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Sodium butyrate alleviates fructose-induced non-alcoholic fatty liver disease by remodeling gut microbiota to promoteγ-amino butyric acid production

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Food Science and Human Wellness 2024年第2期13卷 961-971页

作者： qu Chen Lei Wu Aijia Zhang Chen Wu Liuping Cai yingping xiao yingdong Ni Key Laboratory of Animal Physiology and Biochemistry Ministry of Agriculture and Rural AffairsNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Managing Biotic and Chemical Threats to the quality and Safety of Agro-products Institute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou 310022China

Sodium butyrate(NaB)can regulate lipid metabolism and inhibit hepatic *** study aimed to investigate whether NaB can alleviate fructose-induced hepat ic steatosis via remodeling the gut microbiota and evaluate the anti-fatty liver *** results showed that NaB and NaB-remodeled gut microbiota significantly alleviated fructose-induced hepatic steatosis and increased plasma uric acid and fructose ***,both NaB and NaB-remodeled gut microbiota increased the abundance of Lactobacillus and altered the levels of plasma amino acids(upregulating gamma-amino butyric acid(GABA)and downregulating L-glutamic acid and L-arginine)in fructose-exposed *** correlation analysis showed that GABA levels positively correlated with Lactobacillus abundance,and increased GABA levels might promote the reduction of the hepatic triglyceride *** studies confirmed that GABA significantly reduced lipid deposition in mouse hepatocytes induced via fructose pretreatment in *** findings suggested that NaB could ameliorate fructose-induced hepatic steatosis by regulating gut microbiota.

关键词： Butyrate Fructose Gut microbiota Hepatic steatosis

Machine learning-based radiomics score improves prognostic prediction accuracy of stage II/III gastric cancer: A multi-cohort study

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 345-356页

作者： ying-Hao Xiang Huan Mou Bo qu Hui-Rong Sun Department of General Surgery Lichuan People's HospitalEnshi 445400Hubei ProvinceChina

BACKGROUND Although accurately evaluating the overall survival(OS)of gastric cancer patients remains difficult,radiomics is considered an important option for studying *** To develop a robust and unbiased biomarker for predicting OS using machine learning and computed tomography(CT)image *** This study included 181 stage II/III gastric cancer patients,141 from Lichuan People's Hospital,and 40 from the Cancer Imaging Archive(TCIA).Primary tumors in the preoperative unenhanced CT images were outlined as regions of interest(ROI),and approximately 1700 radiomics features were extracted from each *** skeletal muscle index(SMI)and skeletal muscle density(SMD)were measured using CT images from the lower margin of the third lumbar *** the least absolute shrinkage and selection operator regression with 5-fold cross-validation,36 radiomics features were identified as important predictors,and the OS-associated CT image radiomics score(OACRS)was cal-culated for each patient using these important *** Patients with a high OACRS had a poorer prognosis than those with a low OACRS score(P<0.05)and those in the TCIA *** and multivariate analyses revealed that OACRS was a risk factor[RR=3.023(1.896-4.365),P<0.001]independent of SMI,SMD,and pathological ***,OACRS outperformed SMI and SMD and could improve OS prediction(P<0.05).CONCLUSION A novel biomarker based on machine learning and radiomics was developed that exhibited exceptional OS discrimination potential.

关键词： Radiomics Machine learning Gastric cancer Skeletal muscle density Skeletal muscle index

Enhanced photoelectrochemical water splitting with a donor-acceptor polyimide

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Frontiers in Energy 2024年第4期18卷 463-473页

作者： Hongyu qu xiaoyu XU Longfei HONG Xintie WANG Yifei ZAN Huiyan ZHANG xiao ZHANG Sheng CHU Key Laboratory of Energy Thermal Conversion and Control of the Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027China

Polyimide(PI)has emerged as a promising organic photocatalyst owing to its distinct advantages of high visible-light response,facile synthesis,molecularly tunable donor-acceptor structure,and excellent physicochemical ***,the synthesis of high-quality PI photoelectrode remains a challenge,and photoelectrochemical(PEC)water splitting for PI has been less ***,the synthesis of uniform PI photoelectrode films via a simple spin-coating method was reported,and their PEC properties were investigated using melamine as donor and various anhydrides as *** influence of the conjugate size of aromatic unit(phenyl,biphenyl,naphthalene,perylene)of electron acceptor on PEC performance were studied,where naphthalene-based PI photoelectrode exhibited the highest photocurrent *** is resulted from the unification of widerange light absorption,efficient charge separation and transport,and strong photooxidation *** paper expands the material library of polymer films for PEC applications and contributes to the rational design of efficient polymer photoelectrodes.

