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Clinicopathological features and prognosis of membranoproliferative-like Henoch-Schönlein purpura nephritis in children

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World Journal of Pediatrics 2015年第4期11卷 338-345页

作者： Yan-Jie Huang xiao-qing yang Wen-Sheng Zhai Xian-qing Ren qing-Yin Guo Xia Zhang Meng yang Tatsuo Yamamoto Yuan Sun Ying Ding Department of Pediatrics First Affi liated Hospital of Henan University of Traditional Chinese MedicineChina Second Department of Medicine Numazu City HospitalNumazuJapan Department of Anesthesia Stanford University School of MedicineCaliforniaUSA

Background: The aim of this retrospective study was to defi ne the clinical manifestations, pathological features and prognosis of children with membranoproliferative-like Henoch-Schönlein purpura nephritis (HSPN), representing International Study of Kidney Disease in Children (ISKDC) grade VI. Methods: Among 245 patients with HSPN treated in our hospital between 2008 and 2010, nine patients (3.7%) were diagnosed with HSPN of ISKDC grade VI (males=5, females=4, age: 9.5±2.03 years, mean±SD). The clinical features, laboratory and pathologicalfi ndings, treatment and outcome of the 9 patients were retrospectively analyzed. Results: Of the 9 patients, 7 (78%) presented with hematuria and nephrotic syndrome, and were treated with steroids (oral prednisone or intravenous methylprednisolone pulse therapy) and immunosuppressants (oral tripterygium glycosides or intravenous cyclophosphamide pulse therapy). One (11%) patient had hematuria and nephrotic range proteinuria (>50 mg/kg per 24 hours) and was treated with oral prednisone and tripterygium glycosides. Another (11%) patient presented with hematuria and moderate proteinuria (25-50 mg/kg per 24 hours) and was treated with oral tripterygium glycoside only. Histopathological examination showed diffuse glomerular mesangial and endocapillary proliferation, mesangial interposition, double-contour formation, podocyte hypertrophy, shedding, and cytoplasmic absorption droplets. The percentages of glomeruli with small cellular crescents varied from 4%-25% in 6 of 9 patients. Follow-up for 2 to 4 years showed excellent recovery in all patients. Conclusions: The main clinical feature of ISKDC grade VI HSPN in children is a nephrotic syndrome with hematuria. The excellent prognosis of the disease was probably related to early diagnosis and treatment with steroids and/or immunosuppressants, and mild degree of glomerulosclerosis and tubulointerstitial damage.

关键词： clinicopathological features Henoch-Schönlein purpura nephritis prognosis

First Observation of Neoclassical Tearing Modes in the HL-2A Tokamak

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Chinese Physics Letters 2010年第6期27卷 137-140页

作者： JI xiao-Quan yang qing-Wei LIU Yi ZHOU Jun FENG Bei-Bin YUAN Bao-Shan Southwestern Institute of Physics Chengdu 610041

The m/n = 2/1 neoclassical tearing modes are first observed in HL-2A low density, low beta plasma with central electron cyclotron resonance heating. The neoclassical tearing modes （NTMs） are triggered by a sawtooth crash with m/n = 1/1 precursors, which are toroidal coupled with a small scale m/n = 2/1 mode. The time history of the island width is compared with the prediction of the NTM theory, showing a good agreement between theory and experiment.

关键词： Tears Scales Neoclassical

Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2014年第14期20卷 4076-4084页

作者： xiao-qing yang Yun-Fei Xu Sen Guo Yi Liu Shang-Lei Ning xiao-Fei Lu Hui yang Yu-Xin Chen Department of Hepatobiliary Surgery Qilu Hospital of Shandong University Department of Pathology Shandong University Department of Gastrointestinal Surgery Central Hospital of Shandong University

AIM: To investigate the correlation between nerve growth factor-tropomyosin-receptor-kinase (NGF-TrkA) signaling pathway and prognosis in intrahepatic cholangiocarcinoma (IHCC).

