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Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity

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Chinese Chemical Letters 2008年第4期19卷 428-430页

作者： Yao liu Jing Su Jun Hai xiao Shi Bo Jiang Hong Lu Wu Zhong Li Li Wang xiao Hong yang Song Li School of Pharmacy Jilin UniversityChangchun 130021China School of Pharmacy Shanghai Jiaotong UniversityShanghai 200240China Institute of Pharmacology and Toxicology Academy of Military Medical SciencesBeijing 100850China Lindsley E Kimball Research Institute The New York Blood CenterNew YorkNY 10021USA

A series of novel benzocycloheptene derivatives have been *** structures were confirmed by MS and ^1H-NMR. These compounds exhibited potent anti-HIV-1 activities.

关键词： HIV-1 entry inhibitors Benzocycloheptene derivatives Synthesis

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刷状草方格固沙障机织工艺与防沙效果研究

中国科学：技术科学 2024年第8期54卷 1601-1610页

作者：屈建军王涛牛清河柳本立谭立海肖建华殷代英南方海洋科学与工程广东省实验室(广州) 广州511458 中国科学院西北生态环境资源研究院干旱区生态安全与可持续发展国家重点实验室兰州730000 西北大学城市与环境学院西安710127

草方格固沙障因其固沙效果好、成本低廉且环保的特点,被认为是中国乃至世界各地防沙治沙的最有效方式,亦被称为“中国魔方”.但长期以来,草方格沙障的施工方法未得到改进,依然需要有经验的工人利用铁锨将麦草扎入沙地中,形成半隐蔽式草... 详细信息

草方格固沙障因其固沙效果好、成本低廉且环保的特点,被认为是中国乃至世界各地防沙治沙的最有效方式,亦被称为“中国魔方”.但长期以来,草方格沙障的施工方法未得到改进,依然需要有经验的工人利用铁锨将麦草扎入沙地中,形成半隐蔽式草方格,这一过程耗时耗力,不能满足当前我国防沙治沙事业提质增效的新时代要求.本文研制了一种将麦草通过机械编织而成的刷状草方格固沙障,使草方格沙障施工效率提高60%以上.通过对刷状草方格固沙障防沙效果开展系统的风洞实验和野外观测研究发现:(1)与传统草方格沙障相同,刷状草方格固沙障内部形成了明显的气流减速区和流向涡旋,沙障顶部出现了明显的抬升气流.当风速低于20 m s^(-1)时,固沙障可使地表风速降低80%以上;(2)刷状草方格与传统草方格沙障对风沙流的扰动作用相同,沙障内输沙率随高度变化不再遵循指数递减规律,输沙率随高度增加先增大后减小,在沙障顶部出现最大值;(3)刷状草方格固沙障固沙效率(Rs)随风速的增大线性减小,但在一般沙漠地区Rs可达到90%以上.刷状草方格有望替代传统草方格固沙障,减轻劳动强度,提高施工效率,为草方格沙障的机械化编织和智能化施工提供技术支撑.

关键词：草方格沙障沙漠化治理风沙流防沙工程风洞实验

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置氢TA10合金焊接接头组织和高温压缩性能

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焊接学报 2024年第8期45卷 79-84,94页

作者：刘全明肖俊峰高斯峰唐文书高松龙伟民西安热工研究院有限公司西安710032 郑州机械研究所有限公司郑州450001

航改燃气轮机焊接修复的钛合金叶片服役于含氢环境中常发生氢脆损伤.试验重点研究了不同置氢量的钛合金氩弧焊接头的微观组织、维氏硬度及氢作用机理、高温压缩性能.结果表明,置氢0.12%(质量分数)焊接接头组织中析出大层片δ氢化物,其... 详细信息

