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Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR

Acta Pharmacologica Sinica 2005年第8期26卷 1009-1016页

作者： xiao-qing tang~1, hu bi~1, jian-qiang feng~2, jian-guo cao~3 ~1 department of physiology, nanhua university, hengyang 421001, china ~2 department of physiology, Zhongshan Medical College, Sun Yat sen university, Guangzhou 510080, china ~3 Institute of Oncology, nanhua university, hengyang 421001, china department of physiology Nanhua University Hengyang China department of physiology Zhongshan Medical College Sun Yatsen University Guangzhou China Institute of Oncology Nanhua University Hengyang China

Aim: To investigate the reversal effects of curcumin on multidrug resistance （MDR） in a resistant human gastric carcinoma cell line. Methods: The cytotoxic effect of vincristine （VCR） was evaluated by MTT assay. The cell apoptosis induced by VCR was determined by propidium iodide （PI）-stained flow cytometry （FCM） and a morphological assay using acridine orange （AO）/ethidium bromide （EB） dual staining. P-glycoprotein （P-gp） function was demonstrated by the accumulation and efflux of rhodamine 123 （Rh123） using FCM. The expression of P-gp and the activation of caspase-3 were measured by FCM using fluorescein isothiocyanate （FITC）-conjugated anti-P-gp and anti-cleaved caspase-3 antibodies, respectively. Results: Curcumin, at concentrations of 5 μmol/L, 10 μmol/L, or 20 μmol/L, had no cytotoxic effect on a parent human gastric carcinoma cell line （SGC7901） or its VCR-resistant variant cell line （SGC7901/VCR）. The VCR-IC50value of the SGC7901/VCR cells was 45 times more than that of the SGC7901ceUs and the SGC7901/VCR cells showed apoptotic resistance to VCR. SGC7901/VCR cells treated with 5 μmol/L, 10μmol/L, or 20 μmol/L curcumin decreased the IC50value of VCR and promoted VCR-mediated apoptosis in a dose-dependent manner. Curcumin （10 μmol/L） increased Rh123 accumulation and inhibited the effiux of Rh123 in SGC7901/VCR cells, but did not change the accumulation and efflux of Rh123 in SGC7901 ceils. P-gp was overexpressed in SGC7901/VCR cells, whereas it was downregulated after a 24-h treatment with curcumin （10 μmol/L）. Resistant cells treated with 1 μmol/L VCR alone showed 77% lower levels of caspase-3 activation relative to SGC7901 cells, but the activation of caspase-3 in the resistant cell line increased by 44% when cells were treated with VCR in combination with curcumin. Conclusion: Curcumin can reverse the MDR of the human gastric carcinoma SGC7901/VCR cell line. This might be associated with decreased P-gp function and expression, and the promotion of caspase-3

关键词： curcumin multidrug resistance apoptosis P-glycoprotein caspase-3

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Measurements of Total Reaction Cross Sections for Exotic Nuclei Close to the Proton Drip-line at Intermediate Energies and Observation of a Proton Halo in ^(27)P

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Chinese Physics Letters 2001年第8期18卷 1033-1036页

作者： FANG De-qing SHEN Wen-qing feng Jun CAI Xiang-Zhou MA Yu-Gang ZHANG hu-Yong ZHONG Chen ZHAN Wen-Long guo Zhong-Yan xiao guo-qing WANG jian-Song WANG Jin-Chuan LI Jia-Xing WANG Meng WANG jian-feng NING Zhen-jiang WANG Quan-Jin CHEN Zhi-qiang Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 Institute of Modern Physics Chinese Academy of SciencesLanzhuo 730000 department of Physics Ningbo UniversityNingbo 315211

Measurements of total reaction cross sections(σR)for some proton-rich nuclei(N=11-15 isotones)on carbon target at intermediate energies have been performed on the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou.A large enhancement ofσR for ^(27)P has been observed than for its *** for a proton halo in ^(27)P has been revealed in the Glauber analysis of the total reaction cross sections in terms of the difference factor d.

