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Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease

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World Journal of Hepatology 2024年第5期16卷 703-715页

作者： Li xu yu-Hong Fan xiao-Jing Zhang Lan Bai State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Gannan Innovation and Translational Medicine Research InstituteGannan Medical UniversityGanzhou 341000China School of Basic Medical Sciences Wuhan UniversityWuhan 430060China

Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary *** complexity stems from genetic predisposition,environmental influences,and metabolic *** processes govern various cellular functions such as transcription,chromatin structure,and cell *** NAFLD,these epigenetic tendencies,especially the process of histone methylation,are intricately intertwined with fat accumulation in the *** methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to *** early-stage NAFLD is reversible,its progression to severe stages becomes almost ***,early detection and intervention in NAFLD are crucial,and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.

关键词： Non-alcoholic fatty liver disease Mechanism Histone methylation Methyltransferases Demethytrasferases Epigenetic modification Adipogenesis

Females adopt sexual catalepsy to facilitate mating

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Current Zoology 2024年第2期70卷 174-181页

作者： Jihe Liu Keke Liu yu Tang Weihua Wang Xiang xu Jianhui Liang Yonghong xiao Mark A.Elgar College of Life Sciences Jinggangshan UniversityJi'anJiangxi 343009China Pharmaceutical Center Tsinghua UniversityBeijing 100084China College of Life Sciences Hunan Normal UniversityChangshaHunan 410081China School of Pharmaceutical Sciences Peking UniversityBeijing 100083China School of BioSciences University of MelbourneMelbourneVictoria 3010Australia School of Life Sciences and Technology Tongii UniversityShanghai 200092China

Theory predicts that males and females of dioecious species typically engage in an evolutionary sexual conflict over the frequency and choice of mating *** sexual cannibalism,a particularly dramatic illustration of this conflict,is widespread in certain animal taxa including ***,females of some funnel weaving spiders that are generally aggressive to conspecifics enter a cataleptic state after male courtship,ensuring the males can mate without risk of *** this study,we demonstrated that the physical posture and duration,metabo-lites,and central neurotransmitters of females of Aterigena aculeata in sexual catalepsy closely resemble females in thanatosis but are distinct from those in anesthesia,indicating that the courted females feign death to eliminate the risk of potentially aggressive responses and thereby allow preferred males to *** the taxonomically widespread thanatosis,which generally represents a deceptive visual signal that acts against the interest of the receivers,sexual catalepsy of females in the funnel weaving spiders may deliver a sexual-receptive signal to the courting males and thereby benefit both the signal senders and ***,sexual catalepsy in *** may not reflect a conflict butrather a confluence of interest betweenthe sexes.

关键词： female catalepsy funnel weaving spiders mate choice mating strategy sexual behavior.

Supramolecular systems for bioapplications:recent research progress in China

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Science China Chemistry 2024年第5期67卷 1397-1441页

作者： yue-Yang Liu xiao-Yong yu yu-Chen Pan Hang Yin Shuang Chao yujie Li He Ma Minzan Zuo Kun-xu Teng Jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang yuxin Pei Zhichao Pei Jiang-Fei xu xiao-yu Hu Chunju Li Qing-Zheng Yang Leyong Wang yu Liu Zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

Constructing inter-diffusive PtCuNi/WO_(3)interface to enhance the catalytic activity and stability in oxygen reduction

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Tungsten 2024年第2期6卷 293-303页

作者： Hao-Zhe xu Dong Li Ying Chen Pin Fang xiao-Xing Ke Olga Demidenko yu-Jing Li Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Scientifi c-Practical Materials Research Centre National Academy of Sciences of Belarus220072 MinskBelarus

Platinum-group-metal-based alloy nanocrystals have been considered as the most effi cient catalysts for oxygen reduction reaction(ORR).However,the poor stability issues limit their further deployment in *** oxide(WO_(3))has received attention due to its intrinsic electrochemical stability and proton absorption/desorption *** this work,we prepared PtCuNi/WO_(3)/C hybrid catalyst with inter-diff usive alloy/WO_(3)interface on *** catalyst exhibits enhanced activity and stability associated with the WO_(3)*** characterization results suggest that the increased activity originates from the complementary proton supply of non-stoichiometric H_(x)WO_(3).Moreover,WO_(3)prevents the particle from dissolution and detachment under vigorous electrochemical *** enhanced stability originates from the electronic interaction established between Pt and *** work provides new strategies to design high-performance ORR catalysts by taking the merits of WO_(3)。

关键词： Tungsten oxide PtCuNi Interface Electronic interaction

Urban spatial cluster structure in metro travel networks:An explorative study of Wuhan using big and open data

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Frontiers of Engineering Management 2024年第2期11卷 231-246页

作者： Longzhu xiao Wangtu xu Department of Urban Planning Xiamen UniversityXiamen 361005China