关键词： Nerve growth factor Tropomyosin-receptor-kinase Prognosis Intrahepatic cholangiocarcinoma Progression

Tripterygium wilfordii Hook F is efficacious in the treatment of Henoch-Schönlein purpura nephritis in children

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World Journal of Pediatrics 2016年第3期12卷 376-379页

作者： Yan-Jie Huang xiao-qing yang Wen-Sheng Zhai Xian-qing Ren Yuan Sun Ying Ding The First Affiliated Hospital of Henan University of Traditional Chinese Medicine 19 Renmin road Zhengzhou 450000China

Our retrospective study was aimed to define the clinical manifestations,pathological features and prognosis of children with grade VI HSPN,our results also showed that tripterygium glycosides(T glycosides)alone or com... 详细信息

关键词： protective nephritis Tripterygium

Elastic modulus affects the growth and differentiation of neural stem cells

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Neural Regeneration Research 2015年第9期10卷 1523-1527页

作者： Xian-feng Jiang Kai yang xiao-qing yang Ying-fu Liu Yuan-chi Cheng Xu-yi Chen Yue Tu Affiliated Hospital of Logistics University of People’s Armed Police Force Liaoning Medical University Logistics University of People’s Armed Police Force

It remains poorly understood if carrier hardness, elastic modulus, and contact area affect neural stem cell growth and differentiation. Tensile tests show that the elastic moduli of Tiansu and SMI silicone membranes are lower than that of an ordinary dish, while the elastic modulus of SMI silicone membrane is lower than that of Tiansu silicone membrane. Neural stem cells from the cerebral cortex of embryonic day 16 Sprague-Dawley rats were seeded onto ordinary dishes as well as Tiansu silicone membrane and SMI silicone membrane. Light microscopy showed that neural stem cells on all three carriers show improved adherence. After 7 days of differentiation, neuron specific enolase, glial fibrillary acidic protein, and myelin basic protein expression was detected by immunofluorescence. Moreover, flow cytometry revealed a higher rate of neural stem cell differentiation into astrocytes on Tiansu and SMI silicone membranes than on the ordinary dish, which was also higher on the SMI than the Tiansu silicone membrane. These findings con- firm that all three cell carrier types have good biocompatibility, while SMI and Tiansu silicone membranes exhibit good mechanical homogenization. Thus, elastic modulus affects neural stem cell differentiation into various nerve cells. Within a certain range, a smaller elastic modulus re- sults in a more obvious trend of cell differentiation into astrocytes.

关键词： nerve regeneration neural stem cells carrier mechanical properties elastic modulus cell differentiation neurons immunofluorescence astrocytes neural regeneration

High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2015年第11期21卷 3256-3265页

作者： Yun-Fei Xu Fu-Jun Ge Bo Han xiao-qing yang Hong Su An-Cheng Zhao Ming-Hong Zhao Yu-Bao yang Jie yang Department of Hepatobilliary Surgery Shandong University Qilu Hospital Department of General Surgery Affiliated Hospital of Shandong Medical School Department of Pathology Shandong University Medical School Department of Clinical Laboratory Yishui Central Hospital Department of Pediatrics Shandong University Qilu Hospital

AIM:To evaluate the prognostic value of high-mobility group box 1(HMGB1) expression in intrahepatic cholangiocarcinoma(IHCC) and the possible underlying ***:Tissue microarray was constructed from 65 IHCC *** was performed to validate expression of HMGB1 and Vascular endothelial growth factor C(VEGF-C).Realtime PCR and Western blot analyses were used to study transcript and protein *** interaction between HMGB1 and VEGF-C was evaluated by si RNA,real-time PCR,and enzyme-linked immuno *** correlation between HMGB1 expression and other clinicopathologic parameters was analyzed byχ2 test,and the univariate as well as multivariate analyses were accomplished by Kaplan-Meier method and Coxregression model,***:Overall,overexpression of HMGB1 was found in 38/65(58.8%)IHCCs,whereas VEGF-C overexpression was present in 30/65(46.2%)*** of HMGB1 was significantly correlated with lymphatic microvessel density(P=0.031,r=0.268)and VEGF-C expression(P=0.041,r=0.254).With univariate analysis,both HMGB1(P=0.001)and VEGF-C(P=0.004)were identified to be significantly associated with overall survival *** indicated that HMGB1 could be served as an unfavorable independent prognostic factor in IHCCs(P=0.005).si RNA knockdown of HMGB1 inhibited transforming growth factor-β-induced epithelialmesenchymal transition(EMT)by elevating E-Cadherin expression and reducing expression of N-Cadherin,Vimentin and Snail in RBE *** in vitro study revealed that HMGB1 silencing significantly decreased the level of VEGF-C,whereas the recombinant HMGB1increased the VEGF-C level in RBE cells(both P<0.05),which suggested that HMGB1 could promote lymphatic microvessel density,and subsequently lymphatic invasion,via promoting VEGF-C ***:Our results define an important role of HMGB1 in the progression of cholangiocarcinoma,and HMGB1 may serve as a prognostic marker for IHCC pati

关键词： Epithelial-mesenchymal transition High-mobility gr

Neural differentiation of human Wharton＇s jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats

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Neural Regeneration Research 2017年第7期12卷 1103-1110页

