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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

Traditional Medicine Research 2025年第1期10卷 1-11页

作者： xiao-xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang xiao-Ge Li Qi-Bao Jiang shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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Metagenomics reveals the resistance patterns of electrochemically treated erythromycin fermentation residue

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Journal of Environmental Sciences 2025年第2期148卷 567-578页

作者： Jieya Zhou HaoWu Haiyan Wang ZongruWu Lihu shi Shulei Tian Li-an Hou State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Inner Mongolia Autonomous Region Solid Waste and Soil Ecological Environment Technology Center Hohhot 010020China

Erythromycin fermentation residue(EFR)represents a typical hazardous waste produced by the microbial pharmaceutical *** electrolysis is promising for EFR disposal,its microbial threats remain ***,metagenomics was coupled with the random forest technique to decipher the antibiotic resistance patterns of electrochemically treated *** showed that 95.75%of erythromycin could be removed in 2 *** temporarily influenced EFRmicrobiota,where the relative abundances of Proteobacteria and Actinobacteria increased,while those of Fusobacteria,Firmicutes,and Bacteroidetes decreased.A total of 505 antibiotic resistance gene(ARG)subtypes encoding resistance to 21 antibiotic types and 150 mobile genetic elements(MGEs),mainly including plasmid(72)and transposase(52)were assembled in *** linear regression models were identified among microbial richness,ARG subtypes,and MGE numbers(r^(2)=0.50-0.81,p<0.001).Physicochemical factors of EFR(Total nitrogen,total organic carbon,protein,and humus)regulated ARG and MGE assembly(%IncMSE value=5.14-14.85).The core ARG,MGE,and microbe sets(93.08%-99.85%)successfully explained 89.71%-92.92%of total ARG and MGE ***,gene aph(3 )-I,transposase tnpA,and Mycolicibacterium were the primary drivers of the resistance dissemination *** study also proposes efficient resistance mitigation measures,and provides recommendations for future management of antibiotic fermentation residue.

关键词： Erythromycin fermentation residue (EFR) Microbial pharmaceutical industry Disposal strategy Metagenomics Antibiotic fermentation residue management

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Geochronology and geodynamic setting of the carbonate-hosted Pb-Zn deposits in world-class Sichuan-Yunnan-Guizhou triangle,South China

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Acta Geochimica 2025年第1期44卷 217-230页

作者： Zhongxi Xue Wenxin shi Chen Wei Tao Wu Zhilong Huang State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China College of Mining Engineering Guizhou University of Engineering ScienceBijie 551700China Helmholtz-Zentrum Dresden Rossendorf Helmholtz Institute Freiberg for Resource Technology09599 FreibergGermany University of Chinese Academy of Sciences Beijing 100049China

Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a *** Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic *** region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and *** the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG *** paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze *** predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian *** secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys *** investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.

关键词： Sichuan-Yunnan-Guizhou triangle Carbonate hosted Pb-Zn deposit Radioisotopic dating Geodynamic setting Mississippi Valley-type(MVT)

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Bond length and interface failure mechanism of anchor cable under continuous radial pressure conditions

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International Journal of Mining Science and Technology 2025年第2期35卷 231-247页

作者： Jian Ouyang Xiuzhi shi Xianyang Qiu Zongguo Zhang Zeyu Li School of Resources and Safety Engineering Central South UniversityChangsha 410083China

The anchoring capacity of the anchor cable is closely related to the bonding length and radial pressure *** field pull-out tests,theoretical analysis,numerical simulation,and industrial tests,this study clarifies the relationship between radial pressure and bonding length for the ultimate pullout force and reveals the microscopic failure process of the resin-rock interface in the anchoring *** results show that the ultimate load increases with the increase of bonding length in three different stages:rapid,slow,and uniform *** new mechanical model developed considering radial pressure describes the inverse relationship between radial pressure and the plastic zone on the bonding section,and quantifies the reinforcing effect of confining pressure on the anchoring *** the pull-out process of the anchor cable,the generation of failure cracks is in the order of orifice,bottom,and middle of the *** pressure can effectively enhance the ultimate pull-out force,alleviate the oscillation increase of pull-out force,and inhibit resin cracking,but will produce an external crushing *** also reveals the synergistic effect between bonding length and radial pressure,and successfully carries out industrial tests of anchor cable support,which ensures the stability of the stope roof and provides an important reference for the design of anchor cable support in deep high-stress mines.

