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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： Dandan Chu Mengyang Zhao Shisong Rong Wonho Jhe xiaolu Cai yi xiao Wei Zhang Xingchen geng Zhanrong Li Xingcai Zhang Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual *** incidence of DED is gradually increasing with the highfrequency use of electronic *** inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from ***,current therapies merely targeting inflammation show the failure of DED ***,a novel dual-atom nanozymes(DAN)-based eye drops are *** antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic *** in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell ***,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious *** findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

Representation learning: serial-autoencoder for personalized recommendation

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Frontiers of Computer Science 2024年第4期18卷 61-72页

作者： yi ZHU yishuai geng Yun LI Jipeng QIANG Xindong WU School of Information Engineering Yangzhou UniversityYangzhou 225127China Key Laboratory of Knowledge Engineering with Big Data(Ministry of Education of the People’s Republic of China) Hefei University of TechnologyHefei 230009China School of Computer Science and Information Engineering Hefei University of TechnologyHefei 230009China

Nowadays,the personalized recommendation has become a research hotspot for addressing information *** this,generating effective recommendations from sparse data remains a ***,auxiliary information has been widely used to address data sparsity,but most models using auxiliary information are linear and have limited *** to the advantages of feature extraction and no-label requirements,autoencoder-based methods have become quite ***,most existing autoencoder-based methods discard the reconstruction of auxiliary information,which poses huge challenges for better representation learning and model *** address these problems,we propose Serial-Autoencoder for Personalized Recommendation(SAPR),which aims to reduce the loss of critical information and enhance the learning of feature ***,we first combine the original rating matrix and item attribute features and feed them into the first autoencoder for generating a higher-level representation of the ***,we use a second autoencoder to enhance the reconstruction of the data representation of the prediciton rating *** output rating information is used for recommendation *** experiments on the MovieTweetings and MovieLens datasets have verified the effectiveness of SAPR compared to state-of-the-art models.

关键词： personalized recommendation autoencoder representation learning collaborative filtering

Charge transfer and excitation processes in low energy collisions of He ions with Li atoms

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Research in Astronomy and Astrophysics 2021年第8期21卷 275-284页

作者： xiao-Xia Wang Kun Wang yi-geng Peng Chun-Hua Liu Ling Liu Yong Wu Heinz-Peter Liebermann Robert J.Buenker yi-Zhi Qu College of Material Sciences and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China Institute of Environmental Science Shanxi UniversityTaiyuan 030006China Department of Applied Physics Nanjing University of Science and TechnologyNanjing 210094China School of Physics Southeast UniversityNanjing 210094China Data Center for High Energy Density Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Fachbereich C-Mathematik und Naturwissenschaften Bergische Universitat WuppertalD-42097 WuppertalGermany

Electron capture between solar wind ions and neutral species has contributed to the understanding of X-ray production from solar system *** charge transfer and excitation processes in solar wind ions of He^(+)(1 s) colliding with Li(1 s^(2)2 s) atoms are studied by utilizing the full quantum-mechanical molecular-orbital close-coupling(QMOCC) method with impact energies of 0.003-2 keV *** of cross sections from single-and multi-configurational calculations for a selfconsistent field(SCF and MCSCF) process are carried *** show that the dominant reaction channels are He(1 s2 l ^(1,3) L)+Li^(+)(1 s^(2) ^(1) S).Good consistency is found among present total and state-selective charge transfer and excitation cross sections with other theoretical and experimental data in the same energy *** to the differences between coupling matrix elements in high-energy states,the charge transfer cross sections calculated from SCF and MCSCF split slightly as E> 0.4 keV *** Stueckelberg oscillations for charge transfer appear in the present *** addition,the differences of cross sections for electron excitation to Li(ls^(2)2 p) in the singlet/triplet molecular states with He+(1 s) are much smaller than those of charge transfer processes because of the similar energy gaps from Li(ls^(2)2 p) to the ground state in singlet/triplet states in the large R region.

