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Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome

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World Journal of Diabetes 2024年第1期15卷 34-42页

作者： Jie Chen Wan-Chao Zhang xiao-Qiang Tang Ruo-Han Yin Tao Wang xiao-yu wei Chang-Jie Pan Radiology Department The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Radiology Department The People’s Hospital of WuQia CountyWuqia 845450Xinjiang Uygur Autonomous RegionChina

BACKGROUND Cardiovascular disease is a major complication of diabetes mellitus(DM).Type-2 DM(T2DM)is associated with an increased risk of cardiovascular events and mortality,while serum biomarkers may facilitate the prediction of these *** differential diagnosis of T2DM complicated with acute coronary syndrome(ACS)plays an important role in controlling disease progression and improving *** To investigate the correlation of serum bilirubin andγ-glutamyltranspeptidase(γ-GGT)with major adverse cardiovascular events(MACEs)in T2DM patients with *** The clinical data of inpatients from January 2022 to December 2022 were analyzed *** to different conditions,they were divided into the T2DM complicated with ACS group(T2DM+ACS,n=96),simple T2DM group(T2DM,n=85),and simple ACS group(ACS,n=90).The clinical data and laboratory indices were compared among the three groups,and the correlations of serum total bilirubin(TBIL)levels and serumγ-GGT levels with other indices were discussed.T2DM+ACS patients received a 90-day follow-up after discharge and were divided into event(n=15)and nonevent(n=81)groups according to the occurrence of MACEs;Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in *** The T2DM+ACS group showed higherγ-GGT,total cholesterol,low-density lipoprotein cholesterol(LDL-C)and glycosylated hemoglobin(HbA1c)and lower TBIL and high-density lipoprotein cholesterol levels than the T2DM and ACS groups(P<0.05).Based on univariate analysis,the event and nonevent groups were significantly different in age(t=3.3612,P=0.0011),TBIL level(t=3.0742,P=0.0028),γ-GGT level(t=2.6887,P=0.0085),LDL-C level(t=2.0816,P=0.0401),HbA1c level(t=2.7862,P=0.0065)and left ventricular ejection fraction(LEVF)levels(t=3.2047,P=0.0018).Multivariate logistic regression analysis further identified that TBIL level and LEVF level were protective factor for MACEs,and age andγ-GGT

关键词： Acute coronary syndrome Type-2 diabetes mellitus Total bilirubin Major adverse cardiovascular events

Neighbor Sum Distinguishing Chromatic Index of Sparse Graphs via the Combinatorial Nullstellensatz

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Acta Mathematicae Applicatae Sinica 2018年第1期34卷 135-144页

作者： xiao-wei yu yu-ping GAO Lai-hao DING School of Mathematics Shandong University

Let Ф ： E（G）→ {1, 2,…, k}be an edge coloring of a graph G. A proper edge-k-coloring of G is called neighbor sum distinguishing if ∑eЭu Ф（e）≠∑eЭu Ф（e） for each edge uv∈E（G）.The smallest value k for which G has such a coloring is denoted by χ＇Σ（G） which makes sense for graphs containing no isolated edge（we call such graphs normal）. It was conjectured by Flandrin et al. that χ＇Σ（G） ≤△（G）＋ 2 for all normal graphs,except for C5. Let mad（G） = max{（2｜E（H）｜）/（｜V（H）｜）｜HЭG}be the maximum average degree of G. In this paper,we prove that if G is a normal graph with△（G）≥5 and mad（G）〈 3-2/（△（G））, then χ＇Σ（G）≤△（G）＋ 1. This improves the previous results and the bound △（G）＋ 1 is sharp.

关键词： proper edge coloring neighbor sum distinguishing edge coloring maximum average degree Combinatorial Nullstellensatz

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地质勘查和深部地质找矿技术探微

世界有色金属 2024年第15期 55-57页

作者：余飞翔肖宇威周梦阁陈小凡湖北省核工业地质局

随着社会经济的发展和城市化建设的不断深入，我国已迈入全新的发展阶段，这一进程极大地促进了各行业的发展。然而，在此背景下，对矿产资源的需求亦持续攀升，进而凸显了地质勘查与深部地质找矿技术的重要性。因此，需紧密结合实际情... 详细信息

随着社会经济的发展和城市化建设的不断深入，我国已迈入全新的发展阶段，这一进程极大地促进了各行业的发展。然而，在此背景下，对矿产资源的需求亦持续攀升，进而凸显了地质勘查与深部地质找矿技术的重要性。因此，需紧密结合实际情况，合理运用地质勘查与深部地质找矿技术，旨在有效提升勘查质量，以满足经济发展对矿产资源的迫切需求。本文首先概述地质勘查与深部地质找矿技术的基本概念；其次，深入分析其意义与实施原则；最后，提出具体应用这两项技术的措施。