关键词： polyimide(PI)film photoelectrochemistry band structure engineering aromatic unit

Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-Fei qu xiao Ma Lu-Yao Ma xiao-xiao Chen Yu-Qin Wang xiao-Bing Qin Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human *** to challenges in early diagnosis,most patients lose the opportunity for radical treatment when ***,recent advancements in cancer immunotherapy provide new directions for the treatment of *** instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with ***,tumor cells can evade the immune system through various *** the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer *** review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

Migratable Power System Transient Stability AssessmentMethod Based on Improved XGBoost

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Energy Engineering 2024年第7期121卷 1847-1863页

作者： ying qu Jinhao Wang Xueting Cheng Jie Hao Weiru Wang Zhewen Niu Yuxiang Wu Electric Power Science Research Institute State Grid Shanxi Electric Power CompanyTaiyuan030000China Department of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan030024China

The data-driven transient stability assessment(TSA)of power systems can predict online real-time prediction by learning the temporal features before and after ***,the accuracy of the assessment is limited by the quality of the data and has weak *** on this,this paper proposes a method for TSA of power systems based on an improved extreme gradient boosting(XGBoost)***,the gradient detection method is employed to remove noise interference while maintaining the original time series *** this basis,a focal loss function is introduced to guide the training of theXGBoostmodel,enhancing the deep exploration of minority class samples to improve the accuracy of the model ***,to improve the generalization ability of the evaluation model,a transfer learning method based on model parameters and sample augmentation is *** simulation analysis on the IEEE 39-bus system demonstrates that the proposed method,compared to the traditional machine learning-based transient stability assessment approach,achieves an average improvement of 2.16%in evaluation ***,under scenarios involving changes in topology structure and operating conditions,the accuracy is enhanced by 3.65%and 3.11%,***,the model updating efficiency is enhanced by 14–15 times,indicating the model’s transferable and adaptive capabilities across multiple scenarios.

关键词： Transient stability assessment data-driven segmented focusing approximation portability

Changes in posterior corneal elevation after small incision lenticule extraction for different myopic diopters

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 491-498页

作者： xiao-Tong Sun Yang Zhang xiao-Kun Mei Nan-Nan Zheng Ling-Zhi Niu xiao-Li qu Ai-Ping Song Jian Zhuo Department of Ophthalmology the First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina

●AIM:To study the changes and effect factors of posterior corneal surface after small incision lenticule extraction(SMILE)with different myopic diopters.●METHODS:Ninety eyes of 90 patients who underwent SMILE were included in this retrospective *** were allocated into three groups based on the preoperative spherical equivalent(SE):low myopia(SE≥-3.00 D),moderate myopia(-3.00 D>SE>-6.00 D)and high myopia(SE≤-6.00 D).Posterior corneal surfaces were measured by a Scheimpflug camera preoperatively and different postoperative times(1wk,1,3,6mo,and 1y).Posterior mean elevation(PME)at 25 predetermined points of 3 concentric circles(2-,4-,and 6-mm diameter)above the best fit sphere was analyzed.●RESULTS:All surgeries were completed uneventfully and no ectasia was found through the *** difference of myopia group was significant at the 2-mm ring at 1 and 3mo postoperatively(1mo:P=0.017;3mo:P=0.018).The effect of time onΔPME was statistically significant(2-mm ring:P=0.001;4-mm ring:P<0.001;6-mm ring:P<0.001).The effect of different corneal locations onΔPME was significant except 1wk postoperatively(1mo:P=0.000;3mo:P=0.000;6mo:P=0.001;1y:P=0.001).Posterior corneal stability was linearly correlated with SE,central corneal thickness,ablation depth,residual bed thickness,percent ablation depth and percent stromal bed thickness.●CONCLUSION:The posterior corneal surface changes dynamically after *** protrusion is observed on the posterior corneal surface in patients with different degrees of myopia within one year after *** has good stability,accuracy,safety and predictability.

关键词： myopia posterior corneal elevation corneal ectasia small incision lenticule extraction

Time-Periodic Solutions to quasilinear Hyperbolic Systems on General Networks

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 41-72页

作者： Peng qu School of Mathematical Sciences Fudan UniversityShanghai 200433China

For quasilinear hyperbolic systems on general networks with time-periodic boundary-interface conditions with a dissipative structure,the existence and stability of the time-periodic classical solutions are discussed.

