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Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

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Asian Journal of Andrology 2024年第4期26卷 426-432页

作者： Yu-Fan Yang Hai-Lu ma Xi wang Min Nie Jiang-Feng mao xue-Yan Wu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China.

Fibroblast growth factor receptor 1(FGFR1)mutations are associated with congenital hypogonadotropic hypogonadism(CHH)through inheritance or spontaneous *** detected FGFR1 mutations in a Chinese cohort of 210 CHH patients at Peking Union Medical College Hospital(Beijing,China)using next-generation and Sanger *** assessed missense variant pathogenicity using six bioinformatics tools and compared clinical features and treatment outcomes between inherited and de novo mutation *** 19 patients with FGFR1 mutations,three were recurrent,and 16 were novel *** of the novel mutations were likely pathogenic according to the American College of Medical Genetics and Genomics(ACMG)guidelines,with the prevalent P366L *** majority of FGFR1 mutations was inherited(57.9%),with frameshift mutations exclusive to the de novo mutation *** inherited mutation group had a lower incidence of cryptorchidism,short stature,and skeletal *** the inherited mutation group,luteinizing hormone(LH)levels were 0.5 IU l−1,follicle-stimulating hormone(FSH)levels were 1.0 IU l−1,and testosterone levels were 1.3 nmol l−*** contrast,the de novo group had LH levels of 0.2 IU l−1,FSH levels of 0.5 IU l−1,and testosterone levels of 0.9 nmol l−1,indicating milder hypothalamus–pituitary–gonadal axis(HPGA)functional deficiency in the inherited *** inherited mutation group showed a tendency toward higher spermatogenesis *** conclusion,this study underscores the predominance of inherited FGFR1 mutations and their association with milder HPGA dysfunction compared to de novo mutations,contributing to our understanding of the genetic and clinical aspects of FGFR1 mutations.

关键词： congenital hypogonadotropic hypogonadism de novo FGFR1 inherited

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mapping soil organic matter in cultivated land based on multi-year composite images on monthly time scales

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Journal of Integrative Agriculture 2024年第4期23卷 1393-1408页

作者： Jie Song Dongsheng Yu Siwei wang Yanhe Zhao Xin wang lixia ma Jiangang li State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Agricultural and Rural Bureau of Luanping County Luanping 068250China Chinese Academy of Sciences University Beijing 100049China

Rapid and accurate acquisition of soil organic matter(SOM)information in cultivated land is important for sustainable agricultural development and carbon balance *** study proposed a novel approach to predict SOM with high accuracy using multiyear synthetic remote sensing variables on a monthly *** obtained 12 monthly synthetic Sentinel-2 images covering the study area from 2016 to 2021 through the Google Earth Engine(GEE)platform,and reflectance bands and vegetation indices were extracted from these composite *** the random forest(RF),support vector machine(SVM)and gradient boosting regression tree(GBRT)models were tested to investigate the difference in SOM prediction accuracy under different combinations of monthly synthetic *** showed that firstly,all monthly synthetic spectral bands of Sentinel-2 showed a significant correlation with SOM(Pmarch,April,October,and ***,in terms of single-monthly composite variables,the prediction accuracy was relatively poor,with the highest R^(2)value of 0.36 being observed in *** monthly synthetic environmental variables were grouped in accordance with the four quarters of the year,the first quarter and the fourth quarter showed good performance,and any combination of three quarters was similar in estimation *** overall best performance was observed when all monthly synthetic variables were incorporated into the ***,among the three models compared,the RF model was consistently more accurate than the SVM and GBRT models,achieving an R^(2)value of *** for band 12 in December,the importance of the remaining bands did not exhibit significant *** research offers a new attempt to map SOM with high accuracy and fine spatial resolution based on monthly synthetic Sentinel-2 images.

