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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1438-1452页

作者： Shasha qu yingju Li Bingyu Lu Cuiping Wang Yuansheng Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Guangdong Institute of Special Equipment Inspection and Research Foshan 528251China College of Materials and Fujian Provincial Key Laboratory of Materials Genome Xiamen UniversityXiamen 361005China

The effects of B addition on microstructure and mechanical properties of aγ′-strengthened CoNi-base superalloy are *** addition of B leads to a substantial increase in the volume fraction of both the eutectic structure and *** CoNi-base alloy shows a high solubility limit for the element *** become noticeable in the area surrounding the eutectic structure after the B level exceeds 0.46 at.%.It is found that the compression property and stress rupture life of the 4W2Ta alloys exhibit an initial rise followed by a subsequent drop as the B content gradually increases from 0.08 to 0.78 at.%.The 4W2Ta0.46B alloy demonstrates the most excellent high-temperature strength and stress rupture life,revealing that a moderate amount of B in the alloy noticeably enhances its mechanical properties by enhancing the grain boundary cohesion.

关键词： CoNi-base superalloy Borides Grain boundary Microstructure Mechanical properties

Comparison of life cycle assessment of large-scale biogas projects with different raw materials in China

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 268-279页

作者： Jiazheng Sun Youpei qu xiaoyi Lyu Xinjie Ding Xinying Miao Mukesh Kumar Awasthi Jingbo qu School of Energy and Environment City University of Hong KongHong Kong 999077China College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Agricultural Renewable Resources Utilization Technology and Equipment in Cold Areas of Heilongjiang Province Harbin 150030China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100Shaanxi China

The anaerobic digestion(AD)disposal of stover and cattle manure is of great significance to the development of low-carbon economy and green energy in China,but it will also have an impact on the environment,and the degree of influence is different for various raw *** this study,life cycle assessment(LCA)methods were applied to analyze and compare the impact of corn stovers biogas projects(CSBP)and dairy manure biogas projects(DMBP)on the environment during the whole operation *** results of inventory analysis were evaluated by ReCiPe2016 Hierarchy(H)mid-point(problem-oriented)and end-point(destruction-oriented)method,*** results showed that the net energy efficiency of CSBP was higher(763.903 kW·h/FU)and the greenhouse gas(GHG)emission reduction of DMBP was more(5541.418 kg CO_(2)-eq/FU).The anaerobic digestion(AD)units have the greatest environmental impacts,and human carcinogenic toxicity is the largest environmental impact category(1.16-1.43 PE).The key to reducing environmental impact is reducing the input of chemical substances and the waste of electric *** CSBP and DMBP have a favorable impact on ecosystem quality and resources,and CSBP is more beneficial to the environment(-10.297 Pt).Co-digestion is an important measure to reduce the environmental damage from biogas *** research results provide theoretical support for the selection of raw materials for large-scale biogas projects in China,provide technical basis for reducing the impact of actual operation on the environment,and promote the resource utilization of agricultural waste and carbon dioxide emission reduction and sequestration.

关键词： life cycle assessment environmental impact assessment large-scale biogas projects bioenergy carbon dioxide emission reduction

Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei xiaoyu Jiang Daoyuan Huang ying Jing Shanshan Yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

Earthquake potential across the North–South seismic belt of China

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Science Bulletin 2024年第2期69卷 179-182页

作者： Yanchuan Li Xinjian Shan Chunyan qu Guohong Zhang xiaogang Song State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China

The elastic rebound theory,which frames our understanding of earthquakes,suggests that the accumulated elastic strain on faults will ultimately be released through earthquakes[1].As such,identifying the location,rate,and accumulation of slip deficit on faults constitutes a basis for seismic potential assessment[2].Interseismic coupling(ISC)refers to the ratio of the slip deficit rate on a fault to the far-field loading rate,where full and no coupling correspond to 100%and 0%slip deficits,respectively.

关键词： seismic belt fault

Fault Analysis on AES:A Property-Based Verification Perspective

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Tsinghua Science and Technology 2024年第2期29卷 576-588页

作者： xiaojie Dai Xingxin Wang Xue qu Baolei Mao Wei Hu School of Cybersecurity Northwestern Polytechnical UniversityXi’an 710072China School of Cyber Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Fault analysis is a frequently used side-channel attack for ***,existing fault attack methods usually involve complex fault fusion analysis or computation-intensive statistical analysis of massive fault *** this work,we take a property-based formal verification approach to fault *** derive fine-grained formal models for automatic fault propagation and fusion,which establish a mathematical foundation for precise measurement and formal reasoning of fault *** extract the correlations in fault effects in order to create properties for fault *** further propose a method for key recovery,by formally checking when the extracted properties can be satisfied with partial keys as the search *** results using both unprotected and masked advanced encryption standard(AES)implementations show that our method has a key search complexity of 216,which only requires two correct and faulty ciphertext pairs to determine the secret key,and does not assume knowledge about fault location or pattern.