关键词： Time-periodic solution quasilinear hyperbolic system General net-work Classical solution Asymptotic stability

Effect of short-time low-temperature austenitizing on microstructure and mechanical properties of DT300 ultra-high strength steel fabricated by laser powder bed fusion

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1763-1777页

作者： Chen-yang Jiang xiao-qiang Li Jin-tao Wang Hao Luo Sheng-qing Gao Sheng-guan qu Chao Yang National Engineering Research Centre of Near-Net-Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640GuangdongChina Institute of New Materials Guangdong Academy of ScienceGuangzhou 510650GuangdongChina

To address the inhomogeneous microstructure and improve the mechanical properties of DT300 ultra-high strength steel specimens fabricated by laser powder bed fusion,different post-heat treatment schedules are *** the increase in austenitizing temperature and time,the migration rate of austenite grain boundaries continuously increases with the dissolution of nano-carbides,and the formation of nano-oxides and twin martensite is also inhibited *** rapid growth in the size of prior austenite grains and martensite laths,as well as the decrease in the content of nano-oxides and twin martensite,led to a rapid decrease in the strength(yield strength and ultimate tensile strength)from HT2 to HTF *** HT1 specimens(austenitizing at 830℃for 30 min,then oil quenching and tempering at 300℃for 120 min and finally air cooling)display excellent mechanical properties of yield strength of 1572 MPa,ultimate tensile strength of 1847 MPa,elongation of 9.84%,and fracture toughness of 106 MPa m^(1/2),which are counterparts to those of conventional DT300 steel forgings after heat treatment.

关键词： DT300 ultra-high strength steel Laser powder bed fusion-Short-time low-temperature austenitizing Microstructure Mechanical property

Effect of inorganic arsenic in paddy soil on the migration and transformation of selenium species in rice plants

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Journal of Environmental Sciences 2024年第9期143卷 35-46页

作者： Ganga Raj Pokhrel Kaiteng Wang Kaiyang ying Yongchen Wu Ze Wang Xi Zhu Can qu Hong Li Fengfu Fu Guidi Yang Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring Key Laboratory for Medicinal Plant Chemistry and Chemical BiologyCollege of JunCao Science and EcologyFujian Agriculture and Forestry UniversityFuzhou 350002China Department of Chemistry Birendra Multiple CampusTribhuvan UniversityChitwan 00977-44200BharatpurNepal Key Laboratory for Analytical Science of Food Safety and Biology of Ministry of Education Fujian Provincial Key Lab of Analysis and Detection for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350116China

Selenium(Se)in paddy rice is one of the significant sources of human Se ***,the effect of arsenic(As)pollution in soil on the translocation of Se species in rice plants is *** this research,a pot experiment was designed to examine the effect of the addition of 50 mg As/kg soil as arsenite or arsenate on the migration of Se species from soil to indica Minghui 63 and *** results showed that the antagonism between inorganic As and Se was closely related to the rice cultivar and Se oxidation state in *** to the standalone selenate treatment,arsenite significantly(p<0.05)decreased the accumulation of selenocystine,selenomethionine and selenate in the roots,stems,sheaths,leaves,brans and kernels of both cultivars by 21.4%-100.0%,40.0%-100.0%,41.0%-100%,5.4%-96.3%,11.3%-100.0% and 26.2%-39.7% respectively,except for selenocystine in the kernels of indica Minghui 63 and selenomethionine in the leaves of indica Minghui 63 and the stems of indica *** also decreased(p<0.05)the accumulation of selenocystine,selenomethionine and selenate in the roots,stems,brans and kernels of both cultivars by 34.9%-100.0%,30.2%-100.0%,11.3%-100.0% and 5.6%-39.6%respectively,except for selenate in the stems of indica Minghui ***,relative to the standalone selenite treatment,arsenite and arsenate decreased(p<0.05)the accumulation of selenocystine,selenomethionine and selenite only in the roots of indica Minghui 63 by 45.5%-100.0%.Our results suggested that arsenite and arsenate had better antagonism toward Se species in selenate-added soil than that in selenite-added soil;moreover,arsenite had a higher inhibiting effect on the accumulation of Se species than arsenate.

关键词： Rice(Oryza sativa L.) Inorganic arsenic Selenium species Translocation Antagonistic effect