航改燃气轮机焊接修复的钛合金叶片服役于含氢环境中常发生氢脆损伤.试验重点研究了不同置氢量的钛合金氩弧焊接头的微观组织、维氏硬度及氢作用机理、高温压缩性能.结果表明,置氢0.12%(质量分数)焊接接头组织中析出大层片δ氢化物,其尺寸随H元素含量增加而增大,母材、热影响区及焊缝微观组织发生明显改变;置氢0.21%的硬度明显高于其它置氢量,高氢提升焊接接头硬度;低氢时氢固溶强化使α晶粒硬度略提升,高氢时氢化物析出伴随晶格体积膨胀使金属局部塑性变形产生大量位错,位错运动需绕或切过氢化物,导致α晶粒硬度明显提升.压下量对高温压缩流变应力影响有限,再结晶软化作用主要受变形温度控制,随压下量增大,焊缝组织中层片α晶粒连同氢化物沿垂直压下方向被拉长或与压下方向呈一定角度被弯折,氢化物沿层片α晶界生长,热压缩过程中组织再结晶现象不明显.

关键词：钛合金焊接接头置氢微观组织维氏硬度高温压缩性能

Brainstem folding in an influenza child with Dandy-Walker variant

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World Journal of Clinical Cases 2020年第2期8卷 382-389页

作者： Su-Yun Li Pei-Qing Li Wei-Qiang xiao Hong-Sheng liu Si-Da yang Department of Pediatric Emergency Medicine Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina Department of Radiology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina Department of Pediatric Neurology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina

BACKGROUND Influenza in children is a major cause of morbidity and mortality *** system diseases are a factor relating to increased mortality ***, reports of how these underlying diseases contribute to the death of children with influenza are *** SUMMARY A 4-year-old-girl developed type A influenza-related encephalopathy(IAE) with seizures, acute disorder of consciousness, and intracranial hypertension(cerebrospinal fluid pressure: 250 mm H2O), and the Dandy-Walker variant was found by her first magnetic resonance imaging(MRI) when admission. Three days later, she suddenly presented anisocoria, acute pulmonary edema, and coma, and the later MRI found that she had compressed brainstem, oblongata "Zlike folding", and swelling bilateral basal ganglia. After admission, the patient were tested for routine and special biomarkers and underwent neuroimaging and neuroelectrophysiology examinations as well as Oseltamivir and intravenous immunogloblin treatments. When predicting that unstable intracranial structures detected by MRI might have disastrous consequences in the progression of IAE,she was transferred into the pediatric intensive care unit and underwent continuous assessment of clinical condition while she did not have instability of basic vital signs;at the same time, her parents were fully informed about the risk and prognosis. Although she was ultimately dead from brain stem failure, the parents expressed understanding and did not trigger a doctor-patient *** In case of finding an unstable intracranial structure, intensive care should be given to IAE patient and their clinical condition should be monitored continuously.

关键词： Influenza-associated encephalopathy Dandy-Walker variant Predictive intensive care Case report

面向极端事件的配电网差异化韧性供电服务及其定价方法

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电网技术 2024年第10期48卷 4074-4083,I0039,I0040,I0038页

作者：李沛霖刘友波廖红兵许立雄许潇向月刘俊勇四川大学电气工程学院四川省成都市610065 国网四川省电力公司四川省成都市610041

近年来,由极端事件导致的大停电事故给用户的生产生活带来巨大挑战。为解决不同用户对配电网灾后应急供电需求的差异性问题,提出一种面向极端事件的配电网差异化韧性供电服务及其定价方法。首先,基于电网-交通网融合系统提出考虑移动储... 详细信息