关键词： soil organic matter Sentinel-2 monthly synthetic images machine learning model spatial prediction

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Aptasensing biosynthesized phosphatidylserine with a AuNPs nanozyme-based colorimetric aptasensor

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Food Science and Human Wellness 2024年第2期13卷 823-829页

作者： Sai wang Rui ma Chengqiang li ling Zhang Haiyang Zhang xuehan li Xiangzhao mao Qingdao Key Laboratory of Food Biotechnology College of Food Science and EngineeringOcean University of ChinaQingdao 266404China Key Laboratory of Biological Processing of Aquatic Products China National Light IndustryQingdao 266404China Laboratory for marine Drugs and Bioproducts of Qingdao National Laboratory for marine Science and Technology Qingdao 266237China

Sensitive monitoring of the target products during the biosynthesis process is crucial,and facile analytical approaches are urgently ***,phosphatidylserine(PS)was chosen as the model target,a colorimetric aptasensor was developed for the rapid quantitation in biosynthesis samples.A chimeric aptamer was constructed with two homogeneous original PS *** recognition between the chimeric aptamer and PS results in the desorption of aptamer from the surface of the AuNPs nanozyme,and the peroxidase-like enzymatic activity of the AuNPs nanozyme was weakened in a relationship with the different *** developed aptasensor performed well when applied for analyzing PS in biosynthesis *** aptasensor offers good sensitivity and selectivity,under optimal conditions,achieving monitoring and quantitation of PS in the range of 2.5-80.0μmol/L,with a limit of detection at 536.2 nmol/***,the aptasensor provides good accuracy,with comparison rates of 98.17%-106.40%,when compared with the *** study provides a good reference for monitoring other biosynthesized products and promoting the development of aptamers and aptasensors in real-world applications.

关键词： Phosphatidylserine Chimeric aptamer AuNPs nanozyme Colorimetric aptasensor

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Incorporation of source contributions to improve the accuracy of soil heavy metal mapping using small sample sizes at a county scale

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Pedosphere 2024年第1期34卷 170-180页

作者： Jie SONG Xin wang Dongsheng YU Jiangang li Yanhe ZHAO Siwei wang lixia ma State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Chinese Academy of Sciences University Beijing 100049China Agricultural and Rural Bureau of Luanping County Luanping 068250China

Estimating heavy metal(HM) distribution with high precision is the key to effectively preventing Chinese medicinal plants from being polluted by the native soil. A total of 44 surface soil samples were gathered to detect the concentrations of eight HMs(As, Hg, Cu, Cr, Ni, Zn, Pb, and Cd) in the herb growing area of Luanping County, northeastern Hebei Province, China. An absolute principal component score-multiple linear regression(APCS-MLR) model was used to quantify pollution source contributions to soil HMs. Furthermore, the source contribution rates and environmental data of each sampling point were simultaneously incorporated into a stepwise linear regression model to identify the crucial indicators for predicting soil HM spatial distributions. Results showed that 88% of Cu, 72% of Cr, and 72% of Ni came from natural sources;50% of Zn, 49% of Pb, and 59% of Cd were mainly caused by agricultural activities;and 44% of As and 56% of Hg originated from industrial activities. When three-type(natural, agricultural, and industrial) source contribution rates and environmental data were simultaneously incorporated into the stepwise linear regression model, the fitting accuracy was significantly improved and the model could explain 31%–86% of the total variance in soil HM concentrations. This study introduced three-type source contributions of each sampling point based on APCS-MLR analysis as new covariates to improve soil HM estimation precision, thus providing a new approach for predicting the spatial distribution of HMs using small sample sizes at the county scale.

关键词： absolute principal component score-multiple linear regression Chinese herbal medicine influencing factors spatial distribution stepwise multiple regression

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Influence of lithospheric thickness distribution on oil and gas basins,China seas and adjacent areas

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Acta Oceanologica Sinica 2024年第4期43卷 1-14页

作者： Jing ma Wanyin wang Hermann Zeyen Yimi Zhang Zhongsheng li Tao He Dingding wang School of Geology Engineering and Geomatics Key Laboratory of Western China’s Mineral Resources and Geological Engineering of Ministry of EducationChang’an UniversityXi’an 710054China UMR8148 GEOPS CNRS/UniversitéParis-SaclayDépartement des Sciences de la TerreBât.50491405France CNOOC Research Institute Co. Ltd.Beijing 100027China Qingdao Institute of marine geology Qingdao 266071China Department of Earth Sciences Memorial University of NewfoundlandSt.John’sNewfoundland AlB3X5Canada University of Naples Federico Ⅱ Department of Earth SciencesNaples80138Italy

