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Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： Yi-Long Wang Meng-Ying Zhu Zhe-Feng Yuan xiao-yan ren xiao-Tong Guo Yi Hua Lu Xu Cong-Ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia Sheng Pei-Fang Jiang Zheng-yan Zhao Feng Gao Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

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Rotating Massive Strangeon Stars and X-Ray Plateau of Short GRBs

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Research in Astronomy and Astrophysics 2024年第3期24卷 47-57页

作者： Xi-yan yang xiao-Yu Lai Wei-Wei Tan ren-Xin Xu School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhou 434023China Research Center for Astronomy Hubei University of EducationWuhan 4300205China Key Laboratory of Quark and Lepton Physics Central China Normal UniversityMinistry of EducationWuhan 430079China School of Physics Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

Strangeon stars,which are proposed to describe the nature of pulsar-like compact stars,have passed various observational *** maximum mass of a non-rotating strangeon star could be high,which implies that the remnants of binary strangeon star mergers could even be long-lived massive strangeon *** study rigidly rotating strangeon stars in the slowly rotating approximation,using the Lennard-Jones model for the equation of *** can significantly increase the maximum mass of strangeon stars with unchanged baryon numbers,enlarging the mass-range of long-lived strangeon *** spin-down after merger,the decrease of radius of the remnant will lead to the release of gravitational *** into account the efficiency of converting the gravitational energy luminosity to the observed X-ray luminosity,we find that the gravitational energy could provide an alternative energy source for the plateau emission of X-ray *** fitting results of X-ray plateau emission of some short gamma-ray bursts suggest that the magnetic dipole field strength of the remnants can be much smaller than that of expected when the plateau emission is powered only by spin-down luminosity of magnetars.

关键词： dense matter-(stars) pulsars general-(stars) gamma-ray burst general

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Luminescent nanoscale metal–organic frameworks for chemical sensing

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Chinese Chemical Letters 2015年第12期26卷 1439-1445页

作者： xiao-yan ren Le-Hui Lu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Metal–organic frameworks（MOFs） are a fascinating class of crystalline materials constructed from selfassembly of metal cations/clusters and organic ligands. Both metal and organic components can be used to generate luminescence, and can further interact via antenna effect to increase the quantum yield,providing a versatile platform for chemical sensing based on luminescence emission. Moreover, MOFs can be miniaturized to nanometer scale to form nano-MOF（NMOF） materials, which exhibit many advantages over conventional bulk MOFs in terms of the facile tailorability of compositions, sizes and morphologies, the high dispersity in a wide variety of medium, and the intrinsic biocompatibility. This review will detail the development of NMOF materials as chemical sensors, including the synthetic methodologies for designing NMOF sensory materials, their luminescent properties and potential sensing applications.

关键词： luminescent nanometer luminescence crystalline facile sizes fascinating microemulsion nucleation encapsulation

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A new method for evaluating wedges of steel plates and strips

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1719-1735页

作者： xiao-bao Ma xiao-xin Ma Tao Wang Zhong-kai ren Yu-cheng ren College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Ministry of Education Engineering Research Center of Advanced Metal Composite Forming Technology and Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina China National Heavy Machinery Research Institute Co. Ltd.Xi'an 710018ShaanxiChina Faculty of Mechanical Engineering Hebei University of ArchitectureZhangjiakou 075000HebeiChina

To overcome the inaccuracy problem of the traditional wedge evaluation of steel plates and strips caused by the ran-domness of the thicknesses of two local points and improve the reliability of the wedge index,the double-centroid method for the wedge evaluation was proposed,and a model based on the centroid theory was ***,an integral model for the discrete thickness values of the cross-section profiles was *** discussion focused on the distinct characteristics of the two-point method,asymmetric method,and double-centroid method in evaluating the asymmetric distribution of *** three methods were employed to evaluate the wedge values of both the theoretical and measured cross-sections of steel plates and strips,and the accuracies of three wedge evaluation models were analyzed and *** results showed that the double-centroid method objectively reflects the degree and variation characteristics of the wedge values of the cross-sections of steel plates and strips,and this method is feasible,reliable,and outstanding.

