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Small Extracellular Vesicles Secreted by Peri-urethral Tissues Regulate Fibroblast Function and Contribute to the Pathogenesis of Female Stress Urinary Incontinence

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当代医学科学(英文) 2023年第4期43卷 803-810页

作者： Ning CHEN xiao-yan SUN Zhi-chen DING Jia-qi HU Wen-juan LI Li zhan Zhen-wei XIE department of Gynecology Women's HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China

Objective:This study aimed to explore the existence of small extracellular vesicles(sEVs)in peri-urethral tissues and the role of abnormal expression of sEVs in the pathogenesis of female stress urinary incontinence(SUI).Methods:sEVs were extracted from peri-urethral vaginal wall tissues using differential centrifugation and were observed by transmission electron microscopy(TEM).The number of sEVs and their protein contents were compared between SUI and control groups using nanoparticle tracking analysis(NTA)and bicinchoninic acid(BCA)protein *** were cultured separately with SUI(SsEVs group)and normal tissue sEVs(NsEVs group).Proliferation and migration of fibroblasts were compared between groups using CCK-8 and wound healing assays,*** levels of collagenⅠandⅢwere compared among blank control(BC),NsEVs,and SsEVs groups using real-time *** mass spectrometry was used to test the differentially expressed proteins contained in sEVs between ***:sEVs were extracted and found under the electron *** were significantly more sEVs extracted from the SUI group compared to the normal *** showed increased proliferative and decreased migratory abilities,and expressed more collagen in the SsEVs group compared to the NsEVs and BC *** spectrum analysis demonstrated several differentially expressed targets,including components of microfibrils,elastin polymer,and anti-inflammatory ***:sEVs were detected in the peri-urethral *** tissues expressed more sEVs than *** abnormal expression of sEVs and their protein contents may contribute to the pathogenesis and progression of SUI.

关键词： collagen female stress urinary incontinence fibroblasts small extracellular vesicles

The reversible addition-fragmentation chain transfer(RAFT) miniemulsion polymerization of vinyl acetate mediated by xanthate

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chinese Chemical Letters 2009年第6期20卷 733-737页

作者： Bo Jiang Qing Hua zhang xiao Li zhan Feng Qiu Chen department of Chemical and Biochemical engineering Zhejiang University Hangzhou 310027 People's Republic of China

The reversible addition-fragmentation chain transfer （RAFT） miniemulsion polymerization of vinyl acetate （VAc） mediated by methyl （methoxycarbonothioyl） sulfanyl acetate （MMSA） was carried out. The results showed that polymerizations initiated by AIBN and KPS proceeded in a controlled way. The RAFT miniemulsion polymerization of VAc initiated by KPS showed the shorter inhibition period, higher propagation rate coefficient and final conversion than those in experiment initiated by AIBN. When the monomer conversion reached 25%, the polydispersity index （PDI） of polymer became broad, which was related to chain transfer reaction in RAFT miniemulsion of VAc.

关键词： Xinyl acetate Xanthate Reversible addition-fragmentation chain transfer Miniemulsion

Partially reversible photochromic behavior of organic-inorganic perovskites with copper(II) chloride

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Journal of zhejiang university-science A(Applied Physics & engineering) 2009年第5期10卷 710-715页

作者： xiao-wei PAN Gang WU Mang WANG Hong-zheng CHEN State Key Lab of Silicon Materials MOE Key Laboratory of Macromolecule Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

We report that the ultraviolet （UV） light induced photochromic behavior of layered organic-inorganic perovskite material of （C4H9NH3）2CuCl4, changed from yellow to brown after irradiation with UV light （10 mW/cm^2） and partially recovered through storage in the dark. （C4H9NH3）2CuCl4 exhibited two distinct absorption bands centered at 286 nm （band Ⅰ） and 384 nm （band Ⅱ）, which were attributed to the photo-induced exciton formed in 2D inorganic layers sandwiched by organic layers. The blue shift of band Ⅰ from 287 to 269 nm as well as the decrease of the intensity of band Ⅰ and band Ⅱ could be found when samples were irradiated under UV light for different length of time. The simultaneous weakening of the intensity of the N-H...Cl hydrogen bond as well as the vibration of the long Cu-Cl bond in the distorted CuCl6^4- octahedron could be detected from the Fourier transform infrared （FTIR） spectra, which resulted the change of charge distribution of the dissymmetric Cl-Cu...Cl bond and the resulting photochromic behavior.

关键词： Photochromic behavior Perovskite Organic-inorganic hybrid

Self-diffusion coefficients of organic solvents in linear and branched high density polyethylene particles measured by PFG NMR

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chinese Chemical Letters 2008年第1期19卷 110-114页

作者： xiao wei Yan xiao Hong Ren Siegfried Stap Jing Dai Wang Yong Rong Yang department of Chemical engineering Zhejiang University Hangzhou 310027 China FG Technische Physik ll/polymerphysik Fakultat fiir Mathematik und Naturwissenschaften Technische Universitiit Ilmenau Postfach 100565 D-98684 Ilmenau Germany Institut fiir Technische Chemie und Makromolekulare Chemie RWTH Aachen University Worringerweg 1 D-52056 Aachen Germany

Pulsed field gradient nuclear magnetic resonance （PFG NMR） has been performed to study the diffusion of organic solvents into semicrystalline polyethylene particles. Self-diffusion coefficients in different domains of the sample can be extracted through a bi- exponential fit to the echo intensity attenuation, which allows the precise determination of the tortuosity of the polyethylene particles. Further exploration comes from the measurements with branched polyethylene particles and it was found that the diffusion in polymer phase contributed significantly to the slow component of the exponential decay curve. 2007 Jing Dai Wang. Published by Elsevier B.V. on behalf of chinese Chemical Society. All rights reserved.

