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Utility of cooling patches to prevent hand-foot syndrome caused by pegylated liposomal doxorubicin in breast cancer patients

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World Journal of Clinical Cases 2021年第33期9卷 10075-10087页

作者： Yan-fu Zheng xin fu xiao-Xu Wang xiao-Jing Sun xiao-Dan He Department of Breast Oncology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina Department of Gynecology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina

BACKGROUND Pegylated liposomal doxorubicin(PLD)uses the hydrophilic layer of liposomes to reach the sweat on the skin surface or accumulate in the sweat glands,producing toxic free radicals and oxidative damage,resulting in hand-foot syndrome(HFS).Regional cooling can induce vasoconstriction to reduce the release of drugs in the limbs and reduce the accumulation of drugs in sweat glands;thus,decreasing the incidence and severity of *** To study the efficacy of cooling patches to prevent HFS caused by PLD in the *** This is a retrospective cohort *** breast cancer patients(n=101)who were treated with PLD in two breast wards at our department from February 2020 to February 2021 were enrolled in the study and were randomly divided into the cooling group(51 patients)and the control group(50 patients).Patients in the control group only received routine care,while the patients in the cooling group applied cooling patches,based on routine care,to the palm and back of the hands 15 min before chemotherapy infusion for 10 *** patients took a corresponding dose of dexamethasone orally one day before chemotherapy,on the day of chemotherapy,and one day after ***23.0 version was used to analyze the data in this *** occurrence and severity of HFS was analyzed by the Mann-Whitney U test,and scores were analyzed by the Student’s t test or Wilcoxon rank-sum test.A P value<0.05 was regarded as statistically *** In this study,neither group of patients developed Grade 3 *** the control group,the incidence of Grade 1 HFS and Grade 2 HFS was 38%and 2%,***,in the cooling group,only one person developed Grade 1 HFS(2%),and none of the patients developed Grade 2 *** findings showed that cooling patches can effectively reduce the frequency and severity of HFS(P<0.0001)in the *** the fourth chemotherapy cycle,although general self-efficacy scale scores in the cooling group were low,they we

关键词： The cooling patch Hand-foot syndrome Pegylated liposomal doxorubicin Breast cancer Self efficacy Quality of life

Ag^(+)、Zn^(2+)、Cr^(3+)改性Y型分子筛吸附脱除喹啉的模拟计算研究

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原子与分子物理学报 2025年第1期42卷 61-68页

作者：孙潇镝唐克高畅富添王聚财洪新辽宁工业大学化学与环境工程学院锦州121001 葫芦岛市应急管理局葫芦岛125000

首先考察了吸附时间对三种改性Y型分子筛AgY、ZnY、CrY吸附脱除模拟燃料中喹啉的影响,结果发现三种分子筛对喹啉的吸附容量和去除率大小顺序均为:AgY>CrY>ZnY.运用Materials Studio软件,采用巨正则蒙特卡洛(GCMC)和密度泛函理论(DFT)对... 详细信息

首先考察了吸附时间对三种改性Y型分子筛AgY、ZnY、CrY吸附脱除模拟燃料中喹啉的影响,结果发现三种分子筛对喹啉的吸附容量和去除率大小顺序均为:AgY>CrY>ZnY.运用Materials Studio软件,采用巨正则蒙特卡洛(GCMC)和密度泛函理论(DFT)对改性Y型分子筛吸附喹啉机理进行了模拟计算研究,得出以下结论:模拟计算AgY、ZnY、CrY的比表面积和孔体积与其低温N2吸附-脱附表征结果基本一致,并且发现改性Y型分子筛的吸附脱氮能力与比表面积和孔体积关系不大;以fukui函数为基础,采用Mulliken和Hirshfeld两种布局数分析方法模拟计算了三种改性Y型分子筛的相对亲电性并分析Lewis酸强弱,其Lewis酸大小顺序为:AgY>CrY>ZnY;对三种改性分子筛进行了前线轨道分析,其化学吸附活性大小为AgYCrY>ZnY,模拟计算所得各种结果与实验结果顺序完全一致.

