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Effects of gentiana scabra bage on expression of hepatic type Ⅰ,Ⅲ collagen proteins in Paragonimus skrjabini rats with liver fibrosis

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Asian Pacific Journal of Tropical Medicine 2015年第1期8卷 60-63页

作者： Zhao-xia Qu fang Li Chao-Dong Ma Jun Liu Shu-De Li Wen-Lin Wang Zhenjiang Medical School Yuncheng Nursing Vocational College First People's Hospital in Zhenjiang Department of Parasitology Faculty of Basic MedicineKunming Medical University Department of Biochemistry and Molecular Biology Faculty of Basic MedicineKunming Medical University

Objective:To exploit- the effects of gentiana scabra bage on the expression of hepatic collagen proteins in Paragonimus skrjabini rats with liver ***:Immunohistochemical technique was used to observe the changes of content of hepatic type Ⅰ,Ⅲ collagen proteins in Paragonimus skrjabini rats with Liver fibrosis before and after the gentiana scabra bage ***:Comparing with the model group,changes of hepatic tvpe Ⅰ and type Ⅲ collagen proteins in gentiana scabra bage treated group were significantly ***:Gentiana scabra bage treatment can reduce the content of hepatic type Ⅲ and type Ⅰ collagen protein significantly in Paragonimus skrjabini rats with liver fibrosis,thereby,playing the role against hepatic fibrosis.

关键词： Gentiana scabra bage Liver fibrosis Paragonimus skrjabini Collagen protein Ⅰ Collagen protein Ⅲ

某精神专科医院门诊Z类药物处方情况调查分析

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中国药物滥用防治杂志 2024年第4期30卷 609-614,618页

作者：支晓慧李霞王晓孙波王文文刘召英临沂市精神卫生中心药学部山东临沂276005 山东省药品不良反应监测中心山东济南250013 临沂市精神卫生中心精神科山东临沂276005

目的:分析某精神专科医院门诊Z类药物的处方情况,发现该类药物滥用/依赖风险信号,找出影响该类药物滥用/依赖的相关因素。方法:回顾性研究2021年6月—2022年5月门诊处方Z类药物的人群。建立用药风险信号识别要点,筛查出疑似滥用/依赖人... 详细信息

目的:分析某精神专科医院门诊Z类药物的处方情况,发现该类药物滥用/依赖风险信号,找出影响该类药物滥用/依赖的相关因素。方法:回顾性研究2021年6月—2022年5月门诊处方Z类药物的人群。建立用药风险信号识别要点,筛查出疑似滥用/依赖人群,应用调查问卷进行电话回访判断其是否药物滥用/依赖,并对滥用/依赖人群进行分析。结果:筛查出551例疑似滥用/依赖的患者,符合药物依赖/依赖诊断的患者30例。单因素分析显示,是否经历重大事件、依从性、家人对药品合理管理、知晓Z类药物有依赖风险及随诊是该类患者发生药物依赖的影响因素(P<0.05)。二元logistic回归分析显示,未经历重大事件和用药依从性好可能是Z类药物依赖的保护因素,家人对药品不合理管理和不随诊可能是Z类药物依赖的危险因素(P<0.05)。结论:Z类药物存在一定程度的滥用/依赖,大多患者对该类药物认识不足,需进一步加强健康教育和用药行为干预,以减少Z类药物的滥用/依赖。

关键词： Z类药物滥用依赖失眠

第一目击者急救知识技能导师培训模式探讨与实践

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中国急救复苏与灾害医学杂志 2024年第2期19卷 256-260页

作者：肖薇薇张静航陈芳曹彦黄婕祝益民湖南省人民医院(湖南师范大学附属第一医院)急诊医学科湖南长沙410005 湖南省人民医院(湖南师范大学附属第一医院)国际医学部湖南长沙410005 湖南省疾病预防控制中心湖南长沙410028 湖南省急救医学研究所湖南长沙410005

目的分析2018—2022年湖南省第一目击者急救知识技能导师培训的情况,探讨适合我国第一目击者导师培训的特点及模式。方法通过规范第一目击者急救知识技能导师培训的课程设计、信息化平台建设及质量管理控制,总结导师培训的特征及考核... 详细信息