关键词： Self-diffusion coefficients Pulsed field gradient NMR Tortuosity Polyethylene particle

Nonlinear Optical Properties of Some New Conjugated Copolymers

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chinese Physics Letters 1998年第3期15卷 189-191页

作者： YANG Qi-guang SI Jin-hai LIU Xu-chun XU Gang YE Pei-xian LEI Zi-qiang zhan xiao-wei YANG Mu-jie institute of Physics&Center for Condensed Matter Physics Chinese Academy of SciencesBeijing 100080 department of polymer science and engineering Zhejiang UniversityHangzhou 310027

The ground-and the excited-state nonlinearities of two new copolymers are investigated in nanosecond scale at 1064 *** is found that the excited-state susceptibility is dramatically larger than the corresponding ground-state susceptibility for each *** experimental results also give evidence that superlattice structure of the copolymers can enhance,especially for the excited state,the molecular hyperpolarizabilities *** enhancement may be attributed to the confinement effect of the pump-induced carriers.

关键词： excited susceptibility Copolymer

Synthesis of polystyrene-styrene/butadiene diblock copolymers via reversible addition-fragmentation chain transfer miniemulsion polymerization

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chinese Chemical Letters 2010年第12期21卷 1497-1500页

作者： Zhen Xi Wang Qing Hua zhang Yi Tao Yu xiao Li zhan Feng Qiu Chen Ji Hai Xiong department of Chemical and Biological engineering Zhejiang University Hangzhou 310027 China institute of Energy Conversion Jiangxi Academy of Sciences Nanchang 330029 China

Polystyrene-styrene/butadiene diblock copolymers were synthesized via reversible addition-fragmentation chain transfer （RAFT） miniemulsion *** the polymerization process,the molecular weight distribution was narrow and the numerical molecular weight of the copolymers increased with increasing conversion of monomers,which was close to the ***-IR and ^1H NMR results indicated that the microstructure of the polymer was mainly 1,4-trans-butadiene with small amount of 1,2-units,and composition in the copolymers was obtained.

关键词： Reversible addition-fragmentation chain transfer Polystyrene-styrene/butadiene diblock copolymers Miniemulsion polymerization

Alternating Copolymerization of Epoxides and Isothiocyanates to Diverse Functional Polythioimidocarbonates and Related Block polymers

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chinese Journal of chemistry 2023年第23期41卷 3311-3318页

作者： xiao-Feng Zhu Xin-Yu Lu Cheng-Kai Xu Yu-Bo Fang Guan-Wen Yang wei Li Jingdai Wang Guang-Peng Wu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang310027 China zhejiang Provincial Key Laboratory of Advanced Chemical engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhouZhejiang310027 China

Synthesis of diverse polythioimidocarbonates via ring-opening copolymerization of epoxides and isothiocyanates catalyzed by organoboron catalyst was reported *** aromatic and aliphatic isothiocyanates underwent successful copolymerization with terminal and internal epoxides,allowing for the precise tuning of the performance of the resultant copolymers over a broad *** wide scope of available isothiocyanates and epoxides enables the direct construction of sulfur-containing functional polymers featuring both high glass transition temperature and refractive ***,it was observed that aromatic isothiocyanates polymerize much faster than aliphatic ones,and the reactivity difference facilitated the one-step synthesis of block polymers from mixed aromatic isothiocyanates,aliphatic isothiocyanates and epoxides due to the preferential incorporation of aromatic isothiocyanates over the aliphatic analogues during their alternating copolymerization with *** produced polythioimidocarbonates can be used as positive resists for electron beam lithography(sensitivity of 130μC/cm^(2) and contrast of 1.53 for poly(CHO-alt-EITC)).Coupling with their high refractive index(1.58—1.68),polythioimidocarbonates might find functional applications in *** results render ring-opening copolymerization of epoxides and isothiocyanates a facile route to enrich functional polymer library.

关键词： Ring-opening copolymerization Metal-free catalysis Sulfur-containing polymers Block polymers Electron beam lithography High refractive index

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research institute Co. LtdBeijing beijing institute of Technology Beijing beijing Normal university Beijing Brown university ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced science and Technology Beijing china institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East china university Of science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Biomedical polymers: synthesis, properties, and applications

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science china chemistry 2022年第6期65卷 1010-1075页

作者： wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo zhang zhanzhan zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng zhang Xuesi Chen Key Laboratory of Biomedical polymers of Ministry of Education&department of chemistry Wuhan UniversityWuhan430072China institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China School of Materials science and engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China Key Laboratory of Biomedical Materials of Natural Macromolecules(beijing university of Chemical Technology) Ministry of EducationBeijing Laboratory of Biomedical MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai UniversityTianjin300071China Key Laboratory of Advanced Drug Delivery Systems of zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Jinhua institute of zhejiang university Jinhua321299China zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China ZJU-hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Molecular engineering of polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai200438China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nano-scienceNational Center for Nanoscience and Technology(NCNST)Beijing100190China School of Biomedical sciences and engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou510006China institute of Functional Nano and So

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

关键词： biomedical polymer nanomedicine cancer therapy drug delivery bioimaging and biosensing tissue engineering regenerative medicine cytotoxicity biocompatibility