近年来,由极端事件导致的大停电事故给用户的生产生活带来巨大挑战。为解决不同用户对配电网灾后应急供电需求的差异性问题,提出一种面向极端事件的配电网差异化韧性供电服务及其定价方法。首先,基于电网-交通网融合系统提出考虑移动储能(mobile energy storage system,MESS)规划与调度的配电网韧性提升方法。然后,基于用户差异化的灾后供电需求设计多种韧性供电等级下的服务定价菜单。最后,为将韧性供电服务的提供与用户需求相匹配,构建韧性供电服务提供与定价双层模型,上层配电网运营商(distribution system operator,DSO)提供差异化的韧性供电服务并设计定价菜单,下层用户结合服务成本与效益订购最佳的韧性供电服务等级。改进混沌模拟退火粒子群算法(chaoticsimulated annealing particle swarm optimization,CSAPSO),结合gurobi求解器迭代寻找模型的均衡解。算例分析表明,所提方法可有效权衡DSO与用户的效益,满足了用户差异化的灾后供电需求,实现双赢。

关键词：极端事件配电网韧性供电服务双层优化模型

Epoxidation of propylene by molecular oxygen over unsupported AgCu_x bimetallic catalyst

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Rare Metals 2015年第7期34卷 477-490页

作者： Xiang Zheng yang-Long Guo Yun Guo Qing Zhang xiao-Hui liu Li Wang Wang-Cheng Zhan Guan-Zhong Lu Key Laboratory for Advanced Materials Research Institute of Industrial Catalysis East China University of Science and Technology

The unsupported Cu and Ag catalysts with different oxidation states were prepared, and their catalytic performances for propylene epoxidation were *** metallic Cu catalyst exhibits much higher catalytic activity and propylene oxide(PO) selectivity than Cu2 O and Cu O *** Cu0 species are the main active sites for propylene epoxidation, but Cu2 O and Cu O species are in favor of CO2 and acrolein *** PO selectivity of 54.2 % and propylene conversion of 2.6 % can be achieved over the metallic Cu catalyst at 160 °C in initial stage, but metallic Cu catalyst would be oxidized to Cu2 O during propylene epoxidation, resulting in a sharp decrease in the PO selectivity and propylene *** Ag Cuxbimetallic catalysts were *** is found that adding Ag to the metallic Cu catalysts can prevent the oxidation of Cu and make Ag Cuxbimetallic catalysts more stable under the condition of propylene *** Ag/Cu molar ratio can remarkably affect the catalytic performance of Ag Cuxcatalyst and the selectivity to PO and *** Ag Cuxwas supported on MOx-modified a-Al2O3, its catalytic performance can be improved and has a close relationship with the acid–base property of support.

关键词： Epoxidation of propylene Propylene oxide Molecular

Quasi-optimal complexity of adaptive finite element method for linear elasticity problems in two dimensions

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Applied Mathematics and Mechanics(English Edition) 2016年第2期37卷 151-168页

作者： Chunmei liu liuqiang ZHONG Shi SHU Yingxiong xiao Institute for Computational Mathematics College of Science Hunan University of Science and Engineering School of Mathematical Sciences South China Normal University School of Mathematics and Computational Science Xiangtan University College of Civil Engineering and Mechanics Xiangtan University

This paper introduces an adaptive finite element method （AFEM） using the newest vertex bisection and marking exclusively according to the error estimator without special treatment of oscillation. By the combination of the global lower bound and the localized upper bound of the posteriori error estimator, perturbation of oscillation, and cardinality of the marked element set, it is proved that the AFEM is quasi-optimal for linear elasticity problems in two dimensions, and this conclusion is verified by the numerical examples.

关键词： linear elasticity problem adaptive finite element method (AFEM) quasioptimal complexity

超声造影联合血清AFP、GGT与GLR对肝细胞癌微血管侵犯的预测价值

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现代生物医学进展 2024年第13期24卷 2467-2472页

作者：林如君杨晓岑李琪虹陈丽旋陈晓丽刘兵温志坚中国人民解放军陆军第七十三集团军医院超声诊断科福建厦门361000 中国人民解放军陆军第七十三集团军医院普通外科/陆军重点培育专科福建厦门361000