作者： Lei Zhang Lin-mei Wang Wei-wei Chen Zhi Ma xiao Han Cheng-ming Liu Xiang Cheng Wei Shi Jing-jing Guo Jian-bing Qin xiao-qing yang Guo-hua Jin Xin-hua Zhang Department of Anatomy Nantong University Nantong Jiangsu Province China Department of Radiation Oncology Third People's Hospital of Yancheng Yancheng Jiangsu Province China Department of Neurosurgery the-Affiliated Hosptial of Nantong University Nantong Jiangsu Province China Department of Obstetricsand Gynecology the Affiliated Hosptial of Nantong University Nantong Jiangsu Province China Co-innovation Center of Neuroregeneration Nantong University Nantong Jiangsu Province China

Human Wharton＇s jelly-derived mesenchymal stem cells（h WJ-MSCs）have excellent proliferative ability,differentiation ability,low immunogenicity,and can be easily ***,there are few studies on their application in the treatment of ischemic stroke,therefore their therapeutic effect requires further *** this study,h WJ-MSCs were transplanted into an ischemic stroke rat model via the tail vein 48 hours after transient middle cerebral artery *** 4 weeks,neurological functions of the rats implanted with h WJ-MSCs were significantly ***,many h WJ-MSCs homed to the ischemic frontal cortex whereby they differentiated into neuron-like cells at this *** results confirm that h WJ-MSCs transplanted into the ischemic stroke rat can differentiate into neuron-like cells to improve rat neurological function and behavior.

关键词： nerve regeneration human Wharton's jelly-derived mesenchymal stem cells ischemic stroke cell transplantation middle cerebral arteryocclusion neural differentiation neurological function neural regeneration

A simple,universal and multifunctional template agent for personalized treatment of bone tumors

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Bioactive Materials 2022年第6期7卷 292-302页

作者： Wei-bo Liu Su-he Dong Wen-hao Hu Meng Gao Teng Li Quan-bo Ji xiao-qing yang Deng-bin Qi Zhen Zhang Ze-Long Song Yu-jie Liu Xue-song Zhang Department of Orthopaedics The Fourth Medical CentreChinese PLA General Hospital51 Fucheng RoadHaidian DistrictBeijing100048China Department of Orthopedic Oncology and Spine Tumor Center Changzheng HospitalSecond Military Medical UniversityShanghai200001China PLA Rocket Force Characteristic Medical Center Beijing100088China School of Medicine Nankai UniversityTianjin300071China

Bone tumors occur in bone or its accessory *** bone tumors are easy to cure and have good prognosis,while malignant bone tumors develop rapidly and have poor and high *** far,there is no satisfactory treatment ***,we designed a universal template vector for bone tumor therapy that simultaneously meets the needs of bone targeting,tumor killing,osteoclast suppression,and tumor *** template is composed of a polydopamine(PDA)core and a multifunctional *** has excellent biosafety and photothermal *** this study,alendronate sodium(ALN)is grafted to enable its general bone targeting *** core can carry a variety of chemotherapy drugs,and the rich ALN group can carry a variety of metal ions with an imaging ***,more personalized treatment plans can be designed for different bone tumor *** addition,the PDA core enables photothermal therapy and enhanced *** template drug Doxorubicin(DOX)and template imaging ion Fe(II),we systematically verified the therapeutic effect,imaging effect,and inhibition of bone dissolution of the agent on Osteosarcoma(OS),a primary malignant bone tumor,in *** conclusion,our work provides a more general template carrier for the clinical treatment of bone tumors,through which personalized treatment of bone tumors can be achieved.

关键词： Bone tumor Osteosarcoma Polydopamine Photothermal therapy

Prediction model of mercury accumulation in fish of reservoirs

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Journal of Environmental Sciences 2000年第S1期12卷 59-65页

作者： JIN Li\|jun\+1, XU xiao\|qing\+2, HUI yang\+2, ZHANG xiao\|hua\+2 (1.Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, China 2.Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China)

Creation of hydroelectric reservoirs in a certain large water system of China has led to a marked rise in mercury content of fish. Correlation analysis and stepwise regression of R (ratio of mercury content in carp from 12 reservoirs and that from rivers of the same water system) and various hydrologic parameters demonstrated that the ratio of catchment area and runoff was the crucial limiting factor. Other limiting factors were the ratio of flooding area of land and reservoir area of dead storage capacity, and the reciprocal of reservoir area. On this basis, the prediction equations of mercury accumulation in carp after reservoir construction, with one and two parameter respectively, were obtained. All these prediction models were proved to be of high precision.

关键词： reservoir mercury contamination prediction model carp