关键词： Y型分子筛改性吸附喹啉模拟

Processing Maps for Use in Hot Working of Ductile Iron

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Journal of Iron and Steel Research International 2011年第4期18卷 48-51,72页

作者： ZHAO xin YANG xiao-ling JING Tian-fu The Sixth Department Zhengzhou Institute of Aeronautics Zhengzhou 450015 Henan China Zhengzhou Zhongxing Basic Constructions Development Co Ltd Zhengzhou 450015 Henan China State Key Laboratory of Metastable Materials Science and Technology Qinhuangdao 066004 Hebei China

The hot deformation characteristics of ductile iron are studied in the temperature range of 973 to 1273K and strain rate range of 0.001 to 1 s-1 by using hot compression *** maps for hot working are developed on the basis of the variations of efficiency of power dissipation with temperature and strain *** results reveal that the flow stress of ductile iron is sensitive to strain *** the processing map under strain of 0.7,a domain is centered at 1273 K and 1 s-1,and the maximum efficiency is more than 36%.According to the maps,the zone with the temperature range of 1173 to 1273 K and strain rate range of 0.1 to 1 s-1 may be considered as the optimum region for hot working.

关键词： ductile iron processing map hot working

Uncovering the internal structure of five-fold twinned nanowires through 3D electron diffraction mapping

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Chinese Physics B 2020年第6期29卷 517-531页

作者： xin fu GRINM Group Corporation Limited National Analysis and Testing Center for Nonferrous Metals and Electronic MaterialsBeijing 101400China Guobiao(Beijing)Testing&Certification Co. Ltd.Beijing 101400China China United Test&Certification Co. Ltd.Beijing 101400China General Research Institute for Nonferrous Metals Beijing 100088China

Five-fold twinned nanostructures are intrinsically strained or relaxed by extended defects to satisfy the space-filling *** both of metallic and semiconductor five-fold twinned nanostructures show inhomogeneity in their cross-sectional strain distribution,the evident strain concentration at twin boundaries in the semiconductor systems has been found in contrast to the metallic ***,a problem is raised how the chemical bonding characteristics of various five-fold twinned nanosystems affects their strain-relieving defect *** using three-dimensional(3D)electron diffraction mapping methodology,the intrinsic strain and the strain-relieving defects in a pentagonal Ag nanowire and a star-shaped boron carbide nanowire,both of them have basically equal radial twin-plane width about 30 nm,are nondestructively *** non-uniform strain and defect distribution between the five single crystalline segments are found in both of the five-fold twinned *** intensity fine structure analysis for the boron carbide five-fold twinned nanowire indicates the presence of high-density of planar defects which are responsible for the accommodation of the intrinsic angular ***,for the Ag five-fold twinned nanowire,the star-disclination strain field is still present,although is partially relieved by the formation of localized stacking fault layers accompanied by partial *** analysis suggests that the variety in the strain-relaxation ways for the two types of five-fold twinned nanowires could be ascribed to the large difference in shear modulus between the soft noble metal Ag and the superhard covalent compound boron carbide.

关键词： five-fold twinnining elastic strain structural relaxation electron diffraction mapping

Target Tracking and Obstacle Avoidance for Multi-agent Systems

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International Journal of Automation and computing 2010年第4期7卷 550-556页

作者： Jing Yan xin-Ping Guan fu-xiao Tan Institute of Electrical Engineering Yanshan University Qinhuangdao 066004 PRC School of Electronic and Electric Engineering Shanghai Jiao Tong University Shanghai 200240 PRC School of Computer and Information Fuyang Teachers College Fuyang 236041 PRC

This paper considers the problems of target tracking and obstacle avoidance for multi-agent systems. To solve the problem that multiple agents cannot effectively track the target while avoiding obstacle in dynamic environment, a novel control algorithm based on potential function and behavior rules is proposed. Meanwhile, the interactions among agents are also considered. According to the state whether an agent is within the area of its neighbors＇ influence, two kinds of potential functions are presented. Meanwhile, the distributed control input of each agent is determined by relative velocities as well as relative positions among agents, target and obstacle. The maximum linear speed of the agents is also discussed. Finally, simulation studies are given to demonstrate the performance of the proposed algorithm.