关键词： Proton neighbor Observation

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Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats

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Neuroscience Bulletin 2013年第4期29卷 484-492页

作者： Hai-hu Hao Li Wang Zhi-jian guo Lang Bai Rui-Ping Zhang Wei-bing Shuang Yi-Jia Jia Jie Wang xiao-Yu Li qiang Liu department of Orthopaedics Dayi Hospital of Shanxi Medical University department of physiology Shanxi Medical University department of Orthopaedics Taiyuan City Centre Hospital department of Radiology First Hospital of Shanxi Medical University department of Urology First Hospital of Shanxi Medical University

Secondary damage is a critical determinant of the functional outcome in patients with spinal cord injury （SCI）, and involves multiple mechanisms of which the most important is the loss of nerve cells mediated by multiple factors. Autophagy can result in cell death, and plays a key role in the development of SCI. It has been recognized that valproic acid （VPA） is neuroprotective in certain experimental animal models, however, the levels of autophagic changes in the process of neuroprotection by VPA treatment following SCI are still unknown. In the present study, we determined the extent of autophagy after VPA treatment in a rat model of SCI. We found that both the mRNA and protein levels of Beclin-1 and LC3 were significantly increased at 1, 2, and 6 h after SCI and peaked at 2 h; however, Western blot showed that autophagy was markedly decreased by VPA treatment at 2 h post-injury. Besides, post-SCI treatment with VPA improved the Basso-Beattie-Bresnahan scale, increased the number of ventral horn motoneurons, and reduced myelin sheath damage compared with vehicle-treated animals at 42 days after SCI. Together, our results demonstrated the characteristics of autophagy expression following SCI, and foundthat VPA reduced autophagy and enhanced motor function.

关键词： spinal cord injury autophagy valproicacid: LC3:Beclin-1

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Total Reaction Cross Section Measurements at Intermediate Energy for the Proton Halo Candidate ^(23)Al and Its Neighbours

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Chinese Physics Letters 2001年第9期18卷 1189-1191页

作者： CAI Xiang-Zhou SHEN Wen-qing feng Jun FANG De-qing Zhu Zhi-Yuan jianG Wei-Zhou MA Yu-Gang ZHANG hu-Yong ZHONG Chen YU Li-Ping ZHAN Wen-Long guo Zhong-Yan xiao Gu-Qhig WANG jian-Song Zhu Yong-Tai WANG Jin-Chuan LI Jia-Xing WANG Meng WANG jian-feng NING Zhen-jiang WANG Quan-Jin CHEN Zhi-qiang Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 CCAST World Laboratory P.O.Box 8730 Beijing 100080 Institute of Modern Physics Chinese Academy of SciencesLanzhuo 730000 department of Physics Ningbo UniversityNingbo 315211

Total reaction cross sections σR for some proton-rich isotones (N = 10) near ^(23)Al on a carbon target have been measured at intermediate energies in the experiment performed at the Radioactive Ion Beam Line of the Heavy Ion Research Facility in Lanzhou. The Z-dependence of σR shows a remarkable enhancement for ^(23)Al relative to its neighbours. The difference factor d has been deduced from the measured σR by using the Glauber or Boltzmann-Uehling-Uhlenbeck models. From the above analysis, a possible one-proton halo structure is suggested for ^(23)Al.

关键词： deduced Total Boltzmann

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Exploring the key pathways of tetrandrine in the treatment of early silicosis based on bioinformatics and in vitro experiments

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Journal of Hainan Medical university 2022年第23期28卷 32-42页

作者： LIANG Chao ZHOU Jia-wei LIU Ya-feng guo jian-qiang WANG qing-sen SU Yixin XING Ying-ru hu Chun-xiao XIE Jun WU Jing hu Dong School of Medicine Anhui University of Science and TechnologyHuainan 232001China Anhui Occupational Health and Safety Engineering Laboratory Huainan 232001China Key Laboratory of Advanced Industrial Dust Purification and Occupational Health and Safety of Education department Huainan 232001China department of Clinical Laboratory Gengjiu Hospital of Anhui ZhongkeHefei 232001China Affiliated Cancer Hospital of Anhui university of Science and Technology/huainan Oriental Hospital Group Cancer Hospital Huainan 232001China