关键词：地质勘查深部找矿技术应用措施

来源：博看期刊

Overview of yeast environmental stress response pathways and the development of tolerant yeasts

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Systems Microbiology and Biomanufacturing 2022年第2期2卷 232-245页

作者： Nai-Xin Lin Yan Xu xiao-wei yu Lab of Brewing Microbiology and Applied Enzymology School of BiotechnologyJiangnan UniversityWuxi 214122China Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Yeast is widely used for industrial production of various types of products,such as ethanol and ***,its fermentation efficiency is strongly reduced by harmful environmental ***,harmful environmental stresses damage important cellular components,such as cell wall,cell membrane,proteins,***,these damages cause cellular metabolic disorders or even *** the past decades,there has been a portfolio of studies on the environmental stress tolerance of yeasts,which mainly aimed at cell damages caused by different environmental stresses,different ways to improve yeast environmental stress tolerance or a tolerance mechanism for certain environmental ***,a comprehensive overview of how yeasts respond to environmental stresses is lacking,and the correlation of tolerance mechanism between different environmental stresses is *** this review,we summarized the general damages induced by most of environmental stresses,the existing major mechanisms of environmental stress tolerance from the perspective of key signalling pathways,and the common ways to improve the resistance to environmental stresses in yeast *** tolerance mechanisms of yeast cells to different environmental stresses are diverse,but sometimes they share the same signalling *** use sensors on the cell surface to recognize environmental stresses and transmit signals to the nucleus to cause changes in gene *** summarizing the main signalling pathways,including MAPK pathway,cAMP/PKA pathway,YAP1/SKN7 pathway,it will provide a powerful reference for future efforts to promote yeast environmental stress tolerance and study yeast tolerance mechanisms.

关键词： Yeast Environmental stress Signalling pathway Protein aggregation

Statistical Optimization of Medium Components for Improved Product Ion of Recombinant Hyperthermophilic Esterase

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Chemical Research in Chinese Universities 2006年第2期22卷 134-138页

作者： REN xiao-dong yu Da-wei HAN Si-ping FENG Yan Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin University Changchun 130021 P. R. China

The optimization of nutrient levels for the production of recombinant hyperthermophilie esterase by E. coli was carried out with response surface methodology（RSM） based on the central composite rotatable design（CCRD）. A 24 central composite rotatable design was used to study the combined effect of the nutritional constituents like yeast extract, peptone, mineral salt and trace metals. The P-value of the coefficient for the linear effect of peptone concentration was 0. 0081 and trace metals solution was less than 0. 0001, suggesting that these were the principal variables with significant effect on the hyperthermophilic esterase production. The predicted optimal hyperthermophilie esterase yield was 269. 17 U/mL, whereas an actual experimental value of 284. 58 U/mL was obtained.

关键词： Optimization Medium components Recombinant hyperthermophilic esterase and response surface methodology

Thermodynamic nature of black holes in coexistence region

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 27-32页

作者： Shao-Wen wei yu-xiao Liu Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory of Quantum Theory and Applications of Mo ELanzhou UniversityLanzhou 730000China Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China

Studying the system state of coexistence regions will peek into to reveal microscopic interactions between different phases of a thermodynamic ***,there is no effective method to study thermodynamic nature of the coexistence black hole regions for the failure of the equation of *** at these coexistence states,in this work,we develop a general approach by introducing two new ratio *** first one is the ratio of the horizon radii of the saturated coexistence small and large black holes,and the second one measures that of the small black hole molecule number to the total molecule *** demonstrate that the first parameter can serve as an order parameter to characterize the first-order phase *** study also shows that the black hole state in the coexistence region is uniquely determined by these two introduced parameters bounded between 0 and *** results are quite significant in the analytical study of phase transition and the microscopic nature of black hole in the coexistence regions.

