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Choriocarcinoma with lumbar muscle metastases:A case report

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World Journal of Clinical Cases 2020年第20期8卷 5036-5041页

作者： Li Pang xiao-xin ma Department of Obstetrics and Gynecology Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Choriocarcinoma is a highly malignant trophoblastic tumor that presents with early symptoms similar to those of an ectopic *** we present a patient with suspected ectopic pregnancy diagnosed by laparoscopic surgery in our *** patient was found to have choriocarcinoma that had metastasized to the lumbar muscle and presented with symptoms similar to those of an ectopic *** SUMmaRY The patient was a 34-year-old female who complained of amenorrhea lasting 53 d,7 d of right lower back pain,and 3 d of right lower abdominal *** ultrasonography revealed the absence of a gestational sac in the uterus and a mass in the left *** 6 d of re-examination,ultrasound and computed tomography(CT)examination were performed on the mass located in the left adnexa *** also noted that the patient's serumβ-human chorionic gonadotropin(h CG)level was *** an ectopic pregnancy,we performed a laparoscopy and *** the operation,a left ovarian mixed echogenic mass approximately 2.5 cm×2.0 cm with no villous tissue was *** levels of serum h CG continued to *** CT examination showed lung *** CT and magnetic resonance imaging showed a mixed echogenic mass in the lumbar *** lumbar metastasis of choriocarcinoma,six courses of cisplatin,dactinomycin,and etoposide chemotherapy were given after *** patient's serumβ-h CG level decreased to normal and the mixed echogenic mass in the lumbar muscle decreased in size after the fifth course of *** symptoms subsequently disappeared after *** In summary,lumbar metastasis from choriocarcinoma is extremely *** chemotherapy can successfully treat these metastasized tumors.

关键词： Choriocarcinoma Ectopic pregnancy Lumbar malignant trophoblastic tumor Metastasis Human chorionic gonadotropin Case report

Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

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Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue xiao Yan-wei ma Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides

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Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： ma Jing SUN Bo TE Li-ger HUANG xin ZUO xin HAN xiao-ke WANG Shu-song Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate School of Hebei Medical University Shijiazhuang(050017)China School of Chemistry and materials Science Hebei Normal UniversityShijiazhuang(050024)China xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective To determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(TG)-induced reproductive system injury in rats and its underlying *** A reproductive damage model was established in rats by feeding of ***-eight male Sprague Dawley rats were randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and L-carnitine(LC)*** in M,DS and LC groups received 40 mg/kg TGs *** from the 5th week,after administration of TGs for 4 h every day,rats in DS and LC groups were administered with 2.7 g/kg DS and 0.21 g/kg LC,respectively,for protective treatment over the next 4 *** in Group C continued to receive the control ***-eosin staining was used for histopathological analysis of rat testicular ***-linked immunosorbent assay was performed to measure alkaline phosphatase(ALP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(T-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)*** assay was used to determine the serum testosterone *** real-time PCR and Western blotting were conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant *** Oral administration of TGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(P<0.05).On the other hand,sperm concentration,sperm motility,and serum testosterone,serum zinc,testicular zinc,Zrt-,Irt-like protein 1,ALP,luteinizing hormone(LH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 T-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following TG

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

Effects of pyraclostrobin on growth,oxidative stress,and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila

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Journal of Oceanology and Limnology 2024年第1期42卷 150-162页

作者： Yang LIU Jiale ZHANG Peng xiao xin LIU Yisifu ma Jing ZHANG Bangjun ZHANG Henan International Joint Laboratory of Aquatic Ecotoxicology and Health Protection Xinxiang 453007China College of Life Sciences Henan Normal UniversityXinxiang 453007China Journal of Henan Normal University Xinxiang 453007China College of Life and Environmental Science Wenzhou UniversityWenzhou 325035China Department of Ecosystem Studies School of Environmental ScienceUniversity of Shiga PrefectureShiga 522-8533Japan