关键词： Steel plate and strip Wedge Two-point method Double-centroid method Reliability

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Experimental Study on Vortex-Induced Vibration of Rough Risers Coupling with Interference Effect in Tandem Arrangement

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China Ocean Engineering 2024年第3期38卷 394-407页

作者： HU Ze-bo LIU Zhen LI Peng GUO Hai-yan ren xiao-hui HOU Hao HAO Lian-hong College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China

In order to study the response law of vortex-induced vibration(VIV)of marine risers under the combined action of roughness and interference effects,and to reveal the coupling mechanism of roughness and interference effects on the riser,a VIV experiment of rough risers in tandem arrangement was conducted in a wave−current combined *** experiment characterized the risers’roughness by arranging different specifications of attachments on the surface of the *** rough risers with different roughness and smooth risers were arranged in tandem arrangement,with the rough risers arranged *** experimental results indicate that the suppression of the attachments on the downstream risers’vibration are more significant both in the CF and IL directions as the reduced velocity *** the downstream riser,the amplitude response of rough riser is more significantly weakened compared with the smooth one at high reduced *** the upstream risers,changes in the roughness and spacing ratio have an impact on their‘lock-in’*** the roughness of downstream risers is relatively large(0.1300)and the spacing between risers is small(S/D=4.0),the reduced velocity range of‘lock-in’region in the CF direction of upstream risers is obviously expanded,and the displacement in the‘lock-in’region is severer.

关键词： marine riser vortex-induced vibration tandem arrangement roughness interference effect

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Effects of microplastic polystyrene,simulated acid rain and arbuscular mycorrhizal fungi on Trifolium repens growth and soil microbial community composition

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Pedosphere 2024年第2期34卷 424-437页

作者： Wanlin LI yan xiao College of Agro-grassland Science Nanjing Agricultural UniversityNanjing 210095China

Microplastic pollution is a global and ubiquitous environmental problem in the oceans as well as in the terrestrial *** examined the fate of microplastic polystyrene(MPS)beads in experimental soil in the presence and absence of symbiotic arbuscular mycorrhizal fungi(AMF)and simulated acid rain(SAR)to determine whether the combinations of these three factors altered the growth of white clover Trifolium *** found that MPS,SAR,or AMF added singly to soil did not alter *** growth or *** contrast,MPS and AMF together significantly reduced shoot biomass,while SAR and MPS together significantly reduced soil available phosphorus independent of AMF *** polystyrene,AMF,and SAR together significantly reduced soil NO_(3)^(-)-*** mycorrhizal fungi added singly also enriched the beneficial soil bacteria(genus Solirubrobacter),while MPS combined with AMF significantly enriched the potential plant pathogenic fungus *** mycorrhizal fungi inoculation with MPS increased the abundance of soil hydrocarbon degraders independent of the presence of *** addition,the abundance of soil nitrate reducers was increased by MPS,especially in the presence of AMF and ***,SAR alone increased the abundance of soil pathogens within the fungal community including antibiotic *** findings indicate that the coexistence of MPS,SAR,and AMF may exacerbate the adverse effects of MPS on soil and plant health.

关键词： acid deposition arbuscular mycorrhizal fungi symbiosis hydrocarbon degradation microbial alpha diversity microplastic pollution pathogen

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Morphogenesis of Pistillate Flowers of Cercidiphyllum japonicum(Cercidiphyllaceae)

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Journal of Integrative Plant Biology 2007年第9期49卷 1400-1408页

作者： xiao-Ling yan Yi ren Xian-Hua Tian xiao-Hui Zhang College of Life Sciences Shaanxi Normal University Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education Xi'an 710062 China

Floral morphogenesis and the development of Cercidiphyllumjaponicum Sieb. et Zucc. were observed by scanning electron microscopy （SEM）. The results showed that the pistillate inflorescences were congested spikes with the flowers arranged opposite. Great differences between the so-called ＂bract＂ and the vegetative leaf were observed both in morphogenesis and morphology. In morphogenesis, the ＂bract＂ primordium is crescent-shaped, truncated at the apex and not conduplicate, has no stipule primordium at the base but does have some inconspicuous teeth in the margin that are not glandular. The leaf primordium is triangular, cycloidal at the apex, conduplicate, has two stipule primordia at the base, has one gland-tooth at the apex occurring at first and some gland-teeth in the margin that occur later. In morphology, the ＂bract＂ is also different to the vegetative leaf in some characteristics that were also illustrated in the present paper. Based on the hypothesis that the bract is more similar to the vegetative leaf than the tepal, we considered that the so-called ＂bract＂ of *** might be the tepal of the pistillate flower in morphological nature. Therefore, each pistillate flower contains a tepal and a carpel. We did not find any trace of other floral organs in the morphogenesis of the pistillate flower. Therefore we considered that the unicarpellate status of extant Cercidiphyllum might be to highly reduce and advance characteristics that make the extant Cercidiphyllum isolated from both fossil Cercidiphyllum-like plants and its extant affinities.