关键词： transition. state. thermodynamic

Neighbor Sum Distinguishing Edge Coloring of Subcubic Graphs

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Acta Mathematica Sinica,English Series 2017年第2期33卷 252-262页

作者： xiao wei yu Guang Hui WANG Jian Liang WU Gui Ying YAN School of Mathematics Shandong University School of Mathematics Academy of Mathematics and System SciencesChinese Academy of Sciences

A proper edge-k-coloring of a graph G is a mapping from E（G） to {1, 2,..., k} such that no two adjacent edges receive the same color. A proper edge-k-coloring of G is called neighbor sum distinguishing if for each edge uv ∈ E（G）, the sum of colors taken on the edges incident to u is different from the sum of colors taken on the edges incident to v. Let X（G ） denote the smallest value k in such a ＇ G coloring of G. This parameter makes sense for graphs containing no isolated edges （we call such graphs normal）. The maximum average degree mad（G） of G is the maximum of the average degrees of its non-empty subgraphs. In this paper, we prove that if G is a normal subcubic graph with mad（G）〈 5 then x＇（G） ≤ 5. We also prove that if G is a normal subcubic graph with at least two 2-vertices, 6 colors are enough for a neighbor sum distinguishing edge coloring of G, which holds for the list version as well.

关键词： Proper edge coloring neighbor sum distinguishing edge coloring maximum average de-gree subcubic graph planar graph

Prevalence of Three Shrimp Viruses in Zhejiang Province in 2008

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Virologica Sinica 2011年第1期26卷 67-71页

作者： xiao-wei yu Jian-ping Wang wei Zhang Zheng-li Shi Faculty of Life Science and Biotechnology Ningbo University Ningbo 315211China Ningbo Academy of Ocean and Fishery Ningbo 315012 China State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

White spot syndrome virus (WSSV),Taura syndrome virus (TSV) and Infectious hypodermal and haematopoietic necrosis virus (IHHNV) are three shrimp viruses responsible for major pandemics affecting the shrimp farming industry. Shrimps samples were collected from 12 farms in Zhejiang province,China,in 2008 and analyzed by PCR to determine the prevalence of these viruses. From the 12 sampling locations,8 farms were positive for WSSV,8 for IHHNV and 6 for both WSSV and IHHNV. An average percentage of 57.4% of shrimp individuals were infected with WSSV,while 49.2% were infected with IHHNV. A high prevalence of co-infection with WSSV and IHHNV among samples was detected from the following samples:Bingjiang (93.3%),liuao (66.7%),Jianshan (46.7%) and Xianxiang (46.7%). No samples exhibited evidence of infection with TSV in collected samples. This study provides comprehensive information of the prevalence of three shrimp viruses in Zhejiang and may be helpful for disease prevention control in this region.

关键词： Molecular detection White spot syndrome virus (WSSV) Taura syndrome virus (TSV) Infectious hypodermal and haematopoietic necrosis virus (IHHNV)

结直肠癌术后腹腔感染的危险因素及风险模型建立

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中华医院感染学杂志 2024年第9期34卷 1366-1369页

作者：石召强成敏敏于晓卫赵庆美梁海峰东营市东营区人民医院肛肠科山东东营257000 山东省东营市东营区新区医院普外科山东东营257000 东营市利津县中医院药剂科山东东营257447

目的分析结直肠癌术后患者腹腔感染的临床特征及危险因素,并构建风险预测模型。方法选取2020年1月-2022年12月东营市东营区人民医院收治的179例结直肠癌行手术治疗患者,根据术后是否发生腹腔感染分为感染组43例和未感染组136例,回顾性... 详细信息

目的分析结直肠癌术后患者腹腔感染的临床特征及危险因素,并构建风险预测模型。方法选取2020年1月-2022年12月东营市东营区人民医院收治的179例结直肠癌行手术治疗患者,根据术后是否发生腹腔感染分为感染组43例和未感染组136例,回顾性收集患者临床资料,多因素Logistic回归分析结直肠癌患者术后腹腔感染的危险因素,构建风险预测模型并评估其预测价值。结果Logistic回归分析结果显示,合并糖尿病、有低蛋白血症、术后造口、留置引流管时间≥10 d与结直肠癌术后腹腔感染有关(P<0.05);构建的预测模型:Logit(P)=-2.410+合并糖尿病×1.031+低蛋白血症×0.919+术后造口×0.987+留置引流管时间×1.000,Hosmer-Lemeshow拟合优度检验显示模型拟合效果较好(Chi-Square=3.412,P=0.578),校准曲线结果显示,预测概率与实际概率接近,提示该回归模型具有良好的区分、校准和预测能力,受试者工作特征(ROC)曲线分析结果显示,模型预测结直肠癌术后腹腔感染的曲线下面积(AUC)值为0.828。结论结直肠癌术后腹腔感染与合并糖尿病、有低蛋白血症、术后造口、留置引流管时间有关,据此构建的风险预测模型具有较好的预测价值。

关键词：结直肠癌腹腔感染危险因素预测模型诊断价值术后感染