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TLR4/NF-κB信号通路表达与脑梗死患者并发肺部感染的关联及其危险因素

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中华医院感染学杂志 2024年第7期34卷 978-982页

作者：刘真真张潇王丽娟袁梅江国霞四川省医学科学院·四川省人民医院神经内科四川成都621000 成都天府新区将军碑社区卫生服务中心医技科四川成都621000

目的探讨Toll样受体4(TLR4)/核转录因子-κB(NF-κB)通路表达与脑梗死(CI)患者并发肺部感染的关联及其危险因素和应对措施。方法回顾性分析2020年4月-2023年3月四川省人民医院收治的311例脑梗死患者的临床资料,根据肺部感染情况分为感染... 详细信息

目的探讨Toll样受体4(TLR4)/核转录因子-κB(NF-κB)通路表达与脑梗死(CI)患者并发肺部感染的关联及其危险因素和应对措施。方法回顾性分析2020年4月-2023年3月四川省人民医院收治的311例脑梗死患者的临床资料,根据肺部感染情况分为感染组/非感染组(56例/255例)。比较两组临床资料,采用Logistic分析法分析脑梗死患者并发肺部感染的危险因素;采用免疫印迹法检测血清TLR4、NF-κB表达水平;比较感染组和非感染组TLR4、NF-κB表达水平;采用受试者工作特征(ROC)曲线分析TLR4、NF-κB对脑梗死患者并发肺部感染的诊断价值。结果脑梗死患者并发肺部感染发生率为18.01%(56/311);Logistic回归分析结果显示,年龄≥60岁、有吸烟史、有肺部疾病史、入院时美国卫生研究院卒中量表(NIHSS)评分>14分及C-反应蛋白(CRP)/白蛋白(ALB)比值大均是脑梗死患者并发肺部感染的危险因素(P<0.05);感染组血清TLR4、NF-κB水平比非感染组更高(P<0.05);ROC曲线获得TLR4、NF-κB单独及联合检测诊断脑梗死患者并发肺部感染的AUC值分别为0.783、0.726、0.892;其中,联合诊断的AUC高于各项单独检测(P<0.05),敏感度和特异度为83.90%,78.00%。结论脑梗死患者并发肺部感染发生率较高,且与患者年龄、吸烟史、肺部疾病史、入院时NIHSS评分及CRP/ALB比值有关,肺部感染后可激活TLR4/NF-κB通路;联合检测TLR4、NF-κB有助于诊断脑梗死患者并发肺部感染。

关键词：脑梗死肺部感染危险因素 Toll样受体4 核转录因子-κB 诊断价值受试者工作特征曲线

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中链脂肪酸在疾病辅助治疗中的应用及作用机制研究进展

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食品科学 2024年第4期45卷 344-351页

作者：贾惜文徐嘉杰梁雪岩张慧林昊丁凯丽何颖慧刘烙阳韩鲁佳肖卫华中国农业大学工学院北京100083 宁波大学海洋学院浙江宁波315211

随着消费水平和健康意识的逐渐提高,消费者对于功能性食品的需求不断增加。中链脂肪酸作为一种重要的膳食脂肪,因其具有独特的运输系统,在体内迅速代谢的同时可以产生较高的能量,成为高价值的功能性食品。本文在介绍中链脂肪酸类型和结... 详细信息

随着消费水平和健康意识的逐渐提高,消费者对于功能性食品的需求不断增加。中链脂肪酸作为一种重要的膳食脂肪,因其具有独特的运输系统,在体内迅速代谢的同时可以产生较高的能量,成为高价值的功能性食品。本文在介绍中链脂肪酸类型和结构的基础上,详细阐述其在人体内的代谢途径;同时,总结归纳中链脂肪酸在不同疾病辅助治疗方面的研究案例;此外,重点概述中链脂肪酸在阿尔茨海默症、癫痫、癌症、糖尿病和肥胖等疾病辅助治疗中发挥的积极作用,并明晰其作用机制。最后对中链脂肪酸未来发展前景进行总结展望,以期为中链脂肪酸在食品及医药领域的高效应用及推广提供理论参考。