Rail transit plays a crucial role in improving urban sustainability and *** many Chinese cities,the planning of rail transit routes and stations is focused on facilitating new developments rather than revitalizing existing built-up *** approach reflects the local governments’expectations of substantial growth to reshape the urban ***,existing research on transit-oriented development(TOD)rarely explores the spatial interactions between individual transit stations and investigates how they can be integrated to achieve synergistic effects and balanced *** study proposes that rail transit systems impact urban structure through two“forces”:the provision of additional and reliable carrying capacity and the reduction of travel time between *** passenger flow is used as a proxy for these forces,and community detection techniques are employed to identify the actual and optimal spatial clusters in Wuhan,*** results reveal that the planned sub-centers align reasonably well with the optimal spatial clusters in terms of spatial ***,the actual spatial clusters tend to have longer internal travel times compared to the optimal *** exploration suggests the need for equalizing land use density within planned spatial clusters served by the metro ***,promoting concentrated,differentiated,and mixed functional arrangements in metro station areas with low passenger flows within the planned clusters could be *** paper presents a new framework for investigating urban spatial clusters influenced by a metro system.

关键词： urban spatial clusters metro travel flows land use metro smartcard data Wuhan

Simultaneously enhancing erosion and compression resistance:designing AlCoCrFeNi high-entropy alloy strengthened Ag-based contacts

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Rare Metals 2024年第9期43卷 4476-4492页

作者： xiao-Yang xue Zhe Wang Hui-Ling Nie Zhao yuan Jun Wang Chang-Hu xu Kai Wen Cong-Hao yu School of Materials Science and Engineering Xi’an Polytechnic University School of Physics Xi’an Jiaotong University Key Laboratory of Pulsed Power Technology School of Electrical and Electronic EngineeringHuazhong University of Science and Technology State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and Technology

Designing microstructures and unveiling dynamic erosion mechanisms remain important challenges for Ag-based contacts. To simultaneously enhance erosion and compression resistance, an Al Co Cr Fe Ni high-entropy alloy(HEA) is introduced into Ag-based materials to fabricate novel Ag-HEA contacts with island-and skeletonrestricted microstructures. The arc erosion experimental results reveal that the skeleton-restricted HEA microstructure is the key factor in reducing the hill and crater morphologies of the contact surface, effectively delaying material transfer between the movable and stationary contacts. The molten bridge evolution and compressive deformation behavior of Ag-HEA contacts with various microstructures are investigated using molecular dynamics(MD) simulations. MD results indicate that the constraint of Ag atom diffusion in the molten pool and the involvement of HEA atoms in the molten bridge are the primary mechanisms for improving erosion resistance. The skeleton-restricted HEA microstructure reduces the total energy and structural stability of the molten bridge system and promotes its fracture and disintegration. Moreover, the synergistic effect of the twin and Lomerz–Cottrell lock structures can hinder dislocation glide, generating dispersed and small-area stacking faults in the Ag matrix and mitigating the concentration of shear strains. Thus, the skeleton-restricted HEA microstructure contributes positively to compression resistance. This study presents a novel approach to designing Ag-based contacts.

关键词： Arc erosion Electrical contact materials High entropy alloys Microstructures Molecular dynamics

Influence of oxygen-rich hot air composite gas medium on sintering performance and function mechanism

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Journal of Iron and Steel Research International 2024年第5期31卷 1071-1081页

作者： Min Gan Hao-xiang Zheng xiao-hui Fan Zhi-yun Ji Qiang Li Ming Wu Yi-fan Wang xiao-long Wang yu-feng Wu xu-ling Chen Zeng-qing Sun xiao-xian Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Shanxi Taigang Stainless Steel Co. Ltd.Taiyuan030003ShanxiChina

Hot air sintering technology is used to improve the quality and production efficiency of sintered ***,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering ***,it is considered to use oxygen enrichment sintering to improve the environment of hot air *** sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was *** air reduced the vertical sintering velocity,while improved the yield and tumbler ***-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production *** the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was *** oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.

关键词： Iron ore sintering Hot air sintering Oxygen enrichment Function mechanism

Embracing the age of artificial intelligence:paradigm shifts,opportunities,and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Science China(Life Sciences) 2024年第6期67卷 1302-1304页

作者： Zhuo-yu An xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an important medical development in treating hematological ***,the risk of acute graft-versus-host disease(a GVHD)severely limits its use.a GVHD is a sev... 详细信息

关键词： hematopoietic graft artificial

Clinical analysis of secondary penile cancer:a case series at a tertiary referral center in China

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Asian Journal of Andrology 2024年第2期26卷 225-226页

作者： xiao-yu Li Chun-Ru xu Xing Ji Zhen-Peng Zhu Zhen-Ke Guo Tian-yu Cai Jian Lin Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China

Dear Editor,Secondary penile cancer is an extremely rare condition that refers to the metastasis of other malignancies to the *** are limited reports on secondary penile cancer in Asian populations,and perceptions about this disease are extremely *** reviewed and analyzed the data of patients diagnosed with secondary penile cancer based on the pathological findings at Peking University First Hospital in Beijing,China,aiming to expand the clinical reference for this rare disease.

关键词： cancer rare finding