Objective:Exploring the key pathways affecting the development of early silicosis based on bioinformatics and in vitro ***:Collecting differentially expressed genes in silicosis patients through literature mining;Collecting differentially expressed genes in silicon dioxide infusion mice by using a high-throughput gene expression database(GEO);Obtaining disease targets related to silicosis by means of online human Mendelian genetic database(OMIM),GeneCards and comparative toxicgenomics database(CTD);differentially expressed genes and disease targets were subjected to gene ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genome(KEGG)enrichment analysis via R-package and Metascape platforms,*** Schrödinger and Pymol software were used for molecular docking and *** dioxide-stimulated macrophages and epithelial cells were modeled and analyzed by PCR and western blot(WB).Result:2065 differentially expressed genes in silicosis patients,2291 differentially expressed genes in rat infused with silicon dioxide,and 803 targets for silicosis-related diseases were screened *** enrichment analysis mainly involves G protein-coupled receptor binding,the regulation of inflammatory response,and participation in immune *** enrichment analysis of KEGG pathway mainly included ECM-receptor interaction,TNF signaling pathway,and IL-17 signaling ***-17 signaling pathway was screened out from different genes and disease targets,indicating that IL-17 signaling pathway might be the key pathway for the development of *** docking results showed that the silicosis drug tetrandrine had good binding effect with the RAF/MEK/ERK pathway in the IL-17 signaling *** experiments showed that tetrandrine reduced the expression of inflammatory factors such as IL-6 and TGF-βin macrophages by regulating the RAF/MEK/ERKpathway,and inhibited the epithelialmesenchymal transition and expression of inflam

关键词： Silicosis Tetrandrine bioinformatics Molecular docking signal pathway

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun bi Yuanjie bi Tianjian bian Fabrizio bianchi Thomas biekotter Michela biglietti Shalva bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang guofu cao jianshe cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Efficacy of a Chinese herbal formula on hepatitis B e antigenpositive chronic hepatitis B patients

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World Journal of Gastroenterology 2020年第30期26卷 4501-4522页

作者： Yu-feng Xing Chun-Shan Wei Tian-Ran Zhou Dan-Ping huang Wei-Chao Zhong bin Chen hua Jin xiao-Yu hu Zhi-Yun Yang qing He Kai-Ping jiang Jun-Min jiang Zhen-bin hu Xin Deng Fan Yang feng-Yi Li Gang Zhao Li-Chun Wang Yu-qiang Mi Zuo-Jiong Gong Peng guo jian-hua Wu Wei-Qun Shi Hong-Zhi Yang Da-Qiao Zhou Guang-Dong Tong department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina department of Hepatology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina department of Integrated Traditional and Western Medicine on Liver Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China department of Infectious Disease The Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610032Sichuan ProvinceChina department of Integrated Traditional and Western Medicine on Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China The First department of Hepatology Shenzhen No.3 People’s HospitalShenzhen 518100Guangdong ProvinceChina department of Hepatology Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina department of Hepatology Guangdong Hospital of Traditional Chinese MedicineGuangzhou 510006Guangdong ProvinceChina department of Hepatology The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530012Guangxi ProvinceChina department of Hepatology Ruikang HospitalGuangxi University of Chinese MedicineNanning 530012Guangxi ProvinceChina hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430060Hubei ProvinceChina Treatment and Research Center of Infectious Disease 302 Military Hospital of ChinaBeijing 100039China department of Hepatology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201204China Center of Infectious Disease Huaxi HospitalSichuan UniversityChengdu 610044Sichuan ProvinceChina department of Infectious Disease Tianjin Infectious Disease HospitalTianjin 300192China department of Infectious Disease Hubei People’s HospitalWuhan 430060Hubei ProvinceChina department of Hepatology Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing 100080China C

