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Text Mining and Analysis of Treatise on Febrile Diseases Based on Natural Language Processing

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World Journal of Traditional Chinese Medicine 2020年第1期6卷 67-73页

作者： Kai Zhao Na Shi Zhen sa Hua-Xing Wang Chun-Hua Lu xiao-ying Xu School of Traditional Chinese Medicine Beijing University of Chinese Medicine School of Life Science Beijing University of Chinese Medicine Beijing 100029China

Objective:With using natural language processing (NLP) technology to analyze and process the text of "Treatise on Febrile Diseases (TFDs)"for the sake of finding important information, this paper attempts to apply NLP in the field of text mining of traditional Chinese medicine (TCM)literature. Materials and Methods:Based on the Python language, the experiment invoked the NLP toolkit such as Jieba, nltk, gensim,and sklearn library, and combined with Excel and Word software. The text of "TFDs" was sequentially cleaned, segmented, and moved the stopped words, and then implementing word frequency statistics and analysis, keyword extraction, named entity recognition (NER) and other operations, finally calculating text similarity. Results:Jieba can accurately identify the herbal name in "TFDs." Word frequency statistics based on the word segmentation found that "warm therapy" is an important treatment of "TFDs." Guizhi decoction is the main prescription,and five core decoctions are identified. Keyword extraction based on the term "frequency-inverse document frequency" algorithm is *** accuracy of NER in "TFDs" is about 86%;latent semantic indexing model calculating the similarity,"Understanding of Synopsis of Golden Chamber (SGC)" is much more similar with "SGC" than with "TFDs." The results meet expectation. Conclusions:It lays a research foundation for applying NLP to the field of text mining of unstructured TCM literature. With the combination of deep learning technology,NLP as an important branch of artificial intelligence will have broader application prospective in the field of text mining in TCM literature and construction of TCM knowledge graph as well as TCM knowledge services.

关键词： Knowledge discovery natural language processing text mining traditional Chinese medicine literature treatise on febrile diseases

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动态虚拟患者技术在口腔修复领域的应用进展

中华口腔医学杂志 2024年第3期59卷 267-273页

作者：高雨童撒悦杨静文武汉大学口腔医(学)院修复科、口颌系统重建与再生全国重点实验室、口腔生物医学教育部重点实验室、口腔医学湖北省重点实验室武汉430079 北京大学口腔医学院·口腔医院修复科、国家口腔医学中心、国家口腔疾病临床医学研究中心、口腔生物材料和数字诊疗装备国家工程研究中心、口腔数字医学北京市重点实验室北京100081

随着面部扫描、口内扫描、虚拟面弓、下颌运动轨迹记录等技术在口腔修复领域的发展及应用,动态虚拟患者技术逐渐被应用于口腔修复的术前分析、美学诊断、治疗设计及修复体制作,并成为近年的研究热点。本文从口腔动静态数据获取、动态口... 详细信息

随着面部扫描、口内扫描、虚拟面弓、下颌运动轨迹记录等技术在口腔修复领域的发展及应用,动态虚拟患者技术逐渐被应用于口腔修复的术前分析、美学诊断、治疗设计及修复体制作,并成为近年的研究热点。本文从口腔动静态数据获取、动态口腔虚拟患者的构建、动态口腔虚拟患者的应用优势等方面对动态虚拟患者技术在口腔修复领域中的应用和研究展开综述,以期为相关数字化技术的临床应用提供参考。

关键词：计算机辅助设计牙修复体设计义齿修复术动态虚拟患者

Resection of Intracranial Giant Cavernous Malformation: Case Report and Literature Review

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Surgical Science 2024年第2期15卷 28-35页

作者： Vinicios Rivelli Da Fonseca Cleverson Martins Kill Mariana Alcantara Hugo Fialho Leonnan De sa Oliveira Lucidio Souza Filho Department of Neurosurgery Hospital Santa Rita Belo Horizonte Brazil

Cerebral cavernous malformations are a rare and congenital vascular malformation that can present as a challenge in neurosurgical management. The term “giant cerebral cavernous malformations” still does not have a clear definition in the literature, with a wide variety of results. It is known, however, that there is an association between the size of the cavernoma and postoperative sequelae, especially in those with a size greater than 3 cm in its largest diameter. We present a case report of resection of a giant brain cavernoma measuring approximately 8 cm in its largest diameter, emphasizing on clinical presentation, diagnoses and postoperative evolution. Additionally, we performed a comprehensive review of the existing literature on the subject, addressing the epidemiology, pathophysiology, diagnostic methods, treatment options, and prognosis associated with this condition.