关键词： Sun:solar wind ISM:molecules ISM:kinematics and dynamics molecular processes

Prognostic Value of D-Dimer in Patients with Diffuse Large B-cell Lymphoma:A Retrospective Study

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Current Medical Science 2019年第2期39卷 222-227页

作者： Yu-di geng yi-ren CHEN Jin JIN xiao-di WANG Shu ZHANG Deng-ju LI Department of Hematology Tongji HospitalTongji Medical CollegeHua zhong University of Science and TechnologyWuhan 430030China College of Mathematics and Statistics Shenzhen UniversityShenzhen 518060China

This study evaluated the significance of serum D-Dimer for predicting survival of patients with diffuse large B-cell lymphoma(DLBCL).We analyzed the clinical data from 113 patients who were newly diagnosed with DLBCL at Tongji Hospital from January 2012 to January *** results indicated that there were higher levels of D-Dimer in DLBCL patients with the following characteristics:stage HI/IV,lymphocyte monocyte ratio(LMR)upper limit of normal(ULN),albumin(ALB)60 years,stage m/IV,LDH>ULN,LMR*** analysis showed that only LDH>ULN(P=0.038)and age>60 years(P=0.047)were independent adverse prognostic ***,it was suggested that D-Dimer could be regarded as a marker of high tumor burden and a potential prognostic screening tool for patients with DLBCL,not otherwise specified(NOS).

关键词： diffuse large B-cell lymphoma D-Dimer prognosis

Tire pyrolysis wastewater treatment by a combined process of coagulation detoxification and biodegradation

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Environmental Science and Ecotechnology 2021年第4期8卷 94-101页

作者： xiao-ran Shen Chun-Xiang geng Bing-Qian Lv Wei Xu yi Xu Hua-Zhang Zhao Key Laboratory of Water and Sediment Sciences(Ministry of Education) College of Environmental Sciences and EngineeringPeking UniversityBeijing100871People's Republic of China College of Chemistry and Chemical Engineering China University of PetroleumQingdao266555People's Republic of China

Recycling waste tires through pyrolysis technology generates refractory wastewater,which is harmful to the environment if not disposed *** this study,a combined process of coagulation detoxification and biodegradation was used to treat tire pyrolysis *** removal characteristics at the molecular level were investigated using electrospray ionization(ESI)coupled with Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS).The results showed that nearly 90%of the organic matter from the wastewater was removed through the *** of the two coagulants for different classes of organics in tire pyrolysis wastewater was *** covalently bound inorganicorganic hybrid coagulant(CBHyC)used in this work had a complementary relationship with biodegradation for the organics removal:this coagulant reduced toxicity and enhanced the biodegradation by preferentially removing refractory substances such as lignin with a high degree of oxidation(O/C>0.3).This study provides molecular insight into the organics of tire pyrolysis wastewater removed by a combined treatment process,supporting the advancement and application of waste rubber recycling *** also contributes to the possible development of an effective treatment process for refractory wastewater.

关键词： Refractory wastewater Molecular composition Recalcitrant substances Biodegradability ESI FT-ICR MS

Gel electrolytes containing several kinds of particles used in quasi-solid-state dye-sensitized solar cells

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Rare Metals 2006年第z1期25卷 201-206页

作者： geng yi SUN xiaodan CAI Qiang SHI Yantao LI Hengde Laboratory of Advanced Materials Department of Materials Science&EngineeringTsinghua UniversityBeijing 100084China

Composite gel electrolytes containing several kinds of particles used as the quasi-solid-state electrolytes in dye-sensitized solar cells(DSSCs)were *** particles(MCM-41)with unique structures composed of ordered nanochannels were served as a new kind of gelator for quasi-solid-state ***-41,hydrophobic fumed silica Aerosil R972 and TiO_(2)nanopatricles P25 were dispersed into gel electrolytes *** solar energy-to-electricity conversion efficiency of these cells is 4.65%,6.85%and 5.05%respectively under 30 mW·cm^(-2)*** preparation methods and the particles sizes exert an influence on the performance of corresponding solar *** to unique pore structures and high specific BET surface area,mesoporous silica MCM-41 was expected to have the potential to afford conducting nanochannels for redox couple diffusion.

关键词： dye-sensitized solar cells nanocomposite gel electrolyte mesoporous nanoparticle

Specificity-preserving RGB-D saliency detection

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Computational Visual Media 2023年第2期9卷 297-317页

作者： Tao Zhou Deng-Ping Fan geng Chen yi Zhou Huazhu Fu School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of System Control and Information Processing Ministry of EducationShanghaiChina Computer Vision Lab ETH Z¨urichZ¨urichSwitzerland School of Computer Science and Engineering Northwestern Polytechnical UniversityXi’anChina School of Computer Science and Engineering Southeast UniversityNanjingChina Inception Institute of Artificial Intelligence Abu DhabiUnited Arab Emirates

Salient object detection(SOD)in RGB and depth images has attracted increasing research *** RGB-D SOD models usually adopt fusion strategies to learn a shared representation from RGB and depth modalities,while few methods explicitly consider how to preserve modality-specific *** this study,we propose a novel framework,the specificity-preserving network(SPNet),which improves SOD performance by exploring both the shared information and modality-specific ***,we use two modality-specific networks and a shared learning network to generate individual and shared saliency prediction *** effectively fuse cross-modal features in the shared learning network,we propose a cross-enhanced integration module(CIM)and propagate the fused feature to the next layer to integrate cross-level ***,to capture rich complementary multi-modal information to boost SOD performance,we use a multi-modal feature aggregation(MFA)module to integrate the modalityspecific features from each individual decoder into the shared *** using skip connections between encoder and decoder layers,hierarchical features can be fully *** experiments demonstrate that our SPNet outperforms cutting-edge approaches on six popular RGB-D SOD and three camouflaged object detection *** project is publicly available at https://***/taozh2017/SPNet.

关键词： salient object detection(SOD) RGB-D cross-enhanced integration module(CIM) multi-modal feature aggregation(MFA)

Evidence for two types of Aquilegia ecalcarata and its implications for adaptation to new environments

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Plant Diversity 2022年第2期44卷 153-162页

作者： Lei Huang Fang-Dong geng Jing-Jing Fan Wei Zhai Cheng Xue xiao-Hui Zhang yi Ren Ju-Qing Kang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China College of Life SciencesShaanxi Normal UniversityXi'anShaanxi 710119China

Spurs have played an important role in the radiation of the genus Aquilegia,but little is known about how the spurless state arose in *** we aim to characterize the genetic divergence within *** and gain insights into the origin of this species.A total of 19 populations from *** and 23 populations from three of its closest relatives(Aquilegia kansuensis,Aquilegia rockii and Aquilegia yabeana)were sampled in this *** sequenced fifteen nuclear gene fragments across the genome and three chloroplast loci to conduct phylogenetic,PCoA and STRUCTURE *** analyses indicate that *** may not be monophyletic and can be divided into two distinct lineages(***Ⅰand ***Ⅱ).***Ⅰis genetically close to ***,whereas ***Ⅱis close to ***-with-migration analysis suggested that historical gene flow was low between ***Ⅰand ***,as well as between ***Ⅱand *** two distinct lineages of *** show significant divergence in 13 floral traits and also have distinct *** addition,both ***ⅠandⅡare adapted to a stony environment that differs from that of their closest relatives,indicating a habitat shift may have driven new *** findings enrich the understanding of how floral evolution contributes to species diversification.

关键词： Aquilegia ecalcarata Phylogeny Population structure Gene flow Spur loss

Current strategies for preventing the recurrence of hepatocellular carcinoma after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 145-149页

作者： Zhuo-yi Wang Lei geng Shu-Sen Zheng Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND：Liver transplantation is the optimal treatment for a selected group of patients with moderate to severe cirrhosis and hepatocellular carcinoma（HCC）.Despite the strict selection of candidates,post-transplant recurrence often occurs and markedly reduces the long-term survival of patients with *** present review focuses on the current strategies on preventing the recurrence of HCC after liver *** SOURCES： Relevant articles were identified by exten- sive searching of PubMed using the keywords ＂hepatocellular carcinoma＂, ＂recurrence＂ and ＂liver transplantation＂ between January 1996 and January 2014. Additional papers were searched manually from the references in key articles. RESULTS： The current theories of HCC recurrence after liver transplantation are：（i） the growth of pre-transplant occult metastases; （ii） the engraftment of circulating tumor cells released at the time of transplantation. Pre-transplant treatment aims to control local tumor by radiofrequency ablation, transarterial embolization and transarterial chemoembolization. The main objective during the operation is to prevent tumor cell dissemination. Post-transplant treatment includes systemic anticancer therapy, antiviral therapy, and most recently, immunotherapy. These strategies concentrate on the control of the tumor when the patients are waiting for transplant, to reduce the release of HCC cells during surgical procedures and to dear the occult HCC cells after ***： Much can be done to prevent HCC recurrence after liver transplantation. In future, effort is likely to be di- rected towards combining multidisciplinary approaches and various treatment modalities.

关键词： hepatocellular carcinoma recurrence liver transplantation