目的分析2018—2022年湖南省第一目击者急救知识技能导师培训的情况,探讨适合我国第一目击者导师培训的特点及模式。方法通过规范第一目击者急救知识技能导师培训的课程设计、信息化平台建设及质量管理控制,总结导师培训的特征及考核评价效果。结果 2018—2022年湖南省共培训第一目击者急救知识技能导师4 504名,主要由医护人员组成,占98.8%;83.42%为中级及以上职称。设计第一目击者急救知识技能导师培训课程和考核方式,导师经培训后考核,理论成绩为(96.11±3.61)分,心肺复苏操作评分为(90.49±2.90)分,AED使用评分为(90.37±3.09)分,创伤四项操作评分为(88.90±3.37)分。导师在理论课程、心肺复苏操作、AED使用、创伤四项操作四方面的掌握程度同质性较好。结论第一目击者急救知识技能导师培训的模式具有科学性与合理性,值得进一步推广。

关键词：第一目击者急救知识技能导师培训心肺复苏

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Chinese Medical Journal 2020年第19期133卷 2308-2314页

作者： Xi-fang Zhang Li-Ya Qiao xiao-Gu Cai xiao-xia Li Jia-Xuan Tan Zheng Guan Ye Zhang Kai Cao Ning-Li Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China.

Background:In recent years,visual quality has been extensively investigated in various *** this community-based population study,we analyzed the effects of aging,refraction,and Lens Opacification Classification System III(LOCSIII)score on retinal imaging quality in healthy Chinese ***:This cross-sectional study was conducted on sub-group subjects from The Handan Eye Study between October 2012 and January *** subjects over 30-years-old with logarithm of the minimal angle of resolution(logMAR)best-corrected visual acuity(BCVA)less than 0 were *** image quality was measured by optical quality analysis system(OQAS)and recorded as modulation transfer function cutoff frequency(MTFcutoff),OQAS value(OV)100%,OV20%,OV9%,Strehl ratio(SR),and objective scatter index(OSI).The correlation between age,spherical equivalent refraction(SE),LOCSIII score,and optical quality parameters were investigated by multivariate ***:Among 1108 verified subjects,690 subjects(1380 eyes)met the inclusion *** age ranged from 30 to 76 years,SE ranged from-4.75 to 2.75 *** were divided into five age groups(30–39,40–49,50–59,60–69,and≥70 years)for further *** multivariate analysis by mixed-effect linear model,SR(t=-3.03,P=0.002),OV20%(t=-2.39,P=0.017),and OV9%(t=-3.16,P=0.001)significantly decreased with the increasing age,whereas logMAR BCVA(t=4.42,P<0.001)and OSI(t=4.46,P<0.001)significantly increased with *** SE increased,SR(t=2.74,P=0.01),OV20%(t=2.31,P=0.02),and OV9%(t=2.79,P=0.005)significantly elevated,and OSI(t=-3.38,P<0.001)significantly *** the increase in cortical opacity score,all optical quality parameters except for SR significantly decreased,including MTFcutoff(t=-2.78,P=0.01),OV100%(t=-2.78,P=0.005),OV20%(t=-2.60,P=0.009),and OV9%(t=-2.05,P=0.04).As posterior sub capsular opacity score increased,MTFcutoff(t=-2.40,P=0.02)and OV100%(t=-2.40,P=0.01)significantly decreased,while OSI(t=7.56,P<0.00

关键词： Cross-sectional study Prospective study Vision Aging Refractive errors Cataract

Population characteristics of Macrocheles glaber (Acari: Macrochelidae) and Stratiolaelaps scimitus (Acari: Laelapidae) reared on a mushroom fly Coboldia fuscipes (Diptera: Scatopsidae)

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Insect Science 2019年第2期26卷 322-332页

作者： Mei-fang Wen Hsin Chi Ying-xiao Lian Yu-Hao Zheng Qing-Hai Fan Min-Sheng You State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry University Fuzhou China Institute of Applied Ecology Fujian Agriculture and Forestry University Fuzhou China Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests Fujian Agriculture and Forestry University Fuzhou China Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops Ministry of Agriculture Fuzhou China Department of Plant Production and Technologies Faculty of Agricultural Sciences and Technologies Omer Halisdemir University Nigde Turkey Plant Health & Environment Laboratory Ministry for Primary Industries Auckland New Zealand

Subterranean predatory mites are important biological control agents of pests in soil. In order to understand the population characteristics of two predatory mites, Macrocheles glaber Miiller and Stratiolaelaps scimitus Womersley, we studied their development, survival and fecundity data under laboratory conditions using Coboldia fuscipes Meigen as a food source and analyzed them with the age-stage, two-sex life table. Macrocheles glaber had a significantly shorter developmental time, oviposition period, longevity and lower fecundity than those of S. scimitus. The intrinsic rate of increase (λ), finite rate of increase (r), net reproductive rate (C0),net predation rate (C0), and finite predation rate (ω) of M. glaber were significantly lower than those of S. scimitus. Both population parameters and computer simulation implied that S. scimitus is a potential powerful biocontrol agent compared to M. glaber.