关键词： Radial pressure Anchor cable Bond length Numerical simulation Interface failure Microscopic process

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Mach reflection and pressure/heating loads on V-shaped blunt leading edges with variable cross-sections and crotches

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Chinese Journal of Aeronautics 2025年第1期38卷 271-285页

作者： Tao ZHANG Xuhui ZHANG Luoyu RAO Chongguang shi Chengxiang ZHU Yancheng YOU School of Aerospace Engineering Xiamen UniversityXiamen 361005China China Academy of Aerospace Science and Innovation Beijing 100176China

The primary Mach Reflection(MR)and pressure/heating loads on V-shaped Blunt Leading Edges(VBLEs)with variable elliptic cross-sections and conic crotches are theoretically investigated in this *** simplified continuity method is used to forecast the shock *** theoretical predictions and the numerical simulations for the Mach stem and the triple point as well as the curved shock accord *** on the theoretical model,an analysis of the impact of the axial ratio a/b of the cross-sectional shape and the eccentricity e of the crotch sweep path on shock structures is carried *** shock configurations obtained from the theoretical model enable the derivation of the transition boundaries between the primary MR and the same family Regular Reflection(sRR).It is found that the increase of a/b and e can both facilitate the primary MR to sRR *** resulting transition and the corresponding generation of the wall pressure and heat flux are then *** results indicate that higher values of the ratio a/b can significantly reduce the wall pressure and heating loads by inducing the primary MR to sRR ***,the increase in the eccentricity e results in increased loads,despite causing the same transition.

关键词： Aerodynamics Hypersonic flow Shock waves Heat flux V-shaped blunt leading edges

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Oxalate modification enabled advanced phosphate removal of nZVI:In Situ formed surface ternary complex and altered multi-stage adsorption process

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Journal of Environmental Sciences 2025年第3期149卷 79-87页

作者： shiyu Cao Jiangshan Li Yanbiao shi Furong Guo Tingjuan Gao Lizhi Zhang Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Institute of Environmental&Applied ChemistryCollege of ChemistryCentral China Normal UniversityWuhan 430079China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China

Nano zero-valent iron(nZVI)is a promising phosphate adsorbent for advanced phosphate ***,the rapid passivation of nZVI and the low activity of adsorption sites seriously limit its phosphate removal performance,accounting for its inapplicability to meet the emission criteria of 0.1 mg P/L *** this study,we report that the oxalate modification can inhibit the passivation of nZVI and alter the multi-stage phosphate adsorption mechanism by changing the adsorption *** expected,the stronger antipassivation ability of oxalate modified nZVI(OX-nZVI)strongly favored its phosphate ***,the oxalate modification endowed the surface Fe(III)sites with the lowest chemisorption energy and the fastest phosphate adsorption ability than the other adsorption sites,by in situ forming a Fe(III)-phosphate-oxalate ternary complex,therefore enabling an advanced phosphate removal *** an initial phosphate concentration of 1.00 mg P/L,pH of 6.0 and a dosage of 0.3 g/L of adsorbents,OX-nZVI exhibited faster phosphate removal rate(0.11 g/mg/min)and lower residual phosphate level(0.02 mg P/L)than nZVI(0.055 g/mg/min and 0.19 mg P/L).This study sheds light on the importance of site manipulation in the development of high-performance adsorbents,and offers a facile surface modification strategy to prepare superior iron-basedmaterials for advanced phosphate removal.

关键词： Oxalate modification Advanced phosphate removal Nano zero-valent iron(nZVI) Surface ternary complex Multi-stage adsorption

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The regulatory network and critical factors promoting programmed cell death during embryogenesis

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Journal of Integrative Plant Biology 2025年第1期67卷 55-70页

作者： An Luo Ce shi Pan Luo Zifu Zhao Meng-Xiang Sun College of Life Sciences Yangtze UniversityJingzhou 434023China State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China

Programmed cell death(PCD)is essential for animal and plant ***,the knowledge of the mechanism regulating PCD in plants remains limited,largely due to technical ***,we determined that the protease NtCP14 could trigger PCD in the embryonic suspensor of tobacco(Nicotiana tabacum),providing a unique opportunity to overcome the limitations by creating synchronous two-celled proembryos with ongoing PCD for transcriptome analysis and regulatory factor ***,we performed comparative transcriptome analysis using isolated two-celled proembryos and explored the potential regulatory network underlying NtCP14-triggered *** phytohormones,calcium,microtubule organization,the immunity system,soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins,long non-coding RNAs and alternative splicing are addressed as critical factors involved in the early stage of suspensor *** thought to play crucial roles in suspensor PCD are ***,decreased antioxidant gene expression and increased reactive oxygen species(ROS)levels during suspensor PCD suggest a critical role for ROS signaling in the initiation of NtCP14-triggered ***,five genes in the regulatory network are recommended as immediate downstream elements of ***,our analysis outlines an overall molecular network underlying protease-triggered PCD and provides a reliable database and valuable clues for targeting elements immediately downstream of NtCP14 to overcome technical bottlenecks and gain deep insight into the molecular mechanism regulating plant PCD.

