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Optomechanical sensing with on-chip microcavities

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Frontiers of physics 2013年第5期8卷 475-490页

作者： Yi-Wen Hu Yun-Feng xiao yong-Chun liu Qihuang Gong State Key Laboratory for Artificial Microstructure and Mesoscopic Physics School of Physics Peking University Beijing 100871 China

The coupling between optical and mechanical degrees of freedom has been of broad interest for a long time. However, it is only until recently, with the rapid development of optical mierocavity research, that we are able to manipulate and utilize this coupling process. When a high Q microeavity couples to a mechanical resonator, they can consolidate into an optomeehanieal system. Benefitting from the unique characteristics offered by optomeehanical coupling, this hybrid system has become a promising platform for ultrasensitive sensors to detect displacement, mass, force and acceleration. In this review, we introduce the basic physical concepts of cavity optomechanies, and describe some of the most typical experimental cavity optomechanical systems for sensing applications. Finally, we discuss the noise arising from various sources and show the potentiality of optomechanical sensing towards quantum-noise-limited detection.

关键词： optical microcavities mechanical resonators cavity optomechanics optical sensing,integrated photonics

EXPERIMENTAL AND NUMERICAL STUDIES OF AERODYNAMIC PERFORMANCE OF TRUCKS

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Journal of Hydrodynamics 2011年第6期23卷 752-758页

作者： QI xiao-ni liu yong-qi DU Guang-sheng School of Transportation and Vehicle Engineering Shandong University of Technology Zibo 255049 China School of-Energy and Power Engineering Shandong University Jinan 255061 China

This article studies the truck-induced airflow. The results of numerical investigations are used to assess the effectiveness of the installed hash symbol （#） shaped fence on the truck. The Reynolds-averaged Navier-Stokes equations are solved using the finite volume method. The computed distributions of the pressure and the air velocity as well as the computed aerodynamic drag coefficients reveal the effects of a fence on the aerodynamic performance of the truck. It is shown that the hash symbol shaped fence plays its role due to its aerodynamic characteristics, better than those of the original model. For various gaps, the optimal position and height of fences are discussed in the *** experiments in a low speed wind tunnel provide the edidence for validation.

关键词： truck numerical simulation wind tunnel fence

In vitro tissue engineering of lamellar cornea using human amniotic epithelial cells and rabbit cornea stroma

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 425-429页

作者： xiao-yong liu Jian Chen Qing Zhou Jing Wu xiao-Ling Zhang Li Wang xiao-Yan Qin Department of Ophthalmology the First Affiliated Hospital of Jinan University Laboratory of Ophthalmology School of MedicineJinan University

AIM:To reconstruct the lamellar cornea using human amniotic epithelial(HAE) cells and rabbit cornea stroma in vitro using tissue engineering technology.·METHODS:Human amnia taken from uncomplicated caesarean sections were digested by collagenase to obtain HAE cells,and the cells were cultured to *** corneal epithelial cells were removed by n-heptanol to make lamellar matrix *** second passage of HAE cells were cultured on the corneal stroma sheets for 1 or 2 days,then transferred to an air-liquid interface environment to culture for *** engineered lamellar cornea(TELC)morphology was observed by Hematoxylin-eosin(HE)staining;its ultrastructure was observed by transmission electron microscopy(TEM) and scanning electron microscopy(SEM);corneal epithelial cell-specific keratin3 and keratin 12 were detected with immunofluorescence microscopy.·RESULTS:HAE cells grew on the rabbit corneal stroma,forming a monolayer after 1-2 *** 4-5 layers of epithelial cells developed after 2 weeks of air-liquid interface cultivation,a result similar to normal corneal *** corneal stromal cells were significantly reduced after one week,then almost completely disappeared after 2 *** showed desmosomes between the epithelial cells;hemidesmosomes formed between the epithelial cells and the basement *** revealed that the HAE cells which grew on the lamellar cornea had abundant *** tissue-engineered cornea expressed keratin 3 and keratin 12,as detected by immunofluorescence assay.·CONCLUSION:Functional tissue-engineered lamellar corneal grafts can be constructed in vitro using HAE cells and rabbit corneal stroma.

关键词： amniotic epithelial cells cornea tissue engineering keratin

Bevacizumab versus ranibizumab for neovascular agerelated macular degeneration: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 138-147页

作者： Wen-Jie Wang Jian Chen xiao-Ling Zhang Min Yao xiao-yong liu Qing Zhou Yi-Xin Qu Department of Ophthalmology the First Affiliated Hospital of Jinan University