目的:分析超声造影(CEUS)联合血清甲胎蛋白(AFP)、γ-谷氨酰转肽酶(GGT)、淋巴细胞计数比值(GLR)对肝细胞癌(HCC)微血管侵犯(MVI)的预测价值。方法:选择2018年10月至2023年10月中国人民解放军陆军第七十三集团军医院行肝切除手术治疗的... 详细信息

目的:分析超声造影(CEUS)联合血清甲胎蛋白(AFP)、γ-谷氨酰转肽酶(GGT)、淋巴细胞计数比值(GLR)对肝细胞癌(HCC)微血管侵犯(MVI)的预测价值。方法:选择2018年10月至2023年10月中国人民解放军陆军第七十三集团军医院行肝切除手术治疗的177例HCC患者,患者均于术前1周行CEUS及血清AFP、GGT、GLR检查。根据术后病理检查MVI结果,将患者分为MVI阳性组(n=52)与MVI阴性组(n=125)。采用多因素Logistic回归分析影响HCC患者MVI的危险因素,受试者工作特征(ROC)曲线分析CEUS联合AFP、GGT、GLR对HCC患者MVI的预测价值。结果:MVI阳性组始增时间、达峰时间、廓清时间短于MVI阴性组(P<0.05)。MVI阳性组AFP、GGT和GLR明显高于MVI阴性组(P<0.05)。多因素Logistic回归分析显示AFP升高、GGT升高、GLR升高、病灶形态不规则、始增时间缩短、达峰时间缩短、廓清时间缩短为HCC患者MVI的独立危险因素(P<0.001)。ROC结果显示:始增时间缩短、达峰时间缩短、廓清时间缩短联合血清AFP、GGT与GLR预测HCC患者MVI的曲线下面积为0.901,明显大于单独检测(P<0.05)。结论:HCC术后MVI患者血清AFP、GGT、GLR升高,始增时间、达峰时间、廓清时间缩短,且为HCC患者MVI的独立危险因素。CEUS联合AFP、GGT、GLR对HCC患者MVI的预测价值较高。

关键词：肝细胞癌超声造影甲胎蛋白 γ-谷氨酰转肽酶淋巴细胞计数比值微血管侵犯

Recent Advances and Progress for the Fabrication and Surface Modification of AIE-active Organic-inorganic Luminescent Composites

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Chinese Journal of Polymer Science 2019年第4期37卷 340-351,I0005页

作者： liu-Cheng Mao xiao-Yong Zhang Yen Wei Department of Chemistry Nanchang University Department of Chemistry and the Tsinghua Center for Frontier Polymer Research Tsinghua University Department of Chemistry and Center for Nanotechnology and Institute of Biomedical Technology Chung-Yuan Christian University

Organic dyes based hybrid organic-inorganic luminescent nanomaterials with high quantum efficiency, good physical or chemical stability, and favorable biocompatibility, have attracted growing attention recently because of their important applications in the areas of biomedical imaging, chemical sensors, and light-emitting diodes(LEDs). Nevertheless, conventional fluorescence molecules suffer from aggregation-caused quenching(ACQ) when they are doped into inorganic nanomaterials. Aggregation-induced emission(AIE) is an abnormal and intriguing fluorescent phenomenon that has aroused increasing interest for various applications especially in biomedical fields. Compared with conventional organic dyes, the AIE-active molecules will emit more intense fluorescence in their aggregates or solid states. It provides an elegant route to overcome the drawbacks of conventional organic molecules. Over the past few decades, the fabrication and surface modification of various organic-inorganic luminescent composites doped with AIE-active molecules have been reported. Therefore, it is highly desirable to summarize these advances. In this review, recent advances and progress in constructing various AIEgens-doped organic-inorganic hybrid nanocomposites and their subsequent surface modification were summarized. We hope this review could further promote the research of AIE-active functional materials.

关键词： Aggregation-induced emission Organic-inorganic luminescent composites Surface modification Biomedical applications