关键词： programmed cell death protease reactive oxygen species suspensor transcriptome

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RE-SEGNN:recurrent semantic evidence-aware graph neural network for temporal knowledge graph forecasting

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Science China(Information Sciences) 2025年第2期68卷 103-119页

作者： Wenyu CAI Mengfan LI Xuanhua shi Yuanxin FAN Quntao ZHU Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and Technology

Temporal knowledge graph(TKG) reasoning, has seen widespread use for modeling real-world events, particularly in extrapolation settings. Nevertheless, most previous studies are embedded models, which require both entity and relation embedding to make predictions, ignoring the semantic correlations among different entities and relations within the same timestamp. This can lead to random and nonsensical predictions when unseen entities or relations occur. Furthermore, many existing models exhibit limitations in handling highly correlated historical facts with extensive temporal depth. They often either overlook such facts or overly accentuate the relationships between recurring past occurrences and their current counterparts. Due to the dynamic nature of TKG, effectively capturing the evolving semantics between different timestamps can be *** address these shortcomings, we propose the recurrent semantic evidenceaware graph neural network(RE-SEGNN), a novel graph neural network that can learn the semantics of entities and relations simultaneously. For the former challenge, our model can predict a possible answer to missing quadruples based on semantics when facing unseen entities or relations. For the latter problem, based on an obvious established force, both the recency and frequency of semantic history tend to confer a higher reference value for the current. We use the Hawkes process to compute the semantic trend, which allows the semantics of recent facts to gain more attention than those of distant facts. Experimental results show that RE-SEGNN outperforms all SOTA models in entity prediction on 6 widely used datasets, and 5 datasets in relation prediction. Furthermore, the case study shows how our model can deal with unseen entities and relations.

关键词： knowledge graph reasoning temporal knowledge graph Hawkes process semantic evidence

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Metallogenic model of sandstone-hosted copper deposits:a case study from the Paleogene in Jiashi area,northwestern China

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Journal of Palaeogeography 2025年第01期14卷 105-125页

作者： Long-Qing shi Xing-Yue Qu Carlos Zavala Yang Li College of Earth Science and Engineering Shandong University of Science and Technology Geology Department Universidad Nacional del Sur Geología de Cuencas Sedimentarias (GCS) Argentina Institute of Energy Peking University Ordos Research Institute of Energy Peking University Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and Technology

Sandstone-hosted copper deposits,a type of Sediment-Hosted Stratiform Copper (SSC) deposits,are widely distributed *** economically viable deposits of SSC are relatively scarce,they account for approximately 30%of the world's total discovered copper ***,there is still a lack of comprehensive and in-depth research into the depositional and metallogenic models of these *** Jiashi area of the Tarim Basin in northwestern China,known for its economically significant Paleogene SSC deposit,lacks in-depth studies on metallogenic *** address this,field profile observations were conducted to analyze the sedimentary evolution,sequence stratigraphy,and tectonism of the Paleogene strata in the Jiashi *** with elemental geochemical analysis of samples,the provenance of sediment,and the source of metallogenic materials,a robust metallogenic model was *** results reveal the influence of provenance for the origin of Paleogene copper-rich *** evolution played a crucial role in controlling the distribution of copper and sulfur elements,as well as the spatial arrangement of metallogenic ***,nappe movement potentially generated faults,allowing upward movement of basin fluids,which played a crucial role in the formation of copper deposits within sandstone-hosted ***,this study offers a comprehensive analysis of the metallogenic processes involved in sandstone-hosted copper deposits,thereby contributing significant insights to the broader research on SSC deposits worldwide.

关键词： Tarim Basin Paleogene Sandstone-hosted copper deposits Metallogenic material source Metallogenic model

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Meteorological effects on sources and future projection of nitrogen deposition to lakes in China

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Journal of Environmental Sciences 2025年第5期151卷 100-112页

作者： Cheng shi Hao Guo Xue Qiao Jingsi Gao Ying Chen Hongliang Zhang Department of Biological and Ecological Engineering Oregon State UniversityCorvallisOR 97331USA State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Institute of New Energy and Low-carbon Technology Sichuan UniversityChengdu 610065China Engineering Technology Development Center of Urban Water Recycling Shenzhen PolytechnicShenzhen 518055China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200438China IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghai 200438China

Lake ecosystems are extremely sensitive to nitrogen growth,which leads to water quality degradation and ecosystem health *** depositions,as one of the main sources of nitrogen in water,are expected to change under future climate change ***,it remains not clear how nitrogen deposition to lakes respond to future meteorological *** this study,a source-oriented version of Community Multiscale Air Quality(CMAQ)Model was used to estimate nitrogen deposition to 263 lakes in 2013 and under three RCP scenarios(4.5,6.0 and 8.5)in *** total deposition of 58.2 Gg nitrogen was predicted for all lakes,with 23.3 Gg N by wet deposition and 34.9 Gg N by dry *** and ammonium in aerosol phase are the major forms of wet deposition,while NH3 and HNO_(3)in gas phase are the major forms of dry *** emissions contribute to 57%of wet deposition and 44%of dry *** future meteorological conditions,wet deposition is predicted to increase by 5.5%to 16.4%,while dry deposition would decrease by 0.3%to 13.0%.Changes in wind speed,temperature,relative humidity(RH),and precipitation rates are correlated with dry and wet deposition *** predicted changes in deposition to lakes driven by meteorological changes can lead to significant changes in aquatic chemistry and ecosystem *** from future emission scenarios,different climate scenarios should be considered in future ecosystem health evaluation in response to nitrogen deposition.

关键词： Deposition Nitrogen Lakes CMAQ Meteorological variations

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