关键词： Cavernous Malformation Cerebral Cavernous Malformation Giant Cavernous Malformation Cavernous Hemangioma Cavernous Angioma Cavernoma Giant Cavernoma

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核级截止阀抗冲击性能数值分析

阀门 2024年第4期 454-459页

作者：查洒洒赵晶沈阳工业大学机械工程学院辽宁沈阳110870

为确保对核级截止阀的抗冲击性能进行全面而准确的评估,以核级截止阀为对象,分别采用动力学设计法(DDAM)和时域模拟法在频域和时域上对核级截止阀进行抗冲击计算分析。首先计算截止阀分别在纵向、垂向和横向三个方向上的频域和时域冲击... 详细信息

为确保对核级截止阀的抗冲击性能进行全面而准确的评估,以核级截止阀为对象,分别采用动力学设计法(DDAM)和时域模拟法在频域和时域上对核级截止阀进行抗冲击计算分析。首先计算截止阀分别在纵向、垂向和横向三个方向上的频域和时域冲击载荷,然后对截止阀的抗冲击特性进行仿真计算,得到截止阀三个方向上的位移及应力分布。两种方法计算结果表明,截止阀的阀体两侧拐角部位是截止阀在冲击载荷下的薄弱部分。同时,截止阀对冲击载荷的响应与冲击加载方向有很大关系,截止阀响应的特性都以横向响应为主,要对横向抗冲击设计重点考虑。

关键词：核级截止阀 DDAM方法时域模拟法抗冲击分析

獐牙菜苦苷、灵仙新苷组分配伍对RA模型大鼠血清学指标及踝关节COX-2的影响

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时珍国医国药 2024年第5期35卷 1034-1040页

作者：郝倩莹高慧琴吴国泰李飒王丽明甘肃中医药大学甘肃兰州730101 中国人民解放军96604部队医院甘肃兰州730031

目的探讨獐牙菜苦苷、灵仙新苷组分配伍对类风湿关节炎(Rheumatoid arthritis,RA)模型大鼠血清学指标及踝关节COX-2的影响。方法选取SPF级SD大鼠5~6周龄36只,雌雄各半。除空白组外,均采用II型胶原诱导法复制(Collagen induced arthritis... 详细信息

目的探讨獐牙菜苦苷、灵仙新苷组分配伍对类风湿关节炎(Rheumatoid arthritis,RA)模型大鼠血清学指标及踝关节COX-2的影响。方法选取SPF级SD大鼠5~6周龄36只,雌雄各半。除空白组外,均采用II型胶原诱导法复制(Collagen induced arthritis,CIA)大鼠模型。将造模成功的30只大鼠按随机数字表法分为模型组、阳性药(正清风痛宁)组、獐牙菜苦苷组、灵仙新苷组、獐牙菜苦苷配伍灵仙新苷组(以下简称“獐-灵配伍组”),每组6只。给药组分别给予相应药液灌胃,模型组和空白组给予等量生理盐水灌胃,连续灌胃10 d。实验中对各组大鼠进行一般状态观察记录、关节炎评分(AI),苏木素-伊红(HE)染色法观察大鼠踝关节组织病理变化;酶联免疫吸附测定法(ELIsa)检测大鼠血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、类风湿因子(RF)、C反应蛋白(CRP)、抗环瓜氨酸肽抗体(anti-CCP Ab)及前列腺素E2(PGE2)含量;免疫组织化学法(Immunohistochemistry)及蛋白免疫印迹法(Western blot)检测大鼠踝关节环氧化酶-2(COX-2)蛋白表达;实时荧光定量聚合酶链式反应法(Real-time PCR)检测大鼠踝关节COX-2基因表达。结果与空白组比较,模型组大鼠一般状态较差,大鼠左后足趾AI评分及血清中TNF-α、IL-1β、RF、CRP、anti-CCP Ab、PGE2含量显著高于其他组(P<0.05或P<0.01);踝关节组织结构严重破坏,COX-2蛋白及基因表达显著上调(P<0.01)。与模型组比较,各给药组大鼠一般状态呈不同程度好转;AI评分明显降低(P<0.01),血清中TNF-α、IL-1β、RF、CRP、anti-CCP、PGE2含量明显降低(P<0.05或P<0.01),其中獐-灵配伍组抑制TNF-α、RF、CRP、anti-CCP、PGE2作用最为突出;獐牙菜苦苷在抑制IL-1β作用最突出。踝关节组织病理状态均有不同程度改善;IHC及WB检测结果显示獐-灵配伍组降低踝关节COX-2蛋白表达水平最为显著(P<0.01);PCR检测结果显示獐牙菜苦苷组降低踝关节COX-2基因表达最为显著(P<0.01)。结论獐牙菜苦苷、灵仙新苷及其配伍对RA模型大鼠能起到良好的治疗作用,其中獐-灵配伍组的治疗效果明显优于各单体给药组;獐牙菜苦苷与灵仙新苷具有明显的协同增效作用,其作用机制可能是通过降低炎性细胞因子的分泌,抑制COX-2蛋白活性而发挥作用。

关键词：獐牙菜苦苷灵仙新苷组分配伍类风湿关节炎 COX-2

Present Status of JT-60sa Project and Development of Heating Systems for JT-60sa

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Plasma Science and Technology 2011年第3期13卷 367-375页

作者： Yoshitaka IKEDA JT-60sa Team Japan Atomic Energy Agency 801-1 Mukoyama Naka Ibaraki 311-0193 Japan

Present status of the JT-60sa （JT-60 Super Advanced） project, implemented jointly by Europe and Japan since 2007, is described. The design of the main tokamak components was completed in late 2008, and all the scientific missions are preserved to contribute to ITER and DEMO reactors. The construction of the JT-60sa has begun with procurement activities for the superconducting magnet systems, vacuum vessel, in-vessel components and other components under the relevant procurement arrangements between the implementing agencies of JAEA （Japan Atomic Energy Agency） in Japan and Fusion for Energy in Europe. Designs and developments of the auxiliary heating systems for JT-60sa have been progressing at JAEA so as to provide the total injection power of 41 MW for 100 s.