The distribution of oil and gas resources is intricately connected to the underlying structure of the ***,investigating the characteristics of lithospheric thickness and its correlation with oil and gas basins is highly *** research utilizes recently enhanced geological–geophysical data,including topographic,geoid,rock layer thickness,variable rock layer density,and interface depth *** the principles of lithospheric isostasy and heat conduction,we compute the laterally varying lithospheric thickness in the China seas and adjacent *** these results,two pivotal parameters for different types of oil and gas basins were statistically analyzed:the minimum lithospheric thickness and the relative fluctuation in lithospheric thickness.A semiquantitative analysis was used to explore the connection between these parameters and the hydrocarbon abundance within the oil and gas *** study unveils distinct variations in lithospheric thickness among basins,with oil and gas rich basins exhibiting a thicker lithosphere in the superimposed basins of central China and a thinner lithosphere in the rift basins of eastern ***,the relative fluctuations in lithospheric thickness in basins demonstrate significant disparities:basins rich in oil and gas often exhibit greater thickness ***,in the offshore basins of China,a conspicuous negative linear correlation is observed between the minimum lithospheric thickness and the relative fluctuation in lithospheric *** study posits that deep-seated thermal upwelling results in lithospheric undulations and extensional thinning in oil and gas ***,sustained deep-seated heat influences sedimentary materials in basins,creating favorable conditions for oil and gas *** insights derived from this study contribute to a quantitative understanding of the intricate relationships between deep lithospheric structures and oil and gas basins.

关键词： China seas and adjacent areas lithospheric thickness oil and gas basins

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litter quality and decomposer complexity co-drive effect of drought on decomposition

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Forest Ecosystems 2024年第3期11卷 329-338页

作者： Shumei wang Junwei Luan Siyu li Jinhao ma lin Chen Yi wang Shirong liu Sanya Research Base International Centre for Bamboo and RattanSanya572022China Institute of Resources and Environment Key Laboratory of Bamboo and Rattan Science and Technology of National Forestry and Grassland AdministrationInternational Centre for Bamboo and RattanBeijing100102China Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijing100091China Experimental Center of Tropical Forestry Chinese Academy of ForestryPingxiang532600China Institute of Qinghai-Tibetan Plateau Southwest Minzu UniversityChengdu610041China

litter decomposition is key to ecosystem carbon(C)and nutrient cycling,but this process is anticipated to weaken due to projected more extensive and prolonged *** how litter quality and decomposer community complexity regulate decomposition in response to drought is less ***,in a five-year manipulative drought experiment in a masson pine forest,leaf litter from four subtropical tree species(Quercus griffthii Hook.f.&Thomson ex Miq.,Acacia mangium Willd.,Pinus massoniana Lamb.,Castanopsis hystrix Miq.)representing different qualities was decomposed for 350 d in litterbags of three different mesh sizes(i.e.,0.05,1,and 5 mm),respectively,under natural conditions and a 50%throughfall rain exclusion *** of increasing mesh sizes discriminate decomposer communities(i.e.,microorganisms,microorganisms and mesofauna,microorganisms and meso-and macrofauna)that access the litter and represent an increasing *** amount of litter C and nitrogen(N)loss,and changes in their ratio(C/N_(loss)),as well as small and medium-sized decomposers including microorganisms,nematodes,and arthropods,were *** found that drought did not affect C and N loss but decreased C/N_(loss)(i.e.,decomposer N use efficiency)of leaf litter irrespective of litter quality and decomposer ***,changes in the C/N_(loss)and the drought effect on C loss were both dependent on litter quality,while drought and decomposer complexity interactively affected litter C and N *** decomposer community complexity enhanced litter decomposition and allowing additional access of meso-and macro-fauna to litterbags mitigated the negative drought effect on the microbial-driven ***,both the increased diversity and altered trophic structure of nematode due to drought contributed to the mitigation effects via cascading *** results show that litter quality and soil decomposer community complexity co-drive the effect of

