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International Journal of Minerals,Metallurgy and Materials 2017年第9期24卷 1021-1026页

作者： Lin Liu Xin-da Wang Xiang Li xiao-tong qi Xuan-hui Qu School of Mechanical and Electrical Engineering China University of Mining and Technology(Beijing) School of Material Science and Engineering University of Science and Technology Beijing

The fabrication of 17-4PH micro spool mandrils by micro metal injection molding was described here. The effects of size reduction on deformation, microstructure and surface roughness were studied by comparing a I center dot 500 mu m micro post and a I center dot 1.7 mm cylinder after debinding and sintering. Experimental results show that slumping of the micro posts occurred due to a dramatic increase in outlet vapor pressure initiated at the thermal degradation onset temperature and the moment of gravity. Asymmetrical stress distribution within the micro component formed during the cooling stage may cause warping. Prior solvent debinding and adjustment in a thermal debinding scheme were useful for preventing the deformation of the micro components. Smaller grain size and higher micro hardness due to impeded grain growth were observed for the micro posts compared with the I center dot 1.7 mm cylinder. Surface roughness increased with distance from the gate of the micro spool mandril due to melt front advancement during mold filling and the ensuing pressure distribution. At each position, surface roughness was dictated by injection molding and increased slightly after sintering.

关键词： powder metallurgy deformation microstructure surface roughness sintering

Cole-Hopf Transformation Based Lattice Boltzmann Model for One-dimensional Burgers' Equation

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Communications in Theoretical Physics 2018年第3期69卷 329-335页

作者： xiao-tong qi Bao-Chang Shi Zhen-Hua Chai School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China

In this paper,we present a Cole-Hopf transformation based lattice Boltzmann(LB)model for solving one-dimensional Burgers'equation,and compared to available LB models,the effect of nonlinear convection term can be *** Chapman-Enskog analysis,it can be found that the converted diffusion equation based on the Cole-Hopf transformation can be recovered correctly from present LB *** numerical tests are also performed to validate the present LB model,and the numerical results show that,similar to previous LB models,the present model also has a second-order convergence rate in space,but it is more accurate than the previous ones.

关键词： Burgers'equation Cole-Hopf transformation lattice Boltzmann model

Mesenchymal stem cell therapy in atherosclerosis:A bibliometric and visual analysis

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World Journal of Stem Cells 2024年第12期16卷 1062-1085页

作者： Xing Cheng Ya-Ling Li Heng Wang Rui-Jing Zhang Ke-Yi Fan xiao-tong qi Guo-Ping Zheng Hong-Lin Dong Department of Vascular Surgery The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Centre for Transplant and Renal Research Westmead Institute for Medical ResearchThe University of SydneySydney 2145New South WalesAustralia Department of Nephrology The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Mesenchymal stem cells(MSCs)are capable of self-renewal and differentiation,and extensive studies have demonstrated their therapeutic potential in atherosclerosis(AS).AIM To conduct a bibliometric analysis of studies on the use of MSC therapy for AS over the past two decades,assess key trends and provide insights for future research *** We systematically searched the Web of Science Core Collection database for articles published between 1999 and 2023,yielding a total of 556 *** representation and bibliometric analysis of information and trends were facilitated using CiteSpace,the R package‘bibliometrix’and *** The analyzed articles were predominantly from 52 countries/regions,with prominent contributions from China and the United States.A cohort of 3057 authors contributed to these publications,with the works of Libby P distinguished by their influence and citation *** J Mol Sci has emerged as the journal with the highest publication volume,prominently disseminating influential papers and identifying citation ***,our analysis identified current research hotspots within the field,focusing on vascular progenitor cells,inflammatory mechanisms,and extracellular *** research frontiers,such as extracellular vesicles and oxidative stress,have been highlighted as areas of burgeoning ***,we offer perspectives on the status of research and future directions of MSC therapy in *** This comprehensive analysis provides valuable insights for advancing scientific research on MSC therapy for *** elucidating pivotal trends and research directions,this study aimed to foster innovation and promote the progress of disciplines in this field,thereby contributing to advancing scientific knowledge and clinical practice.

关键词： Atherosclerosis Treatment strategy Bibliometrics Visual analysis CiteSpace

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实施以中为重创建和谐社会

行政与法 2005年第7期 11-12页

作者：童小琴泉州行政学院福建泉州362000

“中”是协调、化解两头之间矛盾的重要关节点,以中为重对于维护群众利益、促进社会公平、创建社会主义和谐社会具有十分重要的意义。在我国现阶段,实施以中为重的发展战略,主要表现为促进中部地区崛起、提高中等收入者比重、发展中等... 详细信息

“中”是协调、化解两头之间矛盾的重要关节点,以中为重对于维护群众利益、促进社会公平、创建社会主义和谐社会具有十分重要的意义。在我国现阶段,实施以中为重的发展战略,主要表现为促进中部地区崛起、提高中等收入者比重、发展中等教育、应用中间技术等四大方面。

关键词：以中为重中部地区中等收入者中等教育中间技术和谐社会

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： xiaodong Yang Haochen Shen xiaoming xiao Zhichao Li qi Zhou Wei Yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li xiaolei Chu qi Li Ruihua Li qingwen Li Kai-Yu tong xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan qi Wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

对氨基苯甲酰谷氨酸制备过程中加氢反应工程设计安全措施

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化工管理 2022年第15期 148-151页

作者：何永刚童晓琪杭州杭氧化医工程有限公司浙江杭州310014

对硝基苯甲酰谷氨酸钾通过加氢反应制备对氨基苯甲酰谷氨酸钾的过程为间歇过程,危险性较大。文章通过对该加氢反应过程在工程设计中的各项程序及工艺、自控等方面的安全措施进行了探讨。

关键词：加氢反应首次工艺安全设计

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： xiao-Man Chen Shuo Zhang Shi-qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

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春用家蚕品种681×682的育成

蚕业科学 2011年第3期37卷 549-554页

作者：黄德辉孙家羿李圣漆学文童晓琪秦凤石凉李庆宝安徽省农业科学院蚕桑研究所合肥230061 安徽省蚕桑服务站合肥230001

为了选育能通过对交种幼虫斑纹及蛾色识别提高杂交率的强健性多丝量春用家蚕品种,根据家蚕暗化型基因(mln)的遗传规律,将mln导入实用家蚕品种,培育出中系强健性灰黑蛾品种681。将681与普通日系白蛾品种682(由现行品种皖6经强健性及繁育... 详细信息

为了选育能通过对交种幼虫斑纹及蛾色识别提高杂交率的强健性多丝量春用家蚕品种,根据家蚕暗化型基因(mln)的遗传规律,将mln导入实用家蚕品种,培育出中系强健性灰黑蛾品种681。将681与普通日系白蛾品种682(由现行品种皖6经强健性及繁育系数改良而来)组配成杂交组合,实现了蚕种繁育中可利用对交品种的蛾色差异,将杂交率提高到99%以上的目的。新品种还具有强健好养、易繁育、眠起齐、丝质优的特点,在安徽省农村饲养鉴定的茧丝长1 401.0 m,解舒率76.16%,解舒丝长1 068.0 m,茧丝纤度3.126 dtex,洁净94.19分。新品种于2010年12月通过安徽省家蚕新品种审定。

关键词：家蚕春用品种 681×682 暗化型灰黑蛾杂交率