关键词： biocontrol life table predatory mites

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互联网背景下耒阳市茶油产业发展现状及对策

南方农业 2024年第4期18卷 172-174页

作者：谢双周鑫刘雅兰蒋芳黄广钤肖静湖南应用技术学院湖南常德415100

山茶油号称“东方橄榄油”,是我国特有的一种优质食用油,具有很高的药用价值和食用价值。湖南省耒阳市是全国油茶生产大县,油茶栽培历史1800多年,油茶种植面积稳居全国县市之首。为提升耒阳市茶油的竞争力,带动当地农村经济的发展,论述... 详细信息

山茶油号称“东方橄榄油”,是我国特有的一种优质食用油,具有很高的药用价值和食用价值。湖南省耒阳市是全国油茶生产大县,油茶栽培历史1800多年,油茶种植面积稳居全国县市之首。为提升耒阳市茶油的竞争力,带动当地农村经济的发展,论述耒阳市茶油产业现状,分析存在的问题,提出提高产品品质,加大茶油良种推广力度;合理设定价格,控制产品成本;融合网络渠道,扩大产品影响力;完善物流体系,做好售后服务等对策。

关键词：油茶新媒体营销农产品湖南省耒阳市

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Effect of thermal deformation on microstructure and properties of TC18 titanium alloy produced by laser additive manufacturing

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Journal of Iron and Steel Research International 2020年第12期27卷 1476-1484页

作者： xiao-dong Li Chang-yue Qiu Yu-ting Liu Hong-fang Wang Dong-dong Zheng Yan-yan Zhu Shu-quan Zhang National Engineering Laboratory of Additive Manufacturing for Large Metallic Components and Engineering ResearchCenter Beijing 100191China Ministry of Education on Laser Direct Manufacturing for Large Metallic Components Beijing 100191China Beijing Engineering Technological Research Center on Laser Direct Manufacturing for Large Critical Metallic Component Beijing 100191China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Grain boundary of α phase damaged ductility of laser melting-deposited TC18 titanium alloy and grain boundary of α phases were difficult to break by nominal heat treatment. An extra thermal deformation was introduced to break the grain boundary of α phase with the improved mechanical property of TC18 titanium alloy fabricated by laser melting deposition *** indicated that after thermal deformation, β grains in alloy seriously elongated. When sample was deformed at temperatures from 750 to 850 ℃, α phase exhibited both rod and irregular morphologies with discontinuous distribution at grain boundary, and the subsequent heat treatment would lead to spheroidization of the α phase. However, after deformation at 900 ℃, α phase transferred into β phase and the subsequent heat treatment would make continuous grain boundary of α phase reappear. The suitable hot deformation can effectively break the continuous grain boundary in laser melting-deposited TC18 alloy with respected improved ductility.

关键词： Laser additive manufacturing Nearβtitanium alloy Thermal deformation Heat treatment Microstructural characteristics

Mechanisms of root-soil reinforcement in bioembankments of sloping farmland in the purple hilly area,China

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Journal of Mountain Science 2019年第10期16卷 2285-2298页

作者： JIN Hui-fang SHI Dong-mei ZENG xiao-ying WANG San-shu DUAN Teng LOU Yi-bao College of Resources and Environment Institute of Soil and Water Conservation and Eco-environmentSouthwestUniversityChongqing400715China Chongqing Institute of Forest Science Chongqing400036China Chongqing Surveying and Design Institute of Water Resources Electric Power and ArchitectureChongqing400020China