关键词： Arthropod Drought Decomposer community Nutrient cycling Nematode

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Laboratory and numerical modelling of irrigation infiltration and nitrogen leaching in homogeneous soils

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Pedosphere 2024年第1期34卷 146-158页

作者： Lei WU Ruizhi li Yan wang Zongjun GUO Jiaheng li Hang YANG xiaoyi ma Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas Ministry of EducationNorthwest A&F UniversityYangling 712100China Blackland Research and Extension Center Texas A&M AgriLife ResearchTexas A&M UniversityTemple TX 76502USA State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China

Nitrogen (N) plays a key role in crop growth and production;however,data are lacking especially regarding the interaction of biochar,grass cover,and irrigation on N leaching in saturated soil *** soil columns with 20-cm diameter and 60-cm height were designed to characterize the effects of different grass cover and biochar combinations,i.e.,bare soil+0%biochar (control,CK),perennial ryegrass+0%biochar (C1),Festuca arundinacea+0%biochar (C2),perennial ryegrass+1%biochar (C3),perennial ryegrass+2%biochar (C4),perennial ryegrass+3%biochar (C5),***+1%biochar (C6),***+2% biochar (C7),and ***+3%biochar (C8),on periodic irrigation infiltration and N leaching in homogeneous loess soils from July to December *** in CK were 10.2%–35.3%higher than those in C1 and *** perennial ryegrass and *** decreased the volumes of leachates and delayed the leaching process in the 1%,2%,and 3%biochar treatments,and the vertical leaching rate decreased with biochar *** N leaching losses were concentrated in the first few leaching tests,and both total N (TN) and nitrate (NO_(3)^(-))-N concentrations in CK and C1–C8 decreased with increasing leaching test *** addition (1%,2%,and 3%) could further reduce the leaching risk of NO_(3)^(-)-N and the NO_(3)^(-)-N loss decreased with biochar ***,compared to 1%biochar,2% biochar promoted the leaching of TN under both grass cover *** N leaching losses in CK,C1,C2,C3,C4,C6,and C7 were primarily in the form of NO_(3)^(-)-*** these treatments,CK,C1,and C2had the highest cumulative leaching fractions NO_(3)^(-)-N (>90%),followed by those in C3,C4,C6,and C7 (>80%).The cumulative leaching fraction of NO_(3)^(-)-N decreased with increasing leaching test times and biochar addition,and 3%biochar addition (i.e.,C5 and C8) reduced it to approximately 50%.The one-dimensional advective-dispersive-reactive transport equation can be used as an effective nume

关键词： leaching loss nitrate nitrogen biochar grass cover analytical modelling

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Effects of Biochar Inoculation with Bacillus megaterium on Rice Soil Phosphorus Fraction Transformation and Bacterial Community Dynamics

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Rice science 2024年第4期31卷 361-365,I0001-I0003页

作者： YU Keru xue Zhaokun FANG Xianzhi ma Jiawei wang Yongjun liU Dan YE Zhengqian State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China Key Laboratory of Soil Contamination Bioremediation of Zhejiang Province Zhejiang A&F UniversityHangzhou 311300China Department of Forest Protection College of Forestry and BiotechnologyZhejiang A&F UniversityHangzhou 311300China

Rice husk biochar inoculated with Bacillus megaterium(BM)(referred to as BM-inoculated biochar, BMB) and uninoculated rice husk biochar(RHB) were added to soil at two rates(0.5%, as BMB1 and RHB1, respectively, and 1.0%, as BMB2 and RHB2, respectively) in an incubation experiment to comprehensively evaluate their effects on basic soil properties, phosphorus(P) fractions, bacterial community composition, and P-cycling genes.