Pyraclostrobin(PYR),a widely used fungicide,has negative effects on fish and algae,but its toxicity in protozoa remains *** this study,the effects of PYR on the growth,oxidative stress,and gene expression related to stress and ATP-binding cassette(ABC)transporters in Tetrahymena thermophila were *** result showed that the 96-h IC_(50)of PYR against *** was 17.2 mg/***,PYR inhibited the growth of *** in concentration-or time-dependent manner.A morphological study revealed that the shape and size of *** changed,and damage of cell membrane surface was observed by scanning electron microscopy after 96 h of PYR *** activities of superoxide dismutase(SOD)and catalase(CAT)increased throughout the *** contrast,the glutathione(GSH)content was increased at 24 h and 48 h of exposure and decreased at 96 ***,a significant increase in malondialdehyde(MDA)level was observed in *** after96 h of ***,PYR upregulated the HSP703,HSP705,GPx2,and ABAC15 gene expression in the 0.1–5-mg/L groups and downregulated the HSP704,HSP90,TGR,and ABCC52 mRNA levels at 96 h of *** results suggest that PYR may exert adverse effects on *** by inducing oxidative stress and changing the gene expression related to ABC transporters and stress,which may enrich the understanding of the toxicity mechanism of PYR in aquatic organisms and provide reference data for aquatic ecological risk assessments.

关键词： pyraclostrobin Tetrahymena thermophila growth oxidative stress gene expression

A NEW LOW-COST DEMODULATOR FOR 2.4 GHZ ZIGBEE RECEIVERS

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Journal of Electronics(China) 2009年第2期26卷 252-257页

作者： Yu Yunfeng Meng xin xiao Shimao ma Chengyan Ye Tianchun Institute of Microelectronics of Chinese Academy of Sciences（CAS） Beijing 100029 China Hangzhou Microelectronics of Chinese Academy of Science Ltd. Hangzhou 310053 China

A new low-cost demodulator for ZigBee receivers satisfying requirements of IEEE802.15.4 standard is presented,which is designed for ISM 2.4 GHz band and based on Zero-IF *** demodulator extracts symbols directly from baseband signal rather than recovering PN code chips,so its structure is *** main techniques are used to improve the performance of *** is Phase-Axis Crossing Detector(PACD) which detects the phase correlation of baseband *** other is symbol synchronization and sampling clock correction *** result shows that this demodulator performance,Symbol Error Rate(SER) and Packet Error Rate(PER) meet IEEE 802.15.4TM standard requirements and the demodulator can handle frequency offset in excess of 200 kHz,involving a Zero-IF receiver with a Noise Figure(NF) lower than 17 dB,which is easily imple-mented in standard CMOS technology.

关键词： ZigBee Demodulator Minimum Shift Keying(MSK) Low-cost Symbol synchronization

SOLVING OPTIMIZATION PROBLEMS OVER THE STIEFEL maNIFOLD BY SMOOTH EXACT PENALTY FUNCTIONS

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Journal of Computational mathematics 2024年第5期42卷 1246-1276页

作者： Nachuan xiao xin Liu The Institute of Operations Research and Analytics National University of SingaporeSingapore State Key Laboratory of Scientific and Engineering Computing Academy of Mathematics and Systems ScienceChinese Academy of Sciencesand University of Chinese Academy of SciencesChina

In this paper,we present a novel penalty model called ExPen for optimization over the Stiefel *** from existing penalty functions for orthogonality constraints,ExPen adopts a smooth penalty function without using any first-order derivative of the objective *** show that all the first-order stationary points of ExPen with a sufficiently large penalty parameter are either feasible,namely,are the first-order stationary points of the original optimization problem,or far from the Stiefel ***,the original problem and ExPen share the same second-order stationary ***,the exact gradient and Hessian of ExPen are easy to *** a consequence,abundant algorithm resources in unconstrained optimization can be applied straightforwardly to solve ExPen.

关键词： Orthogonality constraint Stiefel manifold Penalty function

Species’ geographical range, environmental range and traits lead to specimen collection preference of dominant plant species of grasslands in Northern China

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Plant Diversity 2024年第3期46卷 353-361页

作者： Jingya Zhang Cui xiao xiaoyu Duan xin Gao Hao Zeng Rong'an Dong Gang Feng Keping ma Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection *** study aims to determine whether grassland specimen collection in China is preferred by species traits(i.e.,plant height,flowering and fruiting period),environmental range(i.e.,the temperature and precipitation range)and geographical range(i.e.,distribution range and altitudinal range).Ordinary least squares models and phylogenetic generalized linear mixed models were used to analyze the relationships between specimen number and the explanatory *** Forest models were then used to find the most parsimonious multivariate *** results showed that interannual variation in specimen number between 1900 and 2020 was *** number of these species in southeast China was notably lower than that in northwest *** range and geographical range of species had significant positive correlations with specimen *** addition,there were relatively weak but significant associations between specimen number and species trait(i.e.,plant height and flowering and fruiting period).Random Forest models indicated that distribution range was the most important variable,followed by flowering and fruiting period,and altitudinal *** findings suggest that future floristic surveys should pay more attention to species with small geographical range,narrow environmental range,short plant height,and short flowering and fruiting *** correction of specimen collection preference will also make the results of species distribution model,species evolution and other works based on specimen data more accurate.