Bio-embankment is an important soil and water conservation measure in the purple hilly area in China,which can effectively improve the ability of cultivated soil layers to resist rainfall erosion and runoff *** contrast,the ecological effect of bioembankment depends on the stability of the earth *** the natural grass bank as a control(CK),the root distribution,root tensile properties and shear resistance of root-soil composites for 3 typical soil and water conservation bio-embankments,namely,Morus alba Linn(Morns),Zanthoxylum bungeanum Maxim(Zanthoxylum)and Medicago sativa(Medicago)were *** results included the following:(1)The root system of the bio-embankments generally decreased in extent with the soil depth;fine roots in the o-io cm depth were most prevalent and significantly higher than those at the other depths,and coarse roots were mainly distributed in the o-30cm layer.(2)The stress-strain curves of the roots of each bio-embankment were single-peak curves without clear strain softening *** smaller the root diameters were,the smoother the stress-strain curves,and the lower the capability of the earth bank to resist *** larger the root diameters were,the lower the tensile *** average root tensile force was highest for Zanthoxylum(73.91 N),followed by Medicago(68.07N)and Morus(61.88 N),and the average root tensile strength showed the same trend,16.52 MPa for Zanthoxylum,16.08 MPa for Medicago and 13.02MPa for Morus.(3)The bio-embankment measures significantly improved the soil shear resistance,especially under vertical loads of 1oo kPa and *** soil internal friction angle showed a significant log-positive correlation with root morphological parameters of root length density(RLD),root surface area density(RSAD) and rootweight density(RWD),while the soil cohesion force showed a positive linear correlation with these *** results provide effective parameters supporting for the design of bio-embankm

关键词： Bio-embankments Root distribution Tensile properties Shear strength Earth bank collapse Purple hilly area

UPLC/Q-TOF-MS特征图谱结合化学计量学评价秋海棠属5种药材质量

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中国药事 2024年第4期38卷 439-451页

作者：郑丽慧夏俊锋黄蕾胡敏肖凌汪波徐玲湖北省药品监督检验研究院国家药品监督管理局中药质量控制重点实验室湖北省药品质量检测与控制工程技术研究中心武汉430075 仙桃市公共检验检测中心仙桃433000 武汉市第一医院武汉430022

目的:采用UPLC/Q-TOF-MS技术结合化学计量学方法综合评价秋海棠、中华秋海棠、掌裂叶秋海棠、长柄秋海棠和柔毛秋海棠的质量。方法:采用ACQUITY UPLC HSS T3 C_(18)(2.1 mm×100mm,1.8μm)色谱柱,以乙腈-0.1%甲酸为流动相进行梯度洗脱,... 详细信息

目的:采用UPLC/Q-TOF-MS技术结合化学计量学方法综合评价秋海棠、中华秋海棠、掌裂叶秋海棠、长柄秋海棠和柔毛秋海棠的质量。方法:采用ACQUITY UPLC HSS T3 C_(18)(2.1 mm×100mm,1.8μm)色谱柱,以乙腈-0.1%甲酸为流动相进行梯度洗脱,柱温30℃,流速0.2 mL·min^(-1),检测波长254 nm;采用电喷雾离子源(ESI)正负离子同时扫描,以MSE方式进行采集,建立秋海棠属5种药材UPLC/Q-TOF-MS特征图谱,并对它们各自共有峰进行确认和归属,运用主成分分析法(PCA)和偏最小二乘判别分析法(PLS-DA)对数据进行统计分析。结果:筛选出秋海棠、中华秋海棠、掌裂叶秋海棠、长柄秋海棠和柔毛秋海棠药材各自的共有特征峰分别为15、13、12、12、15个,且共鉴定出29个化合物;秋海棠属5种药材质量存在较大差异,其中,柔毛秋海棠与其他4种药材的化学成分差异显著,秋海棠与中华秋海棠药材之间化学成分差异较小,掌裂叶秋海棠与长柄秋海棠药材之间化学成分差异较小;还筛选出对该5种药材区分贡献显著的8个化学标志物,原花青素B2、表儿茶素、葫芦素D或其同分异构体、葫芦素D葡萄糖苷和葫芦素B为潜在鉴别特征性化学标志物,原花青素B1、儿茶素和芦丁为潜在含量差异性化学标志物。结论:该方法直观、准确地反映了此5种药材的整体质量及化学成分差异情况,并对于建立科学、合理的秋海棠属药材质量评价方法和安全用药具有重要的指导意义,也为其整体质量评价和控制及标准修订提供参考。

关键词：秋海棠属药材 UPLC/Q-TOF-MS特征图谱共有特征峰主成分分析偏最小二乘判别分析