关键词： soil comprehensive Transformation

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Distribution law and susceptibility of geohazards across a gradient belt of the Western Sichuan Plateau

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Journal of Mountain Science 2024年第6期21卷 1849-1867页

作者： li Tianbin wang Jianfeng HE Chaoyang MENG Lubo li Chaofei ma Junjie WEI Daqiang College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China State Key Laboratory of Geohazard Prevention and Geo-environment Protection Chengdu University of TechnologyChengdu 610059China

Across a gradient belt of the Western Sichuan Plateau,geohazards have seriously limited economic and social *** to incomplete statistics,15,673 geohazards have been recorded in the study *** order to mitigate the threat of geohazards to human engineering activities in the region,an overall understanding of the distribution pattern of geohazards and susceptibility assessment are *** this paper,a gradient belt of the Western Sichuan Plateau and its zoning criteria were ***,on the basis of relief amplitude,distance to faults,rainfall,and human activities,three indicators of endogenic process were introduced:Bouguer gravity anomaly gradient,vertical deformation gradient,and horizontal deformation ***,the distribution patterns of geohazards were investigated through mathematical statistics and ArcGIS *** randomly selecting 10,449 hazards,a geohazard susceptibility map was generated using the Information Value(IV)***,the IV model was validated against 5224 hazards using the Area Under Curve(AUC)*** results show that 47.6%of the geohazards were distributed in the zone of steep *** showed strong responses to distance to faults,human activities,and annual *** distribution of geohazards in the gradient belt of the Western Sichuan Plateau is more sensitive to vertical internal dynamics factors(such as vertical deformation gradient and Bouguer gravity anomaly gradient)without any apparent sensitivity to horizontal internal dynamics *** areas of high and very-high risk account for up to 32.22%,mainly distributed in the Longmenshan and Anning River *** to the AUC plot,the success rate of the IV model for generating the susceptibility map is 76%.This susceptibility map and geohazard distribution pattern can provide a reference for geological disaster monitoring,preparation of post-disaster emergency measures,and town planning.

关键词： Gradient belt Geohazards Distribution law Bouguer Gravity anomaly gradient Vertical deformation gradient Susceptibility

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Electron delocalization-enhanced sulfur reduction kinetics on an MXene-derived heterostructured electrocatalyst

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Nano Research 2024年第8期17卷 7153-7162页

作者： Yunmeng li Yinze Zuo Xiang li Yongzheng Zhang Cheng ma xiaomin Cheng Jian wang Jitong wang Hongzhen lin licheng ling State Key Laboratory of Chemical Engineering Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education)East China University of Science and TechnologyShanghai 200237China Institute of New Energy materials and Engineering College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Specially Functional Polymeric materials and Related Technology(Ministry of Education) School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China i-Lab&CAS Key Laboratory of Nanophotonic materials and Device Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China Helmholtz Institute Ulm(HIU) D89081 UlmGermany

lithium-sulfur(li-S)batteries mainly rely on the reversible electrochemical reaction of between lithium ions(li^(+))and sulfur species to achieve energy storage and conversion,therefore,increasing the number of free li^(+)and improving the li^(+)diffusion kinetics will effectively enhance the cell ***,Mo-based MXene heterostructure(MoS_(2)@Mo_(2)C)was developed by partial vulcanization of Mo_(2)C MXene,in which the introduction of similar valence S into Mo-based MXene(Mo_(2)C)can create an electron delocalization *** theoretical simulations and electrochemical characterisation,it is demonstrated that the MoS_(2)@Mo_(2)C heterojunction can effectively promote ion desolvation,increase the amount of free li^(+),and accelerate li^(+)transport for more efficient polysulfide *** addition,the MoS_(2)@Mo_(2)C material is also capable of accelerating the oxidation and reduction of polysulfides through its sufficient defects and vacancies to further enhance the catalytic ***,the li-S battery with the designed MoS_(2)@Mo_(2)C electrocatalyst performed for 500 cycles at 1 C and still maintained the ideal capacity(664.7 mah·g^(−1)),and excellent rate performance(567.6 mah·g^(−1)at 5 C).Under the extreme conditions of high loading,the cell maintained an excellent capacity of 775.6 mah·g^(−1)after 100 *** also retained 838.4 mah·g^(−1)for 70 cycles at a low temperature of 0℃,and demonstrated a low decay rate(0.063%).These results indicate that the delocalized electrons effectively accelerate the catalytic conversion of lithium polysulfide,which is more practical for enhancing the behaviour of li-S batteries.

关键词： delocalized electron lithium sulfur batteries MXene-based heterostructures catalytic desolvation multi-catalytic sites

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