AIM: To systematically compare the efficacy and safety of off-label bevacizumab versus licensed ranibizumab intravitreal injections as well as monthly regimen versus pro re nata [PRN(as needed)] regimen in the treatment of neovascular age-related macular degeneration(n AMD).METHODS: Relevant publications were identified through automatically retrieve of database and manually retrieving. The methodological quality of studies included was assessed using the Jadad score and the risk-of-bias assessment. The efficacy estimates were measured by the weight mean difference(WMD) for the improvement of best-corrected visual acuity(BCVA) and central retinal thickness(CRT) reduction. The safety estimates were measured by odds ratios(OR) for adverse events rates. Statistical analysis was conducted by Revman ***: Seven studies were included in the Metaanalysis. There were no statistically significant differences between bevacizumab and ranibizumab in BCVA at 1 and 2y(P =0.37, P =0.18, respectively),However, both drugs has better BCVA given monthly than given as needed at 1 and 2y(P <0.05). The results demonstrated the mean decrease in CRT was less in bevacizumab group than ranibizumab group at 1y(P <0.05),while the difference was not significant at 2y(P =0.24).Treatment monthly gained much more decrease in CRT at 1 and 2y(P <0.005).There were no differences between drugs in the rates of death, arterial thrombotic events and venous thrombotic events(P =0.41, P =0.55, P =0.10,respectively), while the rates of medical dictionary for regulatory activities(Med DAR) system organ class events and ≥1 systemic serious adverse events were higher in bevacizumab group than ranibizumab group(P <0.05).But the incidences of death, arterial thrombotic events,venous thrombotic events, Med DAR system organ class events as well as ≥1 systemic serious adverse events were not statistically different between both treatment regimens of monthly and as needed(P =0.14, P =0.76,P =0.7

关键词： bevacizumab ranibizumab neovascular age-related macular degeneration Meta-analysis

Effects of resveratrol on ARPE-19 cell proliferation and migration via regulating the expression of proliferating cell nuclear antigen, P21,P27 and p38MAPK/MMP-9

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1725-1731页

作者： xiao-Ning Hao Wen-Jie Wang Jian Chen Qing Zhou Yi-Xin Qu xiao-yong liu Wei Xu Department of Ophthalmology the First Affiliated Hospital of Jinan University Guangzhou 510630 Guangdong Province China Department of Ophthalmology Shenzhen Children's Hospital Shenzhen 518026 Guangdong Province China

AIM： To explore whether resveratrol （Res） can inhibit human retinal pigment epithelial cell （ARPE-19 cell） proliferation and migration, and to research the molecular ***： ARPE-19 cells were pretreated with various concentrations at 0, 50, 100, 150, 200 and 300 μmol/L of Res, and with 0 μmol/L Res as the control for 24, 48 and 72h. The cell proliferation, apoptosis and migration were measured with cell counting kit-8 （CCK-8）, flow cytometry, and wound-healing and Transwell assays, respectively. The expression of proliferating cell nuclear antigen （PCNA）, P21 and P27, as well as matrix metalloproteinase-9 （MMP-9） and p38 mitogen-activated protein kinases （p38MAPK） was identified by Western ***： Cell proliferation was effectively inhibited by Res （P〈0.05）. When pretreated with Res, cells arrested in S-phase increased remarkably （P〈0.05）, but the apoptosis ratios showed no significant difference between the treatment and control groups （P〉0.05）. Cell migration was suppressed by Res both in wound-healing assay and Transwell migration assay （P〈0.05）. Decreases of PCNA, MMP-9 and p38MAPK, as well as increases of P21 and P27 were detected by Western blot （P〈0.05）. CONCLUSION： Res can inhibit APRE-19 cell proliferation and migration in a concentration-dependent manner with up-regulation of the expression of P21 and P27, and down-regulation of PCNA, MMP-9 and p38MAPK.

关键词： retinal pigment epithelium resveratrol cell proliferation cell migration inhibition

Effect of Bensulfuron-Methyl on Growth of Chlorella pyrenoidosa

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Agricultural Sciences in China 2007年第3期6卷 316-321页

作者： YUE Xia-li YU xiao-qing liu yong-hong DONG Yuan-yan College of Basic Science Huazhong Agricultural University Wuhan 430070 P.R.China

To study the growth effects of differing concentrations of bensulfuron-methyl on Chlorella pyrenoidosa and to evaluate the ecological risk, the effects of bensulfuron-methyl on the growth and the content change of chlorophyll and protein in Chlorella pyrenoidosa were studied through 96 h acute toxicity tests. Bensulfuron-methyl accelerated the growth of algae at lower concentrations （〈 1 mg L^-1） with content increase of chlorophyll or protein, and it inhibited the growth of algae at higher concentrations （〉 5 mg L^-1）. The content of chlorophyll or protein in algae cells reduced with the increasing concentration of bensulfuron-methyl, exhibiting the good concentration-effect relationship. The 96 h-EC50 of bensulfuronmethyl upon the algae was 15.7 mg L^-1 Bensulfuron-methyl has inhibiting effect on the growth of Chlorella pyrenoidosa and is low in toxicity.