关键词：中链脂肪酸结构代谢健康疾病辅助治疗

中国季风区降水构成对降水中稳定同位素的影响:以长沙为例

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地球环境学报 2024年第1期15卷 59-68,77页

作者：常昕章新平刘仲藜肖卓勇王迪宙肖雄湖南师范大学地理科学学院长沙410081 湖南师范大学地理空间大数据挖掘与应用湖南省重点实验室长沙410081

降水构成是指对流或平流降水量在总降水量中所占比例,不同的降水构成对降水稳定同位素的丰度会产生重要的影响。基于长沙地区实测的日降水稳定同位素数据和GNIP月降水同位素数据,对不同时间尺度、不同季节时段以及不同降水强度下降水构... 详细信息

降水构成是指对流或平流降水量在总降水量中所占比例,不同的降水构成对降水稳定同位素的丰度会产生重要的影响。基于长沙地区实测的日降水稳定同位素数据和GNIP月降水同位素数据,对不同时间尺度、不同季节时段以及不同降水强度下降水构成对降水中稳定同位素影响的变化特征进行分析和比较,旨在揭示不同的降水构成对降水中稳定同位素影响的差异,深化对季风区降水形成过程中稳定同位素变化规律的认识。结果表明:云中对流强度的差异造成了不同季节对流降水量占总降水量的比例(convective precipitation fraction,CPF)与总降水量之间相关关系的差异。在日和月时间尺度下,在暖半年,CPF随总降水量的增大而减小,而在冷半年,CPF随总降水量的增大而增大。无论是在暖半年还是在冷半年,日时间尺度下长沙站降水中的δ18O随CPF增大不断偏正。在月时间尺度下,包括长沙站在内的中国季风区大部,降水中δ18O与CPF均呈正相关。由于不同季节对流活动的强度不同会造成降水构成的不同,也使得相对于暖半年,冷半年时段降水构成对降水中稳定同位素的影响要强于降水量效应的影响,因此在冷半年长沙地区δ18O—CPF线性回归方程的斜率随降水强度的增大而增大,而在暖半年,δ18O—CPF斜率随降水强度的增大而减小。

关键词：降水构成大气降水稳定同位素时间尺度

Stability analysis for evolutionary variational-hemivariational inequalities with constraint sets

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Science China Mathematics 2022年第7期65卷 1469-1484页

作者： Yi-bin xiao Mou-tao liu Tao Chen Nan-jing Huang School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengdu 611731China College of Mathematics Sichuan UniversityChengdu 610064China

In this paper,we provide the stability analysis for an evolutionary variational-hemivariational inequality in the reflexive Banach space,whose data including the constraint set are ***,by using its perturbed data and the duality mapping,the perturbed and regularized problems for the evolutionary variational-hemivariational inequality are constructed,***,by proving the unique solvability for the evolutionary variational-hemivariational inequality and its perturbed and regularized problems,we obtain two sequences called approximating sequences of the solution to the evolutionary variational-hemivariational inequality,and prove their strong convergence to the unique solution to the evolutionary variationalhemivariational inequality under different mild conditions.

关键词： evolutionary variational-hemivariational inequality L-pseudomonotone duality mapping Mosco convergence smallness condition

Practical construction of globally injective parameterizations with positional constraints

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Computational Visual Media 2023年第2期9卷 265-277页

作者： Qi Wang Wen-Xiang Zhang Yuan-Yuan Cheng Ligang liu xiao-Ming Fu School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

We propose a novel method to compute globally injective parameterizations with arbitrary positional constraints on disk topology *** to this method is the use of a scaffold mesh that reduces the globally injective constraint to a locally flipfree ***,given an initial parameterized mesh containing flipped triangles and satisfying the positional constraints,we only need to remove the flips of a overall mesh consisting of the parameterized mesh and the scaffold mesh while always meeting positional *** successfully apply this idea,we develop two key ***,an initialization method is used to generate a valid scaffold mesh and mitigate difficulties in eliminating ***,edgebased remeshing is used to optimize the regularity of the scaffold mesh containing flips,thereby improving practical *** to state-of-the-art methods,our method is much more *** demonstrate the capability and feasibility of our method on a large number of complex meshes.