关键词： Target tracking obstacle avoidance potential function multi-agent systems

A New Angiosperm Genus from the Lower Cretaceous Yixian Formation, Western Liaoning, China

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Acta Geologica Sinica(English Edition) 2013年第4期87卷 916-925页

作者： HAN Gang fu xiao-ping LIU Zhong-jian WANG xin Palaeontological Center Bohai University Fairylake Botanical Garden Shenzhen Municipality and Chinese Academy of Sciences Shenzhen Key Laboratory for Orchid Conservation and Utilization the National Orchid Conservation Center of China and Orchid Conservation & Research Center of Shenzhen State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology

The abundant fossils of early angiosperms found in the Yixian Formation （125 Ma, Early Cretaceous） have demonstrated unexpectedly high diversity and various reproductive strategies, and thus have shed new light on early angiosperm evolution. Here, using light microscope and scanning electron microscope, we document several fructifications of Baicarpus gen. nov. from Liaoning province, China. Each fructification of the new taxon includes several apocarpous carpels/fruits attached in an urn-formed gynobase. Each fruit/carpel has a persistent straight style and an ovary enclosing a single seed. These fossil plants demonstrate a new floral organization and thus enhance our understanding of the diversity of angiosperms in the Yixian Formation. Together with previously reported ones, this fossil angiosperm suggests an origin time for angiosperms earlier than widely accepted.

关键词： paleobotany fruits Barremian-Aptian Yixian Formation Liaoning province

Optimal design of Stewart platforms based on expanding the control bandwidth while considering the hydraulic system design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第1期10卷 22-30页

作者： Wei WANG Hua-yong YANG Jun ZOU xiao-dong RUAN xin fu State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

We proposed an optimal design method to expand the bandwidth for the control of large hydraulic Stewart *** method is based on generalized natural frequency and takes hydraulic oil into consideration.A Lagrangian formulation which considers the whole leg inertia is presented to obtain the accurate equivalent mass *** the model,the effect of leg inertia and the influence of design parameters on the generalized natural frequency are ***,numerical examples are presented to validate and confirm the efficiency of the mathematical *** results show that the leg inertia,especially the piston part plays an important role in the *** optimum diameter ratio of the base to the moving platform is between 2 and 3,and the optimum joint angle ratio of the base to the moving platform is about *** smaller joint angles and a longer leg stroke are favorable for raising system *** system oil should be preprocessed for large platforms with a requirement for good dynamic performance.

关键词： Large Gough-Stewart platform Optimal design Control bandwidth Leg inertia Generalized natural frequency

Two-Quark Condensate Changes with Quark Current Mass

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Communications in Theoretical Physics 2009年第9期52卷 483-486页

作者： LU Chang-Fang LU xiao-fu WU xiao-Hua ZHAN Yong-xin Department of Physics Sichuan University Chengdu 610064 China Department of Physics Sichuan Agricultural University Ya＇an 625014 China Institute of Theoretical Physics The Chinese Academy of Sciences Beijing 100080 China CCAST （World Laboratory） P.O. Box 8730 Beijing 100080 China

Using the Schwinger Dyson equation and perturbation theory,we calculate the two-quark condensates forthe light quarks u,d,strange quark s and a heavy quark c with their current masses *** results show thatthe two-quark condensate will decrease when the quark mass increases,which hints the chiral symmetry may be restoredfor the heavy quarks.

关键词： quark current mass quark condensates QCD sum rule Schwinger-Dyson equation perturbation theory

Target Tracking and Obstacle Avoidance for Multi-agent Networks with Input Constraints

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International Journal of Automation and computing 2011年第1期8卷 46-53页

作者： Jing Yan xin-Ping Guan xiao-Yuan Luo fu-xiao Tan Department of Electrical Engineering Yanshan University Qinhuangdao 066004 PRC School of Electronic and Electric Engineering Shanghai Jiao Tong University Shanghai 200240 PRC School of Computer and Information Fuyang Teachers College Fuyang 236041 PRC

In this paper, the problems of target tracking and obstacle avoidance for multi-agent networks with input constraints are investigated. When there is a moving obstacle, the control objectives are to make the agents track a moving target and to avoid collisions among agents. First, without considering the input constraints, a novel distributed controller can be obtained based on the potential function. Second, at each sampling time, the control algorithm is optimized. furthermore, to solve the problem that agents cannot effectively avoid the obstacles in dynamic environment where the obstacles are moving, a new velocity repulsive potential is designed. One advantage of the designed control algorithm is that each agent only requires local knowledge of its neighboring agents. Finally, simulation results are provided to verify the effectiveness of the proposed approach.

关键词： Target tracking obstacle avoidance multi-agent networks potential function optimal control.