关键词： side-channel attack fault analysis fault propagation model property extraction fault verification

多值逻辑函数Chrestenson谱的性质

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通信学报 2003年第7期24卷 37-42页

作者：黄晓英李世取张文英信息工程大学信息研究系河南郑州450002

类似于布尔函数Walsh谱的性质,本文得到了两个多值逻辑函数的和函数的Chrestenson循环谱等于这两个多值逻辑函数的Chrestenson循环谱的和的充分必要条件,以及两个多值逻辑函数的和函数的Chrestenson线性谱等于这两个多值逻辑函数的Chres... 详细信息

类似于布尔函数Walsh谱的性质,本文得到了两个多值逻辑函数的和函数的Chrestenson循环谱等于这两个多值逻辑函数的Chrestenson循环谱的和的充分必要条件,以及两个多值逻辑函数的和函数的Chrestenson线性谱等于这两个多值逻辑函数的Chrestenson线性谱的和的充分条件。

关键词：多值逻辑函数 Chrestenson循环谱 Chrestenson线性谱密码学

Digitalizing river aquatic ecosystems

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Journal of Environmental Sciences 2024年第3期137卷 677-680页

作者： Yaohui Bai Hui Lin Chenchen Wang Qiaojuan Wang Jiuhui qu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China School of Environmental and Municipal Engineering Tianjin Chengjian UniversityTianjin 300384China Center for Water and Ecology Tsinghua UniversityBeijing 100084China

Traditional river health assessment relies on limited water quality indices and representative organism activity,but does not comprehensively obtain biotic and abiotic information of the ***,we propose a new approach to evaluate the ecological and health risks of river aquatic ***,detailed physicochemical and biological characterization of a river ecosystem can be obtained through pollutant determination(especially emerging pollutants)and DNA/RNA ***,supervised machine learning can be applied to perform classification analysis of characterization data and ascertain river ecosystem ecology and *** proposed methodology transforms river ecosystem health assessment and can be applied in river management.

关键词： Digitalizing River ecosystem health Emerging pollutants High throughput sequencing Machine learning

The dual-action mechanism of Arabidopsis cryptochromes

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Journal of Integrative Plant Biology 2024年第5期66卷 883-896页

作者： Gao-Ping qu Bochen Jiang Chentao Lin Basic Forestry and Plant Proteomics Research Center Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Chemistry Department of Biochemistry and Molecular BiologyInstitute for Biophysical DynamicsThe University of ChicagoChicagoIL 60637USA

Photoreceptor cryptochromes (CRYs) mediate blue-light regulation of plant growth and development. It has been reported that Arabidopsis CRY1and CRY2 function by physically interacting with at least 84 proteins, including transcription factors or co-factors, chromatin regulators, splicing factors, messenger RNA methyltransferases, DNA repair proteins, E3 ubiquitin ligases, protein kinases and so on. Of these 84 proteins, 47 have been reported to exhibit altered binding affinity to CRYs in response to blue light, and 41 have been shown to exhibit condensation to CRY photobodies. The blue light-regulated composition or condensation of CRY complexes results in changes of gene expression and developmental programs. In this mini-review, we analyzed recent studies of the photoregulatory mechanisms of Arabidopsis CRY complexes and proposed the dual mechanisms of action, including the “Lock-and-Key” and the “Liquid-Liquid Phase Separation (LLPS)” mechanisms. The dual CRY action mechanisms explain, at least partially, the structural diversity of CRY-interacting proteins and the functional diversity of the CRY photoreceptors.

关键词： Arabidopsis blue light cryptochrome CRY1 CRY2 phaseseparation

A novel control strategy for reproducing the floor motions of high-rise buildings by earthquake-simulating shake tables

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Earthquake Research Advances 2024年第1期4卷 67-75页

作者： Yuteng Cao Zhe qu xiaodong Ji Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin150080China Key Laboratory of Civil Engineering Safety and Durability of China Education Ministry Department of Civil EngineeringTsinghua UniversityBeijing100084China

To enable the experimental assessment of the seismic performance of full-scale nonstructural elements with multiple engineering parameters(EDPs),a three-layer testbed named Nonstructural Element Simulator on Shake Table(NEST)has been *** testbed consists of three consecutive floors of steel *** bottom two floors provide a space to accommodate a full-scale *** fully explore the flexibility of NEST,we propose a novel control strategy to generate the required shake table input time histories for the testbed to track the target floor motions of the buildings of interest with high *** control strategy contains two parts:an inverse dynamic compensation via simulation of feedback control systems(IDCS)algorithm and an offline iteration procedure based on a refined nonlinear numerical model of the *** key aspects of the control strategy were introduced in this *** tests were conducted to simulate the seismic responses of a full-scale office room on the 21^(st)floor of a 42-story high-rise *** test results show that the proposed control strategy can reproduce the target floor motions of the building of interest with less than 20%errors within the specified frequency range.

关键词： Shake table test Nonstructural element High-rise building Open-loop IDCS algorithm Off-line iteration

Therapeutic strategies targeting the epidermal growth factor receptor signaling pathway in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2362-2379页

作者： Yi Zhou Shuang Wu Fan-Jie qu Department of Oncology Affiliated Dalian Third People’s Hospital of Dalian Medical UniversityDalian 116033Liaoning ProvinceChina

More than 1.9 million new colorectal cancer(CRC)cases and 935000 deaths were estimated to occur worldwide in 2020,representing about one in ten cancer cases and ***,colorectal ranks third in incidence,but second in *** than half of the patients are in advanced stages at *** options are complex because of the heterogeneity of the patient population,including different molecular *** have included conventional fluorouracil-based chemotherapy,targeted therapy,immunotherapy,*** recent years,with the development of genetic testing technology,more and more targeted drugs have been applied to the treatment of CRC,which has further prolonged the survival of metastatic CRC patients.

关键词： Metastatic colorectal cancer Epidermal growth factor receptor B-type RAF mutation Kirsten rat sarcoma viral oncogene wild type Kirsten rat sarcoma viral oncogene G12C mutation Human epidermal growth factor receptor 2 overexpression/amplification