关键词： JT-60sa ITER DEMO JAEA heating systems

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温室大棚溶解混施智能施肥机设计与实现

农机化研究 2024年第2期46卷 91-96页

作者：王铁广李文勤陈可飞邢凯肖洒方赛银李明西南林业大学机械与交通学院昆明650224 安徽工程大学电气工程学院安徽芜湖241000

为了实现固体水溶性肥料高效溶解与精准施肥,设计了一种温室大棚溶解混施智能施肥机,主要由肥料搅拌单元、供水单元、吸肥单元及控制单元组成,水肥配比采用模糊PID控制调节方式。首先,依据固体水溶性肥料的自身特点搭建带有肥料搅拌装... 详细信息

为了实现固体水溶性肥料高效溶解与精准施肥,设计了一种温室大棚溶解混施智能施肥机,主要由肥料搅拌单元、供水单元、吸肥单元及控制单元组成,水肥配比采用模糊PID控制调节方式。首先,依据固体水溶性肥料的自身特点搭建带有肥料搅拌装置的施肥设备硬件系统;然后,根据施肥设备混肥特性,建立肥料EC值调控模型,设计PID控制器;最后,采用模糊控制方法自适应调节PID参数,提出模糊PID控制系统设计方法。试验结果表明:使用模糊PID控制策略能够显著提高系统性能,特别是在减少系统滞后时间和保持系统稳定性方面。

关键词：智能施肥机固体水溶性肥料温室率模糊PID控制

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The multi-peak point phenomenon of broadband microwave reflection caused by inhomogeneous plasma

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Plasma Science and Technology 2024年第7期26卷 1-11页

作者：杨敏齐凯旋杨玖文贾飒刘浩岩陈燕扬李瑾李小平 School of Aerospace Science and Technology Xidian UniversityXi’an 710071People’s Republic of China Taiyuan satellite Launch Center Taiyuan 030173People’s Republic of China Beijing Institute of Nearspace Vehicle’s Systems Engineering Beijing 100076People’s Republic of China

During spacecraft re-entry,the challenge of measuring plasma sheath parameters directly contributes to difficulties in addressing communication *** this work,we have discovered a phenomenon of multiple peaks in reflection data caused by the inhomogeneous *** results show that the multi-peak points fade away as the characteristic frequency is approached,resembling a series of gradually decreasing *** positions and quantities of these points are positively correlated with electron density,yet they show no relation to collision *** phenomenon is of significant reference value for future studies on the spatial distribution of plasmas,particularly for using microwave reflection signals in diagnosing the plasma sheath.

关键词： plasma sheath microwave reflection inhomogeneous plasma

司美格鲁肽联合二甲双胍治疗2型糖尿病的疗效及对机体免疫功能的影响

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长春中医药大学学报 2024年第7期40卷 801-804页

作者：肖洒朱书瑶李杰于磊四川大学华西医院临床药学部药剂科成都610041

目的探讨司美格鲁肽(semaglutide)联合二甲双胍(metformin)治疗2型糖尿病(T2DM)的疗效,及其对机体免疫功能的影响。方法本研究纳入120例T2DM患者,将其随机分为观察组和对照组,各60例,分别给予司美格鲁肽联合二甲双胍治疗和二甲双胍口服... 详细信息

目的探讨司美格鲁肽(semaglutide)联合二甲双胍(metformin)治疗2型糖尿病(T2DM)的疗效,及其对机体免疫功能的影响。方法本研究纳入120例T2DM患者,将其随机分为观察组和对照组,各60例,分别给予司美格鲁肽联合二甲双胍治疗和二甲双胍口服治疗。在治疗12周后研究观察2组的临床疗效、体质量、体质量指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)水平以及C反应蛋白(CRP)和免疫球蛋白(IgA、IgG、IgM)水平;评估药物不良反应发生率。结果治疗12周后,2组总有效率具有显著差异(观察组vs对照组:95.0%vs 76.7%,P<0.05);治疗12周后,观察组的糖脂代谢指标(FBG、HbA1c、TC、TG)均得到明显改善,效果优于对照组(P<0.05)。治疗12周后,观察组的CRP和IgA水平降低、IgG和IgM水平提高,差异显著于对照组(P<0.05)。结论司美格鲁肽联合二甲双胍治疗T2DM在临床上表现出显著疗效,不仅改善了血糖控制,还对患者的免疫功能产生积极的影响。

关键词： 2型糖尿病司美格鲁肽二甲双胍免疫