关键词： Biological specimen Collection preference Dominant plant species Environmental range Geographical range Species traits

GPa-level pressure-induced enhanced corrosion resistance in TiZrTaNbSn biomedical high-entropy alloy

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China Foundry 2024年第3期21卷 265-275页

作者： xiao-hong Wang Yu-lei Deng Qiao-yu Li Zhi-xin Xu Teng-fei ma xing Yang Duo Dong Dong-dong Zhu xiao-hong Yang Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina School of materials Science and Engineering Taizhou UniversityTaizhou 318000ZhejiangChina

TiZrTaNb-based high-entropy alloys(HEAs)are research frontier of biomedical materials due to their high hardness,good yield strength,excellent wear resistance and corrosion ***,as an essential trace element in the human body that plays a significant role in physiological *** has stable chemical properties and a low elastic *** this study,a new material,TiZrTaNbSn HEAs,was proposed as a potential biomedical *** Ti_(35)Zr_(25)Ta_(15)Nb_(15)Sn_(10)biomedical high-entropy alloys(BHEAs)were successfully prepared through an arc melting furnace and then remelted using a German high-temperature and high-pressure apparatus under GPa-level(4 GPa and 7 GPa).The precipitation behavior of the needle-like HCP-Zr_(5)Sn_(3)phase that precipitates discontinuously at the grain boundary was successfully *** phase constitution,microstructure,and corrosion resistance of the alloy were *** results show that the needle-like HCP-Zr_(5)Sn_(3)phase is eliminated and the(Zr,Sn)-rich nano-precipitated phase is precipitated in the microstructure under high pressure,which leads to the narrowing of grain boundaries and consequently improves the corrosion resistance of the *** addition,the formation mechanisms of(Zr,Sn)-rich nanoprecipitates in BHEAs were *** Zr and Sn dissolve in the matrix due to the effect of high pressure,during the cooling process,they precipitate to form a(Zr,Sn)-rich nano-precipitated phase.

关键词： biomedical HEAs precipitation grain boundary corrosion resistance TiZrTaNbSn

Design and grindability assessment with cup shaped electroplated CBN wheel grinding turbine disc slots of powder metallurgy superalloy FGH96

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CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 521-534页

作者： Li, Benkai Ding, Wenfeng Zhu, Yejun Li, Changhe Zhang, Yanbin Yang, Min ma, xiao Liu, Mingzheng Cui, xin Qingdao Univ Technol Sch Mech Engn Qingdao 266520 Peoples R China Nanjing Univ Aeronaut & Astronaut Natl Key Lab Sci & Technol Helicopter Transmiss Nanjing 210016 Peoples R China Nanjing Agr Univ Coll Engn Nanjing 210031 Peoples R China

The machining surface integrity of aero-engine turbine disc slots has a significant impact on their fatigue life and service performance, and achieving efficiency and high-precision machining is still a great challenge. The high machining requirements of future aeroengine turbine disc slots will be difficult to satisfy using the broaching method. In addition, existing methods of slot machining face difficulties in ensuring surface integrity. This study explored a cup shaped electroplated Cubic Boron Nitride (CBN) abrasive wheel for profile grinding the turbine disc slots of FGH96 powder metallurgy superalloy. The matrix structure of the cup shaped abrasive wheel was designed and verified. A profile grinding experiment was conducted for fir-tree slots on a five-axis machining center. The accuracy and the surface integrity were analyzed. Results show that the key dimension detection results of the slots were within the allowable tolerance range. Meanwhile, an average surface roughness Ra of 0.55 lm was achieved, the residual stress was compressive, the plastic deformation layer thickness was less than 5 lm, and the hardening layer thickness was less than 20 lm. The research findings provide a new approach to machining the slots of aviation engine turbine discs and guidance for the high-quality processing of complex components. (c) 2023 Production and hosting by Elsevier Ltd. on behalf of Chinese Society of Aeronautics and Astronautics.

关键词： Profile grinding Surface integrity Cup shaped CBN abrasive wheel Turbine disc slots FGH96 OF-THE-ART SURFACE INTEGRITY DYNAMIC RECRYSTALLIZATION FATIGUE SPEED maNUFACTURE PARAMETERS MECHANISM ALLOYS TOOLS