关键词： Cercidiphyllumjaponicum leaf morphogenesis pistillate flower tepal.

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Experimental Study on Vortex-Induced Vibration of Rough Risers with Coupling Interference Effect Under Side-by-Side Arrangement

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China Ocean Engineering 2024年第1期38卷 18-28页

作者： HU Ze-bo LIU Zhen LI Peng GUO Hai-yan WANG Shu-bing ren xiao-hui HOU Hao WANG Ye-shuo College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China CHEC Dredging Co. LtdShanghai 200136China

A vortex-induced vibration(VIV)experiment of rough risers with coupling interference effect under a side-by-side arrangement was carried out in a wave-current combined *** roughness of the riser was characterized by arranging different specifications of surface attachments on the surface of the *** risers with three different roughnesses were arranged side by side with smooth risers to explore the VIV response of the riser under the combined action of roughness and interference effect,and to reveal the coupling mechanism between roughness and interference *** experimental results show that,compared with that of a smooth riser,the VIV of a rough riser under the coupling interference effect has a wider"lock-in"region,and the displacement decreases more significantly at a high reduced velocity,which is more likely to excite higher-order modes and frequency *** addition,the displacement response and frequency response of the smooth riser are not significantly affected by wake interference from the rough riser,which is caused by the decrease of the wake region due to the delay of the boundary layer separation point of the rough riser.

关键词： marine riser vortex-induced vibration side-by-side arrangement roughness interference effect

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Numerical Simulation of Rainfall-induced Xianchi Reservoir Landslide in Yunyang,Chongqing,China

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 505-517页

作者： yan Jinkai MA yan LIU Lei WANG Zhihui ren Tianxiang Chinese Academy of Geological Sciences Beijing 100037China Urban Construction School Beijing City UniversityBeijing 100083China

A calamitous landslide happened at 22:00 on September 1,2014 in the Yunyang area of Chongqing City,southwest China,enforcing the evacuation of 508 people and damaging 23 *** landslide volume comprised 1.44 million m^(3) of material in the source area and 0.4 million m^(3) of shoveled *** debris flow runout extended 400 m vertically and 1600 m *** Xianchi reservoir landslide event has been investigated as follows:(1)samples collected from the main body of landslide were carried out using GCTS ring shear apparatus;(2)the parameters of shear and pore water pressure have been measured;and(3)the post-failure characteristics of landslide have been analyzed using the numerical simulation *** excess pore-water pressure and erosion in the motion path are considered to be the key reasons for the long-runout motion and the scale-up of landslides,such as that at Xianchi,were caused by the heavy *** aim of this paper is to acquired numerical parameters and the basic resistance model,which is beneficial to improve simulation accuracy for hazard assessment for similar to potentially dangerous hillslopes in China and elsewhere.

关键词： geohazards landslide post-failure rapid and long runout ring shear test

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High-throughput screening of single-atom catalysts confined in monolayer black phosphorus for efficient nitrogen reduction reaction

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Nano Research 2024年第4期17卷 2360-2367页

作者： xiao-yan Li Manyi Duan Pengfei Ou Department of Electrical and Computer Engineering University of TorontoTorontoOntario M5S 1A4Canada School of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610101China Department of Chemistry Northwestern UniversityEvanstonIL 60208USA

The discovery of metal-nitrogen centers as the active sites for electrolysis has aroused significant interest in utilizing single-atom catalysts for nitrogen reduction reaction(NRR).Properly designed nanostructured catalysts that strongly interact with nitrogen molecules(N_(2))can promote adsorption and activation,thereby resulting in efficient catalysts with high stability,activity,and *** this study,using density functional theory calculations,we selected monolayer black phosphorus(BP)as the substrate and screened a series of single-atom transition metals confined in tri-coordinated and tetra-coordinated active centers(without and with N dopants)to electro-catalyze *** a result,we have identified two promising candidates(Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4)),which exhibit not only low overpotentials of 0.56 and 0.49 V but also high thermodynamic and electrochemical stability,as well as good selectivity towards NRR over the competing hydrogen evolution *** also demonstrate the ability of Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4) to activate and hydrogenate N_(2) by donating electrons and regulating charge *** study not only predicts new BP-based promising catalysts but also provides guidance for the rational design of high-performance NRR electrocatalysts under ambient conditions.

关键词： N_(2) electroreduction reaction single-atom catalysts black phosphorus density functional theory high-throughput calculations

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