morbidities,or post-operative length-of-stay between the robotic-assisted and open groups(all P>0.05).Conclusions:Robotic-assisted radical resection of pCCA may get a larger total number of lymph nodes examined than open *** robotic-assisted surgery may be a feasible and safe technique for selected pCCA patients.

关键词： robotic-assisted surgery perihilar cholangiocarcinoma biliary reconstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The impact of female sex hormones on cardiovascular disease:from mechanisms to hormone therapy

引用

Journal of Geriatric Cardiology 2024年第6期21卷 669-681页

作者： Yi KAN yu-Lu PENG Ze-Hao ZHAO Shu-Tong DONG yin-xiao XU xiao-Teng MA xiao-Li LIU yu-Yang LIU yu-Jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina

Cardiovascular disease remains the leading cause of mortality in women,yet it has not raised the awareness from the *** pathogenesis of cardiovascular disease differs significantly between females and males concerning the effect of sex *** and progestogen impact cardiovascular system through genomic and non-genomic *** menopause,cardiovascular protective effects of estrogens have been well *** were often used in combination with estrogens in hormone *** in sex hormone levels,particularly estrogen deficiency,were considered the specific risk factor in women’s cardiovascular ***,considerable heterogeneity in the impact of hormone therapy was observed in clinical *** heterogeneity is likely closely associated with factors such as the initial time,administration route,dosage,and formulation of hormone *** review will delve into the pathogenesis and hormone therapy,summarizing the effect of female sex hormones on hypertension,pre-eclampsia,coronary heart disease,heart failure with preserved ejection fraction,and cardiovascular risk factors specific to women.

关键词： impact dosage protective

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：