BACKGROUND No guideline recommends antiviral therapy for hepatitis B e antigen(HBeAg)-positive chronic hepatitis B patients with persistently normal alanine aminotransferase levels and a high hepatitis B virus(HBV)DNA viral *** To evaluate the feasibility and safety of a Chinese herbal formula as a therapeutic option for chronic HBV *** In total,395 patients(30–65 years old)with confirmed HBeAg-positive chronic hepatitis B infection and persistently normal alanine aminotransferase were randomized to receive either Chinese herbal formula or placebo for 96 *** to evaluate therapeutic efficacy included:(1)HBV DNA levels decreased to less than 4 log10 IU/mL at weeks 48 and 96;and(2)HBeAg clearance and seroconversion rates at weeks 48 and *** HBV DNA levels≤4 log10 IU/mL were 10.05%at week 48 and 18.59%at week 96 in the treatment *** HBeAg clearance and conversion rates were 8.54%and 8.04%at week 48 and 16.08%and 14.57%at week 96,***,HBV DNA levels≤4 log10 IU/mL were 2.55%and 2.55%at weeks 48 and 96,respectively,and the HBeAg clearance rates were 3.06%and 5.61%at weeks 48 and 96,respectively,in the control *** quantitative hepatitis B surface antigen and HBeAg levels at baseline and changes during the treatment period as well as the alanine aminotransferase elevation at weeks 12 and 24 were strong predictors of HBeAg *** High rates of HBV DNA reduction,HBeAg clearance and seroconversion could be achieved with Chinese herbal formula treatments,and the treatments were relatively safe for HBeAg-positive chronic hepatitis B-infected patients with persistently normal alanine *** ability of the compound to modulate host immune function probably contributed to this effect.

关键词： Chronic hepatitis B Chinese Herbal Formula treatment Hepatitis B e antigen clearance Hepatitis B e antigen seroconversion Hepatitis B virus DNA reduction Clinical trial

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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng huang Wei-Zhu Yang guo-Wen Yin bin-Yan Zhong Jun-hui Sun Zhi-Cheng Jin jian-jian Chen Nai-jian Ge Wen-bin Ding Wen-hui Li Jin-hua huang Wei Mu Shan-Zhi Gu Jia-Ping Li hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming huang Wei Zhao jian-bing Wu Song Wang Xu Zhu jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang guo-hui Xu Wen-Hao hu qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-bing Xu jian Xu qing-hua Wu huan-Zhang Niu jian Wang feng Dai Dui-Ping feng qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-bin Shi jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China department of Interventional Radiology Nantong First People’s HospitalNantong 226001China department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P1).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of china

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biomedical and Environmental Sciences 2014年第5期27卷 353-359页

作者： HOU Xin guo WANG Chuan MA Ze qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min hu Xiu Ping ZHANG Xiu Ping jianG Mei WANG Wei qing NING Guang ZHENG hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu qiang LI Wen Juan xiao Juan GONG Lei WANG Mei jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing jianG Ling CHEN Li department of Endocrinology Qilu Hospital and Institute of Endocrinology and Metabolism Shandong University china National Heavy Duty Truck Group Corporation Hospital Jining Lukang Hospital department of Endocrinology Jining Second People's Hospital Shantui Community Health Center department of Endocrine and Metabolic Diseases Ruijin HospitalShanghai Jiaotong University Medical School

Objective To study the optimal waist circumference （WC） cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of china. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome （MetS） was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of china.

关键词： Waist circumference Metabolic syndrome Central obesity

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun cao Zi-huang cao Jeffrey L.Carlin Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong bing Du Dong-Wei Fan Lei feng jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-hui Hou Wen Hou Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu Zhi-Ying huo Lei Jia Fang-hua jiang Xiang jiang Zhi-Bo jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-hua Li Chang-hua Li Guang-Wei Li Hai-Ning Li jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen huo-Ming Shi Jing Song Yi-Han Song Ding-qiang Su Hong-Jun Su Zheng-Hong tang qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang feng-Fei Wang guo-Min Wang Hai Wang Hong-Chi Wang jian Wang Jia-Ning Wang jian-Ling Wang jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-bing Wu Yu-Zhong Wu xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-hua Yang Hai-feng Yang hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang hua-Wei Zhang jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences university of Science and Technology of china department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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