关键词： Bensulfuron-methyl ChloreUa pyrenoidosa growth chlorophyll protein

Factors affecting the long-term renal allograft survival

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Chinese Medical Journal 2011年第8期124卷 1181-1184页

作者： WANG Wei LI xiao-bei YIN Hang YANG xiao-yong liu Hang REN Liang HU xiao-peng WANG yong ZHANG xiao-dong Department of Urology Beijing Chaoyang Hospital CapitalMedical University Beijing 100020 China

Background In the past decades, the one-year graft survival of cadaveric renal allografts has been markedly improved,but their long-term survival has not kept pace. The attrition rate of renal allografts surviving after one year remains almost unchanged. The causes for late graft loss are multiple. The aim of this study was to analyze the predictive factors that impact long-term survival of grafts after kidney *** We retrospectively analyzed 524 kidney transplantation patients who were treated in our hospital between January 1991 and January 2000, including 254 patients who had lived more than 10 years with normal graft function （long survival group）, and 270 cases whose renal graft had survived less than 10 years （control group）. Specifically, we analyzed 10 factors that may potentially affect graft survival by both univariate and Logistic model multivariate analyses to pinpoint the independent risk *** Univariate analyses showed that no significant differences existed in the age or gender of recipients, dialysis time, lymphotoxin levels, or cold ischemia time between the two groups. However, the ratio of delayed graft function and acute rejection, and the uric acid levels of patients in the long survival group were significantly lower than those in the control group （P ＜0.01）. Furthermore, we found that the concentration of cyclosporin A at one year after transplantation and the histocompatibility antigen match of donor-recipients for patients within the long survival group were significantly higher than those in the control group （P ＜0.01 ）. Furthermore, multivariate analyses showed that these four factors were independent risk factors that impact patient *** The ratios of delayed graft function and acute rejection, the concentration of cyclosporin A at one year after transplantation, and serum uric acid levels are very important factors that affect the long-term survival of renal grafts.

关键词： kidney transplantation long-term survival predictive factors

Activation and involvement of JNK1/2 in hydrogen peroxideinduced neurotoxicity in cultured rat cortical neurons

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Acta Pharmacologica Sinica 2004年第5期25卷 88-94页

作者： Wei WANG, Can GAO, xiao-yu HOU, yong liu, Yan-yan ZONG, Guang-yi ZHANG2Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China Research Center for Biochemistry and Molecular Biology Xuzhou Medical College

AIM: To investigate the role of c-Jun N-terminal protein kinase 1 and 2 (JNK1/2) and the main signal pathway forits activation in hydrogen peroxide (H2O2) induced apoptotic-like cortical cell death. METHODS: Using the modelof oxidative stress induced by H2O2, the expression and diphosphorylation of JNK1/2 was examined by immunoblottinganalysis, and neuronal apoptotic like cell death was determined by 4’,6-diamidino-2-phenylindole (DAPI) ***: The elevation in diphosphorylation level of JNK1/2 (4.40-/5.61-fold vs sham control) was associatedwith the concentration of H2O2 (0-100 mol/L) and the development of apoptotic-like cell death (11.04 %-81.01 %).There was no alteration of JNK1/2 protein expression following H2O2 treatment and recovery at different timepoints. Administration with JNK1/2 antisense oligonucleotides not only significantly decreased JNK1/2 proteinexpression and activation level, but also significantly reduced cortical cell death induced by H2O2 ***, both JNK1/2 diphosphorylation and apoptotic-like cell death were largely prevented by pretreatmentwith (5S,10R)-()-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)or omission of Ca2+ in incubation medium with ethylene glycol-bis(2-aminoethylether)-N,N,N’,N’-tetraacetic acid(EGTA). CONCLUSION: JNK1/2 is activated and participates in H2O2-induced apoptotic-like death in cultured ratcortical neurons mainly via N-methyl-D-aspartate (NMDA) receptor-mediated influx of extracellular Ca2+.

关键词： c-Jun N-terminal protein kinase calcium N-methylaspartate receptors hydrogen peroxide signaltransduction apoptosis cerebral cortex

Vertical transmission of the Yq AZFc microdeletion from father to son over two or three generations in infertile Han Chinese families

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Asian Journal of Andrology 2010年第2期12卷 240-246页

作者： xiao-Bin Zhu Yu-Lin liu Wei Zhang Ping Ping xiao-Rong Cao yong liu Yi-Ran Huang Zheng Li Shanghai Human Sperm Bank Renji Hospital Shanghai Institute of Andrology Shanghai Jiao Tong University School ofMedicine Shanghai 200001 China

This study was carried out to analyze the vertical transmission of Yq AZFc microdeletions from father to son in infertile Han Chinese families to investigate genetic factors and family background affecting fertility *** peripheral blood of infertile males in 19 Han families was extracted and screened with modified multiplex polymerase chain reaction （PCR）. Family trees were drawn according to fertility status and clinical characteristics of the subjects. The vertical transmission of Yq AZFc microdeletions was detected in six cases of 19 investigated families （31.6%,6/19）. Although both fathers and sons showed a similar type of Yq AZFc deletion,the fathers were fertile,whereas the sons were infertile and showed severe oligozoospermia. The vertical transmission of Yq AZFc microdeletion from fertile fathers to infertile sons over generations is not rare. This has different effects on fertility status in fathers and sons in Han Chinese families. Both genetic factors and family background affect spermatogenetic phenotypes.

关键词： infertility microdeletion vertical transmission Y chromosome