关键词： globally injective parameterization constrained parameterization bijection flip-free scaffold mesh

健康信念模式信息传播联合运动干预在血液透析伴衰弱患者康复中的应用效果评价

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中国健康教育 2024年第7期40卷 666-670页

作者：陈灿灿黄维凤陈春丽刘红群徐霞杨晓娟秦晓黎牛世慧李媛媛阚庆贺孙润润合肥市第二人民医院安徽合肥230011

目的评价健康信念模式信息传播联合运动干预在血液透析伴衰弱患者康复中的应用效果。方法采用方便抽样法,选取2022年1—12月合肥市第二人民医院收治的100例血液透析伴衰弱患者为研究对象,按照掷硬币法将其分为对照组和观察组,每组50例... 详细信息

目的评价健康信念模式信息传播联合运动干预在血液透析伴衰弱患者康复中的应用效果。方法采用方便抽样法,选取2022年1—12月合肥市第二人民医院收治的100例血液透析伴衰弱患者为研究对象,按照掷硬币法将其分为对照组和观察组,每组50例。对照组应用常规护理,观察组在对照组基础上应用健康信念模式信息传播联合运动干预。对比2组患者干预前后衰弱状况、躯体功能、骨骼肌质量及体质量指数,采用χ2检验和t检验进行统计分析。结果干预3个月后,观察组中文版蒂尔堡衰弱指标量表得分为(4.51±1.15)分,低于对照组的(5.21±1.24)分(P<0.05);观察组简易机体功能评估得分、握力及步速分别为(9.78±0.86)分、(20.22±1.61)kg和(4.81±1.02)s/4 m,均优于对照组的(8.61±1.13)分、(19.23±2.80)kg、(5.55±1.33)s/4 m(P均<0.05);观察组骨骼肌质量指数、上臂肌围、小腿围和体质量指数分别为(8.01±1.22)kg/m^(2)、(25.86±1.77)cm、(33.61±1.61)cm和(23.84±2.17)kg/m^(2)均高于对照组的(7.35±1.13)kg/m^(2)、(25.01±2.00)cm、(32.74±1.83)cm和(22.66±2.66)kg/m^(2)(P均<0.05)。结论健康信念模式信息传播联合运动干预对衰弱血透患者进行体育锻炼等干预,可显著提高衰弱状态,提高患者躯体功能及肌力情况。

关键词：血液透析伴衰弱健康信念模式信息传播健康教育运动干预

Genesis and mechanisms of organic matter enrichment of the Hongshuizhuang Formation in the Zhoukoudian area of Jingxi sag,North China

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Journal of Palaeogeography 2022年第4期11卷 653-677页

作者： Jin-Hua Zeng xiao-Dong Lan Hao liu Yu-Shuai Wei School of Ocean Sciences China University of GeosciencesBeijing 100083China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China

The Hongshuizhuang Formation is a Meso-Neoproterozoic high-quality source rock in the North China Craton(NCC),comprising abundant organic *** present study focuses on the analysis of the Hongshuizhuang Formation in the Zhoukoudian area of the Jingxi sag,discussing its genesis and mechanisms of organic matter enrichment through geological and geochemical *** Hongshuizhuang Formation is divided into three members from bottom to top respectively as the lower,middle and upper *** elements analysis indicate that the Hongshuizhuang Formation developed restricted neritic facies in an extensional environment within a continental island arc under a post-orogenic *** lower and upper members were deposited in a relatively shallow,strongly retained water mass within a suboxic and saline environment influenced by subhumid climate,while the middle member was deposited in an anoxic deep-water environment with relatively low salinity and weak *** PAAS-normalized rare earth element distributions of the middle and upper members show an enrichment of LREEs and a depletion of HREEs,and a low mean Y/Ho ratio with a positive Eu anomaly,indicating that the regional deposition has been affected by hydrothermal *** negativeδ13 C andδ18 O values and the positive87 Sr/86 Sr values confirm that the deposition of the middle and upper members was accompanied by crustal hydrothermal *** of organic matter and enrichment of Baxsand P indicate that productivity is the basis of organic matter enrichment in the Hongshuizhuang Formation,where high-quality source rocks are concentrated in the middle *** addition,reduced water mass controls the preservation of organic *** activity,humid climate,and salinity support a higher primary productivity and the formation of reduced water ***,due to limitations in depth,the high-quality source rocks in the Jingxi sag are thinner than the Jibei sag.

关键词： Genesis Organic matter enrichment Geochemistry Hydrothermal activity Zhoukoudian area Jingxi sag

Fuzzy optimization design of multicomponent refinery hydrogen network

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Chinese Journal of Chemical Engineering 2022年第8期35卷 125-139页

作者： Chun Deng Xuantong Lu Qixin Zhang Jian liu Jui-Yuan Lee xiao Feng State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and EnvironmentChina University of PetroleumBeijing 102249China PetroChina Daqing Petrochemical Company Daqing 163000China Department of Chemical Engineering and Biotechnology National Taipei University of TechnologyTaipei 10608China School of Chemical Engineering&Technology Xi’an Jiaotong UniversityXi’an 710049China

Hydrogen and light hydrocarbon components are essential resources of the *** optimization of the refinery hydrogen system and recovery of the light hydrocarbon components contained in the gas streams are key strategies to reduce the operating costs for sustainable *** research efforts have been focused on the optimization of single impurity hydrogen network,and the flowrates of the hydrogen sources and sinks are assumed to be ***,their flowrates vary along with the quality of crude oil and refinery processing plans.A general superstructure of multicomponent refinery hydrogen network is proposed,which considers four components,namely H_(2),H_(2)S,CH_(4) and C_(2+),as well as the flowrate variations of hydrogen source and hydrogen *** mathematical model based on the superstructure is developed with objective functions,including the minimization of total annualized cost and the maximization of overall satisfaction of the hydrogen ***,the model considers the removal of hydrogen sulfide and the recovery of light hydrocarbon components(i.e.,C_(2+))in the *** verify the applicability of the proposed mathematical model,a simplified industrial case study with four scenarios is *** optimization results show that the economic benefit can be maximized by considering both the direct reuse of gas streams from high-pressure separator(HP gas stream)and from low-pressure separator(LP gas stream)and the recovery of the light hydrocarbon *** fuzzy optimization method can be used to guide the optimal design of the refinery hydrogen system with multi-period variable flowrates.

关键词： Hydrogen network Mathematical programming Multicomponent Fuzzy optimization Light hydrocarbon recovery

MnBr_(2)catalyzed regiospecific oxidative Mizoroki-Heck type reaction

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Chinese Chemical Letters 2022年第5期33卷 2391-2396页

作者： Xiang Chen Zhihong Zhu Shanshan liu Yi-Hung Chen xiao Shen Institute for Advanced Studies Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationWuhan UniversityWuhan 430072China

Herein, we report an unprecedented regiospecific oxidative Mizoroki-Heck type reaction for the synthesis of α-difluoromethyl homoallylic alcohols. The reaction shows broad substrate scopes and high functional group tolerance. Late-stage functionalization of complex biologically active molecules demonstrates the synthetic potential of this transformation. Mechanistic study supports the involvement of MnBr_(2) catalyzed radical 1,2-silyl transfer.

关键词： Fluoroalkylation Mizoroki-Heck Mn catalysis Radical 1,2